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In Utero Exposure To Endogenous Maternal Polyclonal Anti-Caspr2 Antibody Leads To Behavioral Abnormalities Resembling Autism Spectrum Disorder In Male Mice, C. Bagnall-Moreau, P. T. Huerta, D. Comoletti, A. La-Bella, R. Berlin, C. Zhao, B. T. Volpe, B. Diamond, L. Brimberg 2020 Zucker School of Medicine at Hofstra/Northwell

In Utero Exposure To Endogenous Maternal Polyclonal Anti-Caspr2 Antibody Leads To Behavioral Abnormalities Resembling Autism Spectrum Disorder In Male Mice, C. Bagnall-Moreau, P. T. Huerta, D. Comoletti, A. La-Bella, R. Berlin, C. Zhao, B. T. Volpe, B. Diamond, L. Brimberg

Journal Articles

© 2020, The Author(s). The concept that exposure in utero to maternal anti-brain antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for over a decade. We determined that antibodies targeting Caspr2 are present at high frequency in mothers with brain-reactive serology and a child with ASD, and further demonstrated that exposure in utero to a monoclonal anti-Caspr2 antibody, derived from a mother of an ASD child, led to an-ASD like phenotype in male offspring. Now we propose a new model to study the effects of in utero exposure to anti-Caspr2 antibody. Dams immunized with the ...


Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. VanPatten, Y. Al Abed 2020 Zucker School of Medicine at Hofstra/Northwell

Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Vanpatten, Y. Al Abed

Journal Articles

© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.


Steroid Resistance In Diamond Blackfan Anemia Associates With P57(Kip2) Dysregulation In Erythroid Progenitors, R. J. Ashley, H. Yan, N. Wang, J. Hale, B. M. Dulmovits, J. Papoin, M. E. Olive, A. Vlachos, J. M. Lipton, L. Blanc, +8 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

Steroid Resistance In Diamond Blackfan Anemia Associates With P57(Kip2) Dysregulation In Erythroid Progenitors, R. J. Ashley, H. Yan, N. Wang, J. Hale, B. M. Dulmovits, J. Papoin, M. E. Olive, A. Vlachos, J. M. Lipton, L. Blanc, +8 Additional Authors

Journal Articles

No abstract provided.


Creatinine Fluctuation In Patients With Lupus Nephritis: Considerations For Clinical Trial Endpoints, S. Almaani, U. Bhatt, C. Arriens, E. Bonfa, M. Dall'Era, F. Houssiau, K. Kalunian, M. Mackay, J. Sanchez-Guerrero, B. H. Rovin, +1 additional author 2020 Zucker School of Medicine at Hofstra/Northwell

Creatinine Fluctuation In Patients With Lupus Nephritis: Considerations For Clinical Trial Endpoints, S. Almaani, U. Bhatt, C. Arriens, E. Bonfa, M. Dall'era, F. Houssiau, K. Kalunian, M. Mackay, J. Sanchez-Guerrero, B. H. Rovin, +1 Additional Author

Journal Articles

No abstract provided.


Anodal Block Permits Directional Vagus Nerve Stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, S. Zanos 2020 Northwell Health

Anodal Block Permits Directional Vagus Nerve Stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, S. Zanos

Journal Articles

© 2020, The Author(s). Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of autonomic circuits. Selective activation of afferent or efferent vagal fibers can maximize efficacy and minimize off-target effects of VNS. Anodal block (ABL) has been used to achieve directional fiber activation in nerve stimulation. However, evidence for directional VNS with ABL has been scarce and inconsistent, and it is unknown whether ABL permits directional fiber activation with respect to functional effects of VNS. Through a series of vagotomies, we established physiological markers for ...


