Triterpenoid Modulation Of Il-17 And Nrf-2 Expression Ameliorates Neuroinflammation And Promotes Remyelination In Autoimmune Encephalomyelitis,
2011
Case Western Reserve University
Triterpenoid Modulation Of Il-17 And Nrf-2 Expression Ameliorates Neuroinflammation And Promotes Remyelination In Autoimmune Encephalomyelitis, Tej K. Pareek, Abdelmadjid Belkadi, Sashi Kesavapany, Anita Zaremba, Sook L. Loh, Lianhua Bai, Mark L. Cohen, Colin Meyer, Karen T. Liby, Robert H. Miller, Michael B. Sporn, John J. Letterio
Dartmouth Scholarship
Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects directly through Nrf2-dependent induction of anti-oxidant genes. Derivatives of the natural triterpene oleanolic acid, namely CDDO-trifluoroethyl-amide (CDDO-TFEA), completely suppressed disease in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), by inhibiting Th1 and Th17 mRNA and cytokine production. Encephalitogenic T cells recovered from treated mice were hypo-responsive to myelin antigen and failed to adoptively transfer the disease. Microarray analyses showed significant suppression of …
Kate's Untested Baby (Huntington’S Disease And Abortion - Part Ii),
2011
University of San Diego
Kate's Untested Baby (Huntington’S Disease And Abortion - Part Ii), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
An Angel Fighting For The Cure (Huntington’S Disease And Abortion - Part I),
2011
University of San Diego
An Angel Fighting For The Cure (Huntington’S Disease And Abortion - Part I), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Multiple Sclerosis Is Not A Disease Of The Immune System,
2011
CUNY John Jay College
Multiple Sclerosis Is Not A Disease Of The Immune System, Angelique Corthals
Publications and Research
Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations. Despite great advances in documenting the cell and molecular mechanisms underlying MS pathophysiology, the autoimmunity framework has also been unable to develop a comprehensive explanation of the etiology of the disease. I propose a new framework for understanding MS as a dysfunction of the metabolism of lipids. Specifically, the homeostasis of lipid metabolism collapses during …
Role Of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 And In Immature Neurons,
2011
The University of Texas Graduate School of Biomedical Sciences at Houston
Role Of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 And In Immature Neurons, Yi Chun Chen
Dissertations & Theses (Open Access)
Spinocerebellar Ataxia type 7 (SCA7) is a neurodegenerative disease caused by expansion of a CAG repeat encoding a polyglutamine tract in ATXN7, a component of the SAGA histone acetyltransferase (HAT) complex. Previous studies provided conflicting evidence regarding the effects of polyQ-ATXN7 on the activity of Gcn5, the HAT catalytic subunit of SAGA. Here I showed that reducing Gcn5 expression accelerates both cerebellar and retinal degeneration in a mouse model of SCA7. Deletion of Gcn5 in Purkinje cells in mice expressing wild type Atxn7, however, causes only mild ataxia and does not lead to the early lethality observed in SCA7 mice. …
The Holy Grail Of Huntington's Disease Research: The Gene-Positive, Drug Trials, And Treatments,
2011
University of San Diego
The Holy Grail Of Huntington's Disease Research: The Gene-Positive, Drug Trials, And Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Exploring The Role Of The Solvent In The Denaturation Of A Protein: A Molecular Dynamics Study Of The Dna Binding Domain Of The 434 Repressor,
2011
University of Massachusetts Medical School
Exploring The Role Of The Solvent In The Denaturation Of A Protein: A Molecular Dynamics Study Of The Dna Binding Domain Of The 434 Repressor, Celia Schiffer, Volker Dötsch, Kurt Wuthrich, Wilfred Van Gunsteren
Celia A. Schiffer
Molecular dynamics simulations of the DNA binding domain of 434 repressor are presented which aim at unraveling the role of solvent in protein denaturation. Four altered solvent models, each mimicking various possible aspects of the addition of a denaturant to the aqueous solvent, were used in the simulations to analyze their effects on the stability of the protein. The solvent was altered by selectively changing the Coulombic interaction between water and protein atoms and between different water molecules. The use of a modified solvent model has the advantage of mimicking the presence of denaturant without having denaturant molecules present in …
