A Woman With A Lung Infiltrate And Brain Abscesses: Case Discussion From The University Of Louisville Hospital,
2019
University of Louisville, Louisville, KY
A Woman With A Lung Infiltrate And Brain Abscesses: Case Discussion From The University Of Louisville Hospital, Veronica Corcino, Viswanathan Nagarajan, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
No abstract provided.
The Effect Of Arm Swing On Countermovement Vertical Jump Performance,
2019
University of Nebraska at Omaha
The Effect Of Arm Swing On Countermovement Vertical Jump Performance, Arash Mohammadzadeh Gonabadi
UNO Student Research and Creative Activity Fair
Vertical jumping is one of the popular ways to evaluate ankle-knee efficiency in athletic population. Arm swing can play a crucial role in enhancing vertical jump performance. This study aimed to address the differences in kinetic and kinematic parameters during countermovement jump motion with arm swing (AS) and no arm swing (NAS). We used OpenSim to examine the efficacy of AS in reducing the impulse applied to the body and changes in range of lower limb joint angles at landing instant. We calculated the maximum vertical peak of the ground reaction force and impulse generated at landing in two different …
Assessment Of Pneumonia Severity Indices As Mortality Predictors,
2019
University of Louisville
Assessment Of Pneumonia Severity Indices As Mortality Predictors, Connor L. English, Thomas Chandler, Brian E. Guinn, Stephen P. Furmanek, Julio A. Ramirez
The University of Louisville Journal of Respiratory Infections
BACKGROUND
The leading cause of infectious disease death in the United States is community-acquired pneumonia (CAP). Several pneumonia severity indices exist and are widely used as tools to assist physicians regarding site of care based on risk of death. However, limited data exists that discerns which of the most commonly used severity scores is the best predictor of mortality across multiple time points. The objective of this study is to determine the best mortality predictor at different time points between four of the most commonly used pneumonia severity scores.
METHODS
This was a secondary analysis of a prospective, multicenter, population-based, …
A Man With Acute Severe Pneumonia: Case Discussion From The University Of Louisville Hospital,
2019
University of Louisville
A Man With Acute Severe Pneumonia: Case Discussion From The University Of Louisville Hospital, Viswanathan Nagarajan, Srinivas R. Dontineni, Veronica Corcino, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Current And Future Antiviral Medications To Treat Influenza: Mechanisms Of Action,
2019
University of Louisville
Current And Future Antiviral Medications To Treat Influenza: Mechanisms Of Action, Julio A. Ramirez
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Sphk2−/− Mice Are Protected From Obesity And Insulin Resistance,
2019
University of Kentucky
Sphk2−/− Mice Are Protected From Obesity And Insulin Resistance, Shwetha Ravichandran, Brian S. Finlin, Philip A. Kern, Sabire Özcan
Clinical and Translational Science Faculty Publications
Sphingosine kinases phosphorylate sphingosine to sphingosine 1‑phosphate (S1P), which functions as a signaling molecule. We have previously shown that sphingosine kinase 2 (Sphk2) is important for insulin secretion. To obtain a better understanding of the role of Sphk2 in glucose and lipid metabolism, we have characterized 20- and 52-week old Sphk2−/− mice using glucose and insulin tolerance tests and by analyzing metabolic gene expression in adipose tissue. A detailed metabolic characterization of these mice revealed that aging Sphk2−/− mice are protected from metabolic decline and obesity compared to WT mice. Specifically, we found that 52-week old …
Development Of A Real-Time Pcr Assay For Pneumocystis Jirovecii On The Luminex Aries® Platform,
2019
University of Louisville
Development Of A Real-Time Pcr Assay For Pneumocystis Jirovecii On The Luminex Aries® Platform, Subathra Marimuthu, Kuldeep Ghosh, Leslie A Wolf
