Medicine and Health Sciences Commons^™

Changes In The Plasma Proteome At Asymptomatic And Symptomatic Stages Of Autosomal Dominant Alzheimer's Disease, Julia Muenchhoff, Anne Poljak, Anbupalam Thalamuthu, Veer Gupta, Pratishtha Chatterjee, Mark Raftery, Colin Masters, John Morris, Randall Bateman, Anne Fagan, Ralph Martins, Perminder Sachdev

Research outputs 2014 to 2021

The autosomal dominant form of Alzheimer's disease (ADAD) is far less prevalent than late onset Alzheimer's disease (LOAD), but enables well-informed prospective studies, since symptom onset is near certain and age of onset is predictable. Our aim was to discover plasma proteins associated with early AD pathology by investigating plasma protein changes at the asymptomatic and symptomatic stages of ADAD. Eighty-one proteins were compared across asymptomatic mutation carriers (aMC, n = 15), symptomatic mutation carriers (sMC, n = 8) and related noncarriers (NC, n = 12). Proteins were also tested for associations with cognitive measures, brain amyloid deposition and glucose …

Serum Concentrations Of The Biomarkers Ca125, Ca15-3, Psa And Papp-A In Early Pregnancy, Melissa J. Stemp, Peter Roberts, Allison Mcclements, Vincent Chapple, Phillip Matson

Research outputs 2014 to 2021

Blood samples were collected serially from 14 women with healthy pregnancies, beginning in gestational week 4 at the time of a positive pregnancy test through to the identification of a foetal heart by ultrasound. Six biomarkers were measured in the serum retrospectively including two reproductive hormones (progesterone and human chorionic gonadotrophin (hCG)) and four additional biomarkers (prostate-specific antigen (PSA), cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125) and pregnancy-associated plasma protein A (PAPP-A)) measured on a Siemens Centaur XP and a Roche Cobas e411 automated analysers, respectively. The progesterone and hCG results were unremarkable following established patterns, but distinctive patterns …

Drug Therapy For Obesity With Anti-Aging Genes Modification, Ian J. Martins

Research outputs 2014 to 2021

Nutritional regulation and drug therapy has been the focus of the current obesity epidemic in various countries in the world. Epigenetics is the major mechanism for the development of insulin resistance and obesity with unhealthy diets, oxidative stress and environmental factors relevant to alterations in gene expression with effects on mitochondrial biogenesis, adipose tissue lipid metabolism and energy expenditure. Anti-aging genes are involved in the regulation of adipogenesis with increased sensitivity to anti-aging gene dysfunction associated with adipocyte-neuron interactions compared to other cells. Unhealthy diets downregulate adipocyte anti-aging genes associated with the development of Non Alcoholic Fatty Liver Disease (NAFLD) …

Epidemiology And Risk Factors For Community-Associated Clostridium Difficile Infection: A Narrative Review, Lauren E. Bloomfield, Thomas V. Riley

Research outputs 2014 to 2021

Clostridium difficile infection (CDI) was once considered a primarily nosocomial concern. Emerging evidence from the last 20 years has highlighted a drastic shift in the known epidemiology of CDI, with disease outside of hospitals apparently occurring more frequently and causing severe disease in populations that were thought to be at low risk. This narrative review summarises potential pathways for infection outside of the hospital environment and highlights likely routes of transmission. Further, evidence is presented on potential risk factors for development of disease. Understanding the epidemiology of CDI outside of hospitals is essential to the ability to prevent and control …

Impaired Energy Metabolism: Involvement In Neurodegenerative Processes And Cns Ageing, Veer B. Gupta, Vivek K. Gupta

Research outputs 2014 to 2021

World is experiencing a consistent and steady increase in the ageing population with even higher proportional differences in the developed countries. Increase in ageing populations is directly correlated with the increased prevalence of age-related degenerative diseases of the central nervous system (CNS) such as Alzheimer’s disease and various other forms of dementias, stroke, Parkinson’s disease, retinal degenerative disorders, Huntington’s’ disease, multiple sclerosis, psychiatric and behavioural disorders amongst others.

