Nutritional and Metabolic Diseases Commons^™

Outpatient Fall Prevention In Ambulatory Adults 65 Years Old And Over, Dorothy L. Osborne-White

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Background: In the United States (U.S.), falls are the leading cause of injury among adults 65 and over, resulting in 36 million falls yearly (Moreland et al., 2020). According to the Centers for Disease Control and Prevention (CDC, 2023), one in four older adults experiences a fall each year. Falls are the world's second most prominent cause of accidental deaths (World Health Organization [WHO], 2021). Falls are the leading cause of both fatal and non-fatal injuries among older adults (Moreland et al., 2020).

Methods: A quality improvement project that included a fall bundle was implemented in a primary clinic. A …

Action Apac: Understanding Perceptions, Attitudes And Behaviours In Obesity And Its Management Across South And Southeast Asia, Kwang Wei Tham, Asma Ahmed, Apussanee Boonyavarakul, Mariana Mercado Garcia, Miroslava Guajardo, Zubaidah Nor Hanipah, Tran Quang Nam, Nemencio A. Nicodemus, Faruque Pathan, Jack Garcia Uranga Romano, Sidartawan Soegonda, Edgardo L. Tolentino, Ambika Gopalakrishnan (A G) Unnikrishnan, Brian J. Oldfield

Ateneo School of Medicine and Public Health Publications

To identify perceptions and attitudes among people with obesity (PwO) and healthcare professionals (HCPs) toward obesity and its management in nine Asia-Pacific (APAC) countries, a cross-sectional online survey was conducted among adult PwO with self-reported body mass index of ≥25 kg/m2 (≥27 kg/m2, Singapore), and HCPs involved in direct patient care. In total, 10 429 PwO and 1901 HCPs completed the survey. Most PwO (68%) and HCPs (84%) agreed that obesity is a disease; however, a significant proportion of PwO (63%) and HCPs (41%) believed weight loss was the complete responsibility of PwO and only 43% of PwO discussed weight …

Pathways To Hypertension Control: Unfinished Journeys Of Low-Income Individuals In Malaysia And The Philippines, Benjamin Palafox, Dina Balabanova, Arianna Maever Loreche, Nafiza Mat-Nasir, Farnaza Ariffin, Mazapuspavina Md-Yasin, Mohamad Rodi Isa, Fadhlina Abd-Majid, Lia M. Palileo-Villanueva, Alicia Renedo, Maureen L. Seguin, Antonio L. Dans, Martin Mckee

Ateneo School of Medicine and Public Health Publications

Background

Reducing inequities in hypertension control among those affected in low- and middle-income countries requires person-centred health system responses based on a contextualised understanding of the choices and care pathways taken by those who rely on the services provided, particularly those from poor and marginalised communities. We examine patterns of care seeking and pathways followed by individuals with hypertension from low-income households in the Philippines and Malaysia. This study aims to fill a significant gap in the literature by analysing the stages at which individuals make decisions that may affect the successful control of their blood pressure.

Methods

This study …

Bringing Awareness To The New Treatment Options For Diabetic Ketoacidosis, Raymond Alvarez, Summer Alvarez, Kristina Ledbetter, Sean Quinonez

West Florida Division GME Research Day 2024

No abstract provided.

Insulin For Icu Non-Dka Patients -Qi Project, Carlos Botero Suarez

North Florida Division GME Research Day 2024

No abstract provided.

Improving The Rates Of Diabetic Screening Exams In A Rural Outpatient Clinic, Sofia Rohde, Mohit Mathavan, Shalaka Venkatraman, David Nguyen, Gino Singer, Shivanie Ramdin, Jennifer Abernathy, Nicholas Dorsey

North Florida Division GME Research Day 2024

No abstract provided.

Dka And Sepsis In The Setting Of Early Pregnancy Loss​, Alexis O'Connell, Sohni Pathan, Manashwi Ramanathan

East Florida Division GME Research Day 2024

No abstract provided.

Syncope With Too Much Iron-Y: Hemochromatosis As A Possible Contributing Factor In Acute Liver Failure, Andrew Ondracek, Joshua Wais, Joseph Petkiewicz, Robert Ondracek

West Florida Division GME Research Day 2024

No abstract provided.