The University of Louisville Journal of Respiratory Infections
Pneumocystis pneumonia (PCP) is an opportunistic infection caused by the fungus Pneumocystis jirovecii. Infection with P. jirovecii can result in serious illness in patients with a weakened immune system, and can lead to death if it is not properly diagnosed and treated. Direct detection of P. jirovecii in lower respiratory tract specimens such as bronchoalveolar lavage (BAL) is preferred for rapid diagnosis, a laboratory service currently not available locally. We report here the development of a diagnostic real-time Polymerase Chain Reaction (PCR) assay using BAL specimens to detect P. jirovecii. By targeting the multi-copy mitochondrial large subunit ribosomal …
A Guide For Using Nih Image J For Single Slice Cross-Sectional Area And Composition Analysis Of The Thigh From Computed Tomography,
2019
University of Kentucky
A Guide For Using Nih Image J For Single Slice Cross-Sectional Area And Composition Analysis Of The Thigh From Computed Tomography, Douglas E. Long, Alejandro G. Villasante Tezanos, James N. Wise, Phillip A. Kern, Marcas M. Bamman, Charlotte A. Peterson, Richard A. Dennis
Clinical and Translational Science Faculty Publications
Reports using computed tomography (CT) to estimate thigh skeletal muscle cross-sectional area and mean muscle attenuation are often difficult to evaluate due to inconsistent methods of quantification and/or poorly described analysis methods. This CT tutorial provides step-by-step instructions in using free, NIH Image J software to quantify both muscle size and composition in the mid-thigh, which was validated against a robust commercially available software, SliceOmatic. CT scans of the mid-thigh were analyzed from 101 healthy individuals aged 65 and older. Mean cross-sectional area and mean attenuation values are presented across seven defined Hounsfield unit (HU) ranges along with the percent …
My First Experience Using Clinical Evidence To Change Patient Care,
2019
WSUSOM
My First Experience Using Clinical Evidence To Change Patient Care, Alec Aiello
Clinical Research in Practice: The Journal of Team Hippocrates
This third year medical student reflects upon how his observations and subsequent research into a clinical question was able to influence the way his team thought about administering care in their day-to-day practice.
Npo Or Ama? Patients Allowed Clear Liquids Up To 2 Hours Pre-Procedure Have Equivalent Aspiration Risk And Increased Patient Satisfaction,
2019
University of Wayne State Medical School
Npo Or Ama? Patients Allowed Clear Liquids Up To 2 Hours Pre-Procedure Have Equivalent Aspiration Risk And Increased Patient Satisfaction, Erich Smith
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Itou K, Fukuyama T, Sasabuchi Y, et al. Safety and efficacy of oral rehydration therapy until 2 h before surgery: a multicenter randomized controlled trial. Journal of Anesthesia. 2012;26(1):20-27. doi: 10.1007/s00540-011-1261-x.
Icatibant Is Not Helpful For The Treatment Of Ace Inhibitor-Induced Angioedema,
2019
Wayne State University School of Medicine
Icatibant Is Not Helpful For The Treatment Of Ace Inhibitor-Induced Angioedema, Samantha R. Schwartz
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Sinert R, Levy P, Bernstein JA, et al. Randomized trial of icatibant for angiotensin-converting enzyme inhibitor-induced upper airway angioedema. J Allergy Clin Immunol Pract. 2017; 5(5): 1402-1409. doi: 10.1016/j.jaip.2017.03.003.
Renal Angioplasty Does Not Improve Clinical Outcomes Compared To Standard Medical Therapy In Patients With Atherosclerotic Renal Artery Stenosis,
2019
Wayne State University School of Medicine
Renal Angioplasty Does Not Improve Clinical Outcomes Compared To Standard Medical Therapy In Patients With Atherosclerotic Renal Artery Stenosis, Alexandra Morris
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Cooper CJ, Murphy T, Cutlip D, Jamerson K, Henrich W. Stenting and medical therapy for atherosclerotic renal-artery stenosis. New Eng J Med. 2014;370(1):13-22. doi: 10.1056/NEJMoa1310753.
