Dietetics and Clinical Nutrition Commons^™

Elucidating The Impact Of Western Diet On Bone Marrow Cytokine Signatures: Understanding Poor Outcomes In Susceptibility To Infection And Progression Of Cancer, Lahari Kondeti

Theses, Dissertations and Capstones

Among other disease outcomes, obesity is associated with 1) reduction in long-lasting immune protection and 2) acquisition of cancer. Given our interest in hematopoietic stem and progenitor cell (HSPC) dynamics, we questioned if similar mechanisms in the bone marrow microenvironment contribute to obesity-induced HSPC alterations responsible for 1) decreased immune protection and 2) transformation of HSPCs in the pathogenesis of hematologic malignancies. The negative effects of obesity on immune protection are most notably established in influenza models. Influenza infection susceptibility is increased and influenza vaccine-induced immunity wains in obese individuals. Ongoing studies aim to define mechanisms for waning immunity at …

The Differences Between The Quality Of Life And Personal Health Profile Between Individuals Diagnosed With Celiac Disease And Those Who Follow A Gluten-Free Diet For Non-Celiac Reasons, Ellie Fuechtmann

Theses and Graduate Projects

Background: Celiac disease is an autoimmune disorder triggered by gluten proteins in wheat, barley, and rye, necessitating a strict gluten-free diet. However, many individuals without celiac disease are adopting gluten-free diets for various health reasons.

Purpose: This study compares the quality of life and health profile of individuals with celiac disease and those following a gluten-free diet for non-celiac reasons.

Methods: A survey was conducted and distributed via social media to people diagnosed with celiac disease and those adhering to a gluten-free diet non-celiac. The results were analyzed via Google Forms and Excel to better interpret the data for visualization. …

L-Menthol: An Emerging Athletic Performance Enhancing Aid, Maitham Khanafer

Senior Honors Theses and Projects

Background: L-menthol is an emerging athletic performance-enhancing aid. This review serves as an analytic report of existing controlled trials in the scientific literature that have investigated this compound as a sports aid when administered via the novel method of mouth rinsing followed by expectoration. Methods: Data on menthol mouth rinsing was sourced from EBSCO PowerSearch, Medline, and NCBI. In addition to a systematic review of existing literature, the current review outlines a detailed protocol to evaluate menthol mouth rinsing on a treadmill time-to-exhaustion test. This protocol adds an additional feature of conducting blood work examining any changes in energy substrate …

Prevalence Of Hypoglycemia Induced By Overtreatment In Elderly Type Two Diabetics Using Continuous Blood Glucose Monitors, Alyssa Mae Tubera

Nursing | Senior Theses

Background: The most common way of reading blood glucose (BG) levels in type II diabetics is by manually pricking one’s finger with a needle and measuring the glucose through a monitoring device. There has been an increased use in continuous glucose monitoring (CGM) that permits clients to wear a sensor on their arm that simultaneously records glucose levels throughout the day and reports the results to a smartphone or monitoring device. Depending on the result and whether the patient is using insulin, it will determine how much medication will be administered. There is little research on the impacts of using …

The Effects Of Daily Consumption Of Pepitas (Pumpkin Seeds) On Depression, Anxiety, Stress, And Sleep Quality In Adults, Ru-Yi (Susie) Ou Yang, Chana Leah Schuraytz, Gina Sand

Loma Linda University Research Reports

Depression, anxiety, stress, and poor sleep quality are mental health conditions contributing to the burden of healthcare and society world-wide. Evidence has shown that nutrients and bioactive properties in seeds have been beneficial for mental health conditions in animal studies. This study aims to determine if there are beneficial effects of pepitas (pumpkin seeds) in humans.

