Double Trouble: The Development And Use Of A Novel Spatial Memory Task To Study Depression In A Female Rodent Model,
2022
Colby College
Double Trouble: The Development And Use Of A Novel Spatial Memory Task To Study Depression In A Female Rodent Model, Ekaterina L. Koelliker
Honors Theses
Preclinical rodent models of depression are important for improving our understanding of the behavioral and neurobiological implications of the disorder. However, the current behavioral assays used to assess depressive symptoms in rodents have substantial shortcomings; they are basic, test animals individually, and do not evaluate animals for extended periods. The primary goals of the present study, which was divided into two experiments, were to develop a novel task that could be used to study spatial memory and to apply the task to rodent models of depression. Both experiments used a circular arena with 10 identical jars to analyze the spatial …
The Evolution Of Quantitative Sensitivity,
2022
University of Nebraska-Lincoln
The Evolution Of Quantitative Sensitivity, Margaret A H Bryer, Sarah E. Koopman, Jessica F. Cantlon, Steven T. Piantadosi, Evan L. Maclean, Joseph M. Baker, Michael J. Beran, Sarah M. Jones, Kerry E. Jordan, Salif Mahamane, Andreas Nieder, Bonnie M. Perdue, Friederike Range, Jeffrey R. Stevens, Masaki Tomonaga, Dorottya Ujfalussy, Jennifer Vonk
Jeffrey Stevens Publications
The ability to represent approximate quantities appears to be phylogenetically widespread, but the selective pressures and proximate mechanisms favouring this ability remain unknown. We analysed quantity discrimination data from 672 subjects across 33 bird and mammal species, using a novel Bayesian model that combined phylogenetic regression with a model of number psychophysics and random effect components. This allowed us to combine data from 49 studies and calculate the Weber fraction (a measure of quantity representation precision) for each species. We then examined which cognitive, socioecological and biological factors were related to variance in Weber fraction. We found contributions of phylogeny …
Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention,
2022
University at Albany, State University of New York
Neural Correlates And Neuroanatomy Of Juvenile And Adult Contextual Fear Memory Retention, Natalie Odynocki
Legacy Theses & Dissertations (2009 - 2024)
AbstractFear is an evolutionarily conserved mechanism that allows an organism to discern potential harm and act accordingly by engaging in defensive behaviors. While fear is an adaptive response, dysregulation of fear by means of a traumatic event can lead to psychiatric conditions such as post-traumatic stress disorder (PTSD). Animal research using rodents in Pavlovian context fear conditioning experiments allows for the ability to study the underlying neural circuitry of threat-appropriate and aberrant fear learning and memory that may contribute to PTSD. However, despite reports that women are more than two times more likely to develop PTSD compared to men, the …
Integrating Interpersonal Neurobiology In Healthcare Leadership And Organizations,
2022
Antioch University - PhD Program in Leadership and Change
Integrating Interpersonal Neurobiology In Healthcare Leadership And Organizations, Lynn Redenbach
Antioch University Full-Text Dissertations & Theses
Interpersonal Neurobiology (IPNB) is an interdisciplinary, science-based field that seeks to understand human reality including the nature of mind, brain, and relationships. IPNB has been used extensively by mental health practitioners as well as child development and parenting experts. While practitioners and scholars have described ways that IPNB can be used in leadership and organizations, there has been no systematic inquiry into the practical and phenomenological experience of this application. IPNB offers an alternative to dominant models of care and leading in healthcare settings and fields, which are characterized by disconnection, objectification, and separation. It offers a relationally centered approach …
Does Speech-To-Text Assistive Technology Paired With Graphic Organizers Improve The Written Expression Of Students With Traumatic Brain Injuries?,
2021
Duquesne University
Does Speech-To-Text Assistive Technology Paired With Graphic Organizers Improve The Written Expression Of Students With Traumatic Brain Injuries?, Kayla Cuifolo
Electronic Theses and Dissertations
A traumatic brain injury (TBI) can range from mild to severe and can cause debilitating outcomes that require children to need specialized medical or educational services post-injury. Outcomes vary and are dependent on the location of injury, age, severity, and environmental factors. Some common deficits that happen as a result of a brain injury are fine motor and executive functioning skill difficulties. Fine motor and executive functioning skills are an important component of written expression. Therefore, this current study utilized a brief experimental analysis in order to determine the effects that speech-to-text assistive technology along with a graphic organizer has …