Early Dexamethasone Administration In Adults With Suspected Meningitis Lowers Morbidity And Mortality,
2019
Wayne State University
Early Dexamethasone Administration In Adults With Suspected Meningitis Lowers Morbidity And Mortality, Dana Siegel
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of de Gans J, van de Beek D, Investigators EDiABMS. Dexamethasone in adults with bacterial meningitis. New Eng J Med. 2002;347(20):1549-1556. doi: 10.1056/NEJMoa021334.
Memantine Unproven To Provide Any Clinical Benefit In Cases Of Vascular Cognitive Impairment,
2019
Wayne State University School of Medicine
Memantine Unproven To Provide Any Clinical Benefit In Cases Of Vascular Cognitive Impairment, Irene Kitromelides
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Wilcock G, Möbius HJ, Stöffler A. A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500). Int Clin Psychopharmacol. 2002 Nov;17(6):297-305. doi: 10.1097/00004850-200211000-00005.
Roflumilast Does Not Decrease Copd Exacerbations In Adequately Treated Patients, But Subgroup Analysis Allows For Shared Decision Making,
2019
Wayne State University
Roflumilast Does Not Decrease Copd Exacerbations In Adequately Treated Patients, But Subgroup Analysis Allows For Shared Decision Making, Nathanael Sanchez
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Martinez FJ, Rabe KF, Sethi S, et al. Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. Am J Respir Crit Care Med. Sep 1 2016;194(5):559-567. doi: 10.1164/rccm.201607-1349OC.
Confirmation Bias By Consumers Of Clinical Research Demonstrates The Need For Implementation Science,
2019
Wayne State University School of Medicine
Confirmation Bias By Consumers Of Clinical Research Demonstrates The Need For Implementation Science, James Peter Meza
Clinical Research in Practice: The Journal of Team Hippocrates
The Journal's Editor holds that, although Evidence-based medicine typically only looks for bias of the research design, still evidence-based practice must also include the biases of those using the research evidence and how it is deployed in clinical practice.
Towards Multi-Lingual Pneumonia Research Data Collection Using The Community-Acquired Pneumonia International Cohort Study Database,
2019
University of Louisville
Towards Multi-Lingual Pneumonia Research Data Collection Using The Community-Acquired Pneumonia International Cohort Study Database, William A. Mattingly, Kimberley A. Buckner, Senen Pena
The University of Louisville Journal of Respiratory Infections
Background: Although multilingual interfaces are preferred by most users when they have a choice, organizations are often unable to support and troubleshoot problems involving multiple user languages. Software that has been structured with multiple languages and data interlinking considerations early in its development is more likely to be easily maintained. We describe the process of adding multilingual support to the CAPO international Cohort study database using REDCap.
Methods: Using Google Translate API we extend the supported Spanish language version of REDCap to the most recent version used by CAPO, 8.1.4. We then translate the English data dictionary for CAPO to …
Clinical Research In Pneumonia: Role Of Artificial Intelligence,
2019
Saint Louis University
Clinical Research In Pneumonia: Role Of Artificial Intelligence, Timothy L. Wiemken, Robert R. Kelley, William A. Mattingly, Julio A. Ramirez
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Carbapenem-Resistant Enterobacteriaceae Infections: A Review Of Epidemiology And Treatment Options,
2019
Sullivan University
Carbapenem-Resistant Enterobacteriaceae Infections: A Review Of Epidemiology And Treatment Options, Julie Harting
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Defining Patient-Oriented Research For The Average Person (And Potential Research Partner),
2019
Aurora UW Medical Group, Aurora Health Care
Defining Patient-Oriented Research For The Average Person (And Potential Research Partner), Dennis J. Baumgardner
Journal of Patient-Centered Research and Reviews
In this introduction to the first issue of 2019, the editor-in-chief of Journal of Patient-Centered Research and Reviews offers additional context to the findings of Kaur and Pluye (p. 7), who methodically formalized an operational definition of patient-oriented research for the purposes of searching bibliographic databases. A possible succinct, lay definition of patient-oriented research for the average “person on the street” is proposed.
