Nervous System Diseases Commons^™

A Rare Case Of Maffucci Syndrome Presenting With Cord Compression And Paradoxical Stroke, Fernando Lugo-Hernandez, Nicholas Farelo-Camargo, Adriana Rivera-Diaz, Mariana Villamizar-Suarez, Marwa Hegagi

West Florida Division GME Research Day 2025

No abstract provided.

Enhancing Stroke Rehabilitation: A Quality Improvement Initiative, Clifford Gordon, Olu Oyesanmi, Marc Kallins, Rahul Mhaskar, Sanjiv Tewari, Lisa Gramong, Kristy Ellison-Snow, Cynthia Koski

West Florida Division GME Research Day 2025

No abstract provided.

Bilateral Thalamic And Basal Ganglia Infarcts Secondary To Deep Venous Sinus Thrombosis In The Setting Of Testosterone Use, Cristian Solano

West Florida Division GME Research Day 2025

No abstract provided.

Vascular Trigeminal Neuralgia: Dolichoectasia Of Basilar Artery, Adwait Lonkar, Christopher Koebbe, Mariya Milko, Craig Spergel

West Florida Division GME Research Day 2025

No abstract provided.

A Fatal Case Of Central Pontine Myelinolysis With Chronic Inflammatory Demyelinating Polyneuropathy, Miguel Serrano, Grant Read, Karen Joseph

West Florida Division GME Research Day 2025

No abstract provided.

Use Of Kratom Tea Supplements For The Treatment Of Self-Diagnosed Anxiety And Its Association With New Onset Seizures In A Young Adult Male, Gloria Travieso-Zadan, Lucas Zadan, Daniel Breznau

West Florida Division GME Research Day 2025

No abstract provided.

Reprogramming Of Immunometabolic Functions In Brain Microvascular Endothelial Cells During Neuroinflammation: Insights From Ischemic Stroke And Sepsis, Shokofeh Rahimpourkaldeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ischemic stroke and sepsis-associated encephalopathy (SAE) are two distinct conditions that share common pathophysiological mechanisms affecting brain microvascular endothelial cells (BMECs). Ischemic stroke results from an acute reduction in cerebral blood flow due to thrombosis or embolism, leading to energy failure, oxidative stress, and blood-brain barrier (BBB) dysfunction. SAE, a neurological complication of sepsis, arises from systemic inflammation, endothelial activation, and BBB disruption, leading to cognitive impairment and neuroinflammation. Despite their different etiologies, both conditions involve BMEC dysfunction as a central mediator of neurovascular injury. This dissertation aims to investigate the immunometabolic dysfunction of BMECs in ischemic stroke and sepsis, …

Effects Of High-Frequency Repetitive Transcranial Magnetic Stimulation On Impulse Control Disorders In Patients With Parkinson’S Disease On Dopamine Replacement Therapy, Katherine Muksuris

Graduate Theses, Dissertations, and Problem Reports (ETD)

Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder that causes motor deficits, cognitive impairment, and depression. The mainstay treatment for motor symptoms is dopamine replacement therapy (DRT). DRT takes the form of levodopa or dopamine receptor agonists (DAs) and can be associated with impulse control disorders (ICDs). Currently, the approach to mitigating these side effects is to decrease or stop DRT, which may cause motor symptoms to return, making the management of the disorder more difficult. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation treatment for multiple disorders, including its approved use for smoking cessation. It has also shown …

Computational Approaches For Diagnosing Neurological Impairments And Restoring Functional Movement, Serhii Bahdasariants

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is the primary means by which the nervous system converts intention into interaction with the environment. Voluntary limb motion enables standing, walking, reaching, and grasping—actions that underpin self‑care, communication, and economic participation. When diseases or injuries disrupt the pathways that couple neural commands to muscle forces—whether through cortical stroke, spinal cord injury, or peripheral nerve damage—mechanical outcomes such as weakness, loss of coordination, and ultimately reduced mobility emerge. These impairments cascade into secondary complications, increased dependence on caregivers, and diminished quality of life. Quantifying how the lesion alters the mechanics of movement is therefore essential for designing targeted interventions …

Opioid Tolerance And Withdrawal In The Mouse Colon, James Fune

Theses and Dissertations

Constipation is a major clinical obstacle associated with opioids, prompting patients to discontinue treatment due to pain, discomfort, and psychosocial stressors. Moreover, chronic users become tolerant to the analgesic effects of opioids, but not to their constipating effects. Upon cessation of long-term treatment, serious diarrhea–among other somatic signs of withdrawal–may ensue. These symptoms become a driving factor for relapse, causing patients to restart opioid treatment. In this study, we aim to understand mechanisms that contribute to opioid tolerance and withdrawal in the colon. Previous findings suggest that constipation occurs partly due to the colon’s lack of tolerance to opioids’ inhibitory …

Case Report: Wall-Eyed Bilateral Internuclear Ophthalmoplegia From A Pontine Stroke, Renuka Mahatara, Sahil Parikh, Jeffery Bodle

South Atlantic Division GME Research Day 2025

No abstract provided.

A Case Report Of Fatal Posterior Reversible Encephalopathy Syndrome Associated With Tivozanib In Renal Cell Carcinoma, Chad Michalenko, Ian Whitaker, Abhinav Rao

South Atlantic Division GME Research Day 2025

No abstract provided.

Acute Ischemic Stroke In The Setting Of Lambl’S Excrescenses, Natalia C. Badillo, Jay Heckert, Yoan Rodriguez, Ashu Dhanjal

South Atlantic Division GME Research Day 2025

No abstract provided.

Neurosyphilis Mortality Trends In The United States (1999–2023): A Cdc Wonder Database Analysis, Amy Mackenzie, Barbara Gracious

South Atlantic Division GME Research Day 2025

No abstract provided.

Unmasking Cns Vasculitis: A Neurological Mystery Behind Recurrent Strokes In A Young Patient, Arthika Sakthevel, Vishal Shah, Holden Lewis, Alyssa Rojas, Mohamed Faris

South Atlantic Division GME Research Day 2025

No abstract provided.

Concomitant Diagnoses Of Lymphoma And Pml In An Hiv-Positive Patient, Madelaine Duarte, Delon Altherr, Mohamed Faris

South Atlantic Division GME Research Day 2025

No abstract provided.

A Historic Case Of Relapsing-Remitting Alzheimer's Disease In An Adolescent Attributed To Scarlet Fever., Richard Lathe, Brian J. Balin

PCOM Scholarly Works

We draw attention to a historic case of a boy who suffered from scarlet fever (typically caused by the bacterium Streptococcus pyogenes) at age 7 years and went on to develop the symptoms of Alzheimer's disease (AD). His physicians believed that the subsequent dementia was related to the infection. After death at 24 years of age, postmortem brain examination revealed abundant AD-type senile plaques and fibrils, formally confirming AD. Other potential causes of early-onset dementia are discussed, but these are distinct from patient E.H. This case is pertinent regarding the current debate about the potential role of infection in …

Astrocyte Specific Enhancers In The Cortex And Striatum Of Mice, Mikaela Kottelich

Williams Honors College, Honors Research Projects

Among glial cells, astrocytes have a prevalent influence on supporting neuronal function and overall brain health. Specifically targeting this cell type for disease treatment is an existing issue. Other cell types tend to express the desired treatment, which is not always wanted and can lead to unintended, negative consequences. Astrocytes contribute largely to maintaining the blood brain barrier, which is disrupted in Parkinson’s disease. Certain genes are thought to be the reason for this disruption, so if they can be specifically targeted in astrocytes with a specific enhancer, the disruption of the disease could be reversed. In our experiment, we …

Postoperative Conundrum: Horner Syndrome Secondary To Anterior Cervical Discectomy And Fusion Procedure, Nicholas Mynarski, Sabrina M. Johnson, Aanchal Sawhney, Christine Giesa Do, Rachel Odeyemi Do

Transformative Medicine

IntroductionHorner syndrome is a rare complication following anterior cervical discectomy and fusion (ACDF) surgeries, with an incidence rate of

Case DescriptionWe report a case of a 45-year-old female with a history of non-Hodgkin's lymphoma and chronic obstructive pulmonary disease who developed Horner syndrome post-ACDF. Initially admitted for suspected cholecystitis found on imaging following a fall, the patient's clinical course was complicated by worsening cervical and lumbar pain. This prompted MRI evaluation revealing cervical stenosis at C5-C6 and ACDF was performed without intraoperative complications. However, on postoperative day three, the patient developed left eye ptosis and miosis, consistent with …

Oculomotor Nerve Palsy Recovery Following Microsurgery Vs. Endovascular Treatment Of Posterior Communicating Artery Aneurysms: A Comparative Meta-Analysis Of Short- And Long-Term Outcomes, Rahim Abo Kasem, Conor Cunningham, Sameh Samir Elawady, Mohammad Mahdi Sowlat, Sofia Babool, Saad Hulou, Zachary Hubbard, Atakan Orscelik, Basel Musmar, Alejandro Spiotta

Department of Neurosurgery Faculty Papers

Recent advancements in endovascular treatment (EVT) and different views on optimal management for posterior communicating artery (PComA) aneurysms with oculomotor nerve palsy (ONP) highlight a need to compare recovery timelines between microsurgery and EVT; heterogeneous outcomes and influencing factors may also affect results. A comprehensive systematic review and meta-analysis were conducted by searching PubMed, Embase, Scopus, and Web of Science databases. The extracted data encompassed patient demographics, details on treatment modalities and timing, and characteristics of PComA aneurysms ONP caused by either unruptured or ruptured aneurysms. The primary outcome was ONP favorable recovery, defined as the resolution of admission symptoms, …