Magnesium Therapy Prevents Senescence With The Reversal Of Diabetes And Alzheimer’S Disease, Ian James Martins

Research outputs 2014 to 2021

In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer’s disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions …

Type 3 Diabetes With Links To Nafld And Other Chronic Diseases In The Western World, Ian J. Martins

Research outputs 2014 to 2021

In the year 2015 it is now estimated that 30% of the Western World will now progress to non alcoholic fatty liver disease (NAFLD) and by the year 2050 if NAFLD remains untreated in the Western world the prevalence of the disease may rise to 40% of the global population. Type 3 diabetes and circadian rhythm disturbances may be involved in the induction of NAFLD that may promote insulin resistance and various chronic diseases such as cardiovascular disease, pancreatic disease, kidney disease and neurodegenerative disease. Multiple risk factors that induce Type 3 diabetes and NAFLD include stress, magnesium deficiency, bacterial …

Abcb5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth, Sonja Kleffel, Nayoung Lee, Cecilia Lezcano, Brian Wilson, Kristine Sobolewski, Karim Saab, Hansgeorg Mueller, Qian Zhan, Christian Posch, Christopher Elco, Andrew Dorosario, Sarah Garcia, Manisha Thakuria, Yaoyu Wang, Linda Wang, George Murphy, Markus Frank, Tobias Schatton

Research outputs 2014 to 2021

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with profound but poorly understood resistance to chemotherapy, which poses a significant barrier to clinical MCC treatment. Here we show that ATP-binding cassette member B5 (ABCB5) confers resistance to standard-of-care MCC chemotherapeutic agents and provide proof-of-principle that ABCB5 blockade can inhibit human MCC tumor growth through sensitization to drug-induced cell cytotoxicity. ABCB5 expression was detected in both established MCC lines and clinical MCC specimens at levels significantly higher than those in normal skin. Carboplatin- and etoposide-resistant MCC cell lines exhibited increased expression of ABCB5, along with enhanced ABCB1 and …

A Meta-Analytic Review Of The Efficacy Of Physical Exercise Interventions On Cognition In Individuals With Autism Spectrum Disorder And Adhd, Wei Z. Tan, Julie Ann Pooley, Craig P. Speelman

Research outputs 2014 to 2021

This review evaluates the efficacy of using physical exercise interventions on improving cognitive functions in individuals with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD). This review includes a meta-analysis based on a random-effects model of data reported in 22 studies with 579 participants aged 3–25 year old. The results revealed an overall small to medium effect of exercise on cognition, supporting the efficacy of exercise interventions in enhancing certain aspects of cognitive performance in individuals with ASD and/or ADHD. Specifically, similar to the general population literature, the cognitive benefits of exercise are not consistent across all aspects …

The Effectiveness Of Self-Management Mobile Phone And Tablet Apps In Long-Term Condition Management: A Systematic Review, Lisa Whitehead, Philippa Seaton

Research outputs 2014 to 2021

Background:

Long-term conditions and their concomitant management place considerable pressure on patients, communities, and health care systems worldwide. International clinical guidelines on the majority of long-term conditions recommend the inclusion of self-management programs in routine management. Self-management programs have been associated with improved health outcomes; however, the successful and sustainable transfer of research programs into clinical practice has been inconsistent. Recent developments in mobile technology, such as mobile phone and tablet computer apps, could help in developing a platform for the delivery of self-management interventions that are adaptable, of low cost, and easily accessible.

Objective:

We conducted a systematic review …

Musculoskeletal Asymmetry In Football Athletes: A Product Of Limb Function Over Time, Nicolas H. Hart, Sophia Nimphius, Jason Weber, Tania Spiteri, Timo Rantalainen, Michael Dobbin, Robert Newton

Research outputs 2014 to 2021

Purpose

Asymmetrical loading patterns are commonplace in football sports. Our aim was to examine the influence of training age and limb function on lower-body musculoskeletal morphology.

Methods

Fifty-five elite football athletes were stratified into less experienced ( ≤ 3 yr; n = 27) and more experienced ( > 3 yr; n = 28) groups by training age. All athletes underwent whole-body dual-energy x-ray absorptiometry scans and lower-body peripheral quantitative computed tomography tibial scans on the kicking and support limbs.

