Examining The Potential Clinical Value Of Curcumin In The Prevention And Diagnosis Of Alzheimer's Disease,
2016
Edith Cowan University
Examining The Potential Clinical Value Of Curcumin In The Prevention And Diagnosis Of Alzheimer's Disease, K. G. Goozee, T. M. Shah, Hamid R. Sohrabi, Stephanie Rainey-Smith, B. Brown, Guiseppe Verdile, Ralph Martins
Research outputs 2014 to 2021
Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer’s disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on the exclusion of other causes of dementia. In addition, phase III clinical trials of potential treatments have mostly failed, leaving disease-modifying interventions elusive. AD can be characterised neuropathologically by the deposition of extracellular β amyloid (Aβ) plaques and intracellular accumulation of tau-containing neurofibrillary tangles. Disruptions in Aβ metabolism/clearance contribute to …
The Effects Of Latrepirdine On Amyloid-Β Aggregation And Toxicity,
2016
Edith Cowan University
The Effects Of Latrepirdine On Amyloid-Β Aggregation And Toxicity, Tenielle Porter, Prashant Bharadwaj, David Groth, Adrian Paxman, Simon Laws, Ralph Martins, Guiseppe Verdile
Research outputs 2014 to 2021
Latrepirdine (DimebonTM) has been demonstrated to be a neuroprotective and cognition improving agent in neurodegenerative diseases that feature protein aggregation and deposition, such as Alzheimer's disease (AD). The accumulation of amyloid-β (Aβ) protein aggregates is a key event in the neurodegenerative process in AD. This study explores if latrepirdine modulation of protein aggregation contributes to its neuroprotective mechanism of action. Assessment of neuronal cell death showed that there was a significant reduction in lactate dehydrogenase release at an equimolar ratio of Aβ:latrepirdine and with lower concentrations of latrepirdine. The ability of latrepirdine to alter the formation of Aβ42 aggregates was …
The Role Of Oxidative Stress In The Mechanisms Of Ammonia-Induced Brain Swelling And Tolerance In The Goldfish (Carassius Auratus),
2016
Wilfrid Laurier University
The Role Of Oxidative Stress In The Mechanisms Of Ammonia-Induced Brain Swelling And Tolerance In The Goldfish (Carassius Auratus), David F. Jones Lisser Mr.
Theses and Dissertations (Comprehensive)
Toxic build-ups of ammonia can cause potentially fatal brain swelling in mammals, but such swelling is reversible in the anoxia- and ammonia-tolerant goldfish (Carassius auratus). The mechanisms of ammonia-induced brain swelling and tolerance remain elusive, but several studies have suggested a role for reactive oxygen species (ROS), which may damage proteins and lipids in the plasma membrane of astrocytes in the brain. As a result, osmotic gradients across cell membranes may be altered leading to water uptake by astrocytes and swelling. While a role for ROS has been proposed in mammals, no studies have addressed this question in …
‘Concussion’: Advocating For The Truth About Brain Diseases,
2015
University of San Diego
‘Concussion’: Advocating For The Truth About Brain Diseases, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Twas The Morning After Christmas – And Huntington's Disease Hit Us Like A Ton Of Bricks,
2015
University of San Diego
‘Twas The Morning After Christmas – And Huntington's Disease Hit Us Like A Ton Of Bricks, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Feedforward And Feedback Controls On Gait In Adults With Diabetes,
2015
University of Nebraska Medical Center
The Feedforward And Feedback Controls On Gait In Adults With Diabetes, Chun-Kai Huang
Theses & Dissertations
There are nearly 26 million people with diabetes mellitus (DM) in the US, and half of chronic DMs develop somatosensory deficits due to diabetic polyneuropathy or diabetic peripheral neuropathy (DPN). The absence or impaired somatosensory feedback (e.g. touch sensation or joint proprioception) resulted from the damage of large nerve fiber, and motor deficits such as attenuated muscle strength and abnormal plantar pressure of lower extremity have been identified in DPN, and these sensorimotor impairments lead to an increased number of falls. To reduce the risk of falling, a well-coordinated and adapted limb movement driven by the feedforward (anticipatory) and feedback …
How To Make Law Enforcement A Friend – Not A Foe – Of People With Huntington's Disease (And Other Disabilities),
2015
University of San Diego
How To Make Law Enforcement A Friend – Not A Foe – Of People With Huntington's Disease (And Other Disabilities), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Levels Of Glycosaminoglycans In The Cerebrospinal Fluid Of Healthy Young Adults, Surrogate-Normal Children, And Hunter Syndrome Patients With And Without Cognitive Impairment.,
2015
George Washington University
Levels Of Glycosaminoglycans In The Cerebrospinal Fluid Of Healthy Young Adults, Surrogate-Normal Children, And Hunter Syndrome Patients With And Without Cognitive Impairment., Christian J Hendriksz, Joseph Muenzer, Adeline Vanderver, Jonathan M Davis, Barbara K Burton, Nancy J Mendelsohn, Nan Wang, Luying Pan, Arian Pano, Ann J Barbier
Neurology Faculty Publications
In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls.
