Virus Diseases Commons^™

Regenerative Medicine Therapy: Adipose Derived Extracellular Vesicles In Viral Myocarditis, David Gorelov, Damian N. Di Florio, Gary R. Salomon, Angita Jain, Nick E. Saikaili, Danielle J. Beetler, Swikriti Shrestha, Ming Tian, Joy Wolfram Phd, Delisa Fairweather Phd, Katelyn Bruno Phd, Judith D. Ochrietor Phd

Showcase of Osprey Advancements in Research and Scholarship (SOARS)

Objective: Myocarditis, inflammation of the heart muscle, is an autoimmune heart disease that can be caused by viruses, bacteria and toxins. Myocarditis can lead to dilated cardiomyopathy (DCM) and heart failure. Currently there are no disease-specific therapies for treating myocarditis or preventing progression to DCM. Adipose Extracellular Vesicles (AEVs) are lipid bilayer nanoparticles that are released into the outside environment of adipocytes and provide promising regenerative potential for inflammatory diseases like myocarditis.

Methods: Lipoaspirate was obtained from women and men and AEVs isolated from the lipoaspirate using tangential flow filtration. We injected wild type male BALB/c mice with 250uL AEVs …

Comorbidity Factors Influence Covid-19 Mortality Much More Than Age, Steven Gjerstad, Andrea Molle

ESI Working Papers

This paper demonstrates that once we control for comorbidity factors, age has a minor effect on COVID-19 mortality. This has implications for the treatment of current and recovered COVID-19 patients, including health screenings of recovered COVID-19 patients, triage decisions for patients in critical care, and prioritization of vaccinations when one is developed. The coronavirus epidemic in Italy has strained hospital resources, including ICU beds and ventilators for those experiencing acute respiratory failure. Studies of COVID-19 in China [1], Italy [2], and the United States [3] show that fatality rates increase rapidly with age, especially beyond age 60. The same studies …

Osteopathy And The Pandemic Of 1918, Robyn Oro

Notes from the Archives

No abstract provided.

Old Habits—A Semester At Home In 2020, Hannah Tienvieri

Reflections, Poetry, Photos, and other Writings

This is a poem I wrote after the student body was sent home for the remainder of the spring semester. This piece is an expression of the isolation and unique feeling of regression that came in the early days of the pandemic, particularly caused by being confined to my childhood bedroom.

Validation Of A Lysis Buffer Containing 4 M Guanidinium Thiocyanate (Gitc)/ Triton X-100 For Extraction Of Sars-Cov-2 Rna For Covid-19 Testing: Comparison Of Formulated Lysis Buffers Containing 4 To 6 M Gitc, Roche External Lysis Buffer And Qiagen Rtl Lysis Buffer, Martina F. Scallan, Catherine Dempsey, John Mcsharry, Isabelle O'Callaghan, Paula M. O'Connor, Conor P. Horgan, Edel Durack, Paul D. Cotter, Sarah Hudson, Humphrey A. Moynihan, Brigid Lucey

Dept. of Biological Sciences Preprints

The COVID-19 pandemic has resulted in increased need for diagnostic testing using reverse transcriptase real-time PCR (RT-PCR). An exponential increase in demand has resulted in a shortage of numerous reagents in particular those associated with the lysis buffer required to extract the viral RNA. Herein, we describe a rapid collective effort by hospital laboratory scientists, academic researchers and the biopharma industry to generate a validated lysis buffer. We have formulated a 4M Guanidinium thiocyanate (GITC)/ Triton X-100 Lysis buffer which provides comparable results with the recommended reagents. This buffer will ease the burden on hospital labs in their heroic efforts …

Information Mining For Covid-19 Research From A Large Volume Of Scientific Literature, Sabber Ahamed, Manar D. Samad

Computer Science Faculty Research

The year 2020 has seen an unprecedented COVID-19 pandemic due to the outbreak of a novel strain of coronavirus in 180 countries. In a desperate effort to discover new drugs and vaccines for COVID-19, many scientists are working around the clock. Their valuable time and effort may benefit from computer-based mining of a large volume of health science literature that is a treasure trove of information. In this paper, we have developed a graph-based model using abstracts of 10,683 scientific articles to find key information on three topics: transmission, drug types, and genome research related to coronavirus. A subgraph is …

Ua94/6/1 Reflection, Janice Kampsen

Student/Alumni Personal Papers

Report regarding COVID-19 by Janice Kampsen for Military Science 490 class.

My Story, Tesia Juraschek

Reflections, Poetry, Photos, and other Writings

My first reactions to COVID as we learned that it would affect our schooling.