An Hd Thanksgiving Toast,
2011
University of San Diego
An Hd Thanksgiving Toast, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Finding America’S Passion: The Nfl And Huntington’S Disease,
2011
University of San Diego
Finding America’S Passion: The Nfl And Huntington’S Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Huntington’S Disease In The News And Entertainment Media - Part Ii: A Suicide On Tv,
2011
University of San Diego
Huntington’S Disease In The News And Entertainment Media - Part Ii: A Suicide On Tv, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Huntington’S Disease In The News And Entertainment Media - Part I: Stigma And Genetic Testing,
2011
University of San Diego
Huntington’S Disease In The News And Entertainment Media - Part I: Stigma And Genetic Testing, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Huntington’S Disease And The Financial Jitters,
2011
University of San Diego
Huntington’S Disease And The Financial Jitters, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Bdnf And ‘Neurobics’: Building A ‘Beautiful Mind’ Against Huntington's,
2011
University of San Diego
Bdnf And ‘Neurobics’: Building A ‘Beautiful Mind’ Against Huntington's, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Neuroprotective Effects Of Bilobalide Are Accompanied By A Reduction Of Ischemia-Induced Glutamate Release In Vivo,
2011
Goethe University Frankfurt
Neuroprotective Effects Of Bilobalide Are Accompanied By A Reduction Of Ischemia-Induced Glutamate Release In Vivo, Dorothee Lang, Cornelia Kiewert, Alexander Mdzinarishvili, Tina Maria Schwarzkopf, Rachita K. Sumbria, Joachim Hartmann, Jochen Klein
Pharmacy Faculty Articles and Research
Neuroprotective properties of bilobalide, a specific constituent of Ginkgo extracts, were tested in a mouse model of stroke. After 24 h of middle cerebral artery occlusion (MCAO), bilobalide reduced infarct areas in the core region (striatum) by 40–50% when given at 10 mg/kg 1 h prior to MCAO. Neuroprotection was also observed at lower doses, or when the drug was given 1 h past stroke induction. Sensorimotor function in mice was improved by bilobalide as shown by corner and chimney tests. When brain metabolism in situ was monitored by microdialysis, MCAO caused a rapid disappearance of extracellular glucose in the …
Making Sense Of Huntington’S Organizations, And A Call For Unity,
2011
University of San Diego
Making Sense Of Huntington’S Organizations, And A Call For Unity, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Waiting For Symptoms: How Long Can I Hang On?,
2011
University of San Diego
Waiting For Symptoms: How Long Can I Hang On?, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
One Man's Story: Entering The Light,
2011
University of San Diego
One Man's Story: Entering The Light, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Do-Or-Die Time For Huntington’S Clinical Trials,
2011
University of San Diego
Do-Or-Die Time For Huntington’S Clinical Trials, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Upregulation Of Reactive Oxygen Species During The Retrovirus Life Cycle And Their Roles In A Mutant Of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration,
2011
The University of Texas Graduate School of Biomedical Sciences at Houston
Upregulation Of Reactive Oxygen Species During The Retrovirus Life Cycle And Their Roles In A Mutant Of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration, Soo Jin Kim
Dissertations & Theses (Open Access)
Viral invasion of the central nervous system (CNS) and development of neurological symptoms is a characteristic of many retroviruses. The mechanism by which retrovirus infection causes neurological dysfunction has yet to be fully elucidated. Given the complexity of the retrovirus-mediated neuropathogenesis, studies using small animal models are extremely valuable. Our laboratory has used a mutant moloney murine leukemia retrovirus, ts1-mediated neurodegneration. We hypothesize that astrocytes play an important role in ts1-induced neurodegeneration since they are retroviral reservoirs and supporting cells for neurons. It has been shown that ts1 is able to infect astrocytes in vivo and in …
No Time For Complacency: Get Ready For Hd Clinical Trials,
2011
University of San Diego
No Time For Complacency: Get Ready For Hd Clinical Trials, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