With More Huntington’S Disease Clinical Trials, Volunteers Need Help With Comparison Shopping,
2015
University of San Diego
With More Huntington’S Disease Clinical Trials, Volunteers Need Help With Comparison Shopping, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Might I Finally Take Part In A Huntington’S Disease Clinical Trials? An Update On The Latest Research,
2015
University of San Diego
Might I Finally Take Part In A Huntington’S Disease Clinical Trials? An Update On The Latest Research, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Physiology And Psychology Of Exercise And Parkinson's Disease,
2015
Liberty University
The Physiology And Psychology Of Exercise And Parkinson's Disease, Jess Gibson
Senior Honors Theses
Parkinson’s disease is one of the most common degenerative neurological disorders and is currently lacking a cure. While physicians have long debated over the best treatment for Parkinson’s symptoms, treatments such as oral medication and deep brain stimulation have not yet shown to be a permanent solution to the disease. Recently, exercise has emerged as a contender in the fight against Parkinson’s and physicians and physiotherapists have been investigating the benefits of prescribing exercise programs to patients in an effort to slow progression of Parkinson’s symptoms. The following presents an analysis of the effects of exercise on Parkinson’s symptoms and …
Local And Distributed Pib Accumulation Associated With Development Of Preclinical Alzheimer's Disease,
2015
Washington University School of Medicine in St. Louis
Local And Distributed Pib Accumulation Associated With Development Of Preclinical Alzheimer's Disease, Matthew R. Brier, John E. Mccarthy, Tammie L.S. Benzinger, Ari Stern, Yi Su, Karl A. Friedrichsen, John C. Morris, Beau M. Ances, Andrei G. Vlassenko
Mathematics Faculty Research
Amyloid-beta plaques are a hallmark of Alzheimer's disease (AD) that can be assessed by amyloid imaging (e.g., Pittsburgh B compound [PiB]) and summarized as a scalar value. Summary values may have clinical utility but are an average over many regions of interest, potentially obscuring important topography. This study investigates the longitudinal evolution of amyloid topographies in cognitively normal older adults who had normal (N = 131) or abnormal (N = 26) PiB scans at baseline. At 3 years follow-up, 16 participants with a previously normal PiB scan had conversion to PiB scans consistent with preclinical AD. We investigated the multivariate …
Cross-Sectional Survey Of Relevant Literatures As To The Current Proposed Disease Mechanisms And Treatments Of Amyotrophic Lateral Sclerosis (Als),
2015
Marshall University
Cross-Sectional Survey Of Relevant Literatures As To The Current Proposed Disease Mechanisms And Treatments Of Amyotrophic Lateral Sclerosis (Als), Zachary Sanford
Marshall Journal of Medicine
Amyotrophic Lateral Sclerosis (ALS), more commonly referred to as Lou Gehrig’s disease, is a progressively degenerative neuromuscular disorder affecting both the upper and lower motor neurons and preferentially affecting males in their forties to seventies. Although the pathology of ALS has been clearly elucidated elsewhere, the precise mechanisms by which the disease progresses and the means by which it is acquired are still poorly understood areas of medicine. Current genomic and proteomic studies in human and animal models have yielded exciting and promising new findings that may help elucidate this pathology. It is the purpose of this review article to …
Huntington’S Disease Patients Get First Dosing In Historic Isis Pharmaceuticals' Gene-Silencing Drug Trial,
2015
University of San Diego
Huntington’S Disease Patients Get First Dosing In Historic Isis Pharmaceuticals' Gene-Silencing Drug Trial, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
At-Risk Angels Pitcher Joe Smith At Huntington’S Fundraiser: 'I'D Give Every Dime I Have For A Cure',
2015
University of San Diego
At-Risk Angels Pitcher Joe Smith At Huntington’S Fundraiser: 'I'D Give Every Dime I Have For A Cure', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
At Key Fda Meeting, Huntington's Disease Community Insists On Faster Search For Treatments,
2015
University of San Diego
At Key Fda Meeting, Huntington's Disease Community Insists On Faster Search For Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Initial Validation Of A Novel Method Of Presurgical Language Localization Through Functional Connectivity (Fcmri),
2015
Yale University
Initial Validation Of A Novel Method Of Presurgical Language Localization Through Functional Connectivity (Fcmri), Stephanie M. Noble, Dustin Scheinost, Susan Y. Bookheimer, Patricia Walshaw, R Todd Constable, Christopher F. Benjamin
Yale Day of Data
OBJECTIVE: Neurosurgery is potentially curative in chronic epilepsy but can only be offered to patients if the surgical risk to language is known. Clinical functional magnetic resonance imaging (fMRI) is an ideal, noninvasive method for localizing language cortex yet remains to be validated for this purpose. We have recently presented a novel method for localizing language cortex. Here we present a preliminary evaluation of this method’s validity. We hypothesized language regions identified using this novel method would demonstrate stronger functional connectivity than randomly generated set of proximal networks. METHOD: fMRI data were collected from sixteen temporal lobe patients …
As He Lay Dying: Fda And Huntington’S Disease Families Meet To Ponder Potential Treatments,
2015
University of San Diego
As He Lay Dying: Fda And Huntington’S Disease Families Meet To Ponder Potential Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
New Film Unmasks The Raw Reality Of Huntington’S Disease,
2015
University of San Diego
New Film Unmasks The Raw Reality Of Huntington’S Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Reinforcing The Global Fight Against Huntington’S Disease: A Visit To Brazil And A Reminder Of Our Common Struggles,
2015
University of San Diego
Reinforcing The Global Fight Against Huntington’S Disease: A Visit To Brazil And A Reminder Of Our Common Struggles, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
