Bilingual, Multilingual, and Multicultural Education Commons^™

Application Of The Transtheoretical Model In Hispanic And African American Populations To Assess Deceased Kidney Donor Noncompliance, Cynthia Mancilla, Amy D. Waterman, Phd, Crystal Kynard-Amerson, Mph, Aubre Parnicky, Msw

Journal of Health Disparities Research and Practice

Given existing health disparities such as financial barriers, lack of education and inadequate health care in minority communities, the rates of deceased kidney donation continues to decline. The transtheoretical model (TTM) assesses the patients’ willingness to pursue deceased kidney donation through application of a stage structured curriculum.

Patients are evaluated into five different stage groups; pre-contemplation, contemplation, preparation, action, and maintenance. This assessment of behavior change as applied to the willingness of a patient to pursue a deceased kidney donor transplant can be tracked over time and used to help determine what stage of change a patient is in during …

Exploration Of Antagonist Efficacy For Lpra2 Like Peptide, Ayobami Loye, Ruben R. Gonzalez-Perez, Phd

Journal of Health Disparities Research and Practice

Leptin is a small protein hormone that controls satiety and is produced by adipocytes. Obese people have increased levels of circulating leptin. Excessive leptin levels cause a break down in the control of leptin signaling pathways leading to increased angiogenesis, proliferation, cell migration, invasion, and anti-apoptotic events. Obesity and leptin signaling have been linked to cancer progression. Literature shows that LPrA2 is an effective leptin antagonist as it decreases proliferation of breast cancer cells in vitro.

This project compares the effectiveness of LPrA2 like compounds in breast cancer cell-line MDA-MB-468 (M-468 BCs). We hypothesize that the new peptide antagonists have …

Design And Optimization Of A Mycoplasma Detection Assay, Carlos J. León-Rodríguez, Richard J. Noel, Jr., Phd, Tirtsa Porrata-Doria, Ms

Journal of Health Disparities Research and Practice

Mycoplasma are among the smallest free living microorganisms. These bacteria grow slowly, lack a rigid cell wall and are not eliminated by filter sterilization methods used in tissue culture. Mycoplasma infection affects biochemical and genetic aspects of cultured cells, resulting in experimental inconsistency. Therefore, it is necessary to establish routine testing for mycoplasma contamination in tissue culture laboratories.

Our goal is to develop a reliable and cost-effective test for mycoplasma in cell culture based on established methods found in literature. We first cloned and sequenced a PCR product from a commercial mycoplasma detection kit. Sequencing revealed the 16s rRNA as …

Role Of Hiv-1 Nef Lysine Residues 4 And 7 In The Interaction With Calnexin And Inhibition Of Abca1 Activity, Valeria Kaufman, Michael Burkinsky, Md, Phd, Ruth Hunegnaw, Msc, Phd Candidate

Journal of Health Disparities Research and Practice

Patients infected with HIV are at increased risk of developing atherosclerosis, a result due partly to the functional impairment of cellular cholesterol transporter, ATP-binding cassette transporter A1 (ABCA1). This transporter mediates efflux of cholesterol from cells to high density lipoprotein, thus allowing cells to maintain normal levels of cholesterol. When ABCA1 function is inhibited, cells, and in particular macrophages, accumulate cholesterol, resulting in formation of atherosclerotic plaques. The HIV-1 protein, Nef downregulates ABCA1 and inhibits the activity of this protein, thereby reducing cholesterol efflux and promoting atherosclerosis, but the molecular mechanism by which Nef inhibits ABCA1 is unknown.

Previous studies …

Collagen Iv Assembly: Production Of A Recombinant Construct For Mechanistic Studies, Kennedy Harris, Billy Hudson, Phd, Isi Ero-Tolliver, Phd, Kyle Brown, Phd

Journal of Health Disparities Research and Practice

Basement membranes, specialized extracellular matrix, provide mechanical support for epithelial cells and shape cell behavior by interacting with cell receptors. Collagen IV, the predominant component of basement membrane, comprises six genetically distinct alpha chains (α1 to α6) that assemble to form protomers, which associate to form hexamers, in the scaffold. Non-assembly due to mutations within alpha chains give rise to kidney diseases. Yet, the mechanism of assembly is poorly understood.

Preliminary data in our lab indicated that amino acid 78 of collagen IV α2 NC1 (non-collagenous) domains may play a role in a chloride-dependent switch that supports hexamer formation. We …

Sex Differences In The Sex Differences In The Effects Of Environmental Enrichment After An Early Life Stressor, Alfredo Gutierrez, Annelyn Torres-Reverón, Phd, Raura Doreste-Méndez

Journal of Health Disparities Research and Practice

Studies have shown that environmental enrichment can compensate for the effects of an early life stressor such as maternal separation. Behavioral responses and immunohistochemical markers in rats are affected by environmental enrichment after maternal separation. In this study we seek to investigate whether sex influences the behavioral responses of environmental enrichment after maternal separation.