The Effect Of Vitamin D Supplementation On Total Cholesterol(Tc):High Density Lipoprotein(Hdl) Ratio And Body Composition In The General Adult Population, Artemisa Palafox-Castañeda, Yvette Velarde, Stephanie Wiratmo

Loma Linda University Research Reports

Introduction: Two common problems that exist in the adult population in the United States are vitamin D deficiency and coronary heart disease (CHD). According to the National Health and Nutrition Examination Survey 2011-2014, 23.3% of the US population are at risk of vitamin D inadequacy (serum 25(OH)D of 30-49 nmol/L) and vitamin D deficiency (serum 25(OH)D lower than 30 nmol/L). Also, according to Centers for Disease Control data in 2015-2018, 11.4% of the US adult population had high Total Cholesterol (TC) levels, and 17.2% of the US adult populations had low High-Density Lipoprotein (HDL) levels.TC:HDL ratio is used to determine …

Intake Of Dietary Flavonoids And Incidence Of Ischemic Heart Disease In The Danish Diet, Cancer, And Health Cohort, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Guillaume Marquis-Gravel, Aedín Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2022 to 2026

Background/Objectives:

Few studies have investigated the association between dietary flavonoid intake, including all major subclasses, and the long-term risk of ischemic heart disease (IHD). We examined whether dietary flavonoid intake associated with IHD incidence, assessing the possible modifying role of sex and smoking, in participants from the Danish Diet, Cancer, and Health study.

Subjects/Methods:

In a cohort study design, 54,496 adults (46.8 % male), aged 50 – 64 years, without a history of IHD, were followed for up to 23 years. Habitual dietary flavonoid intake was estimated from food frequency questionnaires using Phenol-Explorer. Incident cases of IHD were identified within …

Altered Dietary Behaviour During Pregnancy Impacts Systemic Metabolic Phenotypes, Charlotte E. Rowley, Samantha Lodge, Siobhon Egan, Catherine Itsiopoulos, Claus T. Christophersen, Desiree Silva, Elizabeth Kicic-Starcevich, Therese A. O’Sullivan, Julien Wist, Jeremy Nicholson, Gary Frost, Elaine Holmes, Nina D’Vaz

Research outputs 2022 to 2026

Rationale: Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers. Methods: From the ORIGINS cohort, 51 pregnant women were stratified for persistent high and low alignment to a MD, based on validated MD questionnaires. 1H Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the …

Factors Influencing Nutritional Intake And Interests In Educational Content Of Athletes And Sport Professionals Toward The Development Of A Clinician-Supported Mobile App To Combat Relative Energy Deficiency In Sport: Formative Research And A Description Of App Functions, Jacob T. Mey, Christine A. Karpinski, Shengping Yang, Joseph D. Madere, Tavis Piattoly, Ronnie Harper, John P. Kirwan

Nutrition Faculty Publications

Background: Relative energy deficiency in sport (RED-S) as a consequence of athlete malnutrition remains a prominent issue. However, it remains underrecognized, in part due to the perceived outward health of athletes. The Eat2Win app was designed to combat RED-S and athlete malnutrition by providing education, behavior modification, and direct communication with expert sports dietitians to athletes and sport professionals (professionals who work with athletes, eg, sport coaches and athletic trainers). Objective: The purpose of this formative research was to gain critical insight on motivators and barriers to optimal nutritional intake from both the athletes’ and sport professionals’ perspectives. Additionally, since …

Development Of A Community-Based Plan For An Effective Behavioral Intervention To Reduce Childhood Obesity In A Rural Appalachian Community, Jennifer Stacy Wells

Theses and Dissertations--Nutrition and Food Systems

Rural children experience increased rates of obesity and reduced access to specialized weight management facilities, which makes receiving the recommended frequency of care difficult. Clinical-community partnerships, recommended by the American Academy of Pediatrics (AAP) to expand access, have been shown to be a feasible strategy of care delivery. Examination of literature and stakeholder interviews were used to inform the development of a collaborative pediatric weight management program in a rural, Appalachian community. Screening articles as well as intervention articles were reviewed. Outcomes of screening articles reviewed included BMI measures (3), screening practices (7), and referral practices (4). Common outcomes of …

