Serotonin 1a Receptor Modulation On Behavioral Flexibility In Btbr And C57bl/6j Mice, Cassandra Cavazos

Electronic Theses, Projects, and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a subset of symptoms known as restricted repetitive behaviors (RRBs). RRBs are categorized into both lower order and higher order RRBs, where the latter can be described as behavioral inflexibility. The BTBR T+ tf/J (BTBR) mouse strain has been an extensively used animal model that demonstrate the behavioral symptoms of these individuals, including inflexible behavior. Currently, there are few effective treatments for individuals with ASD that express RRBs. Past research has investigated treatments that target serotonin due its historic involvement in ASD. 8-OH-DPAT (8-hydroxy-2-(di-n-propylamine) tetralin) is a research …

The Role Of 5-Ht6 Receptor Activation In Learning Consolidation, Jasmine Alyssa Robinson

Electronic Theses, Projects, and Dissertations

The focus on serotonergic dysfunction as a contributor to cognitive deficits in disorders such as autism spectrum disorder, Alzheimer's disease, and schizophrenia drives researchers to investigate the functional impact of specific serotonin receptor types on executive functioning. By discerning the potential enhancement or impairment effects, this endeavor seeks to unravel the complex interplay between serotonin receptors and cognitive abilities. Specifically, within the three domains of learning, acquisition, consolidation, and retrieval, we find serotonergic modulation to be pivotal. Recent studies have highlighted the 5-HT6 receptor as a novel target for cognitive enhancement. However, the majority of the research investigates the effects …

The Archeology Of Adoption: Tracing The Journey From Birth Through Adoption Using Pre-Adoptive Artifacts, Ellen Reeve

Educational Studies Dissertations

Adults adopted in childhood often face a heightened susceptibility to psychological and behavioral challenges compared with their non-adopted peers. Scholars examining this phenomenon associate various factors, including an adoptee’s sense of self as an individual within a complex adoption background. This qualitative study utilized a material engagement theory to explore birth through adoptive narratives among adults adopted in closed settings during childhood. Through participatory research, participants examined a range of artifacts related to maternal relinquishment, encompassing foster and adoption records, original birth certificates, letters, photographs, birthmarks, clothing, hair, scars, and DNA test results. The study focused on understanding these artifacts’ …

Grief Like Mine: A Literature Review Exploring Culturally Informed Grief Work For Black Youth Using Dance/Movement Therapy, Darrell Hyche

Expressive Therapies Capstone Theses

Black American youth are exposed to more death related circumstances than their peers yet are severely underrepresented in literature focused on the broader scope of children’s bereavement. More research and analysis are required to develop and implement culturally relevant interventions as they embark on their grief journey. Dance/movement therapy has the capacity for providing support that is culturally specific and able to meet the developmental levels of children, yet its grief focus work is limited. This literature review aims to bridge the gap between Black grief and dance/movement therapy as a culturally informed practice. An analysis of various forms of …

Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander

Student Theses and Dissertations

Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H₂O₂ (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …

Mate Guarding Against Strong Men Displaying Affiliative And Aggressive Humor, Jacob Pauley

Biological Sciences Undergraduate Honors Theses

Mate retention behaviors serve to discourage partner defection from a current pairbond. Such behaviors are oftentimes more prevalent toward intrasexual rivals exhibiting physical and behavioral cues implicating that rival as an optimal mate. Among these features in men are their upper body strength, a feature diagnostic of heritable fitness, and men's ability to produce humor, a cue to their social competence. This study considered the intersection of these desirable features in shaping men's mate retention behavior toward an intrasexual rival. After learning of a hypothetical interloper exhibiting high or low upper body strength while similarly using humor in an affiliative …

Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff

Electronic Theses, Projects, and Dissertations

Escitalopram (EST), a selective serotonin reuptake inhibitor (SSRI), is an antidepressant frequently used during pregnancy, yet there is limited knowledge of its long-term effects on maternal use. Past studies suggest that maternal exposure may adversely affect the fetus, which may be due to the hyperserotonergic environment caused by the nature of SSRIs during early development. Modifications of the serotonergic system in offspring during certain critical periods of development may result in long-term behavioral and cognitive changes in adulthood. Further, recent human studies have demonstrated that prenatal exposure to SSRIs in humans may increase susceptibility to autism spectrum disorder (ASD) and …

Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs

Psychological Science Undergraduate Honors Theses

Women overrepresent men for sub-optimal sleep, a consequence of hormone fluctuation in the menstrual cycle affecting sleep regulatory pathways. While research has examined the prevalence of sub-optimal sleep through cycle phases, little research has examined how hormonal contraceptives (HC’s) could similarly affect women’s sleep, while also neglecting to utilize subjective sleep measures. In this study, we examine subjective sleep quality among naturally cycling (NC) women, women using different HC types, and between active and inactive phase pill users by subjecting 463 women to a subjective sleep battery. We hypothesized that HC users would report more sub-optimal sleep than NC women. …

Examining The Effects Of Acute And Chronic Stress On The Interrogative Suggestibility Of Young Adults, Claudia Cota

Open Access Theses & Dissertations

High-stress situations, like police interrogations, can hinder an individual's decision-making and critical-thinking ability (Liston et al., 2009), making them more susceptible to suggestive or leading messages during questioning. While research on suggestibility mainly focuses on children and adolescents, young adults may also be vulnerable to suggestion because of their sensitivity to social feedback (Blakemore & Mills, 2014; Redlich & Goodman, 2003). Since the legal consequences of suggestibility for young adults are more severe than for children or adolescents, it is essential to examine the role of stress in young adults' suggestibility. The present study used objective and subjective methods to …

Exposure To The Trier Social Stress Test Enhances Central Detail Memory, Reduces False Memory, And Results In Intrusive Memories That Last For Days, Mercedes L. Stanek, Kayla Boaz, Taylor D. Niese, Kristen E. Long, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Boyd R. Rorabaugh, Phillip R. Zoladz

ONU Student Research Colloquium

Recent work has used a modified version of the well-known laboratory stressor, the Trier Social Stress Test (TSST), to study participant memory for a stressful experience. The paradigm is useful because, unlike most studies examining stress effects on memory, it allows investigators to measure what participants remember about the stressor, not unrelated information. It also presents an opportunity to model other stress-related symptoms, such as intrusive memories, but these have yet to be assessed with this paradigm. Intrusive memories have been notoriously difficult to measure in laboratory settings; most of this research involves participants watching arousing videos and subsequently reporting …

Gender, Graduate School Stage, And The Impostor Phenomenon, John-Scott B. Kelley, Angela T. Barlow

Journal of Graduate Education Research

The impostor phenomenon (IP) includes five central factors: (a) a sense of fraudulence or phoniness; (b) a fear of failure and discovery; (c) compensatory perfectionism (i.e., procrastination and/or over-preparation); (d) interpersonal anxiety; and (e) externalized success and/or discounted positive feedback. After the final stage, the process starts over with reinforced vigor, creating a self-reinforcing cycle in which success is associated with psychological suffering. IP was initially used to describe the reports of high-achieving women, but recent studies have shown that IP is experienced across genders. Additionally, while graduate school is an achievement-oriented environment with many characteristics that could promote IP, …

Neurobiology And Treatment Of Relationships, Harvey Joanning

University Faculty and Staff Publications

This paper presents a neurobiological theory of how intimate human relationships develop over the life span. It begins with an exploration of affective neuroscience, the study of emotions, and applies these concepts to the stages of relationship development. It goes on to explore the role of neurobiology in parenting, family life, divorce, and death of a spouse. Therapeutic interventions appropriate to each stage of relationship development are also explored. Every attempt is made to make this theory scientifically sound by basing the concepts described on published scientific research. “Hard science” has been differentiated from “clinical lore.” The reader is invited …

The Relationship Between Cognitive Impairment In Psychiatric Patients And Readmission Rate To An Inpatient Facility, Cherilyn Isis Schuff

Theses and Dissertations

The primary intention of this study was to further understand the impact of assessing cognitive impairment in psychiatric patients, as a mediating factor on readmission rates. Mild cognitive dysfunction impacts a patient’s functional outcomes (Bowie & Harvey, 2006; Davis et al., 2012; Marcantonio, et al., 2001). Little information exists to guide best practices in the treatment of adults with cognitive impairment who are hospitalized for acute conditions (Davis et al., 2012). A cognitive impairment may impact patient prognosis and ability to function outside of a setting focused on stabilization. Neuropsychological testing is a valuable tool in predicting a patient’s cognitive …

Effects Of Foster Children’S Epigenetics In Abusive Environments, Shamika Ellis, Theresa Moore

Undergraduate Research Symposium

Abstract: Effects of Foster Children’s Epigenetics in Abusive Environments

Shamika Ellis, Theresa A. Moore, Hannah B. White, PhD

This presentation will review the literature on the epigenetics of abused foster children, and the subsequent acute, delayed, and long-term physiological, cognitive, and behavioral effects. One study experimentally investigated the effects of sexual and physical abuse on 150 foster children from 8 to 19 years of age and found post-traumatic stress disorder (PTSD) was diagnosed in 64% of children who experienced sexual abuse and 42% of children who experienced physical abuse Further, of the foster children who had not experienced either form …

The Behavioral Origins Of Phylogenic Responses And Ontogenic Habits, W. David Stahlman, Kenneth J. Leising

Psychological Science

An examination of innate behavior and its possible origins suggests parallels with the formation of habitual behavior. Inflexible but adaptive responses-innate reflexive behavior, Pavlovian conditioned responses, and operant habits-may have evolved from variable behavior in phylogeny and ontogeny. This form of "plasticity-first" scientific narrative was unpopular post-Darwin but has recently gained credibility in evolutionary biology. The present article seeks to identify originating events and contingencies contributing to such inflexible but adaptive behavior at both phylogenic and ontogenic levels of selection. In ontogeny, the development of inflexible performance (i.e., habit) from variable operant behavior is reminiscent of the genetic accommodation of …

Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg

Psychology Division Scholarship

Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were employed for this purpose. Metods: An immunofluorescent multiplex platform and an aptamer-based method were used to evaluate 32 protein analytes from 153 individuals with moderate to severe major depressive disorder (MDD) and healthy controls (HCs). The study focused on determining the level of agreement between the two platforms and evaluating the ability of individual analytes and principal components (PCs) to differentiate between the MDD and HC groups. …

Stress-Induced Oxytocin Reactivity As A Predictor Of Daily Support Seeking After Stress, Cecile Sunahara

Psychology Theses and Dissertations

The current study examined whether stress-induced peripheral oxytocin (OT) was associated with support-seeking behaviors after stress in daily life. Healthy male and female participants (N=94) performed a standardized laboratory stressor, the Trier Social Stress Test (TSST), and then completed two weeks of daily assessments of support seeking after stress. In line with preregistered hypotheses, plasma OT reactivity to the TSST (indexed as the area under the curve with respect to increase; AUCi) was associated with more frequent support seeking behaviors following stress in daily life. Moreover, this association was stronger for individuals with higher levels of attachment anxiety, relative to …

Cognitive Functioning In Well-Controlled Asthma, Erin Walsh

West Chester University Doctoral Projects

Asthma is a common lung disease that impacts lung functioning through inflammatory based mechanisms. Past research suggests that decreased blood oxygenation due to asthma attacks may impair cognitive capabilities (Irani et al., 2017). Moreover, the observed differences in cognition between those with and without asthma may be associated with disease severity or asthma control respectively in asthma populations. The current study explored differences in cognitive functioning between college students with and without self-reported asthma. Sociodemographic data, self-reported asthma severity, and measures of asthma control were collected. The current study did not find significant differences in measures of cognitive efficiency between …

Nobody's Perfect: Examining The Relationship Between Parenting Traits And Perfectionism And The Impact Of Maladaptive Versus Adaptive Perfectionism On Cortisol Regulation After Receiving Criticism, Olivia G. Baron

MSU Graduate Theses

The trait of perfectionism has been related to both internalizing and externalizing psychopathology. Parenting traits, and attachment tendencies affect how children develop relationships and impact them into their adult lives. Parents have a large impact on their child’s personality traits, coping styles, and modeling reactions to outward criticism. Criticism, especially criticism delivered by parents, has been linked to perfectionism. Perfectionism often involves a self-critical component, though perfectionists have not been studied to examine stress responses (e.g. cortisol change) when receiving criticism. This study examined the relationships between parenting traits (positive and negative) and perfectionism (adaptive and maladaptive). Cortisol change scores …

Identifying Patterns For Neurological Disabilities By Integrating Discrete Wavelet Transform And Visualization, Soo Yeon Ji, Sampath Jayarathna, Anne M. Perrotti, Katrina Kardiasmenos, Dong Hyun Jeong

Computer Science Faculty Publications

Neurological disabilities cause diverse health and mental challenges, impacting quality of life and imposing financial burdens on both the individuals diagnosed with these conditions and their caregivers. Abnormal brain activity, stemming from malfunctions in the human nervous system, characterizes neurological disorders. Therefore, the early identification of these abnormalities is crucial for devising suitable treatments and interventions aimed at promoting and sustaining quality of life. Electroencephalogram (EEG), a non-invasive method for monitoring brain activity, is frequently employed to detect abnormal brain activity in neurological and mental disorders. This study introduces an approach that extends the understanding and identification of neurological disabilities …