Prior scientific evidence suggests that there are behavioral sex differences in: 1) neural processes underlying successful or failed fear extinction (Gruene et al, 2014); (2) prenatal stress exposure and response to behavioral anxiety tests (Said et al, 2015); and (3) glutamate receptor expression in response to …

Cox2 Plays An Important Role In Maintenance Of Mammary Cancer Stem Cell Population In Human Breast Cancer Cell Lines, Mayra Garcia, Shehla Pervin, Phd, Easter Thames, Meher Parveen, Phd, Melanie Baker

Journal of Health Disparities Research and Practice

Breast cancer is a malignant growth in the adipose-rich mammary gland. Initiation and progression of breast tumors involve multiple cell types, among which mammary cancer stem cells play an important role. There are two main types of adipocytes; white adipocytes have previously been found to influence the disease while brown adipocytes, which uniquely express uncoupling protein 1 (UCP1), were recently detected in breast tumors.

We have detected Myf5, a transcription factor, which is expressed in the progenitor population of brown adipocytes, in breast cancer cell lines. We also found an association between expression of Myf5 and COX2 (or Ptgs2), which …

The Role Of Integrin-Associated Protein “Pinch” In Kidney Development, Tyrone Gamble Jr, Roy Zent, Phd, Bertha C. Elias, Phd

Journal of Health Disparities Research and Practice

PINCH (a particularly interesting new cysteine-histidine-rich protein) is a protein that binds with Integrin-linked kinase and Parvin, to form an IPP complex. This complex is formed only when integrin molecules are activated upon interaction with the basement membrane. The IPP complex then acts as a platform for other proteins to come together and regulate cell signaling to and from the extracellular matrix (ECM). This allows for various cellular activities to progress like cell adhesion, migration, proliferation, etc. There are two types of PINCH proteins, PINCH-1 and PINCH-2. Studies from our group have shown that the lack of PINCH-1 in the …

Nitric Oxide And Cyclic Gmp Signaling In Cancer Therapy, Armond Dorsey, Ferid Murad, Md, Phd, Ka Bian, Md, Phd

Journal of Health Disparities Research and Practice

The nitric oxide-3’,5’-cyclic guanosine monophosphate signaling pathway (NO-cGMP signaling pathway) is a well-known signal transduction pathway which elicits several physiological processes including: cell proliferation, vasodilation, cardiac protection, etc. In this pathway, NO binds to the ferrous heme of histidine-105 on the prosthetic heme of the β₁ subunit of soluble guanylyl cyclase, resulting in the production of cGMP. This pathway, however, is inhibited in certain cancer cells—as observed in glioma cell lines. As a result, the production of cGMP is reduced. This mechanism may facilitate uncontrolled tumor cell growth.

The cancers under research—lung carcinoma, glioma, and pancreatic carcinoma—are all highly …

Potential Cost Savings Of Not Doing Cd4 Counts In Hiv Positive People In Rhode Island With An Undetectable Viral Load, Ruth Dele-Oni, Ferdinand Schumacher, Zachary Markus, Timothy Flanigan, Md

Journal of Health Disparities Research and Practice

CD4 cells fight infections in the body. When someone contacts Human Immunodeficiency Virus (HIV), their CD4 cells are taken over by HIV which turns them into manufacturers of many copies of the virus. The Viral Load (VL) measures the amount of virus in the blood. When HIV takes over the CD4 cells, the VL increases while the number of necessary CD4 cells decreases. When patients maintain stable treatment, their CD4 counts rise, and VLs may become undetectable, indicating the virus is too little to be detected in their blood. Knowing this, is frequent CD4 counts necessary for those with undetectable …

Defining The Role For Zbp-89 In Atm-Mediated Dna Damage Response To Irradiation In The Intestine, Christine Carethers, Juanita L. Merchant, Md, Phd

Journal of Health Disparities Research and Practice

ZBP-89 (ZNF148, Zfp148) is a zinc-finger transcription factor that inhibits cellular proliferation when overexpressed in cell lines. ZBP-89 forms a protein-protein interaction with p53 and Ataxia-telangiectasia mutated (ATM). However, it is unclear how the interaction modulates the function of these two proteins in vivo.

Double strand DNA breakage induced by -irradiation induces ATM phosphoinositol kinase activity, which initiates a cascade of events culminating in cell cycle arrest, DNA repair or apoptosis. Elevated levels of ZBP-89 induce growth arrest and apoptosis in gastrointestinal cell lines. Therefore, we hypothesize that ZBP-89 facilitates cell growth arrest and activation of the DNA repair pathway …

Induction Of Dusp9 In Xenografts From Human Breast Cancer Cell Lines Increases Mammary Cancer Stem Cells, Albert Barrios, Meher Parveen, Phd, Easter Thames, Melanie Baker, Shelha Pervin, Phd

Journal of Health Disparities Research and Practice

Breast cancer remains a complex disease that kills 40,000 women every year. Initiation and progression of breast cancer is influenced by heterogeneous groups of cells, including mammary cancer stem cells (MCSCs). Progression of this dreadful disease is driven by many signaling pathways among which MAPK pathway is highly prominent. Since targeting prominent kinases in MAPK pathway has been unsuccessful to control breast cancer, it is important to examine the phosphatases that regulate the activity of these kinases.

