Medicine and Health Sciences Commons^™

Models For Community Based Day Care For Older People: A Narrative Review, Caroline Bulsara, Christopher Etherton-Beer, Rosemary Saunders

Research outputs 2014 to 2021

Objectives:

Older Australians are choosing to live within the community and there are a number of initiatives to enable this sector of the population to do so for longer. In an effort to ensure that they remain both physically and psychologically engaged, one initiative has been to provide community based day care (CBDC).

Method:

A narrative review was undertaken through searching MEDLINE, CINAHL Plus, Scopus and AgeInfo using keywords related to facility related, target group related and purpose/program of CBDC services.

Results:

Results indicated that there is a much research investigating different approaches but little consensus regarding the optimal delivery …

Goal Fluency, Pessimism And Disengagement In Depression, Joanne M. Dickson, Nicholas Moberly, Christian O'Dea, Matt Field

Research outputs 2014 to 2021

Despite the development of prominent theoretical models of goal motivation and its importance in daily life, research has rarely examined goal dysregulation processes in clinical depression. Here we aimed to investigate problematic aspects of goal regulation in clinically depressed adults, relative to controls. Depressed participants (n = 42) were recruited from two Improving Access to Psychological Therapy clinics in north-west England. Control participants (n = 51) were recruited from the same region. Participants generated personal approach goals (e.g., improve my marathon time) and avoidance goals (e.g., avoid getting upset over little things) and completed self-report measures of goal attainment likelihood …

Motor Subtype As A Predictor Of Future Working Memory Performance In Idiopathic Parkinson's Disease, Andrew R. Johnson, Romola S. Bucks, Robert T. Kane, Meghan G. Thomas, Natalie Gasson, Andrea M. Loftus

Research outputs 2014 to 2021

Parkinson’s disease is a progressive neurodegenerative disorder associated with reduced spatial and verbal working memory ability. There are two established motor subtypes of PD, tremor dominant (TD) and postural instability and gait difficulty (PIGD). This study used structural equation modelling to explore the longitudinal relationship between the two subtypes and working memory assessed at a 2-year follow-up. The study comprised 84 males and 30 females (N = 114), aged between 39 and 85 (M = 64.82, SD = 9.23) with confirmed PD. There was no significant relationship between motor subtype at Time 1 and working memory at Time 2. Postural …

The Effects Of Either A Mirror, Internal Or External Focus Instructions On Single And Multi-Joint Tasks, Israel Halperin, Steven Hughes, Derek Panchuk, Chris Abbiss, Dale W. Chapman

Research outputs 2014 to 2021

Training in front of mirrors is common, yet little is known about how the use of mirrors effects muscle force production. Accordingly, we investigated how performing in front of a mirror influences performance in single and multi-joint tasks, and compared the mirror condition to the established performance effects of internal focus (IF) and external focus (EF) instructions in a two part experiment. In the single-joint experiment 28 resistance-trained participants (14 males and 14 females) completed two elbow flexion maximal voluntary isometric contractions under four conditions: mirror, IF, EF and neutral instructions. During these trials, surface EMG activity of the biceps …

Incidence, Risk Factors And The Healthcare Cost Of Falls Postdischarge After Elective Total Hip And Total Knee Replacement Surgery: Protocol For A Prospective Observational Cohort Study, Anne-Marie Hill, Gail Ross-Adjie, Steven M. Mcphail, Leanne Monterosso, Max Bulsara, Christopher Etherton-Beer, Sarah-Jayne Powell, Gerard Hardisty

Research outputs 2014 to 2021

Introduction:

The number of major joint replacement procedures continues to increase in Australia. The primary aim of this study is to determine the incidence of falls in the first 12 months after discharge from hospital in a cohort of older patients who undergo elective total hip or total knee replacement.

