Other Medicine and Health Sciences Commons^™

Comparison Of The Effects Of Energy Flux On Metabolic Conditions And Satiety In Young Adults, Molly Madison Demello

Theses and Dissertations

Within the United States, 68% of all adults have been classified as overweight to obese, as defined by 25 kg/m2 ≤ BMI ≤ 35 kg/m2. Research has shown that overweight/obese individuals can still gain health benefits through participation in aerobic activity without losing weight. These improvements include improved glucose control, CRF, HDL and quality of life. More research is necessary to understand the health benefits associated with a chronic aerobic intervention under weight stable conditions. We therefore examined the health benefits of an aerobic 6-month intervention under weight stable conditions on body composition, cholesterol and measurements of appetite and satiety …

Temporal Trends Of Corporate Sponsorship In Medical Research, Elijah Bodey

Honors Projects

Data will be collected from medical journals to assessed changes in the nature and prevalence of corporate sponsorship. The journals that will be reviewed are the Journal of the American Medical Association (JAMA), the New England Journal of Medicine (NEJM), the British Medical Journal (BMJ), and the Lancet. These journals were chosen because of their high impact on medical research representing both American and British Medical editorials. It has been shown that corporate sponsorship has been associated with bias results (Kjaergard et al 2002). Changes in the nature of corporate sponsorship would be linked to changes in economic climate and …

The Differentiation And Protective Function Of Cytolytic Cd4 T Cells In Influenza Infection, Deborah M. Brown, Anna T. Lampe, Aspen M. Workman

School of Biological Sciences: Faculty Publications

CD4 T cells that recognize peptide antigen in the context of class II MHC can differentiate into various subsets that are characterized by their helper functions. However, increasing evidence indicates that CD4 cells with direct cytolytic activity (CD4 CTL) play a role in chronic as well as acute infections, such as influenza A virus (IAV) infection. In the last couple of decades, techniques to measure the frequency and activity of these cytolytic cells has demonstrated their abundance in infections, such as human immunodeficiency virus, mouse pox, murine gamma herpes virus, cytomegalovirus, Epstein–Barr virus, and influenza among others. We now appreciate …

Markerless Lung Tumor Trajectory Estimation From Rotating Cone Beam Computed Tomography Projections, Shufei Chen

Theses and Dissertations

Respiration introduces large tumor motion in the thoracic region which influences treatment outcome for lung cancer patients. Tumor motion management techniques require characterization of temporal tumor motions because tumor motion varies patient to patient, day to day and cycle to cycle. This work develops a markerless algorithm to estimate 3 dimensional (3D) lung-tumor trajectories on free breathing cone beam computed tomography (CBCT) projections, which are 2 dimensional (2D) sequential images rotating about an axis and are used to reconstruct 3D CBCT images.

A gold standard tumor trajectory is required to guide the algorithm development and estimate the tumor detection accuracy …

The Regulation Of Alternative Pre-Mrna Splicing In Photoreceptor Cells., Daniel P. Murphy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Alternative pre-mRNA splicing provides an important mechanism for generating the diverse array of proteins required to generate complex tissue and cell types from a limited genome. Therefore, the proper regulation of alternative splicing is vital to shape cellular identity and function. As consequence, defects in alternative splicing are associated with disease phenotypes that can range from systemic syndromes to the dysfunction of single cell types. For example, heterozygous mutations in ubiquitously expressed components of the spliceosome lead to photoreceptor specific cell death. This suggests that the topography of alternative splicing in photoreceptors cells may be unique, a notion which is …

The Effect Of Curcumin On Cardiovascular Health In Obese Men, Marilyn S. Campbell

Theses and Dissertations--Kinesiology and Health Promotion

Cardiovascular disease is the leading cause of death in the United States, and conventional treatment often emphasizes pharmaceutical approaches. Research has recently started exploring non-pharmaceutical approaches, including nutritional interventions. This research study was conducted to test the effectiveness of a novel nutritional approach, curcumin, on the improvement of cardiovascular health in young, obese males (BMI≥30 kg/m²). This study included 22 men, matched based on BMI and randomly assigned to the intervention (n=11) or placebo group (n=11). The intervention consisted of 12 weeks of curcumin supplementation (1.0 g/day) with fenugreek added to enhance the curcumin bioavailability; the placebo consisted …

Il-15 Mediates Mitochondrial Activity Through A Ppar𝛿-Dependent-Ppar𝛼-Independent Mechanism In Skeletal Muscle Cells, Shantaé M. Thornton, James E. Krolopp, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed “myokines,” has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPAR𝛼 and/or PPAR𝛿 as targets of IL-15 signaling. C2C12 SKM cells were differentiated for 6 days and treated every other day with IL-15 (100 ng/mL), a PPAR𝛼 inhibitor (GW-6471), a PPAR𝛿 …