Plant-Based Dietary Patterns And Parkinson's Disease: A Prospective Analysis Of The Uk Biobank, Anna Tresserra-Rimbau, Alysha S. Thompson, Nicola Bondonno, Amy Jennings, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Background: Plant-based diets have been associated with a lower risk of several chronic diseases, but the relationship with PD is unknown. Objectives: We examined the association of three different plant-based diets with PD incidence in the UK Biobank cohort. Methods: We conducted a prospective study among 126,283 participants from the UK Biobank cohort. Three plant-based diet indices (overall plant-based diet index, PDI; healthful plant-based diet index, hPDI; and unhealthful plant-based diet index, uPDI) were derived from 24-hour dietary recalls based on 17 food groups. Multivariable Cox regression models were used to estimate the risk of PD across quartiles of the …

Toddlers May Be Getting Enough Iron In Long Day-Care Services After All, Michaela Johnston, Therese O'Sullivan, Amanda Devine, Ruth Wallace, Leesa Costello, Ros Sambell

Research outputs 2022 to 2026

Background: Previous research has suggested that toddlers are not provided with adequate dietary iron in long-day care (LDC) services. However, the iron bioavailability provided is unknown. The present study aimed to investigate the amount and bioavailability of iron provided to toddlers aged 2–3 years at LDC services. Methods: A cross-sectional audit was conducted using a 2-day weighed food record of 30 LDC services. Iron provision (not child intake) in LDC services across Perth, Australia was compared with the estimated average requirements (EAR) and LDC services provision guidelines (50% of EAR = 2 mg/day based on a 14% bioavailability factor). Bioavailability …

Investigating The Perspectives Of Older Adults In Residential Aged Care On Oral Health-Related Quality Of Life, Parisa Malekpour, Amanda Devine, Julie Dare, Leesa Costello

Research outputs 2022 to 2026

Objective

The objective of the study was to explore how older people living in a residential aged care facility perceived that their oral health influenced their food preferences and attitudes towards food, their social interactions and their self-esteem.

Background

Poor oral health can have biological, behavioural and social impacts on quality of life among older adults (aged 65+ years). In terms of biological impacts, oral health impairments may cause older adults to avoid many types of foods. This shift in dietary pattern can lead to malnutrition among older people, undermine general health and negatively impact quality of life (QOL).

Materials …

A Comprehensive Examination Of The Evidence For Whole Of Diet Patterns In Parkinson's Disease: A Scoping Review, Joanna Rees, Jillian Ryan, Manja Laws, Amanda Devine

Research outputs 2022 to 2026

Both motor and non-motor symptoms of Parkinson’s disease (PD), a progressive neurological condition, have broad-ranging impacts on nutritional intake and dietary behaviour. Historically studies focused on individual dietary components, but evidence demonstrating ameliorative outcomes with whole-of-diet patterns such as Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is emerging. These diets provide plenty of antioxidant rich fruits, vegetables, nuts, wholegrains and healthy fats. Paradoxically, the ketogenic diet, high fat and very low carbohydrate, is also proving to be beneficial. Within the PD community, it is well advertised that nutritional intake is associated with disease progression and symptom severity but understandably, …

Risk Of Low Energy Availability, Disordered Eating, And Menstrual Dysfunction In Female Recreational Runners, Marissa Miles

All Master's Theses

Running is characterized by high physiological demands with an emphasis on weight, which may lead to a greater risk of developing low energy availability (LEA) and/or disordered eating (DE). Recreational runners are a population that is often overlooked due to a lack of resources readily available to them. Purpose: This study investigated (1) the prevalence of menstrual dysfunction, risk of DE and LEA and (2) compare the risk of DE, training volume, and weight dissatisfaction between female recreational runners at risk for LEA versus not at risk for LEA. Methods: Female recreational runners (n= 1,923) completed an online questionnaire that …