Method and analyses:

A prospective longitudinal observational cohort study starting in July 2015, enrolling patients aged ≥ 60 years who are admitted for elective major joint replacement (n = 267 total hip replacement, n = 267 total knee replacement) and are to be discharged to the community. Participants are followed …

Exploratory Psychomteric Properties Of The Farsi And English Version Of Spiritual Needs Questionnaire (Spnq), Nejat Nazi, Lisa Whitehead, Marie Crowe

Research outputs 2014 to 2021

The aim of this study was to translate and test the psychometric properties of a Farsi and an English version of the spiritual needs questionnaire (SpNQ) a measure originally developed in German. The World Health Organization guideline for translating and validating questionnaires was used. Participants were recruited from hospitals in Iran and New Zealand during an outpatient follow-up appointment after cancer treatment. People diagnosed with cancer in Iran (68) and New Zealand (54) completed and returned the SpNQ (at time 1) and within the two week time period (time 2). Cronbach’s alpha ranged from 0.79 to 0.92, except for the …

Investigation Of The Relationship Between Chronic Stress And Insulin Resistance In A Chinese Population, Yuxiang Yan, Huanbo Xiao, Sisi Wang, Jing Zhao, Yan He, Wei Wang, Jing Dong

Research outputs 2014 to 2021

Background:

Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the stress system, selected parameters of energy homeostasis, and insulin resistance in a Chinese population.

Methods:

We recruited 766 workers employed at four companies in Beijing. The degree of insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). The highest quartile of HOMA-IR among all study subjects was further defined as insulin resistance in our …

The Impact Of Adding Assistants In Nursing To Acute Care Hospital Ward Nurse Staffing On Adverse Patient Outcomes: An Analysis Of Administrative Health Data, Diane E. Twigg, Helen Myers, Christine M. Duffield, Judith Dianne Pugh, Lucy Gelder

Research outputs 2014 to 2021

Objectives:

The aim of this study was to assess the impact of adding assistants in nursing to acute care hospital ward nurse staffing on adverse patient outcomes using administrative health data.

Design:

Logistic regression modelling was used with linked administrative health data to examine the association between seven adverse patient outcomes and use of assistants in nursing utilising a pre-test/ post-test design. Outcomes included were in-hospital 30-day mortality, failure to rescue, urinary tract infection, pressure injury, pneumonia, sepsis and falls with injury.

Setting:

Eleven acute care metropolitan hospitals in Western Australia. Sample: Patients were retained in the dataset if they …

Integration Of Suboptimal Health Status And Endothelial Dysfunction As A New Aspect For Risk Evaluation Of Cardiovascular Disease, Vitalli Kupaev, Oleg Borisov, Ekaterina Marutina, Yuxiang Yan, Wei Wang

Research outputs 2014 to 2021

Background:

Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction.

Methods:

A community-based cross-sectional study was conducted in a sample of 459 residents of Samara, Russia, who had no history of clinical diagnosed disease and did not receive any treatment in the last 2 weeks. The SHS score was derived from the data collected in …

Suppression Of Neutrophil-Mediated Tissue Damage—A Novel Skill Of Mesenchymal Stem Cells, Dongsheng Jiang, Jana Muschhammer, Yu Qi, Andrea Kügler, Juliane C. De Vries, Mona Saffarzadeh, Anca Sindriaru, Seppe V. Beken, Meinhard Wlaschek, Mark A. Kluth, Christoph Ganss, Natasha Y. Frank, Markus H. Frank, Klaus T. Preissner, Karin Scharffetter-Kochanek

Research outputs 2014 to 2021

Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and regeneration. Though of prime interest, their potentially protective role on neutrophil-induced tissue damage, associated with high morbidity and mortality, has not been explored in sufficient detail. Here we report the therapeutic skill of MSCs to suppress unrestrained neutrophil activation and to attenuate severe tissue damage in a murine immune-complex mediated vasculitis model of unbalanced neutrophil activation. MSC-mediated neutrophil suppression was due to intercellular adhesion molecule 1-dependent engulfment of neutrophils by MSCs, decreasing overall neutrophil numbers. Similar to MSCs in their endogenous niche of murine and human vasculitis, therapeutically injected MSCs …

Review Of Diabetes Among Aboriginal And Torres Strait Islander People, Samantha Burrow, Kathy Ride