Results

Significant interactions between training age and limb function were evident across all skeletal parameters (F16, 91 = 0.182, P = 0.031, …

Compliance, Palatability And Feasibility Of Paleolithic And Australian Guide To Healthy Eastin Diets In Healtthy Women: A 4-Week Dietary Intervention, Angela Genoni, Johnny Lo, Philippa Lyons-Wall, Amanda Devine

Research outputs 2014 to 2021

(1) Background/Objectives:

The Paleolithic diet has been receiving media coverage in Australia and claims to improve overall health. The diet removes grains and dairy, whilst encouraging consumption of fruits, vegetables, meat, eggs and nuts. Our aim was to compare the diet to the Australian Guide to Healthy Eating (AGHE) in terms of compliance, palatability and feasibility;

(2) Subjects/Methods:

39 healthy women (age 47 ± 13 years, BMI 27 ± 4 kg/m²) were randomised to an ad-libitum Paleolithic (n = 22) or AGHE diet (n = 17) for 4-weeks. A food checklist was completed daily, with mean discretionary consumption …

An Approach To Measuring And Encouraging Research Translation And Research Impact, Andrew M. Searles, Chrisotpher M. Doran, John R. Attia, Darryl A. Knight, John H. E. Wiggers, Simon Deeming, Joërg Mattes, Brad Webb, Steve Hannan, Rod Ling, Kim Edmunds, Penny Reeves, Michael Nilsson

Research outputs 2014 to 2021

Background:

Research translation, particularly in the biomedical area, is often discussed but there are few methods that are routinely used to measure it or its impact. Of the impact measurement methods that are used, most aim to provide accountability - to measure and explain what was generated as a consequence of funding research. This case study reports on the development of a novel, conceptual framework that goes beyond measurement. The Framework To Assess the Impact from Translational health research, or FAIT, is a platform designed to prospectively measure and encourage research translation and research impact. A key assumption underpinning FAIT …

Discriminant Validity Of The Hospital Anxiety And Depression Scale, Beck Depression Inventory (Ii) And Beck Anxiety Inventory To Confirmed Clinical Diagnosis Of Depression And Anxiety In Patients With Chronic Obstructive Pulmonary Disease, Tina Phan, Owen Carter, Claire Adams, Grant Waterer, Li Ping Chung, Maxine Hawkins, Cobie Rudd, Mel R. Ziman, Natalie Strobel

Research outputs 2014 to 2021

The objective of this study was to investigate the discriminant validity of commonly used depresson and anxiety screening tools in order to determine the most suitable tool for patients with chronic obstructive pulmonary disease (COPD). COPD patients (n = 56) completed the Hospital Anxiety and Depression Scale (HADS), Beck Depression Inventory (BDI-II) and Beck Anxiety Inventory (BAI). These scores were compared to confirmed clinical diagnosis of depression and anxiety using the Mini Neuropsychiatric Interview. HADS depression subscale (HADS-D) sensitivity/specificity was 78/81 %; BDI-II 89/77 %; HADS anxiety subscale (HADS-A) 71/81 %; and BAI 89/62 %. HADS-D sensitivity/specificity was improved …

Learning Preferences Of Enrolled Nursing Students: Educational Preparation And Training For Workplace Readiness, Kalpana Raghunathan, Sonia Allen, Elisabeth R. Jacob

Research outputs 2014 to 2021

In Australia there are two entry levels in nursing: the Registered Nurse (RN) and the Enrolled Nurse (EN). Nursing education research is predominately focused on higher education for Registered Nurses and postgraduate nursing students; as a result, the educational preferences of Enrolled Nursing students in the vocational education and training (VET) setting have not been identified. Enrolled Nursing students have some distinct educational needs as they transition through education into the workforce due to their diversity in learner characteristics and backgrounds. As the role of this group continues to expand in the workplace to meet the demands of the health …

Discriminating Talent Identified Junior Australian Footballers Using A Fundamental Gross Athletic Movement Assessment, Carle T. Woods, Henry Banyard, Ian Mckeown, Job Fransen, Sam J. Robertson

