Reproductive and Urinary Physiology Commons^™

The Perspectives Of Men In Mexico City About Vasectomy, Isabel Vieitez Martínez, Adriana Ramos

Reproductive Health

As part of World Vasectomy Day, the Population Council Mexico conducted an exploratory study about the reasons and concerns that led men to seek a no-scalpel vasectomy (NSV) during the 24-hour “Vasectomy-athon” in Mexico City in 2017. This study was intended as the first part of a longer cohort study that would follow up with the men, and their partners, to learn about their experiences with the procedure and its effects, if any, on their relationships. Based on the findings, the report recommends that the Mexican Ministry of Health (SSA) continue integrating NSV information, counseling, and services within the National …

The Perspectives Of Men In Mexico City About Vasectomy—Brief, Isabel Vieitez Martínez, Adriana Ramos

Reproductive Health

On November 17, 2017, Mexico City took part in the global World Vasectomy Day campaign promoting men’s participation in family planning, especially through no-scalpel vasectomy (NSV). During the event the Population Council Mexico conducted an exploratory study to better understand the reasons men chose NSV, as well as their concerns before and after the procedure. The study found that the principal reason for seeking NSV among men surveyed was their achievement of a desired family size, for themselves and their partners. The study further reveals the need to disseminate information through mass media, social networks, and all levels of the …

Developmental Origins Of Health And Disease: Current Knowledge And Potential Mechanisms, Daniel J. Hoffman, Rebecca M. Reynolds, Daniel B. Hardy

Physiology and Pharmacology Publications

Epidemiologic and clinical research has provided a large body of evidence supporting the developmental origins of health and disease (DOHaD), but there has been a relative dearth of mechanistic studies in humans due to the complexity of working with large, longitudinal cohorts. Nonetheless, animal models of undernutrition have provided substantial evidence for the potential epigenetic, metabolic, and endocrine mechanisms behind DOHaD. Furthermore, recent research has explored the interaction between the environment and the gastrointestinal system by investigating how the gut microbial ecology may impact the capacity for nutrient processing and absorption in a manner that may limit growth. This review …

Finasteride As A Model For Personalized Medicine, Ion G. Motofei, David L. Rowland, Ioana Păunică, Octavian C. Tănăsescu, Petrişor Banu, Stana Păunică

Journal of Mind and Medical Sciences

The side effects of Finasteride are currently a subject of controversy. Some studies report minor or acceptable adverse effects, which decrease after a variable period of time so that they do not necessitate terminating Finasteride administration. However, several clinical and neuro-endocrine studies show that some adverse effects persist indefinitely in the form of post-Finasteride syndrome, even after the drug cessation. This paper presents a possible explanation for these inconsistent findings. First, the study design of either informing or not informing patients prior therapy about possible adverse effects can influence the incidence and magnitude of reported adverse effects. Second, structural and …

A Validated Measure For Fertility Awareness: An Essential Step Toward Informed Reproductive Decision-Making, Brennan Peterson

Marriage and Family Therapy Faculty Articles and Research

"The efforts by Kudesia and colleagues (1) to create and validate a fertility awareness survey is a vital development in the field of reproductive health care. The 29-item Fertility and Infertility Treatment Knowledge Score (FIT-KS) was created to measure fertility awareness and infertility treatment knowledge in the general population and among medical trainees. Using a combination of existing questionnaires, consultation with specialists in test construction, and clinical recommendations of an expert panel of 15 reproductive endocrinologists, the FIT-KS is the first of its kind in the United States. The authors should be commended for their foresight and attempts to address …

Relationship Between Self-Efficacy And Patient Knowledge On Adherence To Oral Contraceptives Using The Morisky Medication Adherence Scale (Mmas-8), Daniel M. Tomaszewski, Benjamin D. Aronson, Margarette L. Kading, Donald E. Morisky

Pharmacy Faculty Scholarship

Background
Preconception care, including family planning, is a vital component of healthcare for women of reproductive age. An average female spends the majority of her reproductive life trying to prevent a pregnancy. In order to prevent unintended pregnancy, women often rely on the use of hormonal contraceptives. In the United States, the majority of hormonal contraceptive users are prescribed oral contraceptive pills (OCPs). Reduced adherence to OCPs decreases their ability to prevent pregnancy. The study aimed to measure OCP adherence among female college students, and explore the relationship between OCP adherence, knowledge, and self-efficacy.

