The C-Terminal Phdvc5hch Tandem Domain Of Nsd2 Is A Combinatorial Reader Of Modified H3k4 And Tri-Methylated H3k27 That Regulates Transcription Of Cell Adhesion Genes In Multiple Myeloma,
2025
Thomas Jefferson University
The C-Terminal Phdvc5hch Tandem Domain Of Nsd2 Is A Combinatorial Reader Of Modified H3k4 And Tri-Methylated H3k27 That Regulates Transcription Of Cell Adhesion Genes In Multiple Myeloma, Andrea Berardi, Charlotte Leonie Kaestner, Michela Ghitti, Giacomo Quilici, Paolo Cocomazzi, Jianping Li, Federico Ballabio, Chiara Zucchelli, Stefan Knapp, Jonathan Licht, Giovanna Musco
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
Histone methyltransferase NSD2 (MMSET) overexpression in multiple myeloma (MM) patients plays an important role in the development of this disease subtype. Through the expansion of transcriptional activating H3K36me2 and the suppression of repressive H3K27me3 marks, NSD2 activates an aberrant set of genes that contribute to myeloma growth, adhesive and invasive activities. NSD2 transcriptional activity also depends on its non-catalytic domains, which facilitate its recruitment to chromatin through histone binding. In this study, using NMR, ITC and molecular dynamics simulations, we show that the tandem PHD domain of NSD2 (PHDVC5HCHNSD2) is a combinatorial reader of unmodified histone H3K4 and tri-methylated H3K27 …
Targeted Inhibition Of Aurora Kinase A Promotes Immune Checkpoint Inhibition Efficacy In Human Papillomavirus-Driven Cancers,
2025
The Texas Medical Center Library
Targeted Inhibition Of Aurora Kinase A Promotes Immune Checkpoint Inhibition Efficacy In Human Papillomavirus-Driven Cancers, Soma Ghosh, Madison P O'Hara, Pragya Sinha, Tuhina Mazumdar, Lacin Yapindi, Jagannadha K Sastry, Faye M Johnson
Faculty, Staff and Student Publications
Background: Human papillomavirus (HPV)-driven cancers include head and neck squamous cell carcinoma and cervical cancer and represent approximately 5% of all cancer cases worldwide. Standard-of-care chemotherapy, radiotherapy, and immune checkpoint inhibitors (ICIs) are associated with adverse effects and limited responses in patients with HPV-driven cancers. The integration of targeted therapies with ICIs may improve outcomes. In a previous study, we demonstrated that Aurora kinase A (AURKA, Aurora A) inhibitors lead to apoptosis of human HPV-positive cancer cells in vitro and in vivo. Here, we explored the potential of Aurora A inhibition to enhance response to ICIs in immune-competent …
Genetics And Biology Of Pancreatic Ductal Adenocarcinoma,
2025
The Texas Medical Center Library
Genetics And Biology Of Pancreatic Ductal Adenocarcinoma, Haoqiang Ying, Alec C Kimmelman, Nabeel Bardeesy, Raghu Kalluri, Anirban Maitra, Ronald A Depinho
Faculty, Staff and Student Publications
Pancreatic ductal adenocarcinoma (PDAC) poses a grim prognosis for patients. Recent multidisciplinary research efforts have provided critical insights into its genetics and tumor biology, creating the foundation for rational development of targeted and immune therapies. Here, we review the PDAC genomic landscape and the role of specific oncogenic events in tumor initiation and progression, as well as their contributions to shaping its tumor biology. We further summarize and synthesize breakthroughs in single-cell and metabolic profiling technologies that have illuminated the complex cellular composition and heterotypic interactions of the PDAC tumor microenvironment, with an emphasis on metabolic cross-talk across cancer and …
Multiparametric Mri Along With Machine Learning Predicts Prognosis And Treatment Response In Pediatric Low-Grade Glioma,
2025
Thomas Jefferson University
Multiparametric Mri Along With Machine Learning Predicts Prognosis And Treatment Response In Pediatric Low-Grade Glioma, Anahita Fathi Kazerooni, Adam Kraya, Komal Rathi, Meen Chul Kim, Arastoo Vossough, Nastaran Khalili, Ariana Familiar, Deep Gandhi, Neda Khalili, Varun Kesherwani, Debanjan Haldar, Hannah Anderson, Run Jin, Aria Mahtabfar, Sina Bagheri, Yiran Guo, Qi Li, Xiaoyan Huang, Yuankun Zhu, Alex Sickler, Matthew R Lueder, Saksham Phul, Mateusz Koptyra, Phillip Storm, Jeffrey Ware, Yuanquan Song, Christos Davatzikos, Jessica Foster, Sabine Mueller, Michael J Fisher, Adam Resnick, Ali Nabavizadeh
