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Full-Text Articles in Medicine and Health Sciences

Hospitalized Adult Patient Characteristics Associated With Participation In A Volunteer-Assisted Mobility Program: A Feasibility Study, Gordana Dermody, Tamara Odom-Maryon, Jennifer Zimmerman, Courtney Glass Dec 2020

Hospitalized Adult Patient Characteristics Associated With Participation In A Volunteer-Assisted Mobility Program: A Feasibility Study, Gordana Dermody, Tamara Odom-Maryon, Jennifer Zimmerman, Courtney Glass

Research outputs 2014 to 2021

BACKGROUND:

Physical inactivity during hospitalization commonly results in functional decline. Structured multidisciplinary programs/approaches may be useful to promote mobility in hospitalized adults.

PURPOSE:

The purpose was to determine whether a volunteer-assisted mobility program was feasible to improve the ambulation of hospitalized patients, and examine the characteristics of patients associated with willingness to participate in the program.

METHODS:

A prospective descriptive correlation study was conducted in 2 acute care units. A volunteer-staffed program was implemented with the aim of improving the ambulation of hospitalized patients.

RESULTS:

Hospitalized patients (N = 490) were approached, with 39.2% (n = 192) agreeing to ambulate …


Excisional Treatment Comparison For In Situ Endocervical Adenocarcinoma (Excise): A Phase 2 Pilot Randomized Controlled Trial To Compare Histopathological Margin Status, Specimen Size And Fragmentation After Loop Electrosurgical Excision Procedure And Cold Knife Cone Biopsy, Paul A. Cohen, Yee Leung, Lyndal Anderson, Rachael Van Der Griend, Paola Chivers, Sanela Bilic, Sophie Bittinger, Alison Brand, Max K. Bulsara, Jim Codde, Lois Eva, Louise Farrell, Dianne Harker, Unine Herbst, Stephanie Jeffares, Diane Loh, Orla Mcnally, Ganendra Raj Mohan, Tarryn Nicholson, Aime Powell, Stuart G. Salfinger, Bryony Simcock, Colin Stewart, Julie Silvers, Martin R. Stockler, Peter Sykes, Pennie Stoyles, Adeline Tan, Ai Ling Tan, C. David H. Wrede Dec 2020

Excisional Treatment Comparison For In Situ Endocervical Adenocarcinoma (Excise): A Phase 2 Pilot Randomized Controlled Trial To Compare Histopathological Margin Status, Specimen Size And Fragmentation After Loop Electrosurgical Excision Procedure And Cold Knife Cone Biopsy, Paul A. Cohen, Yee Leung, Lyndal Anderson, Rachael Van Der Griend, Paola Chivers, Sanela Bilic, Sophie Bittinger, Alison Brand, Max K. Bulsara, Jim Codde, Lois Eva, Louise Farrell, Dianne Harker, Unine Herbst, Stephanie Jeffares, Diane Loh, Orla Mcnally, Ganendra Raj Mohan, Tarryn Nicholson, Aime Powell, Stuart G. Salfinger, Bryony Simcock, Colin Stewart, Julie Silvers, Martin R. Stockler, Peter Sykes, Pennie Stoyles, Adeline Tan, Ai Ling Tan, C. David H. Wrede

Research outputs 2014 to 2021

Objective:

Adenocarcinoma in situ (AIS) of the cervix is a precursor to cervical adenocarcinoma. When AIS is detected by cervical screening an excision biopsy is mandatory to exclude invasion. We aimed to compare margins status, specimen size and fragmentation after loop electrosurgical excision procedure (LEEP) and ‘cold knife cone biopsy’ (CKC).

Methods:

The EXCISE Trial was an investigator-initiated, multicenter, open-label, parallel-group, phase 2, randomized study. Patients were enrolled at seven hospitals in Australia and New Zealand. We randomly assigned women aged ≥ 18 to ≤ 45 years with screen detected AIS to LEEP or CKC. Co-primary endpoints were margin status, …


The Impact Of Critical Incidents On Nurses And Midwives: A Systematic Review, Melanie Buhlmann, Beverley Ewens, Amineh Rashidi Dec 2020

The Impact Of Critical Incidents On Nurses And Midwives: A Systematic Review, Melanie Buhlmann, Beverley Ewens, Amineh Rashidi

Research outputs 2014 to 2021

Aims:

To synthesise the existing literature, which focuses on the impact of critical incidents on nurses and midwives, and to explore their experiences related to the support they received in the current healthcare environment to move on from the event.

Design:

Systematic review and qualitative synthesis.