Methods
This cross-sectional study recruited a …

Research Brief: "Reproductive Health Of Active Duty Women In Medically Austere Environments", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the use of contraceptives, the unintended pregnancy rates, and birth defects among active duty servicewomen as compared to the civilian population. In policy and practice, servicewomen and female veterans should use reproductive and health services provided by local VA medical centers and discuss environmental exposures to their healthcare provider, who should conduct full exams with patients and discuss healthcare needs while the servicemembers are deployed; the DoD should look into the use of portable medical equipment and how to support all servicemembers, and policymakers may consider funding DoD programs for counseling about women's reproductive healthcare options. …

Enduring Chronic Kidney Disease: An Investigation Of Psychosocial Factors And Life Satisfaction In Older Adults Receiving Dialysis Treatment, Bailee Sobotka

Honors Program: Senior Projects (Public)

Chronic kidney disease is a condition during which the kidneys begin to shut down and no longer filter blood efficiently. Once the disease has progressed far enough, dialysis treatments are mandatory to sustain life. To further understand how older adults receiving dialysis treatments cope with their disease, psychosocial factors were evaluated to investigate possible correlations with life satisfaction using a Life Satisfaction Index Z (LSI-Z). Expected correlations with life satisfaction were sociability, financial satisfaction, importance of spirituality, and activities of daily living scores. Interviews were conducted with 30 dialysis patients and results were analyzed using various statistical measures. Significant correlations …

Hubungan Obesitas Dengan Kejadian Hipertensi Derajat 1 Di Pos Pembinaan Terpadu Penyakit Tidak Menular (Posbindu Ptm) Kantor Kesehatan Pelabuhan Bandung Tahun 2016, Teguh Dhika Rohkuswara, Syahrizal Syarif

Jurnal Epidemiologi Kesehatan Indonesia

Hipertensi sampai saat ini masih menjadi masalah kesehatan di dunia termasuk Indonesia. Prevalensi hipertensi di Indonesia, cukup tinggi yaitu sebesar 25,8% (Riskesdas, 2013). Sebagian besar penderita hipertensi termasuk dalam kelompok hipertensi derajat 1 dan separuhnya tidak menyadari sebagai penderita. Hipertensi bukan penyakit kausal tunggal, ada berbagai faktor yang berkontribusi terhadap munculnya hipertensi, salah satunya yang sering ditemukan adalah obesitas. Penelitian ini bertujuan untuk mengetahui besarnya hubungan antara obesitas dengan kejadian hipertensi derajat 1 di Posbindu PTM Kantor Kesehatan Pelabuhan Bandung. Desain penelitian adalah cross sectional, menggunakan data sekunder kegiatan Posbindu PTM KKP Bandung tahun 2016. Subjek penelitian adalah pegawai instansi …

Pengaruh Konsumsi Fruktosa Pada Minuman Kemasan Terhadap Toleransi Glukosa Terganggu Pada Kelompok Usia Muda Di Perkotaan Di Indonesia, Nicolaski Lumbuun, Nasrin Kodim

Jurnal Epidemiologi Kesehatan Indonesia

Peningkatan konsumsi minuman kemasan (soft drinks/ bevereges) tampak nyata di dunia, termasuk Indonesia. Peningkatan ini terutama terjadi di kelompok usia muda. Konsumsi minuman tersebut berkaitan dengan gangguan metabolik, antara lain obesitas, toleransi glukosa terganggu (TGT) dan diabetes melitus. Hal ini disebabkan penggunaan pemanis tinggi fruktosa (high fructose corn syrup, HFCS). TGT terutama menjadi masalah kesehatan serius karena umumnya tidak menunjukkan gejala dan terlambat untuk dideteksi sehingga sering kali telah berprogresi menjadi diabetes mellitus. Penelitian ini bertujuan untuk melihat hubungan konsumsi tinggi fruktosa dengan kejadian TGT pada usia muda, serta prevalensi kekerapan mengkonsumsi minuman tinggi fruktosa, baik secara nasional maupun pada …

Prediktor Kejadian Tb Pada Odha Di Salah Satu Rs Pemerintah Bogor, Tahun 2014-2016, Ulya Qoulan Karima, Mondastri Korib Sudaryo, Nuning Maria Kiptiyah

Jurnal Epidemiologi Kesehatan Indonesia

TB merupakan tantangan bagi pengendalian Acquired Immunodeficiency Syndrome (AIDS) karena merupakan infeksi oportunistik terbanyak pada orang dengan HIV/AIDS (ODHA). TB dapat meningkatkan progresivitas HIV dan meningkatkan risiko kematian bagi penderita HIV. Tujuan penelitian ini adalah untuk mengetahui prediktor yang berhubungan dengan kejadian TB pada ODHA di salah satu RS tahun 2014-2016. Desain studi yang digunakan adalah cross sectional dengan menggunakan data register ART dan Rekam Medis. Sampel berjumlah 817 pasien HIV. Analisis data dilakukan dengan menggunakan multiple cox regression. Hasil analisis multivariat menunjukkan adanya peningkatan risiko TB pada kelompok dengan anemia (PR=1,54, 95% CI: 1,17-2,03) dibandingkan kelompok tanpa anemia, adanya …

Pengaruh Jarak Kelahiran Terhadap Kematian Bayi Di Indonesia, Filipina, Dan Kamboja (Analisis Data Survei Demografi Kesehatan), Adelina Fitri, Asri Adisasmita, Renti Mahkota

Jurnal Epidemiologi Kesehatan Indonesia

Kematian bayi didefinisikan sebagai kematian yang terjadi pada tahun pertama kehidupan. Angka kematian bayi di Indonesia dan Kamboja sendiri masih berada diatas AKB Asia Tenggara, sedangkan Filipina sudah sama dengan AKB Asia Tenggara. Jarak kelahiran merupakan salah satu faktor yang memegang peran penting pada kematian bayi. Tujuan penelitian ini adalah untuk mengetahui pengaruh jarak kelahiran terhadap kematian bayi di Indonesia, Filipina dan Kamboja. Penelitian menggunakan data dari Demographic Health Survey (DHS). Desain penelitian adalah cross sectional dan sampel pada masing-masing negara berjumlah 10.162, 4.741 dan 4.330 bayi. Hasil penelitian memperlihatkan, jarak kelahiran < 18 bulan memiliki risiko paling besar terhadap kematian bayi di Indonesia (OR = 2,43: 95% CI 1,26 - 4,70), Kamboja (OR = 4,39: 95% CI 1,76 - 10,94) dibandingkan jarak kelahiran 18 - 23 bulan, 24 - 35 bulan dan > 36 bulan. Sedangkan di Filipina jarak kelahiran 18 …

Determinant Of Timely First-Shot Hepatitis B Immunization In East Lombok, West Nusa Tenggara, Indonesia, Putri Bungsu Machmud, Dwi Gayatri, Tri Yunis Miko Wahyono

Jurnal Epidemiologi Kesehatan Indonesia

Hepatitis B remains as one of health problems in the world. The results of several studies related to factors in predicting of the timely first-shot hepatitis B immunization were still inconsistent. Aim of this study is to identify determinant factors of the timely first-shot hepatitis B immunization in East Lombok, Indonesia. We used a cross sectional design study, and data derived from immunization coverage survey at six districts/ cities in 2013. A Total of 227 children aged 12 to 23 months who already got immunization of a first-shot hepatitis B vaccineand well documented were included as samples in this study. …

Feeding Problems Sebagai Prediktor Kejadian Obestitas Pada Anak Autis, Qisty Afifah Noviyanti

Jurnal Epidemiologi Kesehatan Indonesia

Latar belakang: Obesitas merupakan masalah yang dapat terjadi pada anak autis. Hal ini disebabkan adanya perubahan perilaku dan pola makan akibat kondisi autisme. Akan tetapi, belum banyak studi yang menjelaskan hubungan perilaku makan bermasalah (feeding problems) dengan kejadian obesitas pada anak autis. Tujuan: Penelitian ini untuk melihat hubungan antara masalah perilaku makan (feeding problem) dengan kejadian obesitas anak autis. Metode: Peninjauan artikel dilakukan dengan kata kunci autism OR autism spectrum disorder AND feeding problem OR food selectivity dan autism AND childhood obesity. Dua studi ditemukan sesuai dengan kriteria inklusi yang dibuat Anak autis memiliki perilaku makan bermasalah yang lebih tinggi …

Hubungan Pengetahuan Hiv/Aids Dengan Stigma Terhadap Orang Dengan Hiv/Aids Di Kalangan Remaja 15-19 Tahun Di Indonesia (Analisis Data Sdki Tahun 2012), Berliana Situmeang, Syahrizal Syarif, Renti Mahkota

Jurnal Epidemiologi Kesehatan Indonesia

Stigma terhadap ODHA menjadi salah satu hambatan paling besar dalam pencegahan, perawatan, pengobatan, dan dukungan HIV/AIDS. Pengetahuan tentang HIV/AIDS mempengaruhi terjadinya stigma terhadap ODHA. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan tentang HIV/AIDS dengan stigma terhadap ODHA di kalangan remaja usia 15-19 tahun di Indonesia. Penelitian ini menggunakan data Survei Demografi dan Kesehatan Indonesia (SDKI) Tahun 2012 dengan disain cross-sectional. Sampel penelitian sebanyak 8.316 orang. Hasil studi menunjukkan 71,63% remaja mempunyai stigma terhadap ODHA, 49,10% remaja mempunyai pengetahuan yang kurang tentang HIV. Pengetahuan yang kurang tentang HIV/AIDS berhubungan dengan stigma terhadap ODHA (PR= 1,210 95% CI: 1,149-1,273) setelah dikontrol oleh …

Maternal Nicotine Exposure Leads To Decreased Cardiac Protein Disulfide Isomerase And Impaired Mitochondrial Function In Male Rat Offspring., Nicole G Barra, Maria Lisyansky, Taylor A Vanduzer, Sandeep Raha, Alison C Holloway, Daniel B Hardy

Physiology and Pharmacology Publications

Smoking throughout pregnancy can lead to complications during gestation, parturition and neonatal development. Thus, nicotine replacement therapies are a popular alternative thought to be safer than cigarettes. However, recent studies in rodents suggest that fetal and neonatal nicotine exposure alone results in cardiac dysfunction and high blood pressure. While it is well known that perinatal nicotine exposure causes increased congenital abnormalities, the mechanisms underlying longer-term deficits in cardiac function are not completely understood. Recently, our laboratory demonstrated that nicotine impairs placental protein disulfide isomerase (PDI) triggering an increase in endoplasmic reticulum stress, leading us to hypothesize that this may also …

Increased Incidence Of Non-Alcoholic Fatty Liver Disease In Male Rat Offspring Exposed To Fluoxetine During Fetal And Neonatal Life Involves The Nlrp3 Inflammasome And Augmented De Novo Hepatic Lipogenesis., Nicole E De Long, Daniel B Hardy, Noelle Ma, Alison C Holloway

Physiology and Pharmacology Publications

Up to 10% of women take selective serotonin reuptake inhibitors (SSRI) during pregnancy. Children exposed to SSRIs in utero have an increased risk of being overweight suggesting that fetal exposure to SSRIs can cause permanent metabolic changes. We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non-alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to identify the mechanism(s) underlying the fluoxetine-induced increase in intrahepatic triglyceride content. Female nulliparous Wistar rats were given vehicle or fluoxetine (10 mg/kg/day) …

Maternal Undernutrition And Long-Term Effects On Hepatic Function, Daniel B. Hardy

Physiology and Pharmacology Publications

Undernutrition in utero, regardless of the source, can impair proper liver development leading to long-term metabolic dysfunction. Understanding the molecular mechanisms underlying how nutritional deficits during perinatal life lead to permanent alterations in hepatic gene expression will provide better therapeutic strategies to alleviate the undernourished liver in postnatal life. This chapter addresses the different experimental models of undernutrition in utero, and highlights the direct and indirect mechanisms involved leading to metabolic diseases in the liver. These include hypoxia, oxidative stress, epigenetic alterations, and endoplasmic reticulum (ER) stress. In addition, promising perinatal nutritional and pharmaceutical interventions are highlighted which …

Effects Of Protein Deficiency On Perinatal And Postnatal Health Outcomes, Shelby L. Oke, Daniel B. Hardy

Physiology and Pharmacology Publications

There are a variety of environmental insults that can occur during pregnancy which cause low birth weight and poor fetal health outcomes. One such insult is maternal malnutrition, which can be further narrowed down to a low protein diet during gestation. Studies show that perinatal protein deficiencies can impair proper organ growth and development, leading to long-term metabolic dysfunction. Understanding the molecular mechanisms that underlie how this deficiency leads to adverse developmental outcomes is essential for establishing better therapeuticstrategies that may alleviate or prevent diseases in later life. This chapter reviews how perinatal protein restriction in humans and animals leads …

Perinatal Malnutrition And Epigenetic Regulation Of Long-Term Metabolism In The Liver And Adipose Tissue, Daniel B. Hardy

Physiology and Pharmacology Publications

Maternal malnutrition in perinatal life can have long-lasting adverse effects on glucose and lipid homeostasis in the offspring, culminating in dyslipidemia, insulin resistance and obesity. Understanding the molecular mechanisms underlying how these nutritional deficits during perinatal life lead to permanent changes in hepatic and adipose function will provide efficacious therapeutic strategies to mitigate these metabolic defects short- and long-term. This chapter addresses how epigenetic mechanisms mediate alterations in hepatic and adipose gene expression identified from clinical studies and different experimental models of maternal malnutrition. These include DNA methylation, post-translational histone modifications, and microRNAs.