The Influence Of Emotion Regulation And Neural Cognitive Control On Distress Tolerance,
2021
Old Dominion University
The Influence Of Emotion Regulation And Neural Cognitive Control On Distress Tolerance, Alicia L. Milam
Psychology Theses & Dissertations
Tolerance of negative emotions has been associated with transdiagnostic negative mental health outcomes. Theory and research implicate emotion regulation and cognitive control as factors in tolerance of negative emotions. But their unique contributions to tolerance of negative emotions and interdependency have been unclear due to methodological limitations. This study aimed to explicate cognitive and emotional factors affecting distress tolerance in a non-clinical sample of emerging adults. Undergraduate psychology students completed self-report measures of emotion regulation ability and tolerance of negative emotions. The N2 ERP component elicited by a Go-NoGo task was also used as a neurophysiological marker of cognitive control …
Boosting Brain Waves Improves Memory,
2021
Florida Institute of Technology - Melbourne
Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino
Psychology Faculty Publications
Have you ever wanted to improve your memory? Or have you struggled to remember what you studied? Memory uses special patterns of activity in the brain. This experiment tested a new way to create brain wave patterns that help with memory. We wanted to see if we could improve memory by using lights and sounds that teach the brain waves to be in sync. People wore special goggles that made flashes of light and headphones that made beeping noises. This trained the brain through a process called entrainment. The entrainment put the brain in sync at a specific brain wave …
Boosting Brain Waves Improves Memory,
2021
Florida Institute of Technology - Melbourne
Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino
Psychology Student Publications
Have you ever wanted to improve your memory? Or have you struggled to remember what you studied? Memory uses special patterns of activity in the brain. This experiment tested a new way to create brain wave patterns that help with memory. We wanted to see if we could improve memory by using lights and sounds that teach the brain waves to be in sync. People wore special goggles that made flashes of light and headphones that made beeping noises. This trained the brain through a process called entrainment. The entrainment put the brain in sync at a specific brain wave …
Social Justice Approaches To Cognitive, Emotional, And Language Development During Childhood And Adolescence,
2021
Texas A&M International University
Social Justice Approaches To Cognitive, Emotional, And Language Development During Childhood And Adolescence, Angélique M. Blackburn
Journal of Multicultural Affairs
With contemporary events that have spotlighted social injustices, including the Black Lives Matter movement in the United States and the COVID-19 pandemic, any discussion of child development should take into account the diverse experiences of children facing injustice. In this article, I focus on social justice as it pertains to child development and how this topic has been addressed in literature targeted at students of child development theory. I focus on the contribution of two recent books (Anthis, 2020; De Houwer, 2021) within the greater context of reviewing literature regarding social inequities in cognitive, emotional, and language development. Anthis (2020) …
Alterations To The Brain Following Traumatic Brain Injury,
2021
Bowling Green State University
Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader
Honors Projects
Traumatic brain injuries (TBIs) have been labeled as a modern-day epidemic, increasing exponentially with the advancement of technology and society. Gaining a better understanding of the cognitive paths, including the chemical and electrical signals of the brain, neural correlates, and possible interventions for TBI patients allows for the best possible outcome for every patient, and allows for the further advancement of care. By revising and reassessing the ways in which TBIs are categorized and described the prognosis for recovery paints a more realistic view for each individual patient case. The symptoms and impairments that may occur post-injury can be monitored …
Closeness-Inducing Discussions With A Romantic Partner Increase Cortisol And Testosterone,
2021
University of Michigan - Ann Arbor
Closeness-Inducing Discussions With A Romantic Partner Increase Cortisol And Testosterone, Kristi Chin, Zachary A. Reese, Esra Ascigil, Lester Sim, Robin S. Edelstein
Research Collection School of Social Sciences
Despite progress in understanding the social neuroendocrinology of close relationship processes, most work has focused on negative experiences, such as relationship conflict or stress. As a result, much less is known about the neuroendocrine implications of positive, emotionally intimate relationship experiences. In the current study, we randomly assigned 105 dating or married couples to a 30-minute semi-structured discussion task that was designed to elicit either high or low levels of closeness. Participants provided pre- and post-task saliva samples (to assess cortisol and testosterone) and post-task reports of self-disclosure, closeness, attraction, positive and negative affect, and stress. Participants found the discussion …
The Relationship Between Infant-Family Routines, Number Of Caregivers And Infant Basal Cortisol,
2021
UMSL
The Relationship Between Infant-Family Routines, Number Of Caregivers And Infant Basal Cortisol, Vanessa Newell, Hannah B. White
Undergraduate Research Symposium
Background: Family routines have been found to be related to child adjustment, marital satisfaction, and parenting competence (Fiese, 2002). Persistent stress, and the resulting frequent activation of the body’s stress responses, can result in excessive wear-and-tear on the body and brain known as allostatic load (McEwen, 2000). In infants, basal cortisol levels act as an instrument to measure allostatic load (White, 2020). To our knowledge, no existing work on the impact of routines on infant development has examined the role of family structure. In traditional and minority cultures it is common for caregiving responsibilities to be divided among multiple individuals. …
A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic,
2021
The Graduate Center, City University of New York
A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic, Al Amira Safa Shehab
Dissertations, Theses, and Capstone Projects
Deep breathing practices have shown promise in reducing stress, anxiety, and depression in different populations, including young adults. Specifically, resonant frequency breathing can exert an impact on stress response systems through the vagus nerve and the hypothalamo-pituitary-adrenal (HPA) axis. This may induce reductions in stress and improvement in emotion regulation. Young adults, including college students, tend to be at a higher risk for psychological distress, as they face several psychosocial challenges. The COVID-19 pandemic has imposed new and unique stressors that resulted in higher levels of stress and emotional symptoms and it has been shown that this may have placed …
Oxytocin Does Not Mediate Lithium Chloride (Licl)-Induced Non-Social Environmentally Conditioned Disgust Behaviour (Anticipatory Nausea) In Male Rats,
2021
Western University
Oxytocin Does Not Mediate Lithium Chloride (Licl)-Induced Non-Social Environmentally Conditioned Disgust Behaviour (Anticipatory Nausea) In Male Rats, Vangel Matic
Undergraduate Student Research Internships Conference
Introduction. Anticipatory Nausea (AN) is a form of classical conditioning in which the effects of a nausea-inducing substance, such as lithium chloride (LiCl), become associated with a social or environmental context. In rats, AN can be measured by the frequency of conditioned gaping behaviour, displayed when rats are re-exposed to a context previously associated with LiCl. Oxytocin (OT) may be involved in the mediation of socially conditioned disgust, though its role in mediating non-social environmentally conditioned disgust is unclear. The purpose of the present study was to investigate the role of OT in mediating environmentally conditioned disgust. It was hypothesized …
Is Pristine Inner Experience Linked To Biology? An Examination Of Experience Across The Menstrual Cycle Among Women With Premenstrual Distress,
2021
University of Nevada, Las Vegas
Is Pristine Inner Experience Linked To Biology? An Examination Of Experience Across The Menstrual Cycle Among Women With Premenstrual Distress, Alek E. Krumm
UNLV Theses, Dissertations, Professional Papers, and Capstones
The link between mind and biology is intuitively known: We notice changes in our mood and behavior when hungry, in pain, or under the influence of substances. Yet, the specifics of this link—for example, how changes in biology affect directly apprehended conscious experience— are not well known. The present study was an exploratory attempt toward filling that gap by using a state-of-the-art, beeper-driven method for exploring directly apprehended conscious experience (Descriptive Experience Sampling; DES) across one of the most predictable and wellknown biological cycles: menstruation. We screened approximately 300 college women to identify those who reported clinically significant symptoms of …
Effects Of A Novel, Non-Toxic Histone Deacetylase Inhibitor On Hippocampal Memory Formation, Histone Acetylation, And Bdnf Gene Expression In Male Mice,
2021
University of Wisconsin-Milwaukee