Motivators And Barriers To Adoption Of Plant-Based Meat & Dairy Alternatives– A Comparison Of A Blue Zone And Disadvantaged Communities, Anastasia Tiznado, Maggie Taylor

Loma Linda University Research Reports

Introduction:

Blue Zones are geographical locations where there are low rates of chronic disease diagnosis, risks and mortalities, and people living in these communities live longer than average life spans. Individuals living in the Blue Zone of Loma Linda eat predominantly plant-based diets that incorporate meat and dairy alternatives. These products have been shown to provide health, environmental and affordability benefits. With respect to health, a plant-based diet is effective at preventing, treating and reversing diseases, including heart disease which is the number one killer in the US. In recent years, plant-based diets have gained a wide acceptance beyond the …

Assessment Of Low-Fodmap Diet Knowledge Among Registered Dietitian Nutritionists (Rdn) In The Treatment Of Irritable Bowel Syndrome (Ibs), Heather Cyr, Madison Murphy, Annie Resendiz

Loma Linda University Research Reports

Introduction:

Irritable bowel syndrome (IBS) is the bowel's reaction to certain stimuli causing pain, flatulence, diarrhea, and constipation. IBS currently affects 1 in 10 people worldwide. The low-FODMAP diet can be effective in relieving these symptoms. Studies found that 82% of patients could follow the low-FODMAP diet long-term without comprising their nutrition status, and over half found long-term symptom relief. For optimal success, this complex diet should be implemented with the guidance of a well-informed registered dietitian nutritionist.

The Use Of A Mindful Eating Guided Journal Results In Changes In Food Portion Sizes And Increased Internal Awareness, Valerie Dubuque, Daniele G. Kuhn

Loma Linda University Research Reports

Introduction:

Restrictive dieting practices have repeatedly shown to be limited in their potential to create lasting healthful choices. Alternatively, intuitive eating and mindful eating are frameworks that have been utilized to promote better dietary choices, however, with limited success. Intuitive eating and mindful eating contain components, such as "unconditional permission to eat" and "reliance on hunger and satiety cues," that may be unhelpful. This study presents an alternative framework that selectively combines the best of both frameworks through a mindful eating guided journal.

School-Based Intervention Impacts Availability Of Vegetables And Beverages In Participants’ Homes, Erin A Hudson, Marissa Burgermaster, Sophia M Isis, Matthew R Jeans, Sarvenaz Vandyousefi, Matthew J Landry, Rebecca Seguin-Fowler, Joya Chandra, Jaimie Davis

Faculty, Staff and Student Publications

As rates of metabolic syndrome rise, children consume too few vegetables and too much added sugar. Because children tend to eat what is available at home, the home environment plays a key role in shaping dietary habits. This secondary analysis evaluated the effects of a school-based gardening, cooking, and nutrition education intervention (TX Sprouts) compared to control on the availability of vegetables, fruit juice, and sugar-sweetened beverages (SSBs) at home. In the TX Sprouts cluster-randomized trial, 16 schools were randomized to TX Sprouts (

High Resting Energy Expenditure In Women With Episodic Migraine: Exploring The Use Of Predictive Formulas, Laís Bhering Martins, Jéssica Sales Ribeiro, Ana Maria Dos Santos Rodrigues, Luana Caroline Dos Santos, Antonio Lúcio Teixeira, Adaliene Versiani Matos Ferreira

Faculty, Staff and Student Publications

INTRODUCTION: Migraine is a common and disabling primary headache, and its pathophysiology is not fully understood. Previous studies have suggested that pain can increase humans' Resting Energy Expenditure (REE). However, no previous study has investigated whether the REE of individuals with migraine differs from the general population. Therefore, this study aims to assess whether the REE of women with migraine differs from that of women without headaches. We also tested the accuracy of REE predictive formulas in the migraine patients.

METHODS: This cross-sectional study involves 131 adult women aged between 18 and 65 years, 83 with migraine and 48 without …