Improving Gout Therapy In The Patriot Clinic, Jerativat Satayarekha, Vigelo Servera Jr., Nicholas Maggio, Nathaniel Rosa-Santiago, Fariha N. Mirza, Sahar Safavi, Kaiser Ali, Ashwini Komarla

North Florida Division GME Research Day 2024

No abstract provided.

The Function Of The Insulin Receptor In Liver Subcell Types And Its Dichotomous Role In Hepatic Dysfunction, Wang-Hsin Lee

Theses and Dissertations--Pharmacology and Nutritional Sciences

Insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD) have become significant health issues worldwide. Increased prevalence of hepatic insulin resistance and MASLD worsens the threat of its progressive complications, such as liver fibrosis, which can lead to cirrhosis and death if left untreated. Treatments for MASLD-induced liver fibrosis are mainly insulin sensitizers. However, activating insulin signaling leads to a higher death rate in end-stage liver fibrosis. This dissertation discusses the emerging insights into hepatic insulin resistance and potential treatment targets in the heme degradation pathway for reversal. We also investigated the mechanisms that the insulin receptor (INSR) regulates in …

Exenatide As Chronopharmacotherapy For T2dm Associated Complications: Targeting Nondipping Blood Pressure And Sleep Insufficiency, Aaron Chacon

Theses and Dissertations--Pharmacology and Nutritional Sciences

Although largely impacted by age, race and ethnicity, and socioeconomic factors, Type 2 Diabetes Mellitus (T2DM) is primarily driven by obesity, currently affecting ~30 million in the U.S and ~463 million globally. T2DM carries numerous complications, including high prevalence of hypertension and nondipping blood pressure (BP), sleep insufficiency and fragmentation. Nondipping BP is an inadequate drop in BP (≤ 10%) during sleeping hours compared with waking hours. Lending to this, sleep disturbance acts as both precursor and consequence of metabolic dysregulation, greatly impacting circadian rhythmicity. To model these conditions, we utilized diabetic (db/db) mice. These mice carry a point mutation …

Predictive Modelling Of Metabolic Syndrome In Ghanaian Diabetic Patients: An Ensemble Machine Learning Approach, Emmanuel Acheampong, Eric Adua, Christian Obirikorang, Enoch Odame Anto, Emmanuel Peprah-Yamoah, Yaa Obirikorang, Evans Adu Asamoah, Victor Opoku-Yamoah, Michael Nyantakyi, John Taylor, Tonnies Abeku Buckman, Maryam Yakubu, Ebenezer Afrifa-Yamoah

Research outputs 2022 to 2026

Objectives: The burgeoning prevalence of cardiometabolic disorders, including type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) within Africa is concerning. Machine learning (ML) techniques offer a unique opportunity to leverage data-driven insights and construct predictive models for MetS risk, thereby enhancing the implementation of personalised prevention strategies. In this work, we employed ML techniques to develop predictive models for pre-MetS and MetS among diabetic patients. Methods: This multi-centre cross-sectional study comprised of 919 T2DM patients. Age, gender, novel anthropometric indices along with biochemical measures were analysed using BORUTA feature selection and an ensemble majority voting classification model, which included …

Association Between The Presence Of Helicobacter Pylori And The Development Of De Novo Anemia In Adults Undergoing Sleeve Gastrectomy, Tammy S. Carrillo-Levin, Maria F. Jaramillo-Ocharan, Gustavo Salinas-Sedo, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

Background: Sleeve gastrectomy has gained prominence in obesity treatment, yet it is not without complications, such as the development of anemia in the medium term. Given the high prevalence of Helicobacter pylori infection in Peru, it is imperative to explore its potential association with this postoperative complication. Objective: To evaluate the association between the presence of Helicobacter pylori and the development of anemia 12 months after sleeve gastrectomy. Methods: A retrospective cohort study was carried out based on an analysis of secondary data from a private clinic in Lima, Peru, which included two groups of people over 18 years of …

Effects Of Aerobic And Resistance Exercise For 9 Months On Serum Free Light Chains In Type 2 Diabetes, Youyoung Kim, John P. Campbell, Neil M. Johannsen, Timothy S. Church, Eunhan Cho, Jennifer Heaney, Guillaume Spielmann

