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Bionanotechnology And The Future Of Glioma, Peter A. Chiarelli, Forrest M. Kievit, Miqin Zhang, Richard G. Ellenbogen 2015 University of Washington, Seattle

Bionanotechnology And The Future Of Glioma, Peter A. Chiarelli, Forrest M. Kievit, Miqin Zhang, Richard G. Ellenbogen

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Designer nanoscaled materials have the potential to revolutionize diagnosis and treatment for glioma. This review summarizes current progress in nanoparticle‑based therapies for glioma treatment including targeting, drug delivery, gene delivery, and direct tumor ablation. Preclinical and current human clinical trials are discussed. Although progress in the field has been significant over the past decade, many successful strategies demonstrated in the laboratory have yet to be implemented in human clinical trials. Looking forward, we provide examples of combined treatment strategies, which harness the potential for nanoparticles to interact with their biochemical environment, and simultaneously with externally applied photons or magnetic fields. …


Nanoparticle Mediated Silencing Of Dna Repair Sensitizes Pediatric Brain Tumor Cells To Y-Irradiation, Forrest M. Kievit, Zachary R. Stephen, Kui Wang, Christopher J. Dayringer, Jonathan G. Sham, Richard G. Ellenbogen, John R. Silber, Miqin Zhang 2015 University of Washington

Nanoparticle Mediated Silencing Of Dna Repair Sensitizes Pediatric Brain Tumor Cells To Y-Irradiation, Forrest M. Kievit, Zachary R. Stephen, Kui Wang, Christopher J. Dayringer, Jonathan G. Sham, Richard G. Ellenbogen, John R. Silber, Miqin Zhang

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Medulloblastoma (MB) and ependymoma (EP) are the most common pediatric brain tumors, afflicting 3000 children annually. Radiotherapy (RT) is an integral component in the treatment of these tumors; however, the improvement in survival is often accompanied by radiation-induced adverse developmental and psychosocial sequelae. Therefore, there is an urgent need to develop strategies that can increase the sensitivity of brain tumors cells to RT while sparing adjacent healthy brain tissue. Apurinic endonuclease 1 (Ape1), an enzyme in the base excision repair pathway, has been implicated in radiation resistance in cancer. Pharmacological and specificity limitations inherent to small molecule inhibitors of Ape1 …


Integrating Ecological And Engineering Concepts Of Resilience In Microbial Communities, Hyun-Seob Song, Ryan S. Renslow, Jim K. Fredrickson, Stephen R. Lindemann 2015 Pacific Northwest National Laboratory

Integrating Ecological And Engineering Concepts Of Resilience In Microbial Communities, Hyun-Seob Song, Ryan S. Renslow, Jim K. Fredrickson, Stephen R. Lindemann

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Many definitions of resilience have been proffered for natural and engineered ecosystems, but a conceptual consensus on resilience in microbial communities is still lacking. We argue that the disconnect largely results from the wide variance in microbial community complexity, which range from compositionally simple synthetic consortia to complex natural communities, and divergence between the typical practical outcomes emphasized by ecologists and engineers. Viewing microbial communities as elasto-plastic systems that undergo both recoverable and unrecoverable transitions, we argue that this gap between the engineering and ecological definitions of resilience stems from their respective emphases on elastic and plastic deformation, respectively. We …


Center Pivot Sprinkler Distribution Uniformity Impacts On The Spatial Variability Of Evapotranspiration, Daniel Howes, Sean Ellenson, Lucas Hoffmann, Franklin Gaudi 2014 California Polytechnic State University - San Luis Obispo

Center Pivot Sprinkler Distribution Uniformity Impacts On The Spatial Variability Of Evapotranspiration, Daniel Howes, Sean Ellenson, Lucas Hoffmann, Franklin Gaudi

BioResource and Agricultural Engineering

Understanding variable evapotranspiration (ET) throughout a field can help maximize yield on a per-acre basis, as well as assist with proper irrigation scheduling. The results from this study indicate that irrigation system distribution uniformity (DU) has a significant effect on the uniformity of ET during water-stressed periods. The study site involved intensely managed forage (alfalfa and winter grain hay) irrigated by center pivots being supplied with reclaimed water near Palmdale, California. During spring and early summer 2007 the center pivots were operating under deficit irrigation. In 2010, after the installation of reservoirs, water was applied to meet full evapotranspiration (ETc) …


Nông Thôn Mới And Rural Development In The Mekong Delta: A Comparative Study Of Bàu Môn And Hòa Phụng C Hamlets, Alex Lintz 2014 SIT Study Abroad

Nông Thôn Mới And Rural Development In The Mekong Delta: A Comparative Study Of Bàu Môn And Hòa Phụng C Hamlets, Alex Lintz

Independent Study Project (ISP) Collection

Vietnam’s Nông Thôn Mới or New Rural Development program is a relatively new target program introduced in 2010. As of yet there has been little research done on its effects on the economies in rural areas. This paper attempts to analyze the economic situation in the Bàu Môn and Hòa Phụng C hamlets with a particular emphasis placed on income and factors that affect income in terms of Vietnam’s Nông Thôn Mới or New Rural Development program. In order to assess the economic situation in the hamlets, a survey was administered to 25 participants in each hamlet and leaders from …


Single- And Dual-Porosity Calibration And Long-Term Modeling Of Highly Conductive Floodplain Soils In The Ozark Ecoregion, Ryan P. Freiberger 2014 University of Nebraska-Lincoln

Single- And Dual-Porosity Calibration And Long-Term Modeling Of Highly Conductive Floodplain Soils In The Ozark Ecoregion, Ryan P. Freiberger

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Phosphorus (P) is a critical nutrient for agriculture, but is also responsible for surface water enrichment that leads to algal growth. While P loading to surface waters has traditionally been thought to occur from surface runoff, contributions from subsurface transport can also be significant. Subsurface transport through gravelly soils in the Ozark ecoregion can have a significant, yet poorly-documented effect on P movement to groundwater.

Long-term P modeling was performed in HYDRUS-1D and 2D using data collected from short-term plot experiments featuring gravelly soils. Seven model levels were developed to illustrate a wide variety of laboratory and field conditions. Calibration …


Effect Of Different Extrusion Processing Parameters On Physical Properties Of Soy White Flakes And High Protein Distillers Dried Grains-Based Extruded Aquafeeds, Sushil Kumar Singh, Kasiviswanathan Muthukumarappan 2014 South Dakota State University

Effect Of Different Extrusion Processing Parameters On Physical Properties Of Soy White Flakes And High Protein Distillers Dried Grains-Based Extruded Aquafeeds, Sushil Kumar Singh, Kasiviswanathan Muthukumarappan

Agricultural and Biosystems Engineering Publications

Nutritionally balanced ingredient blends for catla (Catla catla), belonging to the family Cyprinidae, were extruded using single screw extruder. The extrusion was carried out at five levels of soy white flakes content (21%, 29%, 40%, 52%, and 59% db), five levels of moisture content (15, 19, 25, 31, and 35% db) and five levels of barrel temperature (100, 110, 125, 140, and 150 ºC) using three different die nozzles (having L/D ratios 3.33, 5.83, and 7.25). Blends with net protein content of 32.5% contains soy white flakes, along with high protein distillers dried grains (HP-DDG), corn flour, corn gluten meal, …


Modernization Of The Walker River Irrigation District Water Gauges, Stuart Styles, Robert C. Bryan, Kenneth C. Spooner 2014 California Polytechnic State University, San Luis Obispo

Modernization Of The Walker River Irrigation District Water Gauges, Stuart Styles, Robert C. Bryan, Kenneth C. Spooner

BioResource and Agricultural Engineering

The Irrigation Training and Research Center (ITRC) and Walker River Irrigation District (WRID) collaborated on WRID’s Water Gauge Improvement Project with support from the Bureau of Reclamation, U.S. Department of Interior in Carson City, Nevada. This paper presents a summary of the proposed plan and implementation for improving water gauges in WRID with strategic engineering recommendations for new hardware and control equipment; water management strategies; flow measurement devices; and integration of a new district-wide SCADA system. Field investigations and engineering analyses were carried out by the ITRC in 2009 to inspect existing WRID infrastructure, to review current operational procedures, and …