Research outputs 2014 to 2021

Talent identification (TID) is a pertinent component of the sports sciences, affording practitioners the opportunity to target developmental interventions to a select few; optimising financial investments. However, TID is multi-componential, requiring the recognition of immediate and prospective performance. The measurement of athletic movement skill may afford practitioners insight into the latter component given its augmented relationship with functional sport specific qualities. It is currently unknown whether athletic movement skill is a discriminant quality in junior Australian football (AF). This study aimed to discriminate talent identified junior AF players from their non-talent identified counterparts using a fundamental gross athletic movement assessment. …

The Association Between Glycosylation Of Immunoglobulin G And Hypertension: A Multiple Ethnic Cross-Sectional Study, Youxin Wang, Lucija Klarić, Xinwei Yu, Kujtim Thaqi, Jing Dong, Mislav Novokmet, Jim Wilson, Ozren Polasek, Youqin Liu, Jasminka Krištić, Siqi Ge, Maja Pučić-Baković, Lijuan Wu, Yong Zhou, Ivo Ugrina, Manshu Song, Jie Zhang, Xiuhua Guo, Qiang Zeng, Igor Rudan, Harry Campbell, Yurii Aulchenko, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases. A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N-glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity. Five glycans (IgG with digalactosylated glycans) significantly differed in participants …

Medicine In The Early Twenty-First Century: Paradigm And Anticipation - Epma Position Paper 2016, Olga Golubnitschaja, Babak Baban, Giovanni Boniolo, Wei Wang, Rostyslav Bubnov, Marko Kapalla, Kurt Krapfenbauer, Mahmood S. Mozaffari, Vincenzo Costigliola

Research outputs 2014 to 2021

Challenges of “standardisation” and “individualisation” have always been characteristic for medical services. In terms of individualisation, the best possible individual care is the ethical imperative of medicine, and it is a good right of any patient to receive it. However, in terms of standardisation, all the available treatments are based on guideline recommendations derived from large multi-centre trials with many thousands of patients involved. In the most optimal way, the standardisation and individualisation should go hand-in-hand, in order to identify the right patient treating him/her with the right medication and the right dose at the right time point!

Further, …

Anti-Aging Genes Improve Appetite Regulation And Reverse Cell Senescence And Apoptosis In Global Populations, Ian James Martins

Research outputs 2014 to 2021

Appetite regulation by nutritional intervention is required early in life that involves the anti-aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes involved in cell circadian rhythm, senescence and apoptosis. Interests in anti-aging therapy with appetite regulation improve an individual’s survival to metabolic disease induced by gene-environment interactions by maintenance of the anti-aging genes connected to the metabolism of bacterial lipopolysaccharides, drugs and xenobiotics. Interventions to the aging process involve early calorie restriction with appetite regulation connected to appropriate genetic mechanisms that involve mitochondrial biogenesis and DNA repair in neurons. In the aging process …

Diet And Nutrition Reverse Type 3 Diabetes And Accelerated Aging Linked To Global Chronic Diseases, Ian James Martins

Research outputs 2014 to 2021

The acceleration in the rate of chronic diseases that involve insulin resistance has become of global concern. The rate of the most prevalent chronic disease such as cardiovascular disease is linked to the metabolic syndrome, non alcoholic fatty liver disease (NAFLD) and other chronic diseases that include obesity, diabetes and neurodegenerative diseases. The gene-environment interaction in Western countries indicates that with urbanization access to food and its content may lead to induction of epigenetic alterations and identify the gene Sirtuin 1 (Sirt 1) to be responsible for the increased risk for insulin resistance and NAFLD relevant to Type 1, Type …

Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins

Research outputs 2014 to 2021

Bacterial lipopolysaccharides (LPS) and their increase in plasma in individuals in the developing world has become of major concern. LPS can transform cells by their rapid insertion into cell membranes that partition into cholesterol/sphingomyelin domains. LPS alter cell phospholipid dynamics associated with the recruitment of the Alzheimer’s disease amyloid beta (Aβ) peptide with the promotion of toxic Aβ oligomer formation. The common pattern of naturally occurring phospholipids such as1-palmitoyl-2-oleolyl-phosphatidylcholine in cells confers cells with the rapid transfer of Aβ and phospholipids. Phospholipids such as dipalmitoylphosphatidylcholine (DPPC), dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) are poorly transported with delayed metabolism of Aβ oligomers. …

Building Online Community On Snac: A Netnographic Study Of The Early Years Sector, Ruth Wallace, Leesa Costello, Amanda Devine

Research outputs 2014 to 2021

‘‘Build it and they will come,’’ an adage critiqued as a common misconception of participatory engagement with online communities. Previous research indicated that a netnographic approach based upon researcher– participant engagement would provide the best opportunity to build and sustain a successful support community [...].

Developing And Evaluating Complex Interventions: Enhancing The Role Of Qualitative Research, Lisa Whitehead, Marie Crowe, Carol Bugge, Kirsten Coppell

Research outputs 2014 to 2021

The use of qualitative research methods alongside randomized controlled trials of health-care interventions have the potential to contribute to the development and evaluation of both complex and other health interventions. Qualitative evaluations of interventions are rarely reported but can provide insight into the intervention process, and the feasibility and acceptability of the intervention, to improve and adapt interventions.

Humanising The Curriculum: The Role Of A Virtual World, Beverley Ewans, Sara Geale, Caroline Vafeas, Fiona Foxall, Barbara Loessl, Aisling Smyth, Christopher Mccafferty

Research outputs 2014 to 2021

Objective:

Technology has changed our world; changed the way we communicate, the way we do business and the way education is delivered. As a result, undergraduate student cohorts come to university equipped with new technology, and educators need to transform the delivery of the curricula to satisfy a variety of learning styles. Nursing education, in particular, is developing and transforming to incorporate technology into the learning environment. Clinical placement opportunities are often sparse and alternative experiences need to be considered. Across nursing curricula, it has been recognised that technology has the capacity to provide real-life learning experiences that promote …

Setting Research Priorities To Improve Global Newborn Health And Prevent Stillbirths By 2025, Sachiyo Yoshida, Jose Martines, Joy E. Lawn, Stephen Wall, Joao Paulo Souza, Igor Rudan, Simon Cousens, Peter Aaby, Ishag Adam, Ramesh Kant Adhikari, Namasivayam Ambalavanan, Shams El Arifeen, Dhana Raj Aryal, Sk Asiruddin, Abdullah Baqui, Aluisio J.D. Barros, Christine S. Benn, Vineet Bhandari, Shinjini Bhatnagar, Sohinee Bhattacharya, Zulfiqar A. Bhutta, Robert E. Black, Hannah Blencowe, Carl Bose, Justin Brown, Christoph Buehrer, Wally Carlo, Jose Guilherme Cecatti, Po-Yin Cheung, Robert Clark, Tim Colbourn, Agustin Conde-Agudelo, Erica Corbett, Andrew E. Czeizel, Abhik Das, Louise Tina Day, Carolyn Deal, Ashok Deorari, Ugur Dilmen, Mike English, Cyril Engmann, Fabian Esamai, Caroline Fall, Donna M. Ferriero, Peter Gisore, Tabish Hazir, Rosemary D. Higgins, Caroline S.E. Homer, Dewan E. Hoque, Lorentz Irgens, Mohammad T. Islam, Joseph De Graft-Johnson, Martias Alice Joshua, William Keenan, Soofia Khatoon, Helle Kieler, Michael S. Kramer, Eve M. Lackritz, Tina Lavender, Laurensia Lawintono, Richard Luhanga, David Marsh, Douglas Mcmillan, Patrick J. Mcnamara, Ben Willem J. Mol, Elizabeth Molyneux, Gelasius K. Mukasa, Miriam Mutabazi, Luis Carlos Nacul, Margaret Nakakeeto, Indira Narayanan, Bolajoko Olusanya, David Osrin, Vinod Paul, Christian Poets, Uma M. Reddy, Mathuram Santosham, Rubayet Sayed, Natalia E. Schlabritz-Loutsevitch, Nalini Singhal, Mary Alice Smith, Peter G. Smith, Sajid Soofi, Catherine Y. Spong, Shahin Sultana, Antoinette Tshefu, Frank Van Bel, Lauren Vestewig Gray, Peter Waiswa, Wei Wang, Sarah L.A. Williams, Linda Wright, Anita Zaidi, Yanfeng Zhang, Nanbert Zhong, Isabel Zuniga, Rajiv Bahl

Research outputs 2014 to 2021

Background

In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013–2025.

