Bioethics and Medical Ethics Commons^™

A Randomized Study Of Digital Versus Genetic Counselor Return Of Actionable Genetic Research Results To Biobank Participants (Respect3 Study), Anuja Rajendra Godbole, Elisabeth Wood, Brian Egleston, Lily Hoffman-Andrews, Sarah Brown, Sarah Howe, Sanjana Shastri, Rajia Mim, Justin Feng, Anjali Owens, Susan Domchek, Reed Pyeritz, Bryson Katona, Staci Kallish, Giorgio Sirugo, Joellen Weaver, Linda Fleisher, Kuang-Yi Wen, Elena Elkin, Katherine Nathanson, Daniel Rader, Angela Bradbury

Department of Medical Oncology Faculty Papers

BACKGROUND: There is consensus that research participants should be informed about plans for return of genetic research results. However, best practices for return of results in large biobank and cohort studies do not exist currently, and how best to communicate actionable genetic research results remains unclear. While having genetic counselors disclose these results may be ideal to ensure understanding, minimize distress, and optimize medical follow-up, genetic counselor (GC) workforce shortages and costs are barriers. The RESPECT3 study evaluates whether digital delivery alternatives for pre-disclosure education and return of actionable genetic research results is non-inferior to remote telehealth disclosure by a …

Participation In Ethics Consultation And Moral Resilience In Icu Nursing: Findings From An Exploratory Secondary Analysis, Sarah Sumner

Providence Nursing Research Conference 2023 – Present

No abstract provided.

Editorial: Clinical Imaging, Neurophysiological, Neuropathology And Neuroethics Studies On Disorders Of Consciousness, Coma Mechanisms, And Theories Of Consciousness: A Unifying Attempt, Diego Iacono, Manuel Trachsel, Thanh Phan, Charlène Aubinet

Department of Neurology Faculty Papers

No abstract provided.

Conditions Affecting The Gi Tract: The Dental Professional’S Role, Sherri M. Lukes, Rdh, Ms, Faadh

The Journal of the Michigan Dental Association

This article explores the critical role dental professionals play in identifying gastrointestinal (GI) conditions through their oral manifestations. It provides an overview of various pathologies, including HPV-induced oropharyngeal cancer, gastroesophageal reflux disease (GERD), and inflammatory bowel diseases like Crohn’s and ulcerative colitis. The author describes specific oral signs, such as dental erosion and aphthous ulcerations, that can serve as early indicators of systemic disease. The piece advocates for an interdisciplinary approach to patient care, emphasizing that dental practitioners are often on the front lines of diagnosing serious systemic health issues.

When Toxic Behaviors Sneak Into Practice, Amrita Patel, Dds

The Journal of the Michigan Dental Association

This article addresses the challenge for new dentists in identifying and managing toxic workplace behaviors. It details common red flags such as chronic negativity, poor communication, "blame culture," and excessive production pressure that compromises ethics. The author explains how these environments can lead to burnout and practicing defensively rather than confidently. The source emphasizes the importance of developing self-awareness, seeking external mentorship, and establishing professional boundaries. It concludes that recognizing when to leave an unhealthy practice is an act of professional self-respect and essential for long-term career satisfaction.

Post-Dobbs Realities: Ethical Imperatives For Data Transparency And Trust In Maternal Health Care, Faith E Fletcher, Sophie L Schott, Kelley Akhiemokhali, Kari White

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

When Systems Fail: The Impact Of Protocol On Physician Moral Distress, Aya Dudar

Clinical Research in Practice: The Journal of Team Hippocrates

Physicians often face the decision between following rigid hospital protocol and doing the right thing for the patient, creating moral distress and contributing to burnout. This letter describes a case in which an elderly patient with COVID-19 pneumonia and a DNI order developed worsening hypercapnia and required noninvasive ventilation. Despite clinical appropriateness, hospital policy prohibited BiPAP use in obtunded patients due to aspiration risk - even when the resident offered continuous bedside monitoring. This case highlights the ethical tension that arises when rigid hospital policies prevent physicians from making real-time exceptions in appropriate situations. Empowering physicians to make context-driven decisions …

Efficacy Of Etvax, A Vaccine Against Enterotoxigenic Escherichia Coli-Positive Diarrhoea In Gambian Children: A Double-Blind, Randomised, Placebo-Controlled, Phase 2b Trial, M Jahangir Hossain, Fatou Secka, Lady C Sanyang, Raifu Taiwo, Emmanuel C Okoh, Olubunmi A Olubiyi, Mbemba Drammeh, Emmanuel U Richard, Ahmed D Balami, Mama Drammeh, Samba Juma Jallow, Bakary Sonko, Paticia Ezedimbu-Michael, Jacinta Obiaduo, Ousman Secka, Joanna Kaim, Björn Sjöstrand, Agneta Lissmats, Nils Carlin, Umberto D'Alessandro, Ann-Mari Svennerholm, Thomas F Wierzba

Faculty and Staff Publications

Background: Enterotoxigenic Escherichia coli (ETEC) causes 75 million diarrhoea episodes with up to 42 000 deaths annually in children. To prevent ETEC in children, we aimed to evaluate the safety, immunogenicity, and efficacy of ETVAX, an oral, inactivated, whole-cell ETEC vaccine with toxoid and double-mutant heat-labile toxin adjuvant.

Methods: In this phase 2b, double-blind, placebo-controlled trial, Gambian children aged 6-18 months were recruited from four enrolment centres and block-randomised (1:1) via a computer-generated sequence, stratified by enrolment centres, to receive ETVAX or placebo on days 1, 15, and 90. Parents, staff, investigators assessing outcomes, and investigators analysing the data were …

The Racial Politics Of Early Dentistry And The Terrible “Toothache Blues”, Bronwen Mcveigh Phd

Journal of the American College of Dentists

In interwar America, the relatively young profession of dentistry was developing rapidly. As the government, health institutions, and social organizers focused more intently on notions of national wellness, questions about how to achieve a healthy smile—and what a healthy smile should look like—proliferated. Groups like the National Dental Association worked to establish rigorous standards of technique, define ethical behavior, and encourage dentists to develop business acumen, yet the surprising proliferation of blues songs about dubious dentists tricking unassuming clients, or about fraught love affairs allegorized by disastrous dental exams, highlights the equivocal nature of many developments in early dentistry.

This …

The Vipeholm Experiments: A Case Study Of Unethical Dental Research, Lainie Ross Md, Phd

Journal of the American College of Dentists

Modern-day research ethics training often begins with a discussion of the medical research atrocities committed by Nazi health care professionals and the resulting 10-principle Nuremberg Code, which is often considered to be the beginning of modern-day medical research regulations. It is occasionally mentioned that Nazi dentists also conducted unethical research in the concentration camps, and a few were brought to trial. In this manuscript, I compare two studies (one medical and one dental) conducted after World War II that violated the Nuremberg Code.

I describe and compare the well-known Willowbrook Hepatitis studies conducted by infectious disease doctors on vulnerable institutionalized …

The Mouth As A Mirror: A Parent- Hygienist’S Ethical Reflections On Oral Healthcare And Pompe Disease, Anika Atkins Ma, Rdh

Journal of the American College of Dentists

This reflective narrative explores the ethical tensions and emotional realities of a dental hygienist who is also the parent of a child with Pompe disease. Drawing from personal experience and care ethics philosophy, the author examines how traditional clinical frameworks—centered on autonomy, beneficence, and protocol— often fall short when addressing the needs of medically fragile children. The piece weaves in the work of care ethicists and pastoral ministry to embrace the philosophy of caregiving as presence, to suggest that oral healthcare must evolve to include responsiveness, context, and relationship-based decision-making. Through the dual lens of provider and parent, the narrative …

