Chemical Engineering Commons^™

Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules, Daniel J. Valles

Dissertations, Theses, and Capstone Projects

Hypersurface Photolithography (HP) is a printing method for fabricating structures and patterns composed of soft materials bound to solid surfaces and with ~1 micrometer resolution in the x, y, and z dimensions. This platform leverages benign, low intensity light to perform photochemical surface reactions with spatial and temporal control of irradiation, and, as a result, is particularly useful for patterning delicate organic and biological material. In particular, surface- initiated controlled radical polymerizations can be leveraged to create arbitrary polymer and block- copolymer brush patterns. Chapter 1 will review the advances in instrumentation architectures from our group that have made these …

Advances In Modeling Gas Adsorption In Porous Materials For The Characterization Applications, Max A. Maximov

Dissertations

The dissertation studies methods for mesoporous materials characterization using adsorption at various levels of scale and complexity. It starts with the topic introduction, necessary notations and definitions, recognized standards, and a literature review.

Synthesis of novel materials requires tailoring of the characterization methods and their thorough testing. The second chapter presents a nitrogen adsorption characterization study for silica colloidal crystals (synthetic opals). These materials have cage-like pores in the range of tens of nanometers. The adsorption model can be described within a macroscopic approach, based on the Derjaguin-Broekhoff-de Boer (DBdB) theory of capillary condensation. A kernel of theoretical isotherms is …

Shale Softening Based On Pore Network And Laboratory Investigations, Di Zhang

Dissertations

This dissertation consists of two major parts: Firstly, experimental investigation of four major shale softening mechanisms and quantifications of structural parameters. Secondly, numerical simulations of nano-scale flow behaviors using the previous experiments determined parameters based on modified pore network modeling.

Hydraulic fracturing is widely applied to economical gas production from shale reservoirs. Still, the gradual swelling of the clay micro/nano-pores due to retained fluid from hydraulic fracturing causes a gradual reduction of gas production. Four different gas-bearing shale samples are investigated to quantify the expected shale swelling due to hydraulic fracturing. These shale samples are subject to heated deionized (DI) …

Feedstock Powders For Reactive Structural Materials, Daniel Hastings

Dissertations

Metals as fuels have higher energy density per unit mass or volume compared to any hydrocarbon. At the same time, metals are common structural materials. Exploring metals as reactive structural materials may combine their high energy density with attractive mechanical properties. Preparing such materials, however, is challenging. Requirements that need to be met for applications include density, strength, and stability enabling the component to sustain the structure during its desired operation; added requirements are the amount and rate of the energy release upon impact or shock. Powder technology and additive manufacturing are approaches considered for design of reactive structural materials. …

Towards Quality By Design (Qbd) Of Pharmaceutical Oral Films Loaded With Poorly Watersoluble Drugs, Eylul Cetindag

Dissertations

Oral films are an emerging drug delivery dosage form with numerous advantages such as ease of handling, the possibility to circumvent the first-pass metabolism, better patient compliance, capability for continuous manufacturing, and as a platform for personalized medicine. As films are different from other final dosages by their dimensions and their matrix form, further research is required to better understand the impact of excipient and drug on product performance to assure a consistent and good quality product. Therefore, this dissertation aims to contribute towards the processability and manufacturability of films by examining the impact of the materials and processes. First, …

Exploring Fused Deposition Modeling (Fdm) Three-Dimensional Printing Tablet Design Options For Pharmaceutical Dosage Forms, Guluzar Gorkem Buyukgoz

Dissertations

This dissertation examines the use of Fused Deposition Modeling (FDM) based three-dimensional (3D) printing approach for developing patient-specific dosage forms and addressing related technical challenges in such drug delivery systems. The first main objective is to explore pharmaceutical tablet design options using novel FDM 3D printing technology as the drug delivery platform such that drug form and tablet properties are tailored by considering patient age-specific formulations and dissolution control. Of the five different design options, two proposed options meet the main objective of providing similar drug release, whereas the popular option of fixed drug concentration but differing tablet size could …

Development And Characterization Of Composite Membranes For Use In Countercurrent Solvent Extraction, Lydia Neves Rodrigues

Dissertations

Porous membranes having a particular wetting characteristic, hydrophobic or hydrophilic, are used for nondispersive membrane solvent extraction (MSX) where two immiscible phases flow on two sides of the membrane. The aqueous-organic phase interface across which solvent extraction/back extraction occurs remains immobilized on one surface of the membrane. This process requires the pressure of the phase not present in membrane pores to be either equal to or higher than that of the phase present in membrane pores; the excess phase pressure should not exceed a breakthrough pressure. In countercurrent MSX with significant flow pressure drop in each phase, this often poses …

