Biological Psychology Commons^™

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused …

The Effect Of Social Buffering And Gender On Cortisol Response In Emerging Adults, Ashley G. Molchany

West Chester University Graduate Theses, Dissertations, and Final Projects

Abstract

Cortisol, the primary stress hormone in the body, is released in times of challenge, including challenges faced throughout the transition to college. The experience of acute stress can be assessed through cortisol measures. The present study involved a 60-minute lab assessment for first-year students to analyze their physiological response to stress. Previous research has illustrated factors which impact cortisol responses, two of which are social support and gender. In the current study, participants (n = 71) were assigned to work either by themselves (Student Alone Condition) or in a peer triad group (Peer Triad Condition). Additionally, participants identified …

Effects Of Pressure-Based Virtual Reality Training On Mental Toughness In Athletes, Rylee J. Aspinwall

UNF Graduate Theses and Dissertations

Athletes often underperform in high-pressure situations due to challenges in emotional regulation rather than deficits in physical skill. Mental toughness, broadly defined as the ability to maintain performance under stress, is a key determinant of athletic success but remains difficult to train using traditional methods. Virtual reality (VR) offers a controlled and immersive environment for simulating competitive pressure; however, its application for training mental toughness remains limited. The present study examined the effects of pressure-based VR training on psychological and physiological responses in collegiate baseball and softball athletes. Participants completed up to eight VR training sessions under either high-pressure or …

The Relationship Between Symptom Catastrophizing And Sociocultural Factors Among Adults With Persistent Sympathetic Activation Syndromes, Whitney M. Redemer

Theses and Dissertations

Persistent Sympathetic Activation (PSA) has emerged as a potential unifying mechanism underlying a range of complex chronic health conditions yet remains poorly characterized within biomedical and psychosocial research. Limited research has delineated how PSA manifests across diverse populations or how diagnostic and sociocultural factors shape lived experiences of this phenomenon; thus, the objective of the present study was to examine whether diagnostic certainty – operationalized as provider-confirmed versus self-suspected PSA-related diagnoses – is associated with symptom catastrophizing, and whether this relationship varies as a function of sociocultural factors. Drawing on data from a larger study aimed at characterizing the lived …

Patterns Of Ovarian And Gonadotropin Hormones In Emerging Adult Oral Contraceptive Users, Summer Mcormond

UROP Posters

Oral contraceptives (OCs) are often initiated during adolescence and emerging adulthood, a period of continued maturation of the hypothalamic–pituitary–gonadal (HPG) axis. Because hormonal exposure during this window may shape emotional, biological, and reproductive outcomes, it is important to understand the specific formulations young women take and the hormonal profiles these formulations produce. This study characterizes OC formulation features and measured hormone levels in young adult OC users (n = 30).

Ethinyl estradiol (EE) doses ranged from 0.01–0.035 mg (mean = 0.022 mg), with 70% using ≤0.02 mg. Pill regimens included 21/7 packs (83%), 24/4 packs (10%), and 84/7 regimens (3%). …

Daily Rhythms In Psychosocial Stress, Sleep, And Mood: A Multimethod Approach To Transdiagnostic Psychopathology Risk And Intervention, Gabriel Gilmore

Theses and Dissertations--Psychology

Rhythms are central to nearly every core physiological and psychological process and have profound influences on overall health and well-being, particularly in the context of mood disorders. This dissertation emphasizes a rhythm-centered framework for understanding transdiagnostic psychopathology, proposing that the temporal organization of psychosocial stress, sleep, and mood provides crucial information for the development and treatment of mood disorder symptomology. Current literature relies primarily on mean symptom levels, overlooking day-to-day patterns in psychosocial experiences. To address this key methodological gap, three studies are examined. Study 1 develops and validates the Psychosocial Stress Regularity Measure (PSRM), a brief single-item measure of …

The Relationship Between Estradiol And Progesterone Concentration Levels, Alcohol Consumption, And Inhibitory Control, Layne Elizabeth Robinson B.S.

Theses and Dissertations--Psychology

Alcohol use is increasing among women, with estimates for binge drinking having risen to levels similar to those seen in men. Despite this trend, sex differences regarding mechanisms of alcohol consumption have seldom been investigated. Our group and others have found evidence to suggest that ovarian sex hormones are associated with alcohol consumption and mechanisms that might be related to alcohol consumption, such as executive function deficits. The current study sought to extend this prior research in a larger sample with higher drinking rates and more rigorous methods, and to explore inhibitory control associations with drinking. Across the two samples …

Sex Differences In The Use Of Cognitive Strategies In Brown-Headed Cowbirds (Molothrus Ater), Nicole E. Robinson Ms.