The Creation And Implementation Of Guidelines For The Appropriate Termination Of Patient-Provider Relationships, Rowena D. Nolasco

Doctor of Nursing Practice (DNP) Projects

Primary care providers have terminated patient-provider relationships when they deem them no longer therapeutic. Healthcare providers are increasingly considering this an acceptable practice. However, the criteria for this decision remain unclear. As providers discharge challenging or difficult patients from their practices, questions to support this decision arise. Discharged patients face displacement and healthcare is disrupted. This project will (a) describe problematic patient-provider relationships and its effects, (b) identify possible alternatives to the firing of patients, (c) list appropriate reasons for termination, and (d) present recommended procedures to avoid allegations of medical abandonment. The project's product is an Appropriate Discharge or …

Segmentation And Strain Mapping Of A Beating Heart, Kenna Middleton

McKelvey School of Engineering Graduate Student Theses & Dissertations

Conventional methods of estimating deformation optically often compare image intensities before and after deformation to help estimate the strain fields. However, these current meth ods often introduce undesirable error that propagates through the system, growing larger through each strain calculation. These errors create false, concentrated regions of strain throughout the image. Additionally, gathering and evaluating images in three- and four dimensional space creates even more difficulty for conventional methods. Here, by imple menting new techniques of gathering four-dimensional ultrasound data sets and calculating deformation fields with traditional errors reduced three-fold, four-dimensional images were evaluated to create a novel visualization tool …

Exploring Acceptance Of Using An Online Platform To Teach Parents Of Children With Autism Methods In Applied Behavior Analysis (Aba), Marwah S. Zagzoug

Seton Hall University Dissertations and Theses (ETDs)

Background and Purpose of the Study: A diagnosis of autism can lead to lifelong struggles for parents and children. These families face profound difficulties in coping with stress while seeking out early interventions and managing imperative service needs. Parents are increasingly turning to the internet for information, advice, and even formal training. Breakthroughs in technology have made the internet more accessible and more sophisticated. The involvement of parents in applying intervention strategies to help their autistic children has long been advocated as a useful approach. Enabling parents as interventionists provides renewed confidence and reduced stress for parents as well as …

Potential Cellular Mechanisms Of Estrogen's Effects On Maintaining Sperm Production In Aging Rats, Matthew Pate

Honors Theses

Testosterone production by Leydig cells declines during aging in both men and rodent models. Previous results from our lab demonstrated that daily sperm production also declines in aging rats and alterations in the estrogen environment of the testis contribute to this decline. Importantly, estrogen treatment during aging was able to attenuate the age-associated decline in sperm production. However, the cellular and molecular mechanisms by which estrogen maintains sperm production remain unclear. These experiments were designed to further investigate the effects of estrogen on sperm production in an attempt to further define the cellular mechanisms regulated by estrogen within the testis. …

Street Drug Markets Beyond Favelas In Belo Horizonte, Brazil, Elenice De Souza Oliveira, Braulio Figueiredo Alves Silva, Marcos Oliveira Prates

Department of Justice Studies Faculty Scholarship and Creative Works

This study examines whether social disorganization mechanisms that explain clusters of street drug markets in socially disorganized neighborhoods in developed countries can also help explain geographical patterns of drug dealing across neighborhoods in Belo Horizonte, Brazil. Data for this study includes drug arrests from 2007 to 2011 and socio demographic data from the 2010 Census. To examine the influence of exploratory variables on drug market locations, the Negative Binominal regression model was used at two levels of analysis—the Belo Horizonte city center and other neighborhoods including favelas. The findings show that a high hot spot of street drug markets located …

Muscle Cramping During A 161-Km Ultramarathon: Comparison Of Characteristics Of Those With And Without Cramping, Martin D. Hoffman, Kristin J. Stuempfle

Health Sciences Faculty Publications

Background: This work sought to identify characteristics differing between those with and without muscle cramping during a 161-km ultramarathon.

Methods: In this observational study, race participants underwent body weight measurements before, during, and after the race; completed a post-race questionnaire about muscle cramping and “near” cramping (controllable, not reaching full-blown cramping), drinking strategies, and use of sodium supplementation during four race segments; and underwent a post-race blood draw for determination of serum sodium and blood creatine kinase (CK) concentrations.

Results: The post-race questionnaire was completed by 280 (74.5 %) of the 376 starters. A post-race blood sample was provided by …

Today - December 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Terrorist bullets shatter the peace of the holidays in San Bernardino and neighboring communities
-- Loma Linda University Health family remembers victims
-- Advancement team Christmas gathering reflects tragedy and hope
-- Media relations ream inundated with inquiries
-- Faculty and students profess solidarity with victims of San Bernardino terrorist attack
-- Flag of Hope promotes unity, peace, and healing
-- Second graders make Christmas cards for LLUMC emergency department
-- Food distribution event at Highland Springs Medical Plaze provides food supplies for local area families in need
-- Charity Navigator gives LLU coveted 4-star rating …

Mechanisms By Which Dietary Ellagic Acid Attenuates Obesity And Obesity-Mediated Metabolic Complications, Inhae Kang

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Ellagic acid (EA) is a polyphenol found in various fruits and plants, such as berries, pomegranates, muscadine grapes, nuts and bark of oak tree. EA has been known to exhibit anti-inflammatory and anti-proliferative effects in various types of cancer. However, little is known about the effects of EA on obesity. Herein, 1) the lipid-lowering role of EA was identified in primary human adipose stem cells (hASCs) and human hepatoma Huh7 cells; 2) the molecular mechanisms by which EA attenuates adipogenesis by epigenetic modification were identified; 3) the effects of EA on high fat and high sucrose-mediated obesity was …

Alumni Journal - Volume 86, Number 3, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
10 | A Call for Medical Missionaries
12 | They Helped to Establish This Noble Legacy
14 | The Evolution of Graduation
22 | Graduation 2015

Departments
2 | From the Editor
3 | This and That
4 | From the President
5 | From the Dean
6 | The Student Fund
8 | School of Medicine News
38 | AIMS Report
40 | Book Review
42 | Alumni News
43 | In Memoriam
49 | What's Up Doc?

Extras
24 | Note from the Class of 2015 President
48 | 1 Corinthians 13 - Revised Medicalized Version

Fair Weight Loss After Gastric Rebanding For Slippage, Ahmed Dalmar, Maharaj Singh, Sara K. Roloff, Thomas Y. Chua

Journal of Patient-Centered Research and Reviews

Background: Laparoscopic adjustable gastric banding (LAGB) is one of the most common bariatric surgery procedures performed in the United States. LAGB results in safe and satisfactory weight loss, but it is often complicated with slippage, a complication requiring rebanding (reoperation). There is a paucity of studies and no uniform consensus regarding weight loss after rebanding.

Purpose: This study assessed the effect of rebanding for slippage after LAGB on weight loss up to five years.

Methods: This is a historical cohort study of 865 patients who underwent LAGB from 2001 to 2011. Rebanding was performed in 103 (11.9%) patients. Primary outcome …

Today - November 2015, Loma Linda University Health

TODAY

In this issue:

-- First hospital-based proton center hosts celebratory events with reunion of hundreds of former patients and families
-- SAC Health Systems celebrates 20 years of health care to San Bernardino residents
-- New global initiative brings dermatological telemedicine to rural communities on the African continent
-- Loma Linda University Health employees enjoy excellent health care benefits and low premiums
-- The Children's Hospital and Proton Treatment and Research Center: a rare combination
-- Team-building program at Drayson Center brings people together through play
-- More than 2,000 people attend Family Health Fair and 5k run
-- Dishes …

Current Opinion In The Role Of Testosterone In The Development Of Prostate Cancer: A Dynamic Model, Xiaohui Xu, Xinguang Chen, Hui Hu, Amy B. Dailey, Brandie D. Taylor

Health Sciences Faculty Publications

Background: Since the landmark study conducted by Huggins and Hodges in 1941, a failure to distinguish between the role of testosterone in prostate cancer development and progression has led to the prevailing opinion that high levels of testosterone increase the risk of prostate cancer. To date, this claim remains unproven.

Presentation of the Hypothesis: We present a novel dynamic mode of the relationship between testosterone and prostate cancer by hypothesizing that the magnitude of age-related declines in testosterone, rather than a static level of testosterone measured at a single point, may trigger and promote the development of prostate cancer.

Testing …

Loma Linda University Health - San Bernardino Groundbreaking, Loma Linda University Health

Scope

Table of Contents

Features

2 | New facility in San Bernardino to enhance opportunities
4 | Loma Linda shares its story with world church

Campus news

8 | Historic step taken toward unified governance
9 | Quarter-century milestones celebrated
10 | School of Public Health conferences lead the way

Clinical care

11 | Children’s Hospital receives separate license
11 | Pediatric ICU celebrates 25 years of service
12 | Clinicians train with FEMA for disasters
14 | Woman regains her life through bariatric surgery

Research

15 | Grant enables purchase of next-generation DNA sequencer
16 | Potholes and primordial mysteries: …