Research outputs 2014 to 2021

Diabetes is the world’s fastest growing chronic disease. Type 2 diabetes in particular, has reached epidemic proportions globally and in Australia, and poses a challenge for public health systems everywhere. The greatest burden tends to fall on socially disadvantaged groups and Indigenous peoples Aboriginal and Torres Strait Islander Australians experience disproportionately high levels of diabetes. They are three times more likely to have diabetes than non-Indigenous Australians and Aboriginal and Torres Strait Islander women are almost twice as likely to develop gestational diabetes as non-Indigenous women. There is also evidence that Aboriginal and Torres Strait Islander children are eight times …

China Suboptimal Health Cohort Study: Rationale, Design And Baseline Characteristics, Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qui, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang

Research outputs 2014 to 2021

Background:

Suboptimal health status (SHS) is a physical state between health and disease, characterized by the perception of health complaints, general weakness, chronic fatigue and low energy levels. SHS is proposed by the ancient concept of traditional Chinese medicine (TCM) from the perspective of preservative, predictive and personalized (precision) medicine. We previously created the suboptimal health status questionnaire 25 (SHSQ-25), a novel instrument to measure SHS, validated in various populations. SHSQ-25 thus affords a window of opportunity for early detection and intervention, contributing to the reduction of chronic disease burdens.

Methods/design:

To investigate the causative effect of SHS in non-communicable …

A Case-Control Study In An Orcadian Population Investigating The Rrelationship Between Human Plasma N-Glycans And Metabolic Syndrome, Fiona Mclachlan, Maria Timofeeva, Mairead Bermingham, Sarah Wild, Igor Rudan, Gordon Lauc, Wei Wang, Harry Campbell, James Wilson, Evropi Theodoratou

Research outputs 2014 to 2021

Background:

Alterations in glycosylation patterns have long been known to reflect changes in cell metabolism. In this study, we investigated the relationship between human N-glycan profiles and metabolic syndrome.

Method:

Between 2005 and 2011, 2,155 individuals from the Orkney Islands (UK) were recruited and biological material, alongside phenotypic measures were collected. Individual N-glycan profiles were measured in plasma using weak anion exchange high performance liquid chromatography and calibrated hydrophilic interaction liquid chromatography. Pre-specified criteria were used to identify 564 cases with metabolic syndrome and 1475 controls. We applied logistic regression to test for association between this binary outcome against measured …

Accuracy In Measurement Of Elevation Gain In Road Cycling, Paolo Mensaspa, Eric Haakonssen, Avish Sharma, Brad Clark

Research outputs 2014 to 2021

Purpose

Accurate measures of elevation gain are important for monitoring energy expenditure and physical load. The aim of this study was to determine the accuracy of barometric devices used for measuring elevation gain.

Methods

Observational validation study. Twenty-eight barometric altimeter devices (SRM and Garmin) were used to measure total elevation gain during cycling over three different climbs (length range: 3.2-18.4 km), giving a total of 216 climbs. An online mapping tool (http://www.freemaptools.com/elevation-finder.htm) was used to calculate the criterion measure of total elevation gain. Data were categorised into two weather conditions: dry and wet.

Results

The standard errors of the estimate …

Appetite Control With Relevance To Mitochondrial Biogenesis And Activation Of Post-Prandial Lipid Metabolism In Obesity Linked Diabetes, Ian J. Martins

Research outputs 2014 to 2021

In various communities in the developing and developed world the understanding of the ingestion of a healthy diet [1] and hepatic fat metabolism has become of critical importance to the treatment of obesity linked Type 2 diabetes that is now linked to various organ diseases [2]. In the developing world transition to healthy diets has become urgent to prevent insulin resistance [3,4] and the obesity pandemic [5-8]. The liver is the major organ for the metabolism of dietary fat and after consumption of a meal in healthy individuals the fat is rapidly metabolized by the liver. In obesity linked Type …

'Face' And Psychological Processes Of Laid-Off Workers In Transitional China, Bingxin Wang, Kenneth M. Greenwood

Research outputs 2014 to 2021

Objective:

The objective was to explore the psychological experiences of laid-off workers in contemporary transitional China and to formulate a theoretical model of these.

Methods:

In-depth interviews of 26 laid-off workers were conducted and analysed using grounded theory techniques.

Results:

Four themes underline the psychological processes of these laid-off workers - feeling of loss, feeling of physical pain, feeling of fatalism, and final acceptance. These are characterized by Chinese culture and its philosophy - feeling of loss is dominated by their loss of face (diu mianzi), physical pain is a somatization of their mental painfulness, their fatalism is traced back …

Faster Movement Speed Results In Greater Tendon Strain During The Loaded Squat Exercise, Jacob E. Earp, Robert U. Newton, Prue Cormie, Anthony J. Blazevich

Research outputs 2014 to 2021

Introduction:

Tendon dynamics influence movement performance and provide the stimulus for long-term tendon adaptation. As tendon strain increases with load magnitude and decreases with loading rate, changes in movement speed during exercise should influence tendon strain.

Methods:

Ten resistance-trained men [squat one repetition maximum (1RM) to body mass ratio: 1.65 ± 0.12] performed parallel-depth back squat lifts with 60% of 1RM load at three different speeds: slow fixed-tempo (TS: 2-s eccentric, 1-s pause, 2-s concentric), volitional-speed without a pause (VS) and maximum-speed jump (JS). In each condition joint kinetics, quadriceps tendon length (L_T), patellar tendon force (F_{T …}

Expression Of Cell-Surface Marker Abcb5 Causes Characteristic Modifications Of Glucose, Amino Acid And Phospholipid Metabolism In The G3361 Melanoma-Initiating Cell Line, Norbert W. Lutz, Pallavi Banerjee, Brian J. Watson, Jie Ma, Patrick J. Cozzone, Markus H. Frank

Research outputs 2014 to 2021

We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for two groups of human G3361 melanoma cells were compared, i.e. wildtype melanoma cells with intact ABCB5 expression (ABCB5-WT) and corresponding melanoma cell variants with inhibited ABCB5 expression, through shRNA-mediated gene knockdown (ABCB5-KD). A comprehensive metabolomic analysis was performed by using proton and phosphorus NMR spectroscopy of cell extracts to examine water-soluble metabolites and lipids. Parametric and non-parametric statistical analysis of absolute and relative metabolite levels yielded significant differences for …

Prostate-Based Biofluids For The Detection Of Prostate Cancer: A Comparative Study Of The Diagnostic Performance Of Cell-Sourced Rna Biomarkers, Matthew J. Roberts, Renée S. Richards, Clement W. K. Chow, Suhail A. Doi, Horst J. Schirra, Marion A. Buck, Hemamali Samaratunga, Joanna L. Perry-Keene, Diane J. Payton, John W. Yaxley, Martin F. Lavin, Robert A. Gardiner

Research outputs 2014 to 2021

Background

Prostate cancer (PCa) diagnosis requires improvement with the aid of more accurate biomarkers. Postejaculate urethral washings (PEUW) could be a physiological equivalent to urine obtained following rectal prostatic massage, the current basis for the prostate cancer antigen 3 (PCA3) test. The aim of this study was to investigate if PEUW contained prostate-based material, evidenced by the presence of prostate specific antigen (PSA), and to evaluate the diagnostic performance of PEUW-based biomarkers.

Methods

Male patients referred for elevated serum PSA or abnormal digital rectal examination provided ejaculate and PEUW samples. PSA, PCA3, and β2-microglobulin (β2M) were quantified in ejaculate and …

Validation Of Type 2 Diabetes Risk Variants Identified By Genome-Wide Association Studies In Northern Han Chinese, Ping Rao, Yong Zhou, Siqi Ge, Anxin Wang, Xinwei Yu, Mohamed Ali Alzain, Andrea K. Veronica, Jing Qiu, Manshu Song, Jie Zhang, Hao Wang, Honghong Fang, Qing Gao, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Background:

More than 60 genetic susceptibility loci associated with type 2 diabetes mellitus (T2DM) have been established in populations of Asian and European ancestry. Given ethnic differences and environmental factors, validation of the effects of genetic risk variants with reported associations identified by Genome-Wide Association Studies (GWASs) is essential. The study aims at evaluating the associations of T2DM with 29 single nucleotide polymorphisms (SNPs) from 19 candidate genes derived from GWASs in a northern Han Chinese population.

