A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease,
2020
Zucker School of Medicine at Hofstra/Northwell
A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease, D. González-Serna, E. Ochoa, E. López-Isac, A. Julià, F. Degenhardt, N. Ortego-Centeno, T. R. Radstake, P. K. Gregersen, A. T. Lee, A. Gabrielli, +78 Additional Authors
Journal Articles
© 2020, The Author(s). Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases …
Neutrophil Extracellular Traps In Covid-19.,
2020
Northwell Health
Neutrophil Extracellular Traps In Covid-19., Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo, Ja Madison, C Blair, A Weber, Bj Barnes, M Egeblad, Rj Woods, Y Kanthi, Js Knight
Journal Articles
No abstract provided.
Sars-Cov-2 And Interferon Blockade,
2020
Zucker School of Medicine at Hofstra/Northwell
Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Van Patten, Y. Al Abed
Journal Articles
© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
Systemic Inflammation In Traumatic Spinal Cord Injury,
2020
Zucker School of Medicine at Hofstra/Northwell
Systemic Inflammation In Traumatic Spinal Cord Injury, O. Bloom, P. E. Herman, A. M. Spungen
Journal Articles
No abstract provided.
A Pilot Study Testing A Novel 3d Printed Amphibious Lower Limb Prosthesis In A Recreational Pool Setting,
2020
Zucker School of Medicine at Hofstra/Northwell
A Pilot Study Testing A Novel 3d Printed Amphibious Lower Limb Prosthesis In A Recreational Pool Setting, T. Goldstein, A. Oreste, G. Hutnick, A. Chory, V. Chehata, J. Seldin, M. D. Gallo, O. Bloom
Journal Articles
No abstract provided.
Relative Ratios Enhance The Diagnostic Power Of Phospholipids In Distinguishing Benign And Cancerous Ovarian Masses,
2020
Northwell Health
Relative Ratios Enhance The Diagnostic Power Of Phospholipids In Distinguishing Benign And Cancerous Ovarian Masses, T. Yagi, C. E. Kuschner, M. Shoaib, R. C. Choudhary, L. B. Becker, A. T. Lee, J. Kim
Journal Articles
No abstract provided.
Predictive Value Of 18F-Florbetapir And 18F-Fdg Pet For Conversion From Mild Cognitive Impairment To Alzheimer Dementia,
2020
Northwell Health
Predictive Value Of 18F-Florbetapir And 18F-Fdg Pet For Conversion From Mild Cognitive Impairment To Alzheimer Dementia, G. Blazhenets, Y. Ma, A. Sörensen, F. Schiller, G. Rücker, D. Eidelberg, L. Frings, P. T. Meyer
Journal Articles
© 2020 by the Society of Nuclear Medicine and Molecular Imaging. The present study examined the predictive values of amyloid PET, 18F-FDG PET, and nonimaging predictors (alone and in combination) for development of Alzheimer dementia (AD) in a large population of patients with mild cognitive impairment (MCI). Methods: The study included 319 patients with MCI from the Alzheimer Disease Neuroimaging Initiative database. In a derivation dataset (n = 159), the following Cox proportional-hazards models were constructed, each adjusted for age and sex: amyloid PET using 18F-florbetapir (pattern expression score of an amyloid-β AD conversion-related pattern, constructed by principle-components analysis); 18F-FDG …
Hmgb1 In Systemic Lupus Erythematosus,
2020
Zucker School of Medicine at Hofstra/Northwell
Hmgb1 In Systemic Lupus Erythematosus, T. Liu, M. Son, B. Diamond
Journal Articles
No abstract provided.
Potential T Cell-Intrinsic Regulatory Roles For Irf5 Via Cytokine Modulation In T Helper Subset Differentiation And Function,
2020
Zucker School of Medicine at Hofstra/Northwell
Potential T Cell-Intrinsic Regulatory Roles For Irf5 Via Cytokine Modulation In T Helper Subset Differentiation And Function, Z. Brune, M. R. Rice, B. J. Barnes
Journal Articles
No abstract provided.
Modulating Cytokine Production Via Select Packaging And Secretion From Extracellular Vesicles,
2020
Zucker School of Medicine at Hofstra/Northwell
Modulating Cytokine Production Via Select Packaging And Secretion From Extracellular Vesicles, B. J. Barnes, C. C. Somerville
Journal Articles
No abstract provided.
Reproducible Metabolic Topographies Associated With Multiple System Atrophy: Network And Regional Analyses In Chinese And American Patient Cohorts,
2020
Northwell Health
Reproducible Metabolic Topographies Associated With Multiple System Atrophy: Network And Regional Analyses In Chinese And American Patient Cohorts, B. Shen, S. Wei, J. Ge, S. Peng, F. Liu, L. Li, S. Guo, P. Wu, D. Eidelberg, Y. Ma, +2 Additional Authors
Journal Articles
© 2020 The Authors Purpose: Multiple system atrophy (MSA) is an atypical parkinsonian syndrome and often difficult to discriminate clinically from progressive supranuclear palsy (PSP) and Parkinson's disease (PD) in early stages. Although a characteristic metabolic brain network has been reported for MSA, it is unknown whether this network can provide a clinically useful biomarker in different centers. This study was aimed to identify and cross-validate MSA-related brain network and assess its ability for differential diagnosis and clinical correlations in Chinese and American patient cohorts. Methods: We included 18F-FDG PET scans retrospectively from 128 clinically diagnosed parkinsonian patients (34 MSA, …
Nono Is A Novel Co-Factor Of Prdm1 And Regulates Inflammatory Response In Monocyte Derived-Dendritic Cells,
2020
Northwell Health
Nono Is A Novel Co-Factor Of Prdm1 And Regulates Inflammatory Response In Monocyte Derived-Dendritic Cells, K. Lee, S. H. Jang, H. Tian, S. J. Kim
Journal Articles
© Copyright © 2020 Lee, Jang, Tian and Kim. Proper expression of the transcription factor, Positive regulatory domain 1 (PRDM1), is required for maintaining homeostasis of human monocyte derived-dendritic cells (MO-DCs). The molecular mechanisms and gene targets of PRDM1 in B and T lymphocytes have been identified. However, the function of PRDM1 in dendritic cells (DCs) remains unclear. We investigate co-regulators of PRDM1 in MO-DCs identified by mass spectrometry (MS) and co-immunoprecipitation (Co-IP). Notably, non-POU domain-containing octamer-binding protein (NonO) was found to be a PRDM1 binding protein in the nucleus of MO-DCs. NonO is recruited to the PRDM1 binding site …
Ultrasound Powered Piezoelectric Neurostimulation Devices: A Commentary.,
2020
Zucker School of Medicine at Hofstra/Northwell
Ultrasound Powered Piezoelectric Neurostimulation Devices: A Commentary., T. Sun, J. Wright, T. Datta-Chaudhuri
Journal Articles
Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piezoelectric neural stimulators work by converting ultrasound energy to electrical charge for neural stimulation. In addition to the benefits of wireless powering and miniaturization leading to less traumatic surgery, piezoelectric neural stimulators can also exhibit prolonged operational lifetimes for a long-term stable neural interface, and show promise for clinical translation. As one of first steps to demonstrate the value of ultrasound-powered piezoelectric neural interface, Li et al. developed a piezoelectric stimulator to …
In Utero Exposure To Endogenous Maternal Polyclonal Anti-Caspr2 Antibody Leads To Behavioral Abnormalities Resembling Autism Spectrum Disorder In Male Mice,
2020
Zucker School of Medicine at Hofstra/Northwell
In Utero Exposure To Endogenous Maternal Polyclonal Anti-Caspr2 Antibody Leads To Behavioral Abnormalities Resembling Autism Spectrum Disorder In Male Mice, C. Bagnall-Moreau, P. T. Huerta, D. Comoletti, A. La-Bella, R. Berlin, C. Zhao, B. T. Volpe, B. Diamond, L. Brimberg
Journal Articles
© 2020, The Author(s). The concept that exposure in utero to maternal anti-brain antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for over a decade. We determined that antibodies targeting Caspr2 are present at high frequency in mothers with brain-reactive serology and a child with ASD, and further demonstrated that exposure in utero to a monoclonal anti-Caspr2 antibody, derived from a mother of an ASD child, led to an-ASD like phenotype in male offspring. Now we propose a new model to study the effects of in utero exposure to anti-Caspr2 antibody. Dams immunized with the …
Prognostic Molecular Signatures For Metastatic Potential In Clinically Low-Risk Stage I And Ii Clear Cell Renal Cell Carcinomas,
2020
Northwell Health
Prognostic Molecular Signatures For Metastatic Potential In Clinically Low-Risk Stage I And Ii Clear Cell Renal Cell Carcinomas, A. J. Shih, N. Murphy, Z. Kozel, O. Yaskiv, A. Liew, L. Kavoussi, S. Hall, M. Vira, X. Zhu, A. T. Lee, +2 Additional Authors
Journal Articles
No abstract provided.
Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models,
2020
Zucker School of Medicine at Hofstra/Northwell
Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. D'Abramo
Journal Articles
No abstract provided.
Expression And Function Of Cathelicidin Hcap18/Ll-37 In Chronic Lymphocytic Leukemia.,
2020
Northwell Health
Expression And Function Of Cathelicidin Hcap18/Ll-37 In Chronic Lymphocytic Leukemia., E. Podaza, F. Palacios, D. O. Croci, D. Risnik, X. J. Yan, M. B. Almejún, A. Colado, E. E. Elías, N. Chiorazzi, M. Giordano, +6 Additional Authors
Journal Articles
No abstract provided.
Sars-Cov-2 And Interferon Blockade,
2020
Zucker School of Medicine at Hofstra/Northwell
Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Vanpatten, Y. Al Abed
Journal Articles
© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
Editorial: The Role Of Hmgb1 In Immunity,
2020
Zucker School of Medicine at Hofstra/Northwell
Editorial: The Role Of Hmgb1 In Immunity, M. Son, B. Diamond, J. Shin
Journal Articles
No abstract provided.
Machine Learning Prediction Of Glioblastoma Patient One-Year Survival,
2020
Illinois Mathematics and Science Academy
Machine Learning Prediction Of Glioblastoma Patient One-Year Survival, Andrew Du '20, Warren Mcgee, Jane Y. Wu
Student Publications & Research
Glioblastoma (GBM) is a grade IV astrocytoma formed primarily from cancerous astrocytes and sustained by intense angiogenesis. GBM often causes non-specific symptoms, creating difficulty for diagnosis. This study aimed to utilize machine learning techniques to provide an accurate one-year survival prognosis for GBM patients using clinical and genomic data from the Chinese Glioma Genome Atlas. Logistic regression (LR), support vector machines (SVM), random forest (RF), and ensemble models were used to identify and select predictors for GBM survival and to classify patients into those with an overall survival (OS) of less than one year and one year or greater. With …