Research outputs 2022 to 2026

Background and aims: Serum polyclonal free light chains (FLCs) levels are associated with overall survival in the general population, reflecting their utility as a biomarker of underlying immune activation and inflammation. Regular exercise is known to ameliorate low-grade inflammation in chronic diseases such as type 2 diabetes; however, the effects of different exercise training modalities on FLCs in adults with type 2 diabetes is unknown. This study investigated the effects of 9-month of aerobic, resistance or combined supervised exercise on serum FLCs in 164 patients with type 2 diabetes (age 58 ± 8 years; 63% female). Methods: 164 participants from …

Childhood Obesity Prevention Programs In Texas, Thao Doan

Gulf Coast Division GME Research Symposium 2024

No abstract provided.

Improving Patient Self-Advocacy And Communication With Providers Through Diabetes Self-Management Education: Analyses From A Randomized Controlled Trial, Brenna Owens Kirk

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: West Virginia (WV), a rural state in Appalachia, has the highest type 2 diabetes mellitus (T2DM) prevalence in the United States. Open communication in the patient-provider relationship is an integral part of comprehensive chronic disease management. This is especially true for patients living with T2DM, a disease that requires many complex, daily self-management activities and is associated with increased emotional distress. However, patients living with T2DM are often reluctant to openly share their concerns regarding self-care with their provider. This study aimed to test the effectiveness of the Diabetes and Hypertension Self-Management Program (DHSMP), a 12-week group lifestyle …

Understanding Guardian Perceptions Of Whole-Foods Plant-Based Diets As Interventions In Pediatric Medicine, Vijay R. Luthra

Honors Undergraduate Theses

The obesity epidemic is widespread in American society, often affecting children who bear its consequences innocently. Due to a lack of nutrition knowledge, children rely on caregivers to meet their nutritional needs and instill healthy habits. This study examines parents' attitudes, knowledge, and behaviors, as well as perceived barriers to adopting a whole-foods plant-based diet (WFPD) for their children. Using a modified survey instrument by Morton et al., this study focused on parents and children regarding dietary choices. Participants were recruited from the waiting area of a pediatric clinic at the Medical College of Georgia between April and May 2023. …

Bioarchaeological Study Of Patterns Of Juvenile Oral Health In Ancient Peru, Nidhi S. Patel

Honors Undergraduate Theses

Dental caries have been identified for several centuries as a common pathology within individuals’ mouths, more specifically in the posterior teeth surfaces (Jesudass, Prabhu, Rajajee, & Sudheer, 2014). Although there have been modern procedures and preventative methods developed to help treat dental caries, in ancient times this was not always the case. The persistence of anterior teeth dental caries in juveniles is a unique pathology observed in Túcume that has not been studied yet. Through the analysis of skeletal samples, this research aims to study the specific case of the formation of anterior deciduous dental caries in juveniles located at …

The Role Of Micrornas In Cellular Senescence, Inflammation, And Cancer Induced By Childhood Obesity, Sarah S. Siddiqi

Honors Undergraduate Theses

Childhood obesity has escalated into a major public health crisis with serious implications for long-term health. As obesity rates among children continue to rise globally, it is crucial to understand its effects on cellular aging and inflammation—key processes that underpin many metabolic diseases. Obesity not only directly contributes to various metabolic disorders but also disrupts fundamental cellular mechanisms, accelerating aging and fostering systemic inflammation. By examining the impact of obesity on cellular aging and chronic inflammation, as well as the regulatory role of microRNAs (miRNAs) in these pathways, we have been able to identify critical biomarkers and molecular mechanisms involved …

Exploring Treatment Burden In People With Type 2 Diabetes Mellitus (T2dm) In Primary Care Settings, Kai Lin

Theses: Doctorates and Masters

Introduction

Treatment burden is the perceived workload of care by individuals. The treatment burden experienced by individuals with Type 2 Diabetes Mellitus (T2DM) is a major obstacle to achieving effective healthcare outcomes. The aim of this research is to facilitate better management of treatment burden in people with T2DM in primary care settings.

Methods

A systematic review, encompassing narrative analysis was used to characterise the treatment burden of T2DM and critical appraisal was used to identify the appropriate patient-reported outcome measures (PROMs) for measuring this burden. The selected instruments were employed with subsequent questionnaires, followed by patient focus groups. A …