Theses and Dissertations (Comprehensive)

Cognition is widely believed to be adaptive, yet few studies directly show that variation in cognitive performance is related to fitness. Brown-headed cowbirds (Molothrus ater) provide a powerful system for addressing this gap because brood parasitism creates strikingly different reproductive problems for females and males. Females face the spatial demands of nest-prospecting, whereas males face social and competitive demands associated with access to mates. Across five experiments, cowbirds were tested on an outdoor foraging task designed as an analogue of nest prospecting, with manipulations of retention interval, cue conflict, and breeding condition, followed by observations of reproductive behaviour. …

From Molecules To Minds: Integrative Multi-Omics In Psychiatry, Hossein Abbasi, Sage E. Hawn, Arash Javanbakht, Soraya Seedat, Kyle Bourassa, Sinead M. Sinnott, Antonia V. Seligowski, Sian Hemmings, Nathan A. Kimbrel, Alicia K. Smith, Leslie Brick, Divya Mehta

Psychology Faculty Publications

Psychiatric disorders are biologically complex conditions arising from interactions across genomic, epigenomic, transcriptomic, proteomic, metabolomic, and metagenomic layers. Single-omics approaches rarely capture more than a fraction of the variance in complex conditions, underscoring the importance of integrative multi-omics frameworks. This mini-review summarizes key methodologies and their application in psychiatric research, with a focus on systems-level integration of genomic risk scores, transcriptomic networks, and neuroimaging data to advance biological understanding of disorders such as depression, schizophrenia, and Alzheimer’s disease. We also outline the infrastructural requirements for effective multi-omics research, including standardized biobanking, Laboratory Information Management Systems, adherence to FAIR data principles, …

Best Practices For Using Biological Data In Psychological Research, Sage E. Hawn, Sinead M. Sinnott, Alicia K. Smith, Kyle Bourassa, Leslie Brick, Sian Hemmings, Soraya Seedat, Arash Javanbakht, Lauren Smith, Antonia V. Seligowski, Nathan A. Kimbrel, Divya Mehta, Hossein Abbasi, Erika Wolf

Psychology Faculty Publications

Advances in statistical techniques for analyzing biological data have driven the need for larger sample sizes, which are ultimately made possible through team science efforts. Findings from these efforts have led to a significant shift in approaches to biological data collection over the past decade, from traditional approaches relying on single measures or assays collected by individual investigators in small lab-based studies to high-dimensional methodologies embedded within large cohorts or multi-site studies. These recent large scale consortium efforts necessitate careful consideration across the full data pipeline, from pre-data generation and sample collection to processing and statistical analysis, while addressing challenges …

Examining The Physiological Stress-Reducing Effects Of Virtual Nature Exposure And Slow Breathing, Jesse Benefiel

Cal Poly Humboldt theses and projects

In a time of excess stress, it is essential to examine accessible stress-reduction methods. Research has demonstrated that virtual nature exposure and slow breathing can independently reduce stress, but the literature is lacking with regard to their combined effects. The present study aimed to replicate independent effects of breathing and nature on stress and to test for potential effects, including whether their combination would produce an interaction effect. Using a 2 Environment (Natural v. Control) by 2 Breathing (Slow v. Normal) between-subjects design, 63 participants completed a modified color-word Stroop task to induce stress and were then exposed to either …

Joint Associations Of Meditation And Physical Activity With Depression And Anxiety Symptoms In Us Adults: Nhis 2022, Yubing Wang

Human Movement Studies & Special Education Faculty Publications

Objectives

Physical activity and meditation may each relate to mental health, but their joint associations in U.S. adults are unclear. We examined the separate and joint associations of any past-year meditation and meeting physical activity (PA) guidelines with depression and anxiety symptoms.

Method

We analyzed data from the 2022 National Health Interview Survey Sample Adult file (n = 24,927). Exposures were meeting PA guidelines, any past-year meditation, and their four-level combination (Neither, PA only, Meditation only, Both). Outcomes were moderate-to-severe depressive and anxiety symptoms (PHQ-8/GAD-7 >= 10). Survey-weighted modified Poisson models estimated prevalence ratios (PRs), with interaction, sensitivity, and post …

Dispositional Mindfulness And Autonomic Reactivity, Thomas Dylan Boyer

Graduate Theses, Dissertations, and Problem Reports (ETD)

To explain how different facets of mindfulness were associated with task performance in distinctive ways, Lindsay and Creswell (2017) proposed the Monitor and Acceptance Theory (MAT). According to this model, the mindfulness facet of monitoring present state awareness was thought to influence task performance differently than the nonjudgmental acceptance facet of mindfulness, but no studies to date have examined this model with respect to an individual's physiological response to stressful tasks. Because dispositional mindfulness has been associated with both increased and decreased physiological and affective reactions to stress in previous studies, the present study tested whether the Monitoring facet of …

Aba Renewal Of Fentanyl Seeking Using A Drug-Prime And Peer Stimulus In Rats, Meagan Blanchard