Problems Of Modeling And Control Of The Technological Process Of Ore Grinding, Djalolitdin Pakhritdinovich Mukhitdinov, Sanjar Boybutayev

Chemical Technology, Control and Management

The article analyzes the methods of mathematical modeling of the closed-loop process of fine grinding of ore in order to predict the composition of the crushed raw material. Analyzed modeling methods that consider the control of classification of crushed raw materials and finished products by the size of the recirculating load, simulation modeling methods, methods that use neuro-phase netthe research apparatus, in which the fuzzy logic apparatus serves as a fundamental component for the formation of conclusions. The materials presented in the article reflect the theoretical substantiation and generalization of the accumulated practical experience in modeling and control of the …

Structural-Parametric Analysis And Synthesis Of Control Systems With Two Degrees Of Freedom, Azizbek Nodirbekovich Yusupbekov, Khurshid Salim Ugli Turayev

Chemical Technology, Control and Management

Automatic tuning of the parameters of PID - regulators is proposed by means of a modified experiment that takes into account the influence of elements and circuits in the form of additive uncertainty. The use of a multiply connected control scheme with two degrees of freedom for decoupling is proposed in order to facilitate the implementation of a mechanism for combating the phenomenon of integral saturation. Equations are derived for the transition from a circuit with one degree of freedom to a circuit with two degrees of freedom for the general and special cases of a two-dimensional system, which makes …

Algorithm For The Synthesis Of The Control System Of A Double Mass Elastic Dynamic Object, Isomiddin Khakimovich Siddikov, Gulchekhra Rakhimjonovna Alimova, Davronbek Abdalimovich Khalmatov

Chemical Technology, Control and Management

There are dealt with the creation of a control system for a dynamic object with an elastic property, described by a system of second-order differential equations, further transformed into two polynomial equations in matrix form in a paper. In order to solve the problem of synthesizing the control system, two matrix polynomials with unknown parameters were introduced into the system of equations, which is the transfer function of the controller, the order of which is two, giving the system the properties of astatism. To solve the delivered problem posed, the matrix polynomial equation was transformed into a matrix linear equation …

Preparation Of Meta-Nitrobenzoylhydrazone Ferrocenoylacetone And Synthesis On Its Basis, Zilola Abduraxmonovna Sulaymonova, Bako Bafayevich Umarov Doctor Chemical Science, Professor

Chemical Technology, Control and Management

β-diketone-ferrocenoylacetone was obtained by Claisen condensation. Meta-nitrobenzoylhydrazone of ferrocenoylacetone (H₂L) was synthesized by the interaction of meta-nitrobenzoic acid hydrazide with ferrocenoylacetone. On its basis, complexes with copper(II) and nickel(II) ions were synthesized. The obtained compounds were characterized by the methods of elemental analysis, IR-, ¹H NMR andelectronic spectroscopy. The research results showed that H₂L in solution exists in the form of a tautomeric mixture: hydrazone, α-hydroxyazine, and cyclic 5-hydroxypyrazoline forms. According to the results of IR and ¹H NMR spectra, the complexes were assigned a planar-square structure, and in them the doubly deprotonated …

Application Of Methods Of Intermittent Ventilation Of Industrial Premises Using A Digital Data Transmission System, Yuriy Shipulin, Abdullayev Temur, Jamolidin Usmanov, Shahnoza Ergasheva

Chemical Technology, Control and Management

The article is devoted to topical applied issues, the application of methods of intermittent ventilation of industrial buildings using a digital data transmission system. The requirements for the parameters of the environment are determined, which include: composition, purity, temperature, air humidity, the content of positive and negative ions, the presence of fields of various origins (thermal, optical, biological, gas, and electromagnetic). The authors of the article argue that some of the listed parameters can be supported by ventilation and air conditioning (SCA) systems.

It is shown that when the controlled parameters are limited to a multidimensional area, the SCA control …

Algorithms For Controlling The State Of Executive Mechanisms, Farkhod Kasimov, Mirkhalil Ismailov

Chemical Technology, Control and Management

When constructing automatic control systems, the main attention often is paid to determining the optimal parameters of system regulators than other elements that make up the system. The executive mechanisms also significantly affect the function quality of the control system. In this article, the actuators were considered as a sub-system within the control system and control algorithms with open and closed-loop communication relative to the actuators were investigated. To assess the real state of the actuators, and improved control structure with sensors installed on the moving parts has been developed. For this structure, an algorithm for evaluating and controlling the …

Artificial Neural Networks For Measuring The Moisture Of Bulk Materials, Erkin Uljaev, Shohrux Nurali O‘G‘Li Narzullayev