Methods

We used adapted Child …

Spatiotemporal Cluster Patterns Of Hand, Foot, And Mouth Disease At The County Level In Mainland China, 2008-2012, Chao Wang, Xia Li, Yingjie Zhang, Qin Xu, Fangfang Huang, Kai Cao, Lixin Tao, Jin Guo, Qi Gao, Wei Wang, Liqun Fang, Xiuhua Guo

Research outputs 2014 to 2021

Background:

Hand, foot, and mouth disease (HFMD) is known to be a highly contagious childhood illness. In recent years, the number of reported cases of HFMD has significantly increased in mainland China. This study aims at the epidemiological features, spatiotemporal patterns of HMFD at the county/district level in mainland China.

Methods:

Data on reported HFMD cases for each county from 1 January 2008 to 31 December 2012 were obtained from the Chinese Center for Disease Control and Prevention. Cluster analysis, spatial autocorrelation, and retrospective scan methods were used to explore the spatiotemporal patterns of the disease.

Results:

The annual incidences …

Nurse Staffing And Workload Drivers In Small Rural Hospitals: An Imperative For Evidence, Diane E. Twigg, Jennifer H. Cramer, Judith D. Pugh

Research outputs 2014 to 2021

Purpose:

The aim of this study was to explore staffing issues and the workload drivers influencing nursing activities in designated small rural hospitals of Western Australia. A problem for small rural hospitals is an imbalance between nurse staffing resources and work activity.

Sample:

A purposive sample of 17 nurse leaders employed at designated small rural hospitals in Western Australia.

Method:

A qualitative research design was used. Data were collected by focus group and semi-structured interviews and review of Western Australian Country Health Service records. Thematic analysis was used to interpret data.

Findings:

A minimum nurse staffing model is in use. …

Ghanaian Nurses’ Emigration Intentions: The Role Of Workplace Violence, Isaac Mensah Boafo

Research outputs 2014 to 2021

A cross-sectional study was conducted in Ghana to examine the impact of workplace violence on nurses’ emigration intentions from 2013 to 14. A combination of purposive and random sampling techniques was used to select 12 public hospitals and 592 professional nurses. The results showed that 48.9% of the participants had emigration intentions. Junior nurses were 2.8 times more likely to have emigration intentions compared to senior nurses, and those who experienced violence were also more likely than their counterparts who were not involved in such incidents (physical 2.1 times; verbally abused 1.8 times and sexually harassed 2.4 times) to have …

“... They Think We Are Conversing, So We Don ’ T Care About Them ...” Examining The Causes Of Workplace Violence Against Nurses In Ghana, Isaac Mensah Boafo

Research outputs 2014 to 2021

Background:

This study is part of a larger project aimed at exploring the workplace experiences of nurses working in public general hospitals in Ghana. The current paper explores the causes of workplace violence against nurses in Ghana.

Methods:

Twenty-four semi-structured in-depth interviews were conducted with professional nurses working in five regions of Ghana. They were selected through purposive and participant-to-participant snowball sampling techniques. Data was analysed through thematic analyses.

Results:

The findings of the study suggest that nurses are not (always) passive recipients of violence. Workplace violence can be instigated by either of the parties to the nurse-patient/relative interaction. Nurses’ …

Periodization Strategies In Older Adults: Impact On Physical Function And Health, Jennifer Conlon, Greg Haff, James J. Tufano, Robert Newton

Research outputs 2014 to 2021

Purpose

This study compared the effect of periodized versus nonperiodized (NP) resistance training (RT) on physical function and health outcomes in older adults.

Methods

Forty-one apparently healthy untrained older adults (women = 21, men = 20; 70.9 ± 5.1 yr; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified to a NP, block periodized, or daily undulating periodized training group. Outcome measures were assessed at baseline and after a 22-wk × 3 d·wk⁻¹ RT intervention, including; anthropometrics, body composition, blood pressure and biomarkers, maximal strength, functional capacity, balance confidence, and quality of life.

Results

Thirty-three …