First-Time Characterization Of Viable But Non-Culturable Proteus Mirabilis: Induction And Resuscitation, Reham Wasfi, G. R. Abdellatif, H. M. Elshishtawy, Hossam M. Ashour 2020 University of South Florida St. Petersburg

First-Time Characterization Of Viable But Non-Culturable Proteus Mirabilis: Induction And Resuscitation, Reham Wasfi, G. R. Abdellatif, H. M. Elshishtawy, Hossam M. Ashour

Faculty Publications

Pathogenic bacteria can enter into a viable but non-culturable (VBNC) state under unfavourable conditions. Proteus mirabilis is responsible for dire clinical consequences including septicaemia, urinary tract infections and pneumonia, but is not a species previously known to enter VBNC state. We suggested that stress-induced P. mirabilis can enter a VBNC state in which it retains virulence. P. mirabilis isolates were incubated in extreme osmotic pressure, starvation, low temperature and low pH to induce a VBNC state. Resuscitation was induced by temperature upshift and inoculation in tryptone soy broth with Tween 20 and brain heart infusion broth. Cellular ultrastructure and gene ...


Examining The Role Of Metabolic Pathways As Therapeutic Modalities For Triple Negative Breast Cancer, Jeremy Andrew Johnson 2020 University of Kentucky

Examining The Role Of Metabolic Pathways As Therapeutic Modalities For Triple Negative Breast Cancer, Jeremy Andrew Johnson

Theses and Dissertations--Toxicology and Cancer Biology

Triple negative breast cancer (TNBC) comprises 15-20% of breast cancers, affects a younger patient population than other subtypes, and is very aggressive. TNBC is comprised of a diverse group of tumors that have proven refractory to targeted therapy and can be difficult to treat. Patients generally receive neoadjuvant chemotherapy (NAC), surgery, and radiotherapy. The standard of care for NAC includes a taxane, an anthracycline, and/or cyclophosphamide, and administration of NAC has resulted in pathological complete response (pCR) in 30-40% of patients. However, a majority of TNBC patients will not reach pCR and instead have residual disease (RD), which is ...


Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Van Patten, Y. Al Abed 2020 Zucker School of Medicine at Hofstra/Northwell

Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Van Patten, Y. Al Abed

Journal Articles

© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.


Peripheral Nervous System Disease In Systemic Lupus Erythematosus: Results From An International Inception Cohort Study, J. G. Hanly, Q. Li, L. Su, M. B. Urowitz, C. Gordon, S. C. Bae, J. Romero-Diaz, C. Aranow, M. Mackay, V. Farewell, +33 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

Peripheral Nervous System Disease In Systemic Lupus Erythematosus: Results From An International Inception Cohort Study, J. G. Hanly, Q. Li, L. Su, M. B. Urowitz, C. Gordon, S. C. Bae, J. Romero-Diaz, C. Aranow, M. Mackay, V. Farewell, +33 Additional Authors

Journal Articles

© 2019, American College of Rheumatology Objective: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. Results: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ...


Relative Ratios Enhance The Diagnostic Power Of Phospholipids In Distinguishing Benign And Cancerous Ovarian Masses, T. Yagi, C. E. Kuschner, M. Shoaib, R. C. Choudhary, L. B. Becker, A. T. Lee, J. Kim 2020 Northwell Health

Relative Ratios Enhance The Diagnostic Power Of Phospholipids In Distinguishing Benign And Cancerous Ovarian Masses, T. Yagi, C. E. Kuschner, M. Shoaib, R. C. Choudhary, L. B. Becker, A. T. Lee, J. Kim

Journal Articles

No abstract provided.


Potential T Cell-Intrinsic Regulatory Roles For Irf5 Via Cytokine Modulation In T Helper Subset Differentiation And Function, Z. Brune, M. R. Rice, B. J. Barnes 2020 Zucker School of Medicine at Hofstra/Northwell

Potential T Cell-Intrinsic Regulatory Roles For Irf5 Via Cytokine Modulation In T Helper Subset Differentiation And Function, Z. Brune, M. R. Rice, B. J. Barnes

Journal Articles

No abstract provided.