Restoring Trust: A Fair Chance At A Bright Smile And The Human Side Of School-Based Dentistry, Rubin Sorrell Ii, Mph, Dds

Journal of the American College of Dentists

The Fair Chance at a Bright Smile (FCAABS) program represents a humanistic, community- centered approach to dentistry that redefines access, education, and dignity in oral health. Developed and refined through a year-long pilot partnership with the San Francisco Unified School District, FCAABS integrates preventive dental care, oral health education, and career exposure for students from pre-kindergarten through high school. This manuscript argues that beyond clinical outcomes, FCAABS reveals a deeper truth: oral health is intrinsically social, emotional, and moral. It examines the program through the lens of the humanities and ethics, exploring how narrative, empathy, and cultural context inform both …

J Am Coll Dent 2026 92 2a

Journal of the American College of Dentists

This special issue of the Journal of the American College of Dentists responds to a growing but long-underrecognized demand for humanities and ethics in dental education, practice, and scholarship. It emerges from the work of the National Collaborative on Humanities and Ethics in Dentistry (NCHED), a multi-institutional partnership formed in 2023 to address the persistent exclusion of dentistry from broader health humanities conversations. Through national webinars and scholarly collaboration, NCHED has demonstrated substantial interest in ethical reflection, historical analysis, narrative inquiry, and the arts as essential to understanding oral health and dental care. The unexpectedly strong response to the call …

Artificial Intelligence In Medical Ethics Education: A Descriptive Study Of Eight Models In Multiple Choice Question Generation, John Obeid, Christopher Bobier, Alex Gillham, Adam Omelianchuk, Daniel Hurst

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Integrating artificial intelligence (AI) into medical education poses barriers and opportunities for medical educators. One of those opportunities is content creation for medical ethics assessment. Assessing the performance of AI in generating multiple choice questions (MCQs) in ethics that aligns with United States Medical Licensing Examination (USMLE) is important. The present study evaluates the performance of eight AI models-GPT-4 Turbo, GPT-3.5 Turbo 0125, o1 Mini, o1 Preview, GPT-4, Claude 3.5 Sonnet, Claude 3 Opus, and Gemini-in regard to the relevance, clarity, and accuracy of generated ethics-based MCQs.

Methods: Each of the eight models was tasked with generating two sets …

Designing Inclusive Newborn Sequencing Research: Insights From Parents In Underrepresented Communities, Maya C Del Rosario, Sheyenne A Walmsley, Barbara W Harrison, Crystal T Stephens, Bethany Zettler, Greysha Rivera-Cruz, Priyal Agrawal, Amy Brower, Stephanie Chigbu, Kurt D Christensen, Casie A Genetti, Richetta Givens, Nina B Gold, Inez V Reeves, Isabella Schichter, Habib Shariat, Sandra Simon, Hadley Stevens Smith, Melissa Uveges, Robert C Green, Ingrid A Holm, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Background: It is essential that studies of genomic sequencing (GS) in newborns and children include individuals from under-represented racial and ethnic groups (URG) to ensure future applications are equitably implemented. We conducted interviews with parents from URG to better understand their perspectives on GS research, develop strategies to reduce barriers to enrollment, and facilitate research participation.

Methods: Semi-structured interviews with 50 parents from URG.

Results: Nearly all parents said they would be interested in participating in an infant GS study. Parents were interested in participating in GS research for reasons including clinical utility, personal utility, and/or family health benefits. Deterrents …

The Consequences Of Attempted Human Perfection: Genetic Enhancement And Why It Is Immoral, Kiran S. Sajnani

