Biological Psychology Commons^™

The Effects Of Cannabidiol (Cbd) On The Social, Cognitive, And Physical Facets Of Anxiety Sensitivity, Ezri Rathbun

Psychological Science Undergraduate Honors Theses

The current study investigated how repeated administration of 300mg of cannabidiol (CBD), when compared to a placebo, affects the social, cognitive, and physical facets of anxiety sensitivity (AS), a characteristic that reflects fear of the consequences of anxious arousal. Prior work suggests CBD may have anxiolytic effects that may be specific to the social aspects of anxiety. Thus, it was hypothesized that, that, relative to placebo, CBD would reduce self-reported AS-social concerns, but not AS-cognitive or AS-physical concerns, compared to baseline. Participants (N= 79; 52 women; M_age = 22.06) with elevated perceived stress were randomly assigned to 14 …

The Effect Of Facial Adiposity On Hypothetical Medical Treatments As A Function Of Disgust, Lindsey Duran

Biological Sciences Undergraduate Honors Theses

Perceivers are capable of estimating the health of individuals through cues to facial adiposity, with such inferences having accuracy in recognizing worse chronic health among those exhibiting greater adiposity. Nonetheless, these inferences could extend beyond health assessments into subsequent anti-fat prejudice based on perceptions of such individuals as pathogenically threatening. Although potentially functional in ancestral contexts, modern healthcare settings could render this functional stigmatization a liability that results in worse medical care toward those with higher adiposity. In this study, I tasked medical workers to evaluate male and female hypothetical patients at high and low levels of facial adiposity, particularly …

Prefrontal Engagement In Cognitive Flexibility Across Paradigms, Katarina Kalajzic

Honors Scholar Theses

Cognitive flexibility is an executive function that involves dynamically adapting behavior in the face of changing environmental circumstances to achieve a particular goal. Disrupted in numerous psychiatric disorders such as Alzheimer’s disease, schizophrenia, OCD, and depression, the neural correlates of cognitive flexibility are not well understood. However, the prefrontal cortex (PFC) is strongly implicated in executive function and attentional control processes. Thus, we sought to examine the neural circuitry involved in distinct cognitive flexibility tasks – the attentional set-shifting task and the probabilistic 2-armed bandit task. Through optogenetic suppression, we targeted pyramidal neurons of the rodent medial prefrontal cortex, an …

Serotonin 7 Receptor Modulation On Measures Of Working Memory And Anxiety, Antonio Gutierrez

Electronic Theses, Projects, and Dissertations

Serotonin (5-HT) function is critical in the regulation and homeostasis of several neural systems. Alterations in 5-HT levels can directly impact the presence of neuropsychiatric disorders such as schizophrenia. With a wide range of 5-HT receptors, the potential impact each of these modulators have on behavior is important to better understand. The 5-HT7 receptor is the most recently identified 5-HT receptor. 5-HT7 receptors can be found in the thalamus, hypothalamus, and several areas of the hippocampus. Modulation of these receptors impact circadian rhythms, hormonal regulation and memory function. Previous research has that 5-HT7 antagonist compounds lead to conflicting results, highlighting …

Investigating Fentanyl-Xylazine Interactions: Implications For Opioid-Induced Hyperalgesia And Affective Dysregulation In Rats, Alejandra R. Lujan

Electronic Theses, Projects, and Dissertations

The growing prevalence of fentanyl adulterated with xylazine presents a major public health concern, yet the behavioral and physiological effects of this combination remain poorly characterized. This study examined the effects of acute fentanyl administration, alone and in combination with xylazine, on opioid-induced hyperalgesia, affective behavior, and mortality in male and female Sprague-Dawley rats (n=80). Rats received four fentanyl injections (60 µg/kg) administered at 15-minute intervals, with or without xylazine (0, 0.1, 0.333, or 1.0 mg/kg), as well as a saline control condition. Pain sensitivity was assessed using a hot plate assay at 6.5, 12, 24, and 48 hours post-injection. …

Impact Of Escitalopram On Postpartum Sleep/Wake Activity And Maternal Behaviors, Kimberly Guerrero Leon

Electronic Theses, Projects, and Dissertations

The postpartum period is characterized by profound physiological and psychological changes, including disruptions in sleep and activity patterns, which may contribute to the onset of postpartum depression. If left untreated, postpartum depression can result in long-term consequences, including cognitive impairments, emotional dysregulation, impaired maternal-infant attachment, and the onset of sleep-related disorders. Selective serotonin reuptake inhibitor (SSRI), escitalopram, is prescribed for the treatment of postpartum depression due to its efficacy, favorable safety profile, and relatively low cost. While escitalopram is considered an effective treatment for depression and anxiety, far less is known about its impact on maternal behaviors during the postpartum …

Overwhelmed By Competing Priorities: Exploring Women’S Motivational Conflict Across The Menstrual Cycle, Arial S. Bloshinsky

Graduate Theses and Dissertations

This study examined whether the biological context of the menstrual cycle predicted overwhelming feelings due to competing bonding and achievement motivations (i.e., motivational conflict). Building on the motivational shift hypothesis, it was predicted that the luteal phase, characterized by elevated progesterone and heightened bonding motivation, would be associated with more overwhelming feelings from motivational conflict. To assess potential changes across the menstrual cycle, a within-person design was used where women reported their overwhelming feelings daily. Primary analyses did not support the hypothesis. Overwhelming feelings from motivational conflict did not differ across cycle phases. However, the expected mid-cycle peak in sexual …

Heart Rate Variability In The Context Of Mental Health And Substance Use, Sage M. Lopez

Bridges: An Undergraduate Journal of Contemporary Connections

Heart Rate Variability (HRV) has been linked to various areas of cardiovascular disease and mortality in previous research. Within this area, certain mental illnesses and use of psychoactive substances have been associated with low HRV and its health implications. Little research exists that examines the combined effects of mental illness and psychoactive substance use. The current research aims to understand if there is a compounding negative effect of these two factors when studied in tandem. Using a three-phase study design, HRV was analysed at baseline and at physiological relaxation, with participants being included under certain mental health, substance use, or …

A Single Administration Of Psilocybin Is Ineffective In Reversing Ptsd-Like Sequelae In A Rat Model Of Stress-Enhanced Fear Learning, Kylie M. King, Marisa J. Savini, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics produce rapid, long-lasting antidepressant effects. Psychedelics may also exert anxiolytic effects and be useful in treating more complex psychiatric conditions, such as PTSD. However, less is known about the impact of these agents on PTSD-related symptoms. Thus, we aimed to determine whether a single administration of psilocybin could reverse PTSD-like sequelae induced by stress-enhanced fear learning in rats. Sprague-Dawley rats were placed in Context A (circular, white conditioning box) and exposed to several uncontrollable footshocks (Stress) or no footshocks (No Stress). The next day, the rats were placed in Context B (square conditioning box with clear …

Psilocybin And The Related Tryptamine, Norbaeocystin, Exert Acute Anxiogenic Effects That Depend On Sex, Marisa J. Savini, Kylie M. King, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Andrew Jones, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics have demonstrated rapid, long-lasting antidepressant effects. However, psychedelics often produce unfavorable psychoactive effects that could worsen existing psychological distress. Thus, we compared the effects of psilocybin and the related tryptamine, norbaeocystin, on anxiety-like behavior in male and female rats. In Experiment 1, rats were treated with 1 mg/kg psilocybin (PSIL), 1 mg/kg norbaeocystin (NOR), or vehicle 30 min before a 5-min trial on an elevated plus maze (EPM) or in an open field test (OFT). On the EPM, PSIL led to decreased open arm time and fewer arm entries in males and females. NOR led to …

Impact Of Caffeine On Participant Memory For A Stressful Experience And The Development Of Intrusive Memories, Jaycee L. Kirkland, Kaylina R. Mcclenen, Natalina E. Porter, Sarah M. Wood, Julia Gross, Madilyn E. Paphanchith, Kelsey M. Siereveld, Jasmine Ic Ifeakanwa, Caeden M. Gurganus, Koen N. Suzelis, Aiden J. Farrell, Boyd R. Rorabaugh, Phillip R. Zoladz

ONU Student Research Colloquium

Most individuals consume caffeine on a daily basis. Research has shown that caffeine stimulates the release of glucocorticoids and catecholamines and can enhance cognition. Caffeine also amplifies stress-induced increases in arousal and aggravates PTSD-like symptoms. Thus, we examined the impact of caffeine on memory for a stressful experience and intrusive memories related to that experience. Undergraduate students ingested caffeine or a placebo. Thirty minutes later, they were exposed to the Trier Social Stress Test (TSST; stress condition) or friendly-TSST (f-TSST; control condition), both of which were designed to enable participant memory for the experiences to be quantified. In each condition, …

Drd2 Rs6276 Polymorphism And Trait Impulsivity In Individuals With Mixed Behavioral And Substance Addictions, Gabriela Zdunek, Remigiusz Recław, Aleksandra Suchanecka, Krzysztof Chmielowiec, Dariusz Larysz, Patryk Ilków, Kinga Łosińska, Jolanta Chmielowiec, Łukasz Jaworski, Anna Grzywacz

Baltic Journal of Health and Physical Activity

Background/Objectives: Impulsivity is a key transdiagnostic trait linked to dysregulated reward processing in both behavioral and substance-related addictions, as recognized in DSM-5. Dopaminergic genes, including DRD2, may modulate individual differences in impulsivity, particularly under conditions of increased addiction vulnerability. This study examined whether the DRD2 Exon 8 rs6276 polymorphism predicts impulsivity levels in men with mixed addictive behaviors compared with healthy controls. Methods: A total of 328 males (128 with mixed behavioral and substance addictions and 200 controls) were assessed. Diagnoses were confirmed using the MINI interview, and impulsivity was measured with the Barratt Impulsiveness Scale (BIS-11). Genotyping of …

Developing A Coding System To Record Orofacial Movements For Misophonia With Verification From Physiology Data, Rachel P. Sellers

Senior Theses

My thesis aims to develop and evaluate a facial coding system that can quantify facial movements in the context of misophonia. The system uses binary coding to individually quantify and identify each orofacial movement that occurs independent of other movements or artifacts that could interfere with coding data. The system can be used across multiple coders with statistically significant reliability into how orofacial movements are interpreted. The psychophysiological verification study used electromyography to examine the muscle potentiation of the corrugator supercilii and zygomaticus major muscles to map observable facial movement to underlying muscle potentiation. This facial coding system can be …

Emotional And Social Perception In Hearing And Deaf Individuals, Julie Klenotic

Williams Honors College, Honors Research Projects

This study will compare the differences in emotional recognition and social dynamic understanding between hearing and Deaf people. I will investigate the differences in these areas between hearing and Deaf individuals, as well as the role American Sign Language use has in performance. It will utilize point light walkers which will display the emotions happy, angry, sad, and neutral. Participants will be asked which emotion is being displayed based on the presented gait of the point light walker. Second, they will view 15 videos from the Interpersonal Perception Task without audio. The questions from the IPT 15 will then be …

Practical Considerations For Conducting Canine Behavioral Science, Lucrezia Lonardo, Madeline H. Pelgrim, Jeffrey R. Stevens

Jeffrey Stevens Publications

Research on behavior in domestic dogs (Canis familiaris) has increased rapidly recently due to the interest in them as pets, working dogs, and model species for understanding evolution, domestication, and even human health. This interest in canine behavioral science has resulted in the creation of dozens of dog lab worldwide, with more starting every year. Our aim here is to review practical issues that potential dog researchers might consider when deciding how to set up a dog lab and conduct research in canine behavioral science. We hope that this can offer a path forward in promoting high-quality, cutting-edge …

The Relationship Between Physical Activity, Sleep, And Hallucinations In Adults With Charles Bonnet Syndrome, Jarrod Hollis, Rohit Narayan, Eldre W. Beukes, Rosie Lindsay, Aliyah Bharwani, Umair Mughal, Ikra Yaqoob, Justin A. Haegele, Scott Muriden, Peter M. Allen

Human Movement Studies & Special Education Faculty Publications

Physical activity levels, hallucination experiences, sleep quality, and perceived stress were assessed using a survey administered to 57 adults with a confirmed diagnosis of Charles Bonnet Syndrome (CBS). Physical activity demonstrated a significant negative correlation with hallucination severity (r = –0.335, p = 0.011, two-tailed). A significant negative correlation was also observed between physical activity and perceived stress (r = –0.497, p < 0.001, two-tailed). In contrast, no significant association was identified between hallucination frequency and sleep disruption or insomnia. These findings suggest that engaging in appropriate levels of physical activity may help reduce the severity of hallucinations and mitigate stress among individuals with CBS. The observation that higher levels of physical activity are associated with reduced hallucination burden may help the development of evidence-based management strategies for CBS. Additionally, the finding that physical activity was significantly related to hallucination severity, whereas sleep disruption was not, merits deeper exploration in future research.