Modulating Cytokine Production Via Select Packaging And Secretion From Extracellular Vesicles, B. J. Barnes, C. C. Somerville 2020 Zucker School of Medicine at Hofstra/Northwell

Modulating Cytokine Production Via Select Packaging And Secretion From Extracellular Vesicles, B. J. Barnes, C. C. Somerville

Journal Articles

No abstract provided.


Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. d'Abramo 2020 Zucker School of Medicine at Hofstra/Northwell

Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. D'Abramo

Journal Articles

No abstract provided.


Expression And Function Of Cathelicidin Hcap18/Ll-37 In Chronic Lymphocytic Leukemia., E. Podaza, F. Palacios, D. O. Croci, D. Risnik, X. J. Yan, M. B. Almejún, A. Colado, E. E. Elías, N. Chiorazzi, M. Giordano, +6 additional authors 2020 Northwell Health

Expression And Function Of Cathelicidin Hcap18/Ll-37 In Chronic Lymphocytic Leukemia., E. Podaza, F. Palacios, D. O. Croci, D. Risnik, X. J. Yan, M. B. Almejún, A. Colado, E. E. Elías, N. Chiorazzi, M. Giordano, +6 Additional Authors

Journal Articles

No abstract provided.


Allele-Specific Expression Changes Dynamically During T Cell Activation In Hla And Other Autoimmune Loci, M. Gutierrez-Arcelus, Y. Baglaenko, J. Arora, S. Hannes, Y. Luo, T. Amariuta, N. Teslovich, D. A. Rao, P. K. Gregersen, S. Raychaudhuri, +8 additional authors 2020 Zucker School of Medicine at Hofstra/Northwell

Allele-Specific Expression Changes Dynamically During T Cell Activation In Hla And Other Autoimmune Loci, M. Gutierrez-Arcelus, Y. Baglaenko, J. Arora, S. Hannes, Y. Luo, T. Amariuta, N. Teslovich, D. A. Rao, P. K. Gregersen, S. Raychaudhuri, +8 Additional Authors

Journal Articles

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+ T cell regulatory elements1–3. Understanding how genetic variation affects gene expression in different T cell physiological states is essential for deciphering genetic mechanisms of autoimmunity4,5. Here, we characterized the dynamics of genetic regulatory effects at eight time points during memory CD4+ T cell activation with high-depth RNA-seq in healthy individuals. We discovered widespread, dynamic allele-specific expression across the genome, where the balance of alleles changes over time. These genes were enriched fourfold within ...


Correcting Smad1/5/8, Mtor, And Vegfr2 Treats Pathology In Hereditary Hemorrhagic Telangiectasia Models, S. Ruiz, H. Zhao, P. Chandakkar, J. Papoin, P. K. Chatterjee, Y. Al-Abed, P. Wang, C. N. Metz, L. Blanc, P. Marambaud, +8 additional authors 2020 Northwell Health

Correcting Smad1/5/8, Mtor, And Vegfr2 Treats Pathology In Hereditary Hemorrhagic Telangiectasia Models, S. Ruiz, H. Zhao, P. Chandakkar, J. Papoin, P. K. Chatterjee, Y. Al-Abed, P. Wang, C. N. Metz, L. Blanc, P. Marambaud, +8 Additional Authors

Journal Articles

No abstract provided.


