Vitamin D Enhanced Vitamin D Receptor (Vdr) Inhibition Of Nlrp3 Inflammasome Activation Can Attenuate The Development Of Autoimmune Thyroiditis, 2023 Arcadia University
Vitamin D Enhanced Vitamin D Receptor (Vdr) Inhibition Of Nlrp3 Inflammasome Activation Can Attenuate The Development Of Autoimmune Thyroiditis, Alexzon Mandac
Capstone Showcase
Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disease affecting approximately 2% of the population. Characterized by the gradual loss of thyroid function through an autoimmune attack on the thyroid gland, the disease manifests symptoms that negatively affect one’s quality of life. The mechanisms behind the disease’s pathophysiology are not fully understood; however, researchers are examining the involvement of the NLRP3 inflammasome in the disease. This thesis will address the question of whether Vitamin D can act as an inhibitor of the NLRP3 inflammasome and attenuate the progression of AIT in mouse model. Current investigations explore the effects of NLRP3 inhibition …
Pandas Exacerbation Post-Tonsillectomy, Acute Response To Fentanyl & Dexamethasone, 2023 HCA Healthcare
Pandas Exacerbation Post-Tonsillectomy, Acute Response To Fentanyl & Dexamethasone, Austin Peralta-Fogle, Jeffrey Ramsey, Natasha Fazel, Ryan Spilman
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
The Importance Of Recognizing The Many Facets Of Crohn’S Disease, 2023 HCA Healthcare
The Importance Of Recognizing The Many Facets Of Crohn’S Disease, Alexander Howell, Rachel Murray, Ann Church, Karthik Krishnamurthy
South Atlantic Division Research Day 2023
No abstract provided.
Pembrolizumab-Induced Polymyalgia Rheumatica, 2023 HCA Healthcare
Pembrolizumab-Induced Polymyalgia Rheumatica, Jessica Thomas, Alexandra E. Thomson, Savannah Grunhard, Rohit Bishnoi
South Atlantic Division Research Day 2023
No abstract provided.
The Effect Of An Educational Handout On Knowledge, Awareness And Attitudes Of Pre-Exposure Prophylaxis (Prep) Among Participants At A Needle And Syringe Exchange Site, 2023 University of Kentucky
The Effect Of An Educational Handout On Knowledge, Awareness And Attitudes Of Pre-Exposure Prophylaxis (Prep) Among Participants At A Needle And Syringe Exchange Site, Mckenzie Buckel
DNP Projects
Background: In 2018, the total number of HIV cases in the United States was 1.2 million. Almost 186,500 of these cases were attributed to intravenous drug use. With the adherence to pre-exposure prophylaxis (PrEP) there is approximately a 49% decrease in the rates of HIV among people who inject drugs and the most significant barrier to PrEP among this population is a lack of awareness and knowledge.
Objective: The purpose of this study was to determine participants’ of a needle and syringe exchange site knowledge, awareness and attitudes of PrEP after reviewing an educational handout about PrEP.
Methods: A quasi …
Association Between Immunoglobulin G N-Glycosylation And Lupus Nephritis In Female Patients With Systemic Lupus Erythematosus: A Case-Control Study, 2023 Edith Cowan University
Association Between Immunoglobulin G N-Glycosylation And Lupus Nephritis In Female Patients With Systemic Lupus Erythematosus: A Case-Control Study, Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li
Research outputs 2022 to 2026
Background: Lupus nephritis (LN) is a crucial complication of systemic lupus erythematosus (SLE) and has important clinical implications in guiding treatment. N-glycosylation of immunoglobulin G (IgG) plays a key role in the development of SLE by affecting the balance of anti-inflammatory and proinflammatory responses. This study aimed to evaluate the performance of IgG N-glycosylation for diagnosing LN in a sample of female SLE patients. Methods: This case-control study recruited 188 women with SLE, including 94 patients with LN and 94 age-matched patients without LN. The profiles of plasma IgG N-glycans were detected by hydrophilic interaction chromatography with ultra-performance liquid chromatography …
Orthodox Vs Paradox: The Roles Of Glycomics, Genetics And Beyond In Immunity, Immune Disorders And Glycomedicine, 2023 Edith Cowan University
Orthodox Vs Paradox: The Roles Of Glycomics, Genetics And Beyond In Immunity, Immune Disorders And Glycomedicine, Wei Wang
Research outputs 2022 to 2026
The traditional ‘central dogma’ describes the flow of genetic information from DNA to RNA to protein. This process highlights the critical role of genes in living organisms. Nonetheless, ongoing immunological research coming to realize that emerging disciplines like glycomics and epigenetics are challenging the traditional viewpoint and extending the boundaries of the ‘central dogma’. . . .
Kikuchi Disease: A Rare Recurrence, 2023 HCA Healthcare
Kikuchi Disease: A Rare Recurrence, R Levi Sundermeyer, Jessica Bautista
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Multiple Sclerosis In A 32-Year-Old Female With History Of Prolactinoma, 2023 HCA Healthcare
Multiple Sclerosis In A 32-Year-Old Female With History Of Prolactinoma, Aleeza Ali, Jesse Simon, Adekunle Bamgboye
East Florida Research Day 2023
Among disorders affecting the central nervous system (CNS), excluding trauma, multiple sclerosis (MS) is the most common cause of permanent disability in young adults. This condition is characterized by IgG autoantibody-mediated destruction of oligodendrocytes in the brain and spinal cord. Although the origin of MS is not fully understood, some suggest that prolactin may be involved in the development of the disease process evidenced by the fact that it predominately affects women of childbearing age, and the diverse role of prolactin (PRL) as a peptide hormone, cytokine, and immune modulator. Here we review the case of a 32-year-old female with …
Bulbar-Predominant Presentation Of Myasthenia Gravis: Poster Presentation, 2023 HCA Healthcare
Bulbar-Predominant Presentation Of Myasthenia Gravis: Poster Presentation, Duncan Mckinney, Rumana Khan, Edward Griffin
Capital Division Research Day 2023
No abstract provided.