Method:

In this case-control study, 461 T2DM-diagnosed patients and 434 controls were recruited at the Jidong oil field hospital (Hebei, China) from January …

Does Nurses’ Health Affect Their Intention To Remain In Their Current Position?, Lin Perry, Robyn Gallagher, Christine M. Duffield, David Sibbritt, Jen Bichel-Findlay, Rachel Nicholls

Research outputs 2014 to 2021

Aim:

To investigate and describe nurses’ and midwives’ physical health, rates of symptoms and disease, and to determine if these factors contribute to intention to leave.

Background:

The nursing and midwifery workforce is ageing yet little is known about their physical health or its relationship to intention to leave.

Methods:

An online survey of health and work-related assessments was distributed through the New South Wales Nurses and Midwives Association and professional contacts.

Results:

Nurses and midwives (n = 5041) reported good-very good health overall. With 22.2% intending to leave in the next 12 months, older age, better …

Neuroendocrine And Neurotrophic Signaling In Huntington's Disease: Implications For Pathogenic Mechanisms And Treatment Strategies, Danielle Bartlett, Travis M. Cruickshank, Anthony J. Hannan, Peter R. Eastwood, Alpár S. Lázár, Mel R. Ziman Dr

Research outputs 2014 to 2021

Huntington's disease (HD) is a fatal neurodegenerative disease caused by an extended polyglutamine tract in the huntingtin protein. Circadian, sleep and hypothalamic-pituitary-adrenal (HPA) axis disturbances are observed in HD as early as 15 years before clinical disease onset. Disturbances in these key processes result in increased cortisol and altered melatonin release which may negatively impact on brain-derived neurotrophic factor (BDNF) expression and contribute to documented neuropathological and clinical disease features. This review describes the normal interactions between neurotrophic factors, the HPA-axis and circadian rhythm, as indicated by levels of BDNF, cortisol and melatonin, and the alterations in these intricately balanced …

Omics' Biomarkers Associated With Chronic Low Back Pain: Protocol Of A Retrospective Longitudinal Study, M. Allegri, Manuela De Gregori, Cristina E. Minella, Catherine Klersy, Wei Wang, Moira G. Sim, Christian Gieger, Judith Manz, Iain K. Pemberton, Jane Macdougall, Frances M. Williams, Jan Van Zundert, Klaas Buyse, Gordan Lauc, Ivan Gudelj, Dragan Primorac, Andrea Skelin, Yurii S. Aulchenko, Lennart C. Karssen, Leonardo Kapural, Richard L. Rauck, Guido Fanelli

Research outputs 2014 to 2021

Introduction

Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes. Biomarkers that may be objectively used for diagnosis and personalised, targeted and cost-effective treatment are still lacking. Therefore, any data that may be obtained at the-omics' level (glycomics, Activomics and genome-wide …

Using Technology, Bioinformatics And Health Informatics Approaches To Improve Learning Experiences In Optometry Education, Research And Practice, Vivek K. Gupta, Veer B. Gupta

Research outputs 2014 to 2021

Rapid advances in ocular diagnostic approaches and emerging links of pathological changes in the eye with systemic disorders have widened the scope of optometry as the front line of eye health care. Expanding professional requirements stipulate that optometry students get a meticulous training in relevant information and communication technologies (ICT) and various bioinformatics and health informatics software to meet current and future challenges. Greater incorporation of ICT approaches in optometry education can facilitate increased student engagement in shared learning experiences and improve collaborative learning. This, in turn, will enable students to participate in and prepare for the complex real-world situations. …

Food Quality Induces A Miscible Disease With Relevance To Alzheimer’S Disease And Neurological Diseases, Ian J. Martins

Research outputs 2014 to 2021

Food and nutrition guidelines for the handling and processing of fresh fruit, bread, and vegetables are essential and fresh produce may require cold preservation procedures to prevent minimal bacterial and fungi contamination of food. Bacterial lipopolysaccharides (LPS) corrupt lipoprotein and amyloid beta (Aβ) metabolism in diabetes, Alzheimer’s disease (AD) and various neurological diseases. In the developing world the increased plasma LPS levels induce non-alcoholic fatty liver diseases and interfere with albumin and Aβ interactions with spontaneous Aβ oligomer formation in the cerebrospinal fluid and brain that leads to neuronapoptosis by inactivation of Starling’s equation that is responsible for the maintenance …