Expression Of Concern: Redox Modification Of Cysteine Residues Regulates The Cytokine Activity Of High Mobility Group Box-1 (Hmgb1) (Molecular Medicine (2012) 18 (250-259) Doi: 10.2119/Molmed.2011.00389), H. Yang, P. Lundbäck, L. Ottosson, H. Erlandsson-Harris, E. Venereau, M. E. Bianchi, Y. Al-Abed, U. Andersson, K. J. Tracey, D. J. Antoine 2020 Zucker School of Medicine at Hofstra/Northwell

Expression Of Concern: Redox Modification Of Cysteine Residues Regulates The Cytokine Activity Of High Mobility Group Box-1 (Hmgb1) (Molecular Medicine (2012) 18 (250-259) Doi: 10.2119/Molmed.2011.00389), H. Yang, P. Lundbäck, L. Ottosson, H. Erlandsson-Harris, E. Venereau, M. E. Bianchi, Y. Al-Abed, U. Andersson, K. J. Tracey, D. J. Antoine

Journal Articles

© The Author(s). 2020. The Editors-in-Chief would like to alert readers that this article (Yang et al. 2012) is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Liverpool with respect to the quantitative mass spectrometrygenerated results regarding acetylated and redox-modified HMGB1. Appropriate editorial action will be taken once the investigation is concluded. Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, and Kevin J. Tracey agree to this editorial expression of concern. Daniel J. Antoine has not responded to any ...


Aid Overlapping And Polη Hotspots Are Key Features Of Evolutionary Variation Within The Human Antibody Heavy Chain (Ighv) Genes, C. Tang, D. Bagnara, N. Chiorazzi, M. D. Scharff, T. MacCarthy 2020 Zucker School of Medicine at Hofstra/Northwell

Aid Overlapping And Polη Hotspots Are Key Features Of Evolutionary Variation Within The Human Antibody Heavy Chain (Ighv) Genes, C. Tang, D. Bagnara, N. Chiorazzi, M. D. Scharff, T. Maccarthy

Journal Articles

© Copyright © 2020 Tang, Bagnara, Chiorazzi, Scharff and MacCarthy. Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context of WRC/GYW (W = A/T, R = A/G, Y = C/T) and particularly at WGCW overlapping hotspots where hotspots appear opposite each other on both strands. Subsequent recruitment of the low-fidelity DNA repair enzyme, Polymerase eta (Polη), during mismatch repair, creates additional mutations at WA/TW sites. Although there ...


Celebrating 20 Years Of Ighv Mutation Analysis In Cll., N. Chiorazzi, F. K. Stevenson 2020 Zucker School of Medicine at Hofstra/Northwell

Celebrating 20 Years Of Ighv Mutation Analysis In Cll., N. Chiorazzi, F. K. Stevenson

Journal Articles

The division of CLL into 2 broad subsets with highly significant differences in clinical behavior was reported in 2 landmark papers in Blood in 1999.1,2 The simple analysis of the mutational status of the IGV regions provided both a prognostic indicator and an insight into the cellular origins. Derivation from B cells with very low or no IGV mutations generally leads to a more aggressive disease course than derivation from B cells with higher levels. This finding focused attention on surface Ig (sIg), the major B-cell receptor, and revealed dynamic antigen engagement in vivo as a tumor driver ...


Advanced Neuroimaging In Neuropsychiatric Systemic Lupus Erythematosus, M. Mackay, C. C. Tang, A. Vo 2020 Zucker School of Medicine at Hofstra/Northwell

Advanced Neuroimaging In Neuropsychiatric Systemic Lupus Erythematosus, M. Mackay, C. C. Tang, A. Vo

Journal Articles

PURPOSE OF REVIEW: Neuropsychiatric lupus (NPSLE) comprises a disparate collection of syndromes affecting the central and peripheral nervous systems. Progress in the attribution of neuropsychiatric syndromes to SLE-related mechanisms and development of targeted treatment strategies has been impeded by a lack of objective imaging biomarkers that reflect specific neuropsychiatric syndromes and/or pathologic mechanisms. The present review addresses recent publications of neuroimaging techniques in NPSLE. RECENT FINDINGS: Imaging studies grouping all NPSLE syndromes together are unable to differentiate between NPSLE and non-NPSLE. In contrast, diffusion tensor imaging, FDG-PET, resting, and functional MRI techniques in patients with stable non-NPSLE demonstrate abnormal ...


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