Mako: NSU Undergraduate Student Journal

In the field of biomedical ethics, genetic enhancement—the alteration of human DNA to increase characteristics beyond normal function—is a highly contested topic. Genetic enhancement presents serious ethical issues, especially when gene therapy seeks to treat or prevent disease. This paper makes the consequentialist case that genetic enhancement, whether somatic or germline, is intrinsically unethical because of its ethical, societal, and systemic ramifications. The autonomy of future persons is violated by germline enhancement, which also runs the risk of deepening socioeconomic gaps and escalating intergenerational inequity. Even though it only affects the individual, somatic augmentation undermines human diversity and agency by …

The Ethical Limits Of Physician Autonomy In Reproductive Medicine, Isabel Martens

Honors Theses

In vitro fertilization is a relatively new medical practice that helps people who face infertility be able to reproduce. Reproductive medicine providers face ethical dilemmas often in their field, only some of which have standards of care. There are questions in the medical landscape pertaining to physician autonomy versus patient autonomy, which heavily apply to reproductive medicine providers. Patient autonomy is highly valued in medical ethics; however, physician autonomy should also be considered. When a physician decides who can and cannot reproduce, ethical considerations must be followed to maintain the practice of reproductive autonomy. Limited policies exist that manage reproductive …

Stakeholder Perspectives On Humanistic Implementation Of Computer Perception In Health Care: Qualitative Study, Kristin M Kostick-Quenet, Meghan E Hurley, Syed Ayaz, John D Herrington, Casey J Zampella, Julia Parish-Morris, Birkan Tunç, Gabriel Lázaro-Muñoz, Jennifer Blumenthal-Barby, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Background: Computer perception (CP) technologies-including digital phenotyping, affective computing, and related passive sensing approaches-offer unprecedented opportunities to personalize health care, especially mental health care, yet they also provoke concerns about privacy, bias, and the erosion of empathic, relationship-centered practice. At present, it remains elusive what stakeholders who design, deploy, and experience these tools in real-world settings perceive as the risks and benefits of CP technologies.

Objective: This study aims to explore key stakeholder perspectives on the potential benefits, risks, and concerns associated with integrating CP technologies into patient care. A better understanding of these concerns is crucial for responding to …

Reported Safety Practices Of Publicly Advertised Psychedelic Retreats, Amy L Mcguire, Logan Neitzke-Spruill, Jill O Robinson, Caroline S Beit, Nikita Singh, David S Mathai, Lynnette A Averill

Center for Medical Ethics and Health Policy Staff Publications

Importance: The availability of psychedelic retreats has grown to meet the demand for access to these substances. Despite centuries of use among Indigenous communities, psychedelics can pose serious risks for some users.

Objective: To determine safety precautions that retreat organizations that offer psychedelic substances currently use.

Design, setting, and participants: This qualitative study included structured interviews conducted by phone or email with representatives from 49 organizations publicly advertising psychedelic retreat offerings from July to October 2023. Organizations were eligible if they marketed their services in English, offered at least 1 psychedelic substance, and made contact information available online. Organizations were …

Guidance For Authors, Editors And Publishers On The Use Of Generative Ai, Christopher J. Smiley, Julie Frantsve-Hawley Phd, Michael Parks Jd, Ee, Francine Lynch Esq., D.Be, Kelly O'Brien, Ellen Thieme Mlis, Thomas Dodson Dds, Mph, Facs, David Foe, Chester Gary D.D.S., J.D., Kelly Lemke Dds, Ms, Jeffrey Platt Dds, Ms, Ba, Toni M. Roucka Rn, Dds, Ma, Facd, Hugh Wunderlich Dds

Individual Scholarship

This paper from AADEJ presents best-practice guidelines for the ethical use of generative artificial intelligence (GAI) and large language models (LLMs) in the creation, editing, and publication processes in dental writing and publishing. It examines how LLMs, such as ChatGPT, can enhance efficiency across writing and publishing workflows, while also identifying the operational risks associated with their design.

Key areas of focus include the implications of LLM algorithms and training data, particularly regarding the risks they pose to intellectual property, privacy, and the integrity of the profession’s literature. Additionally, the paper provides an overview of the legal, ethical, and copyright …