Department of Neurosurgery Faculty Papers
Pediatric low-grade gliomas (pLGGs) exhibit heterogeneous prognoses and variable responses to treatment, leading to tumor progression and adverse outcomes in cases where complete resection is unachievable. Early prediction of treatment responsiveness and suitability for immunotherapy has the potential to improve clinical management and outcomes. Here, we present a radiogenomic analysis of pLGGs, integrating MRI and RNA sequencing data. We identify three immunologically distinct clusters, with one group characterized by increased immune activity and poorer prognosis, indicating potential benefit from immunotherapies. We develop a radiomic signature that predicts these immune profiles with over 80% accuracy. Furthermore, our clinicoradiomic model predicts progression-free …
Co-Occurrence Of Autoimmune Hepatitis And Pheochromocytoma: A Complex Diagnostic And Treatment Challenge,
2025
Mercer University School of Medicine
Co-Occurrence Of Autoimmune Hepatitis And Pheochromocytoma: A Complex Diagnostic And Treatment Challenge, Himani Patel, Gabrielle Aiello, Taylor Frazier, Sage Havrilla, Payton Williams, Meghan Rosenquist
South Atlantic Division GME Research Day 2025
No abstract provided.
Retrospective Study On Inpatient Performed Guaiac Fecal Occult Blood Screening Tests And Review Of Outcomes,
2025
HCA Healthcare
Retrospective Study On Inpatient Performed Guaiac Fecal Occult Blood Screening Tests And Review Of Outcomes, Amel Tabet Aoul, Jonathan Perez-Colon, Mengjie Yu, Ama Achiamah, Brittney Sille, Olu Oyesanmi, Hayden Dansbury, Pujan Kandel, Sreekanth Chandrupatla
West Florida Division GME Research Day 2025
No abstract provided.
An In Vivo Study Of Lns8801, A Gper Agonist, In A Spontaneous Melanoma-Prone Mouse Model, Tgs.,
2025
Rutgers University - New Brunswick/Piscataway
An In Vivo Study Of Lns8801, A Gper Agonist, In A Spontaneous Melanoma-Prone Mouse Model, Tgs., Christina Marinaro, John Sauer, Christopher A Natale, Todd Ridky, Suzie Chen
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Melanoma is the most aggressive and deadly form of skin cancer that arises from the transformation of melanocytes, the pigment producing cells of the skin. In the year 2024 there will be approximately 10,000 new cases of melanoma diagnosed and approximately 8,000 deaths attributed to melanoma in the United States. In this study we treated a group of male and female transgenic mice that spontaneously develop metastatic melanoma, TGS, with a G-protein-coupled estrogen receptor agonist LNS8801 to assess the efficacy on disease progression. A second group of male and female TGS mice was also exposed to UVB irradiation to mimic …
Hearts Hidden Message: Right Ventricular Thrombus Reveals Esophageal Adenocarcinoma,
2025
HCA Healthcare
Hearts Hidden Message: Right Ventricular Thrombus Reveals Esophageal Adenocarcinoma, Devika Adusumilli, Seline Haci, Jafri Imran, Arman Vaghefi, Mehdi Khalafi, Ikponmwosa Iyamu, Sarvanan Balamuthusamy
North Texas Research Forum 2025
Introduction Right ventricular thrombi are uncommon, usually found with concurrent pulmonary emboli and associated with significant mortality. They often originate from deep vein thrombi but may also be due to primary intracardiac processes . A right ventricular thrombus can be an unexpected marker for underlying malignancies, including esophageal cancer. This occurs due to the hypercoagulable state often induced by malignancy. Here we report a presentation where the identification of a right ventricular thrombus led to the diagnosis of esophageal cancer. Case Presentation Our patient is a 57-year old male with no past medical history who experienced an episode of dizziness …
Atypical Hemorrhoid Or Hidden Malignancy? Anal Melanoma And Palliative Strategies,
2025
HCA Healthcare
Atypical Hemorrhoid Or Hidden Malignancy? Anal Melanoma And Palliative Strategies, Osamuyi Asemota, Kayla Brown, Megan Turley
Central & West Texas and San Antonio GME Research Day 2025
No abstract provided.
Pseudomyxoma Peritonei As Initial Presentation Of Mucinous Appendiceal Adenocarcinoma,
2025
HCA Healthcare
Pseudomyxoma Peritonei As Initial Presentation Of Mucinous Appendiceal Adenocarcinoma, Rajiv Shah, Iren Shabanova, Radhika Mohan, Sirin Khajaviyan, David Ortega, Pooja Paunikar, Dennis Besong, Mitul Patel, Valerie Sinkler
South Atlantic Division GME Research Day 2025
No abstract provided.
Incidental Discovery Of Bilateral Pheochromocytoma In A Patient With Lifelong Hypertension,
2025
HCA Healthcare
Incidental Discovery Of Bilateral Pheochromocytoma In A Patient With Lifelong Hypertension, Umema Irfan, Sara Shahid, Anam Zara
Gulf Coast Division GME Research Day 2025
No abstract provided.
Mycosis Fungoides: A Mimicker Of Atopic Dermatitis,
2025
HCA Healthcare
Mycosis Fungoides: A Mimicker Of Atopic Dermatitis, Christian Scheufele, Paige Loux, Henry Lim, Garrett Furth, Marshall Hall, Michael Carletti, Stephen Weis
North Texas Research Forum 2025
Introduction Cutaneous T cell lymphoma (CTCL) is a rare, cutaneous, malignant neoplasm of the resident T cell lymphocytes within the skin. CTCL encompasses a spectrum of morphologically and prognostically distinct entities, the most common of which is mycosis fungoides (MF). The incidence of mycosis fungoides is about 6 cases per million per year in the United States and Europe. MF is notoriously difficult to diagnose clinically. It can masquerade as several common dermatologic conditions and may be treated as such for years until a biopsy reveals the correct diagnosis. One of the most common diseases that MF mimics is atopic …
Pembrolizumab Induced Myasthenia Gravis,
2025
HCA Healthcare
Pembrolizumab Induced Myasthenia Gravis, Praise Ohabor, Alexis Lopez Cruz, Deekshita Valiveti, Brandi Addison, Zuhair Ali
Gulf Coast Division GME Research Day 2025
No abstract provided.
Prevelence Odds Of Melanoma In Patients With Inflammatory Bowel Disease: An Observational Cross-Sectional Study,
2025
HCA Healthcare
Prevelence Odds Of Melanoma In Patients With Inflammatory Bowel Disease: An Observational Cross-Sectional Study, Nilay Bhatt, Kumail Rizvi
Gulf Coast Division GME Research Day 2025
No abstract provided.
Large Mesenteric Cyst Casting Wide Differential Across Specialties,
2025
HCA Healthcare
Large Mesenteric Cyst Casting Wide Differential Across Specialties, Jessica Harper, Katherine Kleinberg, Jose S. Saldivar
Central & West Texas and San Antonio GME Research Day 2025
No abstract provided.
Liver Metastasis Of Immature Teratoma And Portal Vein Embolization: A Case Report,
2025
HCA Healthcare
Liver Metastasis Of Immature Teratoma And Portal Vein Embolization: A Case Report, Rohan Gupta
Gulf Coast Division GME Research Day 2025
No abstract provided.
What Newly Updated Variables Are Correlated With Colon Cancer Incidence And Death Rates In Florida?,
2025
HCA Healthcare
What Newly Updated Variables Are Correlated With Colon Cancer Incidence And Death Rates In Florida?, Cody Steed, Julia Fashner
East Florida Division GME Research Day 2025
No abstract provided.
Mcl Or Dlbcl - Make Right Choice!,
2025
HCA Healthcare
Mcl Or Dlbcl - Make Right Choice!, Mohammed Shafeay, Mirza Baig, Astrid Sacasa, Ram Madasu, Delbert Benzenhafer, Alexey Glazyrin
East Florida Division GME Research Day 2025
No abstract provided.
Primary Cardiac Lymphoma: A Rare Diagnosis,
2025
HCA Healthcare
Primary Cardiac Lymphoma: A Rare Diagnosis, Astrid Sacasa, Betty Kirimi, Mohtashim Naeem, Susana Ferra
East Florida Division GME Research Day 2025
No abstract provided.
Myxoid Variant: An Unusual Presentation Of Low-Grade Epithelioid Mesothelioma,
2025
HCA Healthcare
Myxoid Variant: An Unusual Presentation Of Low-Grade Epithelioid Mesothelioma, Racquel Fournet, Robert Bender, Rohit Jaishankar, Alexey Glazyrin
East Florida Division GME Research Day 2025
No abstract provided.