Effects Of A Novel, Non-Toxic Histone Deacetylase Inhibitor On Hippocampal Memory Formation, Histone Acetylation, And Bdnf Gene Expression In Male Mice, Sarah Brianna Beamish
Theses and Dissertations
Memory dysfunction is a common symptom of aging, neuropsychiatric disorders, and neurodegenerative disorders, yet truly effective treatments for memory loss do not exist. De novo gene transcription is a molecular requirement for long-term memory formation. The transcription of genes related to synaptic plasticity and learning are regulated in part by histone acetylation, an epigenetic mechanism that regulates chromatin accessibility. Pharmacological compounds that maintain histone acetylation, called histone deacetylase inhibitors (HDACi), enhance memory by preventing deacetylation of core histone proteins, which initiates binding of transcriptional machinery to open chromatin. Therefore, HDACi are potentially promising therapeutics that could be used to prevent …
Preclinical Behavioral Assessment Of Chronic, Intermittent Low-Dose Psilocybin In Rodent Models Of Depression And Anxiety,
2021
Western Michigan University
Preclinical Behavioral Assessment Of Chronic, Intermittent Low-Dose Psilocybin In Rodent Models Of Depression And Anxiety, Harmony I. Risca
Dissertations
Recent studies have demonstrated the clinical efficacy of psychedelic-assisted psychotherapy for treatment-resistant depression and anxiety. Amidst the overall success of recent clinical trials using a single high dose of psilocybin, anecdotal reports indicate anxiolytic and antidepressant effects following a repeated low dose regimen. As therapeutic outcomes are often tightly intertwined with the individual’s subjective experience, animal models are used as objective measures to investigate the underlying mechanisms responsible for the putative antidepressant/anxiolytic effects of psychedelics. Three rodent models predictive of anxiolytic or antidepressant effects were used to evaluate effects of chronic intermittent low dose (CILD) psilocybin treatment; the Light/Dark conflict …
Exploration Of Patient Variables And Characteristics Best Suited For Medical Marijuana Treatment For Anxiety And Depressive Disorders,
2021
National Louis University
Exploration Of Patient Variables And Characteristics Best Suited For Medical Marijuana Treatment For Anxiety And Depressive Disorders, Corey Gazoo
Dissertations
Individuals with posttraumatic stress, anxiety and depressive disorders are currently being prescribed medical marijuana as a treatment in many states across the United States. However, marijuana is still considered a schedule one narcotic by the Drug Enforcement Administration and federal government, which provides several barriers and challenges to conduct research such as approval from the U.S. Food and Drug Administration and following guidelines from the National Institute on Drug Abuse issued by the DEA. Additionally, individuals prescribed medical marijuana for mental health disorders are not always thoroughly instructed on the type of medical marijuana, the dosage, and how frequently to …
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice,
2021
CSUSAN BERNARDINO
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Electronic Theses, Projects, and Dissertations
Pharmacological activation of the 5-HT1B and 1A receptors has been implicated in OCD-like behaviors in rodents such as increased perseverative circling, checking behaviors, and locomotor stereotypy. However, little is understood about the effects of 5-HT1B and 1A receptor activation on behavioral inflexibility, a common symptom associated with OCD. The present study utilized the 5-HT1B/1A receptor agonist RU24969 at 0.01, 0.1, and 1.0 mg/kg to test three hypotheses. The first hypothesis predicted RU24969 would lead to a dose-dependent impairment on behavioral flexibility in C57BL/6J mice. It was also predicted that male C57BL/6J mice would be more inflexible than female C57BL/6J mice …
Medication Versus Brain-Based Treatment: Evaluation Treatment Preferences Of Parents Of Children With Adhd,
2021
Stephen F. Austin State University
Medication Versus Brain-Based Treatment: Evaluation Treatment Preferences Of Parents Of Children With Adhd, Rebecca Recio-Swift
Electronic Theses and Dissertations
Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders across the world. Currently, treatment for ADHD mostly consists of either medication or behavioral therapy or a combination of both. However, research has shown that medication used as therapy for the treatment of ADHD has side effects which parents deem undesirable for their children. Therefore, recent research has focused on patient and parent preferences. Studies have found that behavioral or other treatment options may often be chosen over medications. These same studies have documented the characteristics of parents that prefer certain treatments for their children. The purpose of this …