Using xenograft model from breast cancer cell lines, our lab has found that during the initial stages of xenograft development (week 1-4, 100-200mg …

Preparing Underrepresented High School Students To Increase Diversity In The Research And Health Professions, Dolores E. Caffey-Fleming, Ms, Mph, Christopher Reid, Md, Phd

Journal of Health Disparities Research and Practice

This article introduces the work that was done through the Coordinating Center at Charles R. Drew University of Medicine and Science.

The Step Up Program, Lawrence Agodoa, Md

Journal of Health Disparities Research and Practice

The Short-Term Research Experience Program for Underrepresented Persons (STEP-UP) was established as part of the NIDDK Strategic Plan on Minority Health Disparities. This article provides an overview and introduction of this program. All of the articles that are included in this special issue reflect the work of our coordinating centers, the mentors and their staff, as well as the students.

A National Bilingual Education Policy For The Economic And Academic Empowerment Of Youth In St. Lucia, West Indies, Gabriella Bellegarde

Capstone Collection

This campaign portfolio argues the case for a national bilingual education policy on the island of St. Lucia, where youth speak both St Lucian Creole and St. Lucian standard English. The portfolio consists of a policy paper and brief, an advocacy plan, a communications plan, monitoring and evaluation plan. The Bilingual Education Taskforce (BET), made up of teachers, parents and principals, is an advocacy organization that discovered the need for a bilingual education intervention when they observed, assessed and analyzed the written work of struggling readers at their school, the Anse la Raye Infant School on the west coast of …

Diversifying The Curriculum: An Analysis Of Diversity Course Policies At The University Of California San Diego, Maria Lourdes Amparo

Capstone Collection

As U.S. higher education institutions and the larger society become increasingly global and racially and ethnically diverse, educational institutions are faced with the challenge of adapting their policies and academic curriculum to reflect and meet the demands of a changing environment. As part of a comprehensive plan to address campus climate issues at the University of California, San Diego (UC San Diego), the UC San Diego Academic Senate revised the undergraduate graduation requirement in 2011 to include one course that focuses on Diversity, Equity, and Inclusion (DEI). In addition to having a diverse student population, UC San Diego is ranked …

The Arts Community Without Community: Imagining Aesthetic Curriculum For Active Citizenship, Seungho Moon

Education: School of Education Faculty Publications and Other Works

This article is about teaching art-based inquiry and equity pedagogy. The author introduces an aesthetic-inspired afterschool curriculum in the urban context in the United States and theorizes the meaning of active citizenship and community. Conceptually framed by “community without community,” this article explicates the ways in which the ARtS children (Aesthetic, Reflexive thoughts, & Sharing) investigated the meanings of community through dance, poetry, and clay art. The author imagines and theorizes community that goes beyond emphasizing solidarity and a collective “we”-ness in the pursuit of social transformation. Rather, the author argues that “community without community” could be an important framework …

Cross-Cultural Comparison Of Credit Transfer Practices, Lending And Financial Inclusions In North America, Europe And The Middle East, Jessica Henao Barragan

Mahurin Honors College Capstone Experience/Thesis Projects

Many events highlight the relationship between credit availability and aggregate output. Macroeconomic models and financial market conditions have major impacts on the world economy. In addition, these represent the responses to financial chunks that differ in developed countries like the United Kingdom, France, United Arab Emirates, Saudi Arabia, Canada and the United States. The impact of credit conditions is concerned, as well as the differences in the quality of banking supervision and the effectiveness of monetary policies in different parts of the world. The experience of developed countries sets an example of the integration process inevitably contributing to create an …

Outcomes Of Speech And Language Pilot Program For International Students, Kelly Fussman

Mahurin Honors College Capstone Experience/Thesis Projects

Universities in the United States host a substantial number of international students every academic year. As of the 2015-2016 academic year, Western Kentucky University, located in south-central Kentucky, alone hosts over 1,400 international students. These students often face a number of challenges upon arrival in the United States, especially when it comes to language and cultural differences. A considerable body of research indicates that international students’ educational performance and outcomes are significantly impacted by their cultural identities, psychological and sociocultural experiences, and attitudes in relation to English-speaking societies. Many international students attribute academic and social difficulties to a lack of …

Interacting With Muslim Students: Strategies That Work, Oscar Osindo

Faculty and Staff Institute

This presentation will help faculty to become familiar with Muslim values and customs that might affect classroom relationships and learning. The Muslim and Christian worldviews are in conflict, which is reflected in day to day Muslim practices such as outward manifestation of their faith and practice, in lifestyle and their general view of community structures. This presentation will provide practical suggestions and how to build bridges towards healthy intercultural classroom atmosphere.

View Presentation Recording