Eeg Signatures Of Motor Development In Early Childhood: A Systematic Review, Sonia Khurana, Ashwini Kulkarni, Thomas C. Bulea, Hunter J. Bennett

Rehabilitation Sciences Faculty Publications

Background

Early identification of motor developmental disorders is limited due to lack of objective neural markers that characterize typical neurodevelopmental patterns. This systematic review interprets and synthesizes existing evidence to propose a framework of EEG signatures associated with motor development in children aged 0-5 years, which may help inform future benchmarks for early assessment and intervention.

Methods

Following PRISMA guidelines, we searched published and gray literature across five databases between 2000 and 2025 (registered protocol). Included studies examined EEG during task-based, resting-state, or sleep studies linked to motor milestones, task performance, or standardized motor assessments. Study quality was assessed using …

A Child On Stand: The Impact Of Experiencing Trauma On Children’S Testimonial Efficacy In Legal Proceedings, Morgan Sweger

Williams Honors College, Honors Research Projects

Children who are victims of physical, sexual, emotional, or verbal abuse are nearly always left deeply traumatized by such events. In extreme cases, abused children may be asked to testify against their abuser(s) in legal proceedings, recounting their trauma in front of a room full of strangers. For some, the trauma of abuse may influence a child’s ability to effectively recall and describe their experiences and for others, the process of participating in legal proceedings creates deeper wounds. Research has aimed to understand whether children lack the ability to contribute sufficient testimonies during investigations of abuse and how these investigations …

Neurobiological Determinants Of Psychopathy And Their Ethical Implications In Capital Punishment Cases, Brooklyn Lewis

Williams Honors College, Honors Research Projects

This literature review examines the relationship between the neurobiological determinants of psychopathy and the ethical implications of applying capital punishment to violent offenders. Drawing on research from neuroscience, psychology, and criminal justice, the paper explores how structural and functional differences in brain regions associated with emotional processing, impulse control, and moral reasoning are linked to psychopathic traits. The review synthesizes findings on how these neurobiological factors may contribute to an increased risk of violent behavior while emphasizing that such influences are not deterministic. The paper further analyzes how neuroscientific evidence is interpreted within legal contexts, particularly in relation to assessments …

The Interplay Between Loneliness, Cortisol, And Nk Cell Function: The Role Of Cortisol In Nk Cell Dysfunction, Abhinav Saurabh, Yvonne Baumer, Laurel G. Mendelsohn, Elizabeth M. Aquino Peterson, Dana Sadler, Shirley J. Lopez De Leon, Ayushi Dave, Andrew S. Baez, Lola R. Ortiz-Whittingham, Mario A. Pita, Manuel A. Cintron, Hannatu A. Tarfa, Sandy T. Reynolds, Shelby R. Hicks, Sonal Sharda, J. Eleanor Seo, Maria Lopez-Ocasio, Pradeep K. Dagur, Skyler A. Kuhn, Neelam R. Redekar, James F. Troendle, Ayanna L. Wells, Marie Marah, Katherine J. Tolentino, Michael J. Corley, Alika K. Maunakea, Lynnette K. Nieman, Marcus R. Andrews, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Chronic psychosocial stressors contribute to cardiovascular disease (CVD) and related risk factors, particularly in under-resourced communities. Psychosocial stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to sustained cortisol action on immune cells. Natural killer (NK) cells are altered in distribution and function in cardio-metabolic diseases; however, pathways linking cortisol as a marker of chronic stress to NK cell dysfunction remain understudied. We recruited 186 African American women from the Step It Up Community-Engaged, Digital Health Physical Activity Intervention study and collected cortisol, NK cell measures, and psychosocial stress measures using validated questionnaires, including chronic stress and loneliness. Plasma cortisol levels were …