Data sources:

The electronic databases CINAHL, MEDLINE, PsycINFO, PubMed, Embase and Nursing and Allied Health (ProQuest) were systematically searched from 2013–2018, and core authors and journals identified in the literature were manually investigated.

Review methods:

Qualitative studies of all research design types written in English were included according to the PRISMA reporting guidelines. The …


Pd-L1 Expression On Circulating Tumor Cells May Be Predictive Of Response To Pembrolizumab In Advanced Melanoma: Results From A Pilot Study, Muhammad K. Khattak, Anna L. Reid, James Freeman, Michelle Pereira, Ashleigh Mcevoy, Johnny Lo, Markus Frank, Tarek Meniawy, Ali Didan, Isaac Spencer, Benhur Amanuel, Michael Millward, Mel Ziman, Elin Gray Dec 2020

Pd-L1 Expression On Circulating Tumor Cells May Be Predictive Of Response To Pembrolizumab In Advanced Melanoma: Results From A Pilot Study, Muhammad K. Khattak, Anna L. Reid, James Freeman, Michelle Pereira, Ashleigh Mcevoy, Johnny Lo, Markus Frank, Tarek Meniawy, Ali Didan, Isaac Spencer, Benhur Amanuel, Michael Millward, Mel Ziman, Elin Gray

Research outputs 2014 to 2021

BACKGROUND: PD-1 inhibitors are routinely used for the treatment of advanced melanoma. This study sought to determine whether PD-L1 expression on circulating tumor cells (CTCs) can serve as a predictive biomarker of clinical benefit and response to treatment with the PD-1 inhibitor pembrolizumab.

METHODS: Blood samples were collected from patients with metastatic melanoma receiving pembrolizumab, prior to treatment and 6-12 weeks after initiation of therapy. Multiparametric flow cytometry was used to identify CTCs and evaluate the expression of PD-L1.

RESULTS: CTCs were detected in 25 of 40 patients (63%). Patients with detectable PD-L1

CONCLUSION: Our results reveal the potential of …


Higher Habitual Flavonoid Intakes Are Associated With A Lower Risk Of Peripheral Artery Disease Hospitalizations, Nicola P. Bondonno, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Christian Torp-Pedersen, Augustin Scalbert, Anne Tjonneland, Jonathan M. Hodgson, Frederik Dalgaard Dec 2020

Higher Habitual Flavonoid Intakes Are Associated With A Lower Risk Of Peripheral Artery Disease Hospitalizations, Nicola P. Bondonno, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Christian Torp-Pedersen, Augustin Scalbert, Anne Tjonneland, Jonathan M. Hodgson, Frederik Dalgaard

Research outputs 2014 to 2021

Background

The role of nutrition in the primary prevention of peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular disease, is undetermined. Flavonoids may attenuate atherosclerosis and therefore persons who consume flavonoid-rich foods may have a lower risk of developing PAD.

Objectives

We aimed to examine the association between flavonoid intake and PAD hospitalizations and investigate if the association differs according to established risk factors for PAD.

Methods

Baseline data from 55,647 participants of the Danish Diet, Cancer, and Health Study without PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated …


Serum Midkine, Estimated Glomerular Filtration Rate And Chronic Kidney Disease-Related Events In Elderly Women: Perth Longitudinal Study Of Aging Women, Jeffrey Wang, Joshua R. Lewis, Elizabeth Byrnes, Germaine Wong, Warren D. Raymond, Kun Zhu, Graham R. Robertson, Wai H. Lim, Qi Cao, Richard L. Prince, Vincent W. Lee Dec 2020

Serum Midkine, Estimated Glomerular Filtration Rate And Chronic Kidney Disease-Related Events In Elderly Women: Perth Longitudinal Study Of Aging Women, Jeffrey Wang, Joshua R. Lewis, Elizabeth Byrnes, Germaine Wong, Warren D. Raymond, Kun Zhu, Graham R. Robertson, Wai H. Lim, Qi Cao, Richard L. Prince, Vincent W. Lee

Research outputs 2014 to 2021

© 2020, The Author(s). Midkine (MDK), a heparin-binding growth factor cytokine, is involved in the pathogenesis of kidney diseases by augmenting leukocyte trafficking and activation. Animal models and small case control studies have implicated MDK as a pathological biomarker in chronic kidney diseases (CKD), however this is yet to be confirmed in prospective human studies. In a prospective study of 499 elderly, predominantly Caucasian women aged over 70 years the association between serum MDK collected in 1998, and renal function change and the risk of CKD-related hospitalisations and deaths at 5 and 14.5 years, respectively, was examined. Baseline serum MDK …


Biological System Energy Algorithm Reflected In Sub-System Joint Work Distribution Movement Strategies: Influence Of Strength And Eccentric Loading, Jeffrey M. Mcbride, Sophia Nimphius Dec 2020

Biological System Energy Algorithm Reflected In Sub-System Joint Work Distribution Movement Strategies: Influence Of Strength And Eccentric Loading, Jeffrey M. Mcbride, Sophia Nimphius

Research outputs 2014 to 2021

© 2020, The Author(s). To better understand and define energy algorithms during physical activity as it relates to strength and movement strategy of the hip, knee and ankle, a model of increasing eccentric load was implemented in the current investigation utilizing a countermovement jump and a series of drop jumps from different heights (15, 30, 45, 60, 75 cm). Twenty-one participants were grouped by sex (men, n = 9; women, n = 12) and muscle strength (higher strength, n = 7; moderate strength, n = 7; lower strength, n = 7) as determined by a maximal squat test. Force plates …


Association Between Remnant Lipoprotein Cholesterol Levels And Non-Alcoholic Fatty Liver Disease In Adolescents, Justin Chin, Trevor A. Mori, Leon A. Adams, Lawrence J. Beilin, Rae-Chi Huang, John K. Olynyk, Oyekoya T. Ayonrinde Dec 2020

Association Between Remnant Lipoprotein Cholesterol Levels And Non-Alcoholic Fatty Liver Disease In Adolescents, Justin Chin, Trevor A. Mori, Leon A. Adams, Lawrence J. Beilin, Rae-Chi Huang, John K. Olynyk, Oyekoya T. Ayonrinde

Research outputs 2014 to 2021

Background & Aims: Remnant lipoprotein cholesterol (RLP-C) is an atherogenic lipid profile associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). With increased rates of CVD seen in adults with NAFLD, RLP-C has the potential to identify individuals with NAFLD who are at increased risk of CVD. This study examined in adolescents sex-different associations among RLP-C, NAFLD, and cardiometabolic risk factors, and whether RLP-C is associated with NAFLD beyond traditional cardiometabolic risk factors. Methods: Adolescents in the Raine Study had anthropometry, clinical, biochemistry and arterial stiffness measurements recorded at 17 years of age. Fatty liver, subcutaneous and visceral …


A Race For A Better Understanding Of Covid-19 Vaccine Non-Adopters, Zhaohui Su, Jun Wen, Jaffar Abbas, Dean Mcdonnell, Ali Cheshmehzangi, Xiaoshan Li, Junaid Ahmad, Sabina Šegalo, Daniel Maestro, Yuyang Cai Dec 2020

A Race For A Better Understanding Of Covid-19 Vaccine Non-Adopters, Zhaohui Su, Jun Wen, Jaffar Abbas, Dean Mcdonnell, Ali Cheshmehzangi, Xiaoshan Li, Junaid Ahmad, Sabina Šegalo, Daniel Maestro, Yuyang Cai

Research outputs 2014 to 2021

In this paper, we aim to underscore the need for a more nuanced understanding of vaccine non-adopters. As the availability of vaccines does not translate into their adoption-a phenomenon that may be more pronounced amid "Operation Warp Speed"-it is important for public health professionals to thoroughly understand their "customers" (i.e., end users of COVID-19 vaccines) to ensure satisfactory vaccination rates and to safeguard society at large.


Prospective Reporting Of Injury In Community-Level Cricket: A Systematic Review To Identify Research Priorities, Geordie Mcleod, Siobhán O'Connor, Damian Morgan, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington Nov 2020

Prospective Reporting Of Injury In Community-Level Cricket: A Systematic Review To Identify Research Priorities, Geordie Mcleod, Siobhán O'Connor, Damian Morgan, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

© 2020 Sports Medicine Australia Objectives: Cricket is a popular sport enjoyed worldwide. Injuries in cricket are not well understood at community level but are important to understand for prevention to ensure the game continues to be enjoyed safely. This systematic review was designed to assess the quality of data collection and reporting, and to summarise the injury data, in studies of community cricket players. Design: Systematic review. Methods: Nine databases were searched to November 2018 using the terms “cricket*” and “injur*”. A nine-item critical appraisal and three-item likelihood-of-bias evaluation was conducted on included studies. Data completeness was evaluated against …


Association Between Circulating Osteocalcin And Cardiometabolic Risk Factors Following A 4-Week Leafy Green Vitamin K-Rich Diet, Alexander Tacey, Marc Sim, Cassandra Smith, Mary N. Woessner, Elizabeth Byrnes, Joshua R. Lewis, Tara Brennan-Speranza, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Itamar Levinger Nov 2020

Association Between Circulating Osteocalcin And Cardiometabolic Risk Factors Following A 4-Week Leafy Green Vitamin K-Rich Diet, Alexander Tacey, Marc Sim, Cassandra Smith, Mary N. Woessner, Elizabeth Byrnes, Joshua R. Lewis, Tara Brennan-Speranza, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Itamar Levinger

Research outputs 2014 to 2021

Background:

Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. Materials and

Methods:

Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction …


Development, Psychometrics And Feasibility Of The School Participation Questionnaire: A Teacher Measure Of Participation Related Constructs, Donald Maciver, Vaibhav Tyagi, Jessica M. Kramer, Janet Richmond, Liliya Todorova, Dulce Romero-Ayuso, Hiromi Nakamura-Thomas, Margo Van Hartingsveldt, Lorna Johnston, Anne O'Hare, Kirsty Forsyth Nov 2020

Development, Psychometrics And Feasibility Of The School Participation Questionnaire: A Teacher Measure Of Participation Related Constructs, Donald Maciver, Vaibhav Tyagi, Jessica M. Kramer, Janet Richmond, Liliya Todorova, Dulce Romero-Ayuso, Hiromi Nakamura-Thomas, Margo Van Hartingsveldt, Lorna Johnston, Anne O'Hare, Kirsty Forsyth

Research outputs 2014 to 2021

© 2020 Background: We report development of the SPQ (School Participation Questionnaire) a teacher-completed measure of participation related constructs for schools. The SPQ was developed to support participation-related assessment, interventions, and research in the inclusive school context. Methods: Several iterative steps were undertaken. An international panel of experts reviewed content validity. A 66-item pilot questionnaire was administered in schools. Mokken and Rasch model analysis were applied. Internal consistency was assessed using Cronbach's alpha. Analyses were conducted on associations with teacher and child demographic variables. Feedback was sourced from users. Participants were teachers of 101 children (5−12 years old) with a …


Prognostic Value Of Hla-I Homozygosity In Patients With Non-Small Cell Lung Cancer Treated With Single Agent Immunotherapy, Afaf Abed, Leslie Calapre, Johnny Lo, Suzana Correia, Samantha Bowyer, Abha Chopra, Mark Watson, Muhammad A. Khattak, Michael Millward, Elin Solomonovna Gray Oct 2020

Prognostic Value Of Hla-I Homozygosity In Patients With Non-Small Cell Lung Cancer Treated With Single Agent Immunotherapy, Afaf Abed, Leslie Calapre, Johnny Lo, Suzana Correia, Samantha Bowyer, Abha Chopra, Mark Watson, Muhammad A. Khattak, Michael Millward, Elin Solomonovna Gray

Research outputs 2014 to 2021

Background We aimed to assess the impact of genomic human leukocyte antigen (HLA)-I/II homozygosity on the survival benefit of patients with unresectable locally advanced, metastatic non-small lung cancer treated by single-agent programmed cell death protein-1/programmed death ligand 1 (PD1/PDL1) inhibitors.

Methods We collected blood from 170 patients with advanced lung cancer treated with immunotherapy at two major oncology centers in Western Australia. Genomic DNA was extracted from white blood cells and used for HLA-I/II high-resolution typing. HLA-I/II homozygosity was tested for association with survival outcomes. Univariable and multivariable Cox regression models were constructed to determine whether HLA homozygosity was an …


A Survey Identifying Leadership And Research Activities Among Nurse Practitioners, Mary Ryder, Elisabeth Jacob, Joyce Hendricks Oct 2020

A Survey Identifying Leadership And Research Activities Among Nurse Practitioners, Mary Ryder, Elisabeth Jacob, Joyce Hendricks

Research outputs 2014 to 2021

Background: Nurse Practitioners are identified as the ideal conduit to transform healthcare delivery internationally. Healthcare transformation requires the application of leadership and research skills. Current literature has limited information on NPs as leaders or researchers in the nursing profession.

Objectives: Determine if Nurse Practitioners identify themselves as leaders in nursing. Identify the leadership and research activities and influencing characteristics of Nurse Practitioners in Ireland and Australia. Establish similarities in leadership and research activities between Nurse Practitioners in Ireland and Australia. To identify if there is a relationship between leadership and research activities.

Design: A quantitative electronic survey.

Methods: A …


Perceptual Oscillations In Gender Classification Of Faces, Contingent On Stimulus History, Jason Bell, David C. Burr, Kate Crookes, Maria Concetta Morrone Oct 2020

Perceptual Oscillations In Gender Classification Of Faces, Contingent On Stimulus History, Jason Bell, David C. Burr, Kate Crookes, Maria Concetta Morrone

Research outputs 2014 to 2021

Perception is a proactive ‘‘predictive’’ process, in which the brain takes advantage of past experience to make informed guesses about the world to test against sensory data. Here we demonstrate that in the judgment of the gender of faces, beta rhythms play an important role in communicating perceptual experience. Observers classified in forced choice as male or female, a sequence of face stimuli, which were physically constructed to be male or female or androgynous (equal morph). Classification of the androgynous stimuli oscillated rhythmically between male and female, following a complex waveform comprising 13.5 and 17 Hz. Parsing the trials based …


Association Between Telomere Length In Peripheral Blood Leukocytes And Risk Of Ischemic Stroke In A Han Chinese Population: A Linear And Non‑Linear Mendelian Randomization Analysis, Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang, Youxin Wang Oct 2020

Association Between Telomere Length In Peripheral Blood Leukocytes And Risk Of Ischemic Stroke In A Han Chinese Population: A Linear And Non‑Linear Mendelian Randomization Analysis, Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

Background: Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studies in previous years. This study aims to investigate whether the leukocyte telomere length is associated with an increased IS risk or not, based on the Mendelian randomization (MR) approach. Methods: Based on the NHGRI-EBI GWAS Catalog database, the Chinese online genetic database as well as the previous published studies, twelve single nucleotide polymorphisms (SNPs) with minor allele frequency ≥ 0.05 were selected and the leukocyte telomere length was measured in …


The Effect Of Specific Locomotor Experiences On Infants’ Avoidance Behaviour On Real And Water Cliffs, Carolina Burnay, Rita Cordovil, Chris Button, James L. Croft, Matthew Schofield, Joana Pereira, David I. Anderson Oct 2020

The Effect Of Specific Locomotor Experiences On Infants’ Avoidance Behaviour On Real And Water Cliffs, Carolina Burnay, Rita Cordovil, Chris Button, James L. Croft, Matthew Schofield, Joana Pereira, David I. Anderson

Research outputs 2014 to 2021

© 2020 John Wiley & Sons Ltd Infants’ avoidance of drop-offs has been described as an affordance learning that is not transferable between different locomotor postures. In addition, there is evidence that infants perceive and act similarly around real and water cliffs. This cross-sectional study investigated the effects of specific locomotor experiences on infants’ avoidance behaviour using the Real Cliff/Water Cliff paradigm. The experiments included 102 infants, 58 crawling, but pre-walking, infants (Mage = 11.57 months, SD = 1.65) with crawling experience ranging between 0.03 and 7.4 months (M = 2.16, SD = 1.71) and 44 walking infants (Mage = …


Cochrane Corner Summary Of Review Titled: “Peer Support For People With Schizophrenia Or Other Serious Mental Illness”, Beverley Ewens, Amanda Barnard-Towell, Sheila Mortimer-Jones, Vivien Kemp, Amanda Cole Oct 2020

Cochrane Corner Summary Of Review Titled: “Peer Support For People With Schizophrenia Or Other Serious Mental Illness”, Beverley Ewens, Amanda Barnard-Towell, Sheila Mortimer-Jones, Vivien Kemp, Amanda Cole

Research outputs 2014 to 2021

Serious mental illnesses affect how people feel, think, and behave, and frequently contribute to disability in psychosocial and occupational functioning and quality of life (American Psychiatric Association 2015; Harvey & Strassnig, 2012; Mohamed et al., 2008). Psychosocial interventions designed to support people with schizophrenia and their families have shown to improve the person’s rehabilitation, reintegration into the community, and recovery (The National Collaborating Centre for Mental Health, 2009; Pharoah et al., 2012). Peer workers are defined as individuals with lived experience of mental illness (Aguey-Zinsou et al., 2018), with peer support principles based on shared responsibility and mutual respect (Mead …


Cardiovascular Health In China: Low Level Vs High Diversity, Wei Wang Oct 2020

Cardiovascular Health In China: Low Level Vs High Diversity, Wei Wang

Research outputs 2014 to 2021

No abstract provided.


Fatigue-Related Feedback From Calf Muscles Impairs Knee Extensor Voluntary Activation, Harrison T. Finn, David S. Kennedy, Simon Green, Janet L. Taylor Oct 2020

Fatigue-Related Feedback From Calf Muscles Impairs Knee Extensor Voluntary Activation, Harrison T. Finn, David S. Kennedy, Simon Green, Janet L. Taylor

Research outputs 2014 to 2021

INTRODUCTION:

Fatigue-related group III/IV muscle afferent firing from agonist, antagonist or distal muscles impairs the ability to drive the elbow flexors maximally, that is, reduces voluntary activation. In the lower limb, the effect of feedback from distal muscles on the proximal knee extensors is unknown. Here, we test whether maintained group III/IV afferent feedback from the plantarflexor muscles reduces voluntary activation of the knee extensors.

METHODS:

On 2 d, voluntary activation of the knee extensors during maximal voluntary contractions (MVCs) was assessed in 12 participants before and after a 3-min fatiguing task of the plantarflexors. On 1 d, an inflatable …


Postgraduate Nurse Education And The Implications For Nurse And Patient Outcomes: A Systematic Review, Ma'en Zaid Abu-Qamar, Caroline Vafeas, Beverley Ewens, Manonita Ghosh, Deborah Sundin Sep 2020

Postgraduate Nurse Education And The Implications For Nurse And Patient Outcomes: A Systematic Review, Ma'en Zaid Abu-Qamar, Caroline Vafeas, Beverley Ewens, Manonita Ghosh, Deborah Sundin

Research outputs 2014 to 2021

© 2020 Elsevier Ltd Objectives: To synthesise the current evidence of the implications of postgraduate nursing qualifications on patient and nurse outcomes. Design: A systematic review. Data sources: Primary research findings. Review methods: A systematic search following PRISMA guidelines and the Joanna Briggs Institute's framework was conducted. A structured and comprehensive search of three electronic databases CINAHL, MEDLINE, PsychINFO, search engine Google Scholar, and a manual-search of reference lists was undertaken. The search was limited to articles in English between 2000 and 2019. The combined search yielded 3710 records. Search records were exported to EndNote X8 and duplicates were removed. …


Effects Of An 8-Week Resistance Training Intervention On Plantar Flexor Muscle Quality And Functional Capacity In Older Women: A Randomised Controlled Trial, Pedro Lopez, Brendan James Crosby, Bruna Patrícia Robetti, Douglas Jean Preussler Turella, Thaís Andréia Schepa Weber, Morgana Lima De Oliveira, Anderson Rech Sep 2020

Effects Of An 8-Week Resistance Training Intervention On Plantar Flexor Muscle Quality And Functional Capacity In Older Women: A Randomised Controlled Trial, Pedro Lopez, Brendan James Crosby, Bruna Patrícia Robetti, Douglas Jean Preussler Turella, Thaís Andréia Schepa Weber, Morgana Lima De Oliveira, Anderson Rech

Research outputs 2014 to 2021

© 2020 The present study examined 8 weeks of resistance training and its effects on muscle quality measures, plantar flexor muscle strength, muscle thickness and functional capacity in older women. Moreover, we tested if changes in muscle quality were associated with functional capacity. Twenty-four older women (66.3 ± 5.8 years; 69.0 ± 3.0 kg; 25.3 ± 1.4 kg·m−2) were recruited to the study. After completion of the baseline assessment, participants were randomly assigned to either the resistance training (RET, n = 12) or an active control group (CTR, n = 12). Muscle quality was evaluated through muscle echo intensity (MQEI) …


Associations Between Social And Intellectual Activities With Cognitive Trajectories In Chinese Middle-Aged And Older Adults: A Nationally Representative Cohort Study, Haibin Li, Changwei Li, Anxin Wang, Yanling Qi, Wei Feng, Chengbei Hou, Lixin Tao, Xiangtong Liu, Xia Li, Wei Wang, Deqiang Zheng, Xiuhua Guo Sep 2020

Associations Between Social And Intellectual Activities With Cognitive Trajectories In Chinese Middle-Aged And Older Adults: A Nationally Representative Cohort Study, Haibin Li, Changwei Li, Anxin Wang, Yanling Qi, Wei Feng, Chengbei Hou, Lixin Tao, Xiangtong Liu, Xia Li, Wei Wang, Deqiang Zheng, Xiuhua Guo

Research outputs 2014 to 2021

BACKGROUND: Associations between the frequency of social and intellectual activities and cognitive trajectories are understudied in Chinese middle-aged and older adults. We aimed to examine this association in a nationally representative longitudinal study. METHODS: The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative sample of Chinese middle-aged and older participants. The frequency of social and intellectual activities was measured at baseline. Interview-based cognitive assessments of orientation and attention, episodic memory, and visuospatial skills and the calculation of combined global scores were assessed every 2 years from 2011 to 2016. Cognitive aging trajectories over time were analyzed using …


Otud4 Enhances Tgfβ Signalling Through Regulation Of The Tgfβ Receptor Complex, Patrick William Jaynes, Prasanna Vasudevan Iyengar, Sarah Kit Leng Lui, Tuan Zea Tan, Natali Vasilevski, Sarah Christine Elizabeth Wright, Giuseppe Verdile, Anand D. Jeyasekharan, Pieter Johan Adam Eichhorn Sep 2020

Otud4 Enhances Tgfβ Signalling Through Regulation Of The Tgfβ Receptor Complex, Patrick William Jaynes, Prasanna Vasudevan Iyengar, Sarah Kit Leng Lui, Tuan Zea Tan, Natali Vasilevski, Sarah Christine Elizabeth Wright, Giuseppe Verdile, Anand D. Jeyasekharan, Pieter Johan Adam Eichhorn

Research outputs 2014 to 2021

© 2020, The Author(s). Systematic control of the transforming growth factor-β (TGFβ) pathway is essential to keep the amplitude and the intensity of downstream signalling at appropriate levels. Ubiquitination plays a crucial role in the general regulation of this pathway. Here we identify the deubiquitinating enzyme OTUD4 as a transcriptional target of the TGFβ pathway that functions through a positive feedback loop to enhance overall TGFβ activity. Interestingly we demonstrate that OTUD4 functions through both catalytically dependent and independent mechanisms to regulate TGFβ activity. Specifically, we find that OTUD4 enhances TGFβ signalling by promoting the membrane presence of TGFβ receptor …


Risk Prediction Of Late-Onset Alzheimer’S Disease Implies An Oligogenic Architecture, Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E. Marioni, Margaret J. Wright, Alison M. Goate, Edoardo Marcora, Kuan-Lin Huang, Tenielle Porter, Simon M. Laws, Perminder S. Sachdev, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yeng, Naomi R. Wray Robertson, Allan F. Mcrae, Peter M. Visscher, Steven Collins, Christine Thai, Brett Trounson, Kate Lennon, Qiao Xin Li, Fernanda Yevenes Ugarte, Irene Volitakis, Michael Vovos, Australian Imaging Biomarkers And Lifestyle Sep 2020

Risk Prediction Of Late-Onset Alzheimer’S Disease Implies An Oligogenic Architecture, Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E. Marioni, Margaret J. Wright, Alison M. Goate, Edoardo Marcora, Kuan-Lin Huang, Tenielle Porter, Simon M. Laws, Perminder S. Sachdev, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yeng, Naomi R. Wray Robertson, Allan F. Mcrae, Peter M. Visscher, Steven Collins, Christine Thai, Brett Trounson, Kate Lennon, Qiao Xin Li, Fernanda Yevenes Ugarte, Irene Volitakis, Michael Vovos, Australian Imaging Biomarkers And Lifestyle

Research outputs 2014 to 2021

© 2020, The Author(s). Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (Poptimal) of a genetic risk score (GRS) for prediction of LOAD in three independent datasets comprising 676 cases and 35,675 family history proxy cases. We show that the discriminative ability of GRS in LOAD prediction is maximised when selecting a small number of SNPs. Both simulation results and direct estimation indicate that the number of causal common SNPs for LOAD may be less than 100, suggesting …


Age And Apoe Genotype Affect The Relationship Between Objectively Measured Physical Activity And Power In The Alpha Band, A Marker Of Brain Disease, Jaisalmer De Frutos-Lucas, Pablo Cuesta, Federico Ramírez-Toraño, Alberto Nebreda, Esther Cuadrado-Soto, África Peral-Suárez, David Lopez-Sanz, Ricardo Bruña, Silvia Marcos-De Pedro, María Luisa Delgado-Losada, Ana María López-Sobaler, Inmaculada Concepción Rodríguez-Rojo, Ana Barabash, Juan Manuel Serrano Rodriguez, Simon M. Laws, Alberto Marcos Dolado, Ramón López-Higes, Belinda M. Brown, Fernando Maestú Sep 2020

Age And Apoe Genotype Affect The Relationship Between Objectively Measured Physical Activity And Power In The Alpha Band, A Marker Of Brain Disease, Jaisalmer De Frutos-Lucas, Pablo Cuesta, Federico Ramírez-Toraño, Alberto Nebreda, Esther Cuadrado-Soto, África Peral-Suárez, David Lopez-Sanz, Ricardo Bruña, Silvia Marcos-De Pedro, María Luisa Delgado-Losada, Ana María López-Sobaler, Inmaculada Concepción Rodríguez-Rojo, Ana Barabash, Juan Manuel Serrano Rodriguez, Simon M. Laws, Alberto Marcos Dolado, Ramón López-Higes, Belinda M. Brown, Fernando Maestú

Research outputs 2014 to 2021

BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer's disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using …


Genetic Analysis Of Endometriosis And Depression Identifies Shared Loci And Implicates Causal Links With Gastric Mucosa Abnormality, Emmanuel Adewuyi, Divya Mehta, Yadav Sapkota, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R. Griffiths, Grant W. Montgomery, Daniel I. Chasman, Dale R. Nyholt Sep 2020

Genetic Analysis Of Endometriosis And Depression Identifies Shared Loci And Implicates Causal Links With Gastric Mucosa Abnormality, Emmanuel Adewuyi, Divya Mehta, Yadav Sapkota, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R. Griffiths, Grant W. Montgomery, Daniel I. Chasman, Dale R. Nyholt

Research outputs 2014 to 2021

Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (PFsig-permuted = 9.99 × 10−4). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (rG = 0.27, P = 8.85 × 10−27). A meta-analysis of endometriosis and depression GWAS (sample size = …


Arthropathy In Hereditary Haemochromatosis Segregates With Elevated Erythrocyte Mean Corpuscular Volume, A. Rehman, G. J. Carroll, L. W. Powell, L. E. Ramm, G. A. Ramm, John K. Olynyk Sep 2020

Arthropathy In Hereditary Haemochromatosis Segregates With Elevated Erythrocyte Mean Corpuscular Volume, A. Rehman, G. J. Carroll, L. W. Powell, L. E. Ramm, G. A. Ramm, John K. Olynyk

Research outputs 2014 to 2021

© 2020 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation. Objective: To evaluate the relationship between erythrocyte parameters and the presence or absence of arthritis in HFE C282Y homozygous hereditary haemochromatosis (HH) subjects compared to control groups of non-HH subjects with arthritis. Method: Erythrocyte and arthritis parameters [mean corpuscular volume (MCV) and mean cell haemoglobin (MCH)] were obtained from consecutive HH subjects (n = 119) who were referred for initial evaluation and management. For comparison, MCV and MCH values were collected from randomly selected non-HH subjects with rheumatoid arthritis (n = 100) and osteoarthritis (n = 100), consisting of …


A Pilot Evaluation Of Simulation-Based Interprofessional Education For Occupational Therapy, Speech Pathology And Dietetic Students: Improvements In Attitudes And Confidence, Brennen Mills, Sara Hansen, Charn Nang, Helen Mcdonald, Philippa Lyons-Wall, Jacqui Hunt, Therese O’Sullivan Sep 2020

A Pilot Evaluation Of Simulation-Based Interprofessional Education For Occupational Therapy, Speech Pathology And Dietetic Students: Improvements In Attitudes And Confidence, Brennen Mills, Sara Hansen, Charn Nang, Helen Mcdonald, Philippa Lyons-Wall, Jacqui Hunt, Therese O’Sullivan

Research outputs 2014 to 2021

Many higher education institutions struggle to provide interprofessional practice opportunities for their pre-licensure students due to demanding workloads, difficulties with timetabling, and problems with sourcing suitable placements that provide appropriate practice opportunities. A series of complex unfolding video-based simulation scenarios involving a patient who had experienced a stroke was utilized as a case study for a three-hour interprofessional practice workshop. 69 occupational therapy (OT), speech pathology (SP) and dietetics (DT) students participated in a mixed-methods study comparing interprofessional attitudes before and after the workshop. Attitudes toward interprofessional practice improved pre- vs. post-workshop and overall. Students were highly satisfied with the …


Voluntary Exercise In Mesothelioma: Effects On Tumour Growth And Treatment Response In A Murine Model, Scott A. Fisher, Carolyn J. Peddle-Mcintyre, Kimberley Burton, Robert U. Newton, Elly Marcq, Richard A. Lake, Anna K. Nowak Sep 2020

Voluntary Exercise In Mesothelioma: Effects On Tumour Growth And Treatment Response In A Murine Model, Scott A. Fisher, Carolyn J. Peddle-Mcintyre, Kimberley Burton, Robert U. Newton, Elly Marcq, Richard A. Lake, Anna K. Nowak

Research outputs 2014 to 2021

OBJECTIVE: There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogen-induced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced …