D-Mannose Reduces Cellular Senescence And Nlrp3/Gasdermind/Il-1Β-Driven Pyroptotic Uroepithelial Cell Shedding In The Murine Bladder,
2024
The Texas Medical Center Library
D-Mannose Reduces Cellular Senescence And Nlrp3/Gasdermind/Il-1Β-Driven Pyroptotic Uroepithelial Cell Shedding In The Murine Bladder, Chetanchandra S Joshi, Arnold M Salazar, Caihong Wang, Marianne M Ligon, Rayvanth R Chappidi, Bisiayo E Fashemi, Paul A Felder, Amy Mora, Sandra L Grimm, Cristian Coarfa, Indira U Mysorekar
Faculty, Staff and Students Publications
Aging is a risk factor for disease via increased susceptibility to infection, decreased ability to maintain homeostasis, inefficiency in combating stress, and decreased regenerative capacity. Multiple diseases, including urinary tract infection (UTI), are more prevalent with age; however, the mechanisms underlying the impact of aging on the urinary tract mucosