Virus Diseases Commons^™

Pancytopenia, A Rare Case Associated With Influenza A, Aida Sarita Gonzalez, Ajith Vivek, Gabriela Salazar, Joseph Maslak

West Florida Division GME Research Day 2025

No abstract provided.

First Reported Case Of Upadacitinib-Induced Cmv Viremia And Pneumonitis In Ulcerative Colitis, Wilfredo Jhoel Javier-Rojas, Alvin Boyd Newman-Caro, Mamoon Guellai, Vamsee Mupparaju, Sreekanth Chandrupatla, Yizhi Lin, Ivan Rascon-Aguilar

West Florida Division GME Research Day 2025

No abstract provided.

Limiting H1n1 Replication Via The Dsrnai Pathway Using Sequence-Specific Ldsrna, Shawn Marie Sharon Carr, Stephanie Dewitte-Orr

Theses and Dissertations (Comprehensive)

The seasonal influenza virus causes a common respiratory illness that can be life threatening to the immunocompromised, the very young, and the elderly. The current strategies for avoiding a serious influenza virus infection are good hygiene practices and the annual influenza vaccine. Unfortunately, last year’s influenza virus vaccine effectiveness ranged between 32-60% for children and adolescents and 46-54% for adults. These low efficacy rates are due to the vaccine often targeting hemagglutinin, a highly variable surface protein. This thesis seeks to create a prophylactic treatment via the RNA interference (RNAi) response that targets the virus’s conserved genes that are integral …

The Role Of Sptbn1 Protein In Microglia Cells Actin Structure And Hiv-1 Infection, Rachel Pecka

Graduate Theses/Dissertations

Human immunodeficiency virus (HIV) directly attacks the host immune system by infecting and replicating in CD4-presenting immune cells. Like most viral pathogens, HIV utilizes cellular machinery to assist in viral entry, transport, and export. One of the components HIV is known to utilize for replication is the actin cytoskeleton. By directly binding to actin or actin-binding proteins, HIV can manipulate structural dynamics within the cell. The way HIV hijacks actin for replication post-viral fusion isn’t fully understood, especially during viral transport to the nucleus. A 2013 study conducted by Dai et al. found that lowering the expression of the cellular …

The Role Of Host Factor Sptbn1 In Hiv-1 Capsid Uncoating In Human Microglial Cells, Callie Marie Fry

Graduate Theses/Dissertations

HIV-1 is the virus that causes acquired immunodeficiency syndrome (AIDS), and currently, there is no cure once an individual is infected. The development of new drugs targeting HIV-1 replication steps is essential for keeping viral loads low or undetectable to prevent further transmission. An attractive replication step for new drug targets is viral capsid uncoating, where the virus loses the protein structure encapsulating the genome. The exact mechanism of capsid uncoating is unknown; however, several host-factors may be involved including protein SPTBN1. Recent studies have shown a significant decrease in viral infectivity when SPTBN1 is knocked down, yet its role …

Asymmetric Synthesis Of The Hiv Protease Inhibitor Tmc-126 And An Anti-Malarial Agent Via A Titanium Tetrachloride Mediated Asymmetric Glycolate Aldol Addition Reaction. Redefining The Curtius Rearrangement Reaction Via Dehomologation Of Carboxylic Acids Bearing Alpha-Leaving Groups, Kweku Amaning Affram

Theses and Dissertations

Acquired Immune Deficiency Syndrome (AIDS) and malaria are two devastating infectious diseases caused by HIV and Plasmodium parasites. AIDS is caused by HIV-1 and HIV-2, transmitted through sexual contact, blood transfusions, needle sharing, and perinatal routes. Malaria, caused by plasmodium parasites through mosquito bites. Today, millions of people around the world have been infected with HIV and malaria and much research has been done to treat it. However, despite advancements in therapeutic options, these diseases remain a significant global health threat, particularly in developing countries due to the emergence of drug-resistant strains for both HIV and malaria complicating eradication efforts. …

Immunoglobulin G N-Glycome As A Biomarker Of Mortality Risk In Escherichia Coli Induced Sepsis, Huachen Wang, Houqiang Li, Zheng Guo, Hongda Hou, Haifeng Hou, Bing Chen

Research outputs 2022 to 2026

Background: Sepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis. The role of immunoglobulin G N-glycome in estimating the mortality in patients with sepsis remains unknown. This study aims to reveal the clinical application of immunoglobulin G N-glycome as a potentially novel biomarker to predict mortality risk in Escherichia coli-induced sepsis. Methods: The serum immunoglobulin G N-glycome levels in 100 adult septic patient serum samples on the day of intensive care unit (ICU) admission, and 100 …

Molluscum Dermatitis In A Pediatric Patient, Garrett Furth, Olivia Mayer, Marshall Hall, Henry Lim, Christian Scheufele, Michael Carletti, Stephen Weis

North Texas Research Forum 2025

Atopic dermatitis (AD) is a chronic relapsing condition characterized by irritation, redness, inflammation, and itching of the skin. The cause of AD is theorized to be multifactorial, including genetic components, such as mutations in filaggrin, environmental exposures, and immune predisposition. AD often presents in childhood and adolescence, but can appear at any age. AD eruptions arise through various triggers, which commonly include soaps, detergents, fabrics, and cold or hot weather. Importantly, viral infections can also serve as a trigger, causing systemic inflammation via host defense mechanisms. Molluscum contagiosum (MC) is a double-stranded DNA virus that classically manifests as small, dome-shaped, …

Zika Virus Modulates Arthropod Histone Methylation For Its Survival In Mosquito Cells, Telvin Harrell

Biological Sciences Faculty Publications

Zika virus (ZIKV) is a mosquito-borne human pathogen that causes mild febrile illness in adults and severe neurological complications and microcephaly in newborns. Studies have reported that ZIKV modulates methylation of human and viral RNA critical for its replication in vertebrate cells. In this study, we show that ZIKV modulates mosquito S-adenosyl methionine (SAMe)-synthase, an enzyme involved in the production of SAMe (methyl donor), and histone methylation for its survival in mosquito cells. Reverse transcription quantitative PCR followed by immunoblotting analysis showed increased amounts of SAMe synthase at both RNA and protein levels, respectively, in C6/36 mosquito cells infected with …

Atypical Pityriasis Rosea – A Case Report, Benjamin H. Bridges, Madeline Pham, Meghan Rosenquist

South Atlantic Division GME Research Day 2025

No abstract provided.

The Critical Role Of Early Diagnosis, Multidisciplinary Management, And Social Determinants In Eczema Herpeticum: A Case Study Of A 24-Year-Old Man, Benjamin R. Cooper, Taha Rasul, Christian Castro-Ruiz, Karthik Krishnamurthy

South Atlantic Division GME Research Day 2025

No abstract provided.

Concomitant Diagnoses Of Lymphoma And Pml In An Hiv-Positive Patient, Madelaine Duarte, Delon Altherr, Mohamed Faris

South Atlantic Division GME Research Day 2025

No abstract provided.

Viral Vengeance: A Case Of Hiv Induced Myocarditis, Jacob Keesee, Brenden Pearce, Mohammed Faris

South Atlantic Division GME Research Day 2025

No abstract provided.

Association Of Non-Communicable Diseases With Severe Covid-19 Among People Living With And Without Diagnosed Hiv/Aids In New York State, Ravi Kumar Balu

Electronic Theses & Dissertations (2024 - present)

Background: People living with diagnosed HIV (PLWDH) have a higher chance of co-infections and co-morbidities than the general population. When SARS-CoV-2 was first reported in China in December 2019 and later declared a pandemic, it was speculated that PLWDH might be more prone to SARS-CoV-2 infection and severe disease outcomes given their increased vulnerability to other respiratory infections like influenza, pneumococcal pneumonia and tuberculosis. However, several facets of COVID-19 disease in PLWDH are incompletely understood, including whether non-communicable diseases (NCDs) are strong risk factors for severe disease outcomes and death as they are in the general population.

Methods: The data …

A Review On Wolbachia- A Viable Alternative To Control Aedes-Born Arboviral Diseases, Fatima Khizar, Iqra Mushtaq, Hafsa Masud, Muhammad Sajjad Sarwar

Journal of Bioresource Management

The endemic geographic ranges of mosquitoes are expanding due to various anthropogenic activities including rapid international travel and trade, urbanization, deforestation, and global warming. Hence, Aedes-borne arboviral diseases like dengue, chikungunya, yellow fever, or Zika infections would cause severe future outbreaks in non-endemic regions of the world. This threat to global public health highlights an urgent need for the development of efficient and effective mosquito control strategies. To date, a large number of mosquito vector-control strategies have been developed. Each of them has its strengths and weaknesses but the use of intracellular, endosymbiotic reproductive parasitic bacteria named Wolbachia pipientis …