The Role Of Regulatory B-Cells In Allergic Disease, 2023 HCA Healthcare
The Role Of Regulatory B-Cells In Allergic Disease, Melissa Dang, Justin Yu, Greg Schlessinger
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Neurolupus In A Previously Healthy Young Caucasian Male, 2023 HCA Healthcare
Neurolupus In A Previously Healthy Young Caucasian Male, Kavanya Feustel, Joshua Ralston, Kelly Schulte, Jeffrey Ramsey, Deren Goker, Jacob Keeling, Dmitriy Scherbak
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Hairy Cell Leukemia Presenting As Group B Streptococcus Cellulitis And Abscesses, 2023 HCA Healthcare
Hairy Cell Leukemia Presenting As Group B Streptococcus Cellulitis And Abscesses, Hannah Berrett, Mattias D'Anna, Ajay Iyer, Zachary Hancock, Meg Laures, Muzaffar Iqbal
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
A Curious Case Of Biopsy Proven Usual Interstitial Pneumonia, 2023 HCA Healthcare
A Curious Case Of Biopsy Proven Usual Interstitial Pneumonia, Austin Makadia, Vishesh Persaud, Saiara Choudhury, Asad Chohan, Abhay Vakil
Gulf Coast Division Research Day 2023
No abstract provided.
Severe Case Of Systemic Lupus Erythematosus In A 36-Year-Old Male, 2023 HCA Healthcare
Severe Case Of Systemic Lupus Erythematosus In A 36-Year-Old Male, Aleeza Ali, Max Kaito, Stanley Dennison, Hanan Zisling, Esam Khalifa, John Romano
East Florida Research Day 2023
Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that is capable of involving almost any organ in the body, leading to significant morbidity and mortality in affected patients. SLE is characterized by pathogenic autoantibodies that react with antigens and form immune complexes, resulting in tissue damage and a potential wide array of manifestations, including arthralgias, lupus nephritis, pleuritis, and delirium. Experts cite the effect of estrogens or factors related to the X chromosome as possible explanations regarding the increased prevalence of SLE in women over men, with ratios of up to 15:1. Here, we discuss the case of a …
Metformin-Induced Giant Cell Arteritis: An Uncommon Case Of Drug-Induced Vasculitis, 2023 HCA Healthcare
Metformin-Induced Giant Cell Arteritis: An Uncommon Case Of Drug-Induced Vasculitis, Christine Angeles, Wendy Lee
South Atlantic Division Research Day 2023
No abstract provided.
Anti-Glomerular Basement Membrane Disease Presenting With Renal Failure And Extensive Deep Venous Thrombosis, 2023 HCA Healthcare
Anti-Glomerular Basement Membrane Disease Presenting With Renal Failure And Extensive Deep Venous Thrombosis, Alec Rhodes, Zainab Shakir, Lakshmi Tatineni, Sivatej Sarva, Ramesh Kesavan
Gulf Coast Division Research Day 2023
No abstract provided.
A Unique Presentation Of Libman-Sacks: Non-Bacterial Tricuspid Valve Endocarditis, 2023 HCA Healthcare
A Unique Presentation Of Libman-Sacks: Non-Bacterial Tricuspid Valve Endocarditis, August Rakutt, Lauren Hampton, Johnathan Frunzi
West Florida Division Research Day 2023
No abstract provided.
Genetic And Immunological Insights Into Covid-19 With Acute Myocardial Infarction: Integrated Analysis Of Mendelian Randomization, Transcriptomics, And Clinical Samples, 2023 Edith Cowan University
Genetic And Immunological Insights Into Covid-19 With Acute Myocardial Infarction: Integrated Analysis Of Mendelian Randomization, Transcriptomics, And Clinical Samples, Zequn Zheng, Yueran Zhou, Yongfei Song, Pengxiang Ying, Xuerui Tan
Research outputs 2022 to 2026
Background: Globally, most deaths result from cardiovascular diseases, particularly ischemic heart disease. COVID-19 affects the heart, worsening existing heart conditions and causing myocardial injury. The mechanistic link between COVID-19 and acute myocardial infarction (AMI) is still being investigated to elucidate the underlying molecular perspectives. Methods: Genetic risk assessment was conducted using two-sample Mendelian randomization (TSMR) to determine the causality between COVID-19 and AMI. Weighted gene co-expression network analysis (WGCNA) and machine learning were used to discover and validate shared hub genes for the two diseases using bulk RNA sequencing (RNA-seq) datasets. Additionally, gene set enrichment analysis (GSEA) and single-cell RNA-seq …
Pneumococcal Vaccine Guidance 2022, 2022 Pharmacy Department, Reading Hospital-Tower Health, West Reading, PA
Pneumococcal Vaccine Guidance 2022, Bona Shin, Michael Do, Elaina Lioudis
Transformative Medicine (T-Med)
PCV15 and PCV20 received FDA approval in 2021. This article provides an overview of all pneumococcal vaccines - PPSV23, PCV13, PCV15, and PCV20 and their place in therapy. It provides a summary of pneumococcal disease burden in the U.S., vaccine spectrum of activity, indications, adult/pediatric dosing schedules, efficacy, and common adverse drug reactions.