Chemical Technology, Control and Management

One of the urgent tasks of industrial production is improving the quality of verification of received, manufactured, and stored products, reducing energy consumption in the production of a final product. The solution to this problem is impossible without the creation of devices that control the quality indicators of materials within the limits of the permissible error. One of the most common indicators of the quality of bulk materials is moisture. In the national economy and industrial production, it is required to determine the moisture content of more than 500 different substances and materials. The paper shows the possibility of using …

Analysis Of Errors Of The Ultrasonic Level And Increasing The Accuracy Of Measuring The Level Of Liquid Materials In Non-Stationary Media, Azamat Alijonovich Yusupov

Chemical Technology, Control and Management

This article is devoted to the analysis of the total error of an ultrasonic level meter designed to measure the level of liquid materials in order to improve the accuracy of the measuring system in tanks. The components of the total error of the process of measuring transformation of the liquid level are determined and the analysis of the main characteristics is carried out, to reduce the random error of the measurement system, the task of ensuring the accuracy of measurement and control of the level using an ultrasonic level gauge is presented, by averaging the measurement results when calculating …

Formalization Of The Procedure For Choosing The Optimality Criterion And Formulation The Problem Of Ammonium Nitrate Production Control, Husan Zakirovich Igamberdiev, Uktam Farkhodovich Mamirov

Chemical Technology, Control and Management

The article discusses the questions of formalization of the procedure for choosing an optimality criterion and setting the problem of controlling the production of ammonium nitrate. The analysis of the technical and economic features of the considered production is carried out. As a criterion for the efficient operation of ammonium nitrate production, such a technological indicator as specific technological costs for the main stages, determined by the interval of quasi-stationarity of the object, is used, i.e. the time of its stable work. To solve the control problem, it is proposed to use the decomposition of the control problem into a …

One-Pot Synthesis Of Fe2O3@Fe-N-C Oxygen Reduction Electrocatalyst And Its Performance For Zinc-Air Battery, Hua Lin, Yi-Jin Wu, Jun-Tao Li, Yao Zhou

Journal of Electrochemistry

Oxygen reduction reaction (ORR) plays a profound role in determining cathode performance in metal-air batteries and fuel cells. Owing to its inherently sluggish kinetics, high-performance ORR catalysts which favors the scissoring of O-O bond and formation of O-H bond are a requisite. In this regard, Pt has been explored as the most efficient ORR electrocatalysts. Nevertheless, due to its expensiveness, the usage of Pt catalysts represents one of the major sources of cost in those energy conversion devices. Thus, the development of alternative ORR electrocatalysts with minimized Pt utilization has been widely pursued over the past few decades. Metal-nitrogen-carbon catalysts …

Dft Study Of NiM@Pt1AuN-M-1 (N=19, 38, 55, 79; M = 1, 6, 13, 19) Core-Shell Orr Catalyst, Wen-Jie Li, Dong-Xu Tian, Hong Du, Xi-Qiang Yan

Journal of Electrochemistry

The slow kinetics of oxygen reduction reaction (ORR) limits the performance of low temperature fuel cells. Thus, it needs to design effective catalysts with low cost. Core-shell clusters (CSNCs) show promising activity because of their size-dependent geometric and electronic effects. The ORR activity trend of Ni_m@Pt₁Au_n-m-1(n = 19, 38, 55, 79; m = 1, 6, 13, 19) was studied using the GGA-PBE-PAW methods. The adsorption configurations of *O, *OH and *OOH were optimized and the reaction free energies of four proton electron (H⁺ + e^-) transfer steps …

Preparation And Electrochemical Evaluation Of Mos2/Graphene Quantum Dots As A Catalyst For Hydrogen Evolution In Microbial Electrolysis Cell, Hong-Yan Dai, Hui-Min Yang, Xian Liu, Xiu-Li Song, Zhen-Hai Liang

Journal of Electrochemistry

Microbial electrolysis cell (MEC) is a relatively new bioelectrochemical technology that produces H₂ and meanwhile treats organic wastewater. Cathode hydrogen evolution catalyst plays a key role in MEC. The doping of Graphene Quantum Dots (GQDs) into MoS₂ nanosheets can improve the catalytic activity of MoS₂ by creating abundant defect sites both in the edge plane and the basal plane, as well as enhancing the electrical conductivity. In this paper, using Na₂MoO₄ , cysteine and GQDs as raw materials, a series of MoS₂/GQDs composites were firstly synthesized via hydrothermal method, and then loaded …