Acute Myocarditis Secondary To Human Metapneumovirus: A Case Series And Mini-Review, Hussam Al Hennawi, Aamna Khan, Alexander Shpilman, Jennifer A. Mazzoni

Abington Jefferson Health Papers

Among viral myocarditis, human metapneumovirus (hMPV) is a rare causative agent with associated cardiac complications. This report provides insight into the disease progression and sheds light on reported cases from the literature. We present the clinical courses of two patients, aged 68 and 58, who developed myocarditis secondary to hMPV infection. Despite the typical severity associated with viral myocarditis in older populations, both patients experienced significant improvement in their condition and ultimately survived. This report highlights the necessity of recognizing hMPV as a potential cause of myocarditis, particularly in older adults presenting with simultaneous respiratory and cardiac symptoms. The recovery …

Fda Greenlights Early-Stage Trial For Investigational Long Covid Treatment: Phase Ii Evaluation Pending, Arin Wade, Maria Nguyen, Allie Honigford, Kennedy Kosikowski, Minhwan Yang, Rebecca Willier, Joshua Honaker, Samantha Mccord, Theresa Hempleman

Pharmacy and Wellness Review

Long coronavirus disease (COVID) is a condition that affects millions of individuals worldwide. Long COVID manifests as persistent symptoms following acute COVID-19. These symptoms can include, but are not limited to, fatigue, cognitive dysfunction, and chronic inflammation often lasting for months and significantly impairing patients' quality of life. As the number of Long COVID cases continues to rise and major global health organizations begin to standardize Long COVID’s mechanisms and diagnosis, there is an increasing demand for effective treatments that can address its complex nature. While some therapies, such as metformin and hyperbaric oxygen therapy (HBOT) have shown promise in …

Analysis Of Public Opinion Polls About Covid-19 Vaccines: Theoretical And Policy Implications For Vaccine Communication And Campaigns To Address Vaccine Hesitancy, Muhammad Ittefaq, Hong Tien Vu, Ali Zain, Tayyeb Ramazan, Gary L. Kreps

School of Communication Studies - Faculty Scholarship

This study analyzed 1432 questions asked in 19 surveys (N = 43,014) on COVID-19 vaccines between January 2020 and August 2022 using dimensions including (1) information sources about COVID-19 vaccine, (2) information about the access, effectiveness, and side effects of COVID-19 vaccine, (3) COVID-19 vaccine hesitancy (i.e. false perception, skepticism, and vaccine refusal), (4) motivations to get the COVID-19 vaccine (i.e. to perform routine activities, convenience, incentives, influences, and travel requirement), (5) false perceptions caused vaccine refusal, and (6) intentions to get vaccinated. Our results show that vaccine refusal was rampant throughout the pandemic and mostly attributed to the …

Early Host Defense Against Virus Infections, Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen

Presidential Fellows Articles and Research

Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease. The field of immunology has been shaped by broad concepts, including the pattern recognition theory that currently dominates innate immunology. Focusing on early host responses to virus infections, we analyze the literature to build a working hypothesis for the principles that govern the early line of cellular antiviral defense. Aiming to ultimately arrive at a criteria-based theory with strong explanatory power, we propose that both controlling infection and limiting inflammation are key drivers for the early cellular antiviral …

Induction Of Tier 2 Hiv-Neutralizing Iga Antibodies In Rhesus Macaques Vaccinated With Bg505.664 Sosip, Justin C. Smith, Prabhu S. Arunachalam, Traci H. Legere, Lisa A. Cavacini, Eric Hunter, Bali Pulendran, Rama R. Amara, Pamela A. Kozlowski

School of Graduate Studies Faculty Publications

BACKGROUND: A goal of mucosal human immunodeficiency virus type 1 (HIV-1) vaccines is to generate mucosal plasma cells producing polymeric IgA (pIgA)-neutralizing antibodies at sites of viral entry. However, vaccine immunogens capable of eliciting IgA neutralizing antibodies (nAbs) that recognize tier 2 viral isolates have not yet been identified. METHODS: To determine if stabilized native-like HIV-1 envelope (Env) trimers could generate IgA nAbs, we purified total IgA and IgG from the banked sera of six rhesus macaques that had been found in a previous study to develop serum nAbs after subcutaneous immunization with BG505.664 SOSIP and 3M-052 adjuvant, which is …