The Emotional Intelligence Of Registered Nurses Commencing Critical Care Nursing, Yvette Nagel, Amanda Towell, Elzabe Nel, Fiona Foxall

Research outputs 2014 to 2021

Background: Critical care is described as complex, detailed healthcare in a unique, technologically rich environment. Critical care nursing requires a strong knowledge base and exceptional clinical and technological skills to cope in this demanding environment. Many registered nurses (RNs) commencing work in these areas may lack resilience, and because of the stress of the critical care environment, coping mechanisms need to be developed. To prevent burnout and to enable critical care nurses to function holistically, emotional intelligence (EI) is essential in the development of such coping mechanisms.

Objective: The aim of this study was to describe the EI …

Effect Of Liquid Versus Ice Slurry Ingestion On Core Temperature During Simulated Mining Conditions, Joseph Mate, Rodney Siegel, Jacques Oosthuizen, Paul Laursen, Greig Watson

Research outputs 2014 to 2021

Miners in Australia frequently perform physically demanding work under high ambient temperatures and humidity, often whilst wearing personal protective equipment, leading to heat-related illnesses. This study investigated effects of replacing 100% and 50% sweat losses with 5% carbohydrate liquid or ice-slurry solution on core temperature during simulated mining conditions. Five randomized treadmill trials were performed with: no fluid replacement (NF), 100% (100 ICE) and 50% (50 ICE) sweat loss replaced with ice-slurry (~-1°C) solution and 100% (100 LIQ) and 50% (50 LIQ) sweat loss replaced with liquid (~+4°C) solution. Time to exhaustion was longer in 100 ICE followed by 100 …

Food Intake And Caffeine Determine Amyloid Beta Metabolism With Relevance To Mitophagy In Brain Aging And Chronic Disease, Ian J. Martins

Research outputs 2014 to 2021

In the global world diabetes and mitochondrial disease is expected to cost the developing world in the next 30 years US $400 million. In diabetes an absent peripheral sink amyloid beta clearance pathway is now relevant to amyloid beta induced mitochondrial apoptosis. The quality of food consumed has raised major concerns with increased levels of plasma bacterial lipopolysaccharides (LPS) that induces amyloid beta aggregation and mitochondrial apoptosis with programmed cell death linked to non alcoholic fatty liver disease (NAFLD) and many organ diseases. The amount, nature and time of day of fat consumption in diabetes has become important with relevance …

Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism With Relevance To Nutrition And Appetite Regulation In Diabetes, Ian J. Martins

Research outputs 2014 to 2021

New discoveries in medicine are required to understand the importance of appetite regulation that is associated with the overconsumption of foodin Type 2 and Type 3 diabetes. Food restriction in diabetes is essential to maintain the hepatic metabolism of dietary fat with relevance to defective post-prandial lipid metabolism and to the global non alcoholic fatty liver disease (NAFLD) epidemic [1,2]. Premature brain aging has become important with the development of Type 3 diabetesand Alzheimer’s disease [3] that is associated with repression of the anti-aging gene Sirtuin 1 (Sirt 1) relevant topost-prandial lipid metabolism, amyloid beta metabolism (peptide involved in amyloid …

Examining The Potential Clinical Value Of Curcumin In The Prevention And Diagnosis Of Alzheimer's Disease, K. G. Goozee, T. M. Shah, Hamid R. Sohrabi, Stephanie Rainey-Smith, B. Brown, Guiseppe Verdile, Ralph Martins

Research outputs 2014 to 2021

Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer’s disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on the exclusion of other causes of dementia. In addition, phase III clinical trials of potential treatments have mostly failed, leaving disease-modifying interventions elusive. AD can be characterised neuropathologically by the deposition of extracellular β amyloid (Aβ) plaques and intracellular accumulation of tau-containing neurofibrillary tangles. Disruptions in Aβ metabolism/clearance contribute to …