Preparation Of Coo/Rgo@Ni Foam Electrode And Its Electrocatalytic Reduction Of Co2, Qian Guo, Jia-Long Fu, Cheng-Yan Zhang, Chao-Yue Cai, Cheng Wang, Li-Hua Zhou, Rui-Bo Xu, Ming-Yan Wang

Journal of Electrochemistry

The worldwide extensive release of carbon dioxide (CO₂) has caused serious environmental pollution and unprecedented climate change problems. Thus, for the sustainable development of human society, it is very necessary to convert CO₂ to renewable fuels through clean and economical processes. The electrochemical CO₂ reduction reaction (CO₂RR) is regarded as a promising approach for the recycling of carbon resource and the generation of sustainable fuels. However, the slow kinetics and formation of multiple products in CO₂RR hinder its large-scale application. Hence, great research efforts are made to develop electrocatalysts with high product …

No Ordinary Proteins: Adsorption And Molecular Orientation Of Monoclonal Antibodies, Ankit D. Kanthe, Andrew Ilott, Mary Krause, Songyan Zheng, Jinjiang Li, Wei Bu, Mrinal K. Bera, Binhua Lin, Charles Maldarelli, Raymond S. Tu

Publications and Research

The interaction of monoclonal antibodies (mAbs) with air/water interfaces plays a crucial role in their overall stability in solution. We aim to understand this behavior using pendant bubble measurements to track the dynamic tension reduction and x-ray reflectivity to obtain the electron density profiles (EDPs) at the surface. Native immunoglobulin G mAb is a rigid molecule with a flat, “Y” shape, and simulated EDPs are obtained by rotating a homology construct at the surface. Comparing simulations with experimental EDPs, we obtain surface orientation probability maps showing mAbs transition from flat-on Y-shape configurations to side-on or end-on configurations with increasing concentration. …

Merging Of Horizontally And Vertically Separated Small-Scale Buoyant Flames, Thomas H. Fletcher, Denver Haycock, Seth Tollefsen, David Lignell

Faculty Publications

The purpose of this study was to investigate the merging behavior of small-scale buoyant flames that might be representative of flames from a leaf in a shrub. Zirconia felt pads soaked in n-heptane were suspended on thin rods and spaced both horizontally and vertically. Time-dependent video images from flames from two-pad and three-pad configurations were analyzed to determine merging probability, combined flame characteristics (height, area, and width), and changes in burn time. Correlations of these combined flame characteristics were developed based on horizontal and vertical spacing between the pads. Merging probability correlated with an exponential function that was quadratic in …

Engineering The Surface Of Fe3o4 Nanoparticles For Catalytic And Magnetic Applications, Natalia Da Silva Moura

LSU Doctoral Dissertations

With the rapid depletion of the U.S. energy resources coupled with population growth, heat management technologies must be improved to sustain our quality of life. Precisely, in catalysis, it is estimated that only ~50% of the energy supplied to the reactor is used for product conversion due to dissipation losses. Among the emerging technologies with a promising reduction in heat losses is induction heating, offering targeted heat delivery with magnetic nanoparticles. Under alternating magnetic fields (AMF), these nanoparticles can absorb the energy from Radio-Frequency (RF) fields and dissipate it as heat on the nanoparticle surface. This in situ heat generation …

Gum Arabic-Capped Silver Nanoparticles For Electrochemical Amplification Sensing Of Methylene Blue In River Water, Ziad Khalifa, Moustafa Zahran, Magdy Zahran, Magdi Abdelazzem

Chemical Engineering

Herein, a novel electrochemical amplification sensor is developed for detecting methylene blue (MB) us- ing gum Arabic-capped silver nanoparticles (AgNPs) for the first time. Gum Arabic-AgNPs were fabricated via a direct chemical reduction technique using silver nitrate as an AgNPs precursor and gum Arabic as a reducing and capping agent. They were characterized using ultraviolet-visible (UV–Vis) spectrophotom- etry, square wave voltammetry (SWV), and transmission electron microscopy (TEM). UV–Vis and SWV results show the characteristic absorption and electrochemical oxidation peaks of the AgNPs at 431 nm and 0.18 V, respectively. Additionally, TEM images of the AgNPs show that they are spherical …

Analytical Model For Electromagnetic Induction In Pulsating Ferrofluid Pipe Flows, Huiyu Wang, John G. Monroe, Swati Kumari, Serhiy O. Leontsev, Erick S. Vasquez, Scott M. Thompson, Matthew J. Berg, Dibbon Keith Walters, Keisha B. Walters

Chemical and Materials Engineering Faculty Publications

No abstract provided.

Elementary Reaction-Based Kinetic Model For The Fate Of: N -Nitrosodimethylamine Under Uv Oxidation, Benjamin Barrios, Divya Kamath, Erica Coscarelli, Daisuke Minakata

Michigan Tech Publications, Part 1

UV photolysis is an effective process to remove nitrosamines from contaminated water resources. Nitrosamines represent a class of compounds with high potential for carcinogenicity and, therefore, there are serious concerns regarding their threat to human health and their environmental toxicity. Although the photochemical parameters of parent nitrosamines and their initial reaction pathways are well understood, the fate of nitrogen-containing species and reactive nitrogen species generated from nitrosamine degradation has not yet been elucidated. In this study, we develop an elementary reaction-based kinetic model for the photolysis of N-nitrosodimethylamine (NDMA) and the photochemical transformation products. We use density functional theory quantum …

Novel Method Of Manufacture Of Metal Nanoparticles And Metal Single-Atom Materials On Various Substrates And Novel Compositions, Xinhua Liang, Xiaofeng Wang

Chemical and Biochemical Engineering Faculty Research & Creative Works

The present invention discloses a novel method and novel compositions comprising well-dispersed particulate metal materials, including metal nanoparticles and/or metal single-atom materials, on various substrates, said method comprising the use of atomic layer deposition (ALD) and optimization of the metal precursor dose time and the number of ALD cycles. Illustrative of the metals are Fe, Ni, Co, Ru, Rh, Ir, Os, Pt, Pd, and the like; and illustrative of the various substrates are carbon nanotubes (CNTs) (including multi-walled carbon nanotubes (MWCNTs), SiO₂, TiO₂, alumina, CeO₂, ZnO, ZrO₂, activated carbon, CuO, Fe_{2 …}

Heteroacene-Based Amphiphile As A Molecular Scaffold For Bioimaging Probes, Tharindu A. Ranathunge, Mahesh Loku Yaddehige, Jordan H. Varma, Cameron Smith, Jay Nguyen, Iyanuoluwani Owolabi, Wojciech Kolodziejczyk, Nathan I. Hammer, Glake Hill, Alex Flynt, Davita L. Watkins

Faculty and Student Publications

The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6H-pyrrolo[3,2-b:4,5-b’]bis [1,4]benzothiazine (TRPZ). TRPZ is a heteroacene with a rigid, pi-conjugated structure, multiple reactive sites, and unique spectroscopic properties. Here we coupled TRPZ to a tert-butyl carbamate (BOC) protected 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) dendron via azide-alkyne Huisgen cycloaddition. Deprotection of the protected amine groups on the dendron afforded a cationic terminated amphiphile, TRPZ-bisMPA. TRPZ-bisMPA was nanoprecipitated into water to obtain nanoparticles (NPs) with a hydrodynamic radius that was comparison, TRPZ-PG was encapsulated in pluronic-F127 (Mw = 12 kD), a polymer surfactant …

Electrochemical Micro-Aptasensors For Exosome Detection Based On Hybridization Chain Reaction Amplification, Wenfen Zhang, Zhenhua Tian, Shujie Yang, Joseph Rich, Shuaiguo Zhao, Mikael Klingeborn, Po-Hsun Huang, Zhishang Li, Alexander Stout, Quinn Murphy, Edward Patz, Shusheng Zhang, Guozhen Liu, Tony Jun Huang

Faculty Publications

Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry, such as nucleic acids and proteins. However, most existing exosome-based analytical sensing methods struggle to achieve high sensitivity and high selectivity simultaneously. In this work, we present an electrochemical micro-aptasensor for the highly sensitive detection of exosomes by integrating a micropatterned electrochemical aptasensor and a hybridization chain reaction (HCR) signal amplification method. Specifically, exosomes are enriched on CD63 aptamer-functionalized electrodes and then recognized by HCR products with avidin-horseradish peroxidase (HRP) attached using EpCAM aptamers as …

Threshold Concentration And Random Collision Determine The Growth Of The Huntingtin Inclusion From A Stable Core, Sen Pei, Theresa C. Swayne, Jeffrey F. Morris, Lesley Emtage

Publications and Research

The processes underlying formation and growth of unfolded protein inclusions are relevant to neurodegenerative diseases but poorly characterized in living cells. In S. cerevisiae, inclusions formed by mutant huntingtin (mHtt) have some characteristics of biomolecular condensates but the physical nature and growth mechanisms of inclusion bodies remain unclear. We have probed the relationship between concentration and inclusion growth in vivo and find that growth of mHtt inclusions in living cells is triggered at a cytoplasmic threshold concentration, while reduction in cytoplasmic mHtt causes inclusions to shrink. The growth rate is consistent with incorporation of new material through collision and coalescence. …