University of Kentucky Master's Theses

People with opioid use disorder can experience craving and relapse to use when exposed to cues that were previously paired with the drug-taking environment. These cues can be both social and non-social in nature. This study aimed to explore the effect of a peer cue and a drug-prime cue, both together and separately. First, rats were trained to self-administer fentanyl in Context A (peer and drug present). Then, rats extinguished this behavior in Context B (no peer and no drug present) while self-administering saline instead of fentanyl. Lastly, rats underwent 4 different renewal test conditions (control, peer only, drug only, …

Heat Waves And Heart Rates: Exploring The Correlation Between Temperature And Anxiety, Denise Lori Loewinger, Laci Joy Walmer

Student Scholar Symposium

“Will an individual be more prone to anxiety or panic attacks with an increase in body temperature?” Anxiety is defined as a feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome. Commonly known is the idea that situational factors, such as the death of a family member or financial stress may increase a person’s anxiety levels. Yet, according to research, factors such as physical location or high temperatures may also determine the prominence of anxiety. Using temperature- controlled environments in conjunction with medical instruments, we measured the anxiety levels of participants through …

Examining The Relationship Between Gambling Advertising & Gambling Behavior, Ilkim Green, Eric Wickenhauser, Hannah White Ph.D

Undergraduate Research Symposium

Gambling advertising has become increasingly prevalent across various media platforms such as TV, social media, real-life advertising, etc. With advertisements designed to influence attitudes, intentions, and behaviors of potential and existing consumers, this review aims to compile existing research to examine the measurable effects of gambling advertising. Studies indicate that young people and problem gamblers are especially vulnerable to these advertisements, which normalize gambling and contribute to increases in gambling behavior. This effect on behavior is dose-dependent; increased exposure to advertising is associated with greater gambling engagement. While responsible gambling messages are often included in advertisements, they remain largely ineffective …

Neurobehavioral Mechanisms Of Psychotic-Like Experiences And Cannabis Use, Ethan Campbell

Psychology ETDs

As cannabis use has increased steadily over the past decade, there is critical need to evaluate early cannabis use as a potential risk factor for the development of psychosis. Neurobehavioral mechanisms underlying novelty salience could clarify how cannabis exposure may influence subclinical psychotic-like experiences (PLEs). The present study leveraged dynamic functional connectivity and task-fMRI to assess the role of novelty processing in cannabis use and PLEs. A group of brain regions dynamically tied to the salience network while viewing short films were found to increase their activation as a function of stimulus novelty during a novelty bandit task. PLEs were …

The Timing Of Pubertal Onset Affects Adults Anxiety Behavior In A Sex-Specific Manner, Evan Raubenolt

Honors Projects

This study aims to look at the relationship between the timing of pubertal onset and its long-term effects on adult anxiety behavior in rats. Though the topic of pubertal onset has been frequently discussed in developmental research, its exact effects have been inconsistent. Human models have shown that early and late maturing males are associated with a notable increase in adult anxiety behavior, while in rat models, similar sex-specific effects regarding anxiety have been demonstrated, though those studies focus on a causal relationship between exposure to stress and age of pubertal onset. This study first aims to examine that relationship …

Physiological Response To Concealed Information In A Mock-Crime Paradigm​, Ezra Koenigsberg, Tamya Mchenry, Jasmine Manzana, Taylor Powell, Samantha Jackson

Science University Research Symposium (SURS)

The Concealed Information Test (CIT), based on Lykken’s guilty knowledge framework, measures physiological responses when individuals recognize crime-related details compared to neutral alternatives. Previous studies show that variations in stimulus presentation enhance the CIT’s accuracy, especially through changes in electrodermal activity and heart rate. However, few studies have tested whether a Qualtrics-based mock-crime version of the CIT can replicate these physiological patterns. This study addresses that gap by adapting the CIT for a digital research environment. The goal is to determine whether participants show greater physiological arousal—measured through skin conductance, heart rate, and respiration—when exposed to crime-related “critical” stimuli compared …

The Potential Co-Occurrence Of Perfectionism, Food Insecurity, And Gpa With Orthorexia Nervosa Risk, Samantha Kay Gould

Master's Theses

There are indeterminate risk, prevalence, and correlation data on orthorexia nervosa (ON) as shown by current literature on disordered eating (Rodgers et al., 2021). As a roughly defined disordered eating pattern, ON may be better understood after identifying associations among other attributes in a college student sample (Abdullah et al., 2020; Mavrandrea & Gonidakis, 2023; Parra-Fernández, 2019; Rogowska et al., 2021). A cooccurrence and influence of perfectionism, food insecurity, and grade point average (GPA) with ON risk was hypothesized since current literature suggests college students exhibit each of these characteristics independently (Abdullah et al., 2020; Ambwani et al., 2019; Caferoglu …