First Proof Of Concept Of Sustainable Metabolite Production From High Solids Fermentation Of Lignocellulosic Biomass Using A Bacterial Co-Culture And Cycling Flush System, Wanying Yao, Sue E. Nokes 2014 University of Kentucky

First Proof Of Concept Of Sustainable Metabolite Production From High Solids Fermentation Of Lignocellulosic Biomass Using A Bacterial Co-Culture And Cycling Flush System, Wanying Yao, Sue E. Nokes

Biosystems and Agricultural Engineering Faculty Publications

To improve the lignocellulose conversion for ABE in high solids fermentation, this study explored the feasibility of cycling the process through the cellulolytic or/and solventogenic phases via intermittent flushing of the fermentation media. Five different flushing strategies (varying medium ingredients, inoculum supplement and cycling through phases) were investigated. Flushing regularly throughout the cellulolytic phase is necessary because re-incubation at 65 °C significantly improved glucose availability by at least 6-fold. The solvents accumulation was increased by 4-fold using corn stover (3-fold using miscanthus) over that produced by flushing only through the solventogenic phase. In addition, cycling process was simplified by re-incubating …


Comparison And Cost Analysis Of Growing Hops In A Greenhouse Versus An Outside Environment, Preston Way 2014 California Polytechnic State University, San Luis Obispo

Comparison And Cost Analysis Of Growing Hops In A Greenhouse Versus An Outside Environment, Preston Way

BioResource and Agricultural Engineering

No abstract provided.


Analysis For Updating An Irrigation Pumping Station With Variable Frequency Drives, Kirk Teixeira 2014 California Polytechnic State University, San Luis Obispo

Analysis For Updating An Irrigation Pumping Station With Variable Frequency Drives, Kirk Teixeira

BioResource and Agricultural Engineering

No abstract provided.


Analysis Of San Luis Obispo Historic Precipitation Data And Calibration Of The Cal Poly Weather Station, Hilary Olsen 2014 California Polytechnic State University, San Luis Obispo

Analysis Of San Luis Obispo Historic Precipitation Data And Calibration Of The Cal Poly Weather Station, Hilary Olsen

BioResource and Agricultural Engineering

No abstract provided.


Design And Construction Of A Solar Water Purification System Using Ultraviolet Radiation, Bryan Wilson 2014 California Polytechnic State University, San Luis Obispo

Design And Construction Of A Solar Water Purification System Using Ultraviolet Radiation, Bryan Wilson

BioResource and Agricultural Engineering

No abstract provided.


Irrigation Drip System Design For A Vineyard, Riley Way 2014 California Polytechnic State University, San Luis Obispo

Irrigation Drip System Design For A Vineyard, Riley Way

BioResource and Agricultural Engineering

No abstract provided.


Feedlot Manure Management Considerations Including Anaerobic Digestion Potential And Mineral Retention, Andrea K. Watson 2014 University of Nebraska-Lincoln

Feedlot Manure Management Considerations Including Anaerobic Digestion Potential And Mineral Retention, Andrea K. Watson

Department of Animal Science: Dissertations, Theses, and Student Research

Three anaerobic digestion trials were conducted to evaluate methane production from feedlot manure. As organic matter content of manure decreased, degradation of manure and methane production also linearly decreased (P ≤ 0.02). Quality, or organic matter content of manure, had a greater impact on anaerobic digestion than diet (with and without distillers grains) fed to cattle. Minerals are concentrated in effluent removed from anaerobic digesters.

Knowing mineral retention within cattle allows for more accurate calculation of mineral excretion in manure. Three serial slaughter trials measured mineral retention in growing and finishing cattle. During a growing phase, beef cattle gaining …


Aquaponics Art, Alexander Horton 2014 California Polytechnic State University - San Luis Obispo

Aquaponics Art, Alexander Horton

Liberal Arts and Engineering Studies

Aquaponics has enormous potential to change the way we farm. I wanted to connect more people to Cal Poly's first aquaponics club by creating a functioning aquaponics art installation that allows people to plant their own plants. This paper is catalog of the design process as a reflection of what this project hopes to accomplish.


Potential For Optical Sensor-Based Nitrogen Fertilization In Grain Sorghum (Sorghum Bicolor L. Moench) In Arkansas, Kamil H. Rosales Rodriguez 2014 University of Arkansas, Fayetteville

Potential For Optical Sensor-Based Nitrogen Fertilization In Grain Sorghum (Sorghum Bicolor L. Moench) In Arkansas, Kamil H. Rosales Rodriguez

Graduate Theses and Dissertations

Ground-based active-optical (GBAO) crop sensors have become an effective tool to improve nitrogen (N) use efficiency and to predict yield early in the growing season, particularly for grass crops. Commercially available canopy sensors calculate the normalized difference vegetative index (NDVI) by emitting light in the red and near infrared range of the electromagnetic spectrum. The NDVI is used to evaluate vigor status and to estimate yield potential. However, few studies have been conducted to compare the performance of commercially available sensors. Therefore, a study was conducted using the most common crop canopy sensors: i) N-Tech's GreenSeekerTM (GS), ii) Holland …


Methane Production By A Packed-Bed Anaerobic Digester Fed Dairy Barn Flush Water, Sean Richard Thomson 2014 California Polytechnic State University, San Luis Obispo

Methane Production By A Packed-Bed Anaerobic Digester Fed Dairy Barn Flush Water, Sean Richard Thomson

Master's Theses

Packed-bed digesters are an alternative to covered lagoon digesters for methane production and anaerobic treatment of dilute wastewaters such as dairy barn flush water. The physical media of packed-beds retain biofilms, often allowing increased treatment rates. Previous studies have evaluated several types of media for digestion of dilute wastewaters, but cost and media fouling have setback commercial development. A major operational cost has been effluent recirculation pumping.

In the present effort, a novel approach to anaerobic digestion of flush dairy water was developed at pilot-scale: broken walnut shells were used as a low-cost packed-bed medium and effluent recirculation was replaced …


United States Patent Application Publication, John H. Posselius, Christopher A. Foster, Santosh Pitla, Scott A. Shearer, Joe D. Luck, Michael P. Sama, Rodrigo S. Zandonadi 2014 Ephrata, PA

United States Patent Application Publication, John H. Posselius, Christopher A. Foster, Santosh Pitla, Scott A. Shearer, Joe D. Luck, Michael P. Sama, Rodrigo S. Zandonadi

Department of Agricultural and Biological Systems Engineering: Faculty Publications

A multiple robot control architecture including a plurality of robotic agricultural machines including a first and second robotic agricultural machine. Each robotic agricultural machine including at least one controller configured to implement a plurality of finite state machines Within an individual robot control architecture (IRCA) and a global information module (GIM) communicatively coupled to the IRCA. The GIMs of the first and second robotic agricultural machines being configured to cooperate to cause said first robotic agricultural machine and said second agricultural machine to perform at least one agricultural task.


Winegrape Vineyards And Winery Operations: Energy Efficiency/ Sustainability And Expansion, Stuart Styles, Sierra Layous, Sarah Crable 2014 California Polytechnic State University, San Luis Obispo

Winegrape Vineyards And Winery Operations: Energy Efficiency/ Sustainability And Expansion, Stuart Styles, Sierra Layous, Sarah Crable

BioResource and Agricultural Engineering

Southern California Edison (SCE) provides utility services to the greater southern California area. Vineyards and wineries exist throughout the region, and historical data suggests that that they largely do not utilize incentive programs offered by the utility.

As the first phase in a larger study, the Irrigation Training & Research Center (ITRC), located at the California Polytechnic State University, San Luis Obispo, completed a characterization of the vineyard and winery sector as it pertains to energy and water usage in SCE’s service area, including the following major tasks:

  1. Identification of vineyard and winery demographics in SCE’s service area.
  2. Identification of …


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