Ua94/6/1 Covid-19 Impacts, Shelby Howell

Student/Alumni Personal Papers

Report on the impact of COVID-19 by student Shelby Howell for Military Science 490 class.

Holding My Hand, Marylou Habecker

Reflections, Poetry, Photos, and other Writings

This is a piece that I have written to try to give HOPE to others in the middle of this crisis. A story I witnessed taken from another part of the world during a horrendous time of war gave me HOPE. He is Holding My Hand.

Senior Year Cut Short, Caleb Amick

Reflections, Poetry, Photos, and other Writings

This is my story of what happened to me during the last week of school before we left campus.

Day 10, Elise Wixtrom

Reflections, Poetry, Photos, and other Writings

This is a poem I wrote after visiting the supermarket right after classes closed on Taylor's campus.

Nothing Wasted, Adina Shabe

Reflections, Poetry, Photos, and other Writings

As our world is facing unprecedented interruptions to our sense of "normal" I have been pressing in to receive God's perspective for myself during this time. He is a God who wastes nothing, He uses everything.

Ua94/6/1 My Story: Wku Mens Basketball's Taveion Hollingsworth, Taveion Hollingsworth

Student/Alumni Personal Papers

My Story is a series of first-person feature articles written by WKU student-athletes. The student-athletes will be telling their own stories in their own words. This article written by men’s basketball junior guard Taveion Hollingsworth, whose mission of advancing to the NCAA Tournament with his teammates was halted when the Covid-19 pandemic hit.

Don't Bug Me: Everything Young Kids Need To Know About Coronavirus--In Verse!, Rhea Paul

Community Reflections

A story in verse for young children (3-8) about coronavirus. Narrated by the author, Rhea Paul. Press the "Slide Show" button at the top of the screen, then in the menu that appears, hit "Play from Beginning" all the way to the left.

Ua37/2 Autism Isn't Coronavirus, Tom C. Hunley

Faculty/Staff Personal Papers

Poem written by WKU English professor Tom Hunley during the Covid-19 pandemic.

El Artista Está En Línea: E-Performance En El Tiempo De Covid-19, Ezequiel N. González

Independent Study Project (ISP) Collection

Esta investigación propone una lectura detallada y comparativa de varias e-performances creadas por el artista visual uruguayo Ernesto Rizzo y la performer argentina Susy Shock, trazando un corpus de trabajo creado durante la crisis de COVID-19 y compartido en Instagram desde finales de marzo a finales de mayo de 2020. Al centrarse en el giro digital del arte de performance debido a las particularidades de la cuarentena, esta investigación busca distinguir este momento de "e-performance", entendiendo cuáles serán sus ramificaciones para el/la artista y el arte de performance en general. Así, a través de una reflexión teórica sobre el terreno …

Managing The Threat Of Covid-19, Susan H. Davide, Anty Lam, Christine Macarelli

Publications and Research

Oral health professionals should remain up-to-date on Covid-19 to prevent its transmission in the dental practice.

Optimization Of Methods For Cross-Species Infection Of Cell Cultures With Wolbachia, Sarah J. Lane

Honors Thesis

The common intracellular endosymbiont genus of bacteria called Wolbachia is of interest due to the promise it shows for playing a role in disease control. Wolbachia have a number of widely variable effects on its many species of host insects. In combination with these roles, Wolbachia largely affects reproduction and development of its host species. It can lead to feminization and cytoplasmic incompatibility (Werren et al. 2008). Furthermore, this species is vertically transmitted which means that it passes from mother to offspring (Caragata et al., 2016). In combination with its effects on reproduction, which can allow Wolbachia to propagate through …

Potency And Breadth Of Human Primary Zikv Immune Sera Shows That Zika Viruses Cluster Antigenically As A Single Serotype, Chad M. Nix, Jonathan Salberg, Felicity J. Coulter, Bettie W. Kareko, Zoe L. Lyski, Brian L. Booty, William B. Messer

OHSU-PSU School of Public Health Faculty Publications and Presentations

The recent emergence of Zika virus as an important human pathogen has raised questions about the durability and breadth of Zika virus immunity following natural infection in humans. While global epidemic patterns suggest that Zika infection elicits a protective immune response that is likely to offer long-term protection against repeat infection by other Zika viruses, only one study to date has formally examined the ability of human Zika immune sera to neutralize different Zika viruses. That study was limited because it evaluated human immune sera no more than 13 weeks after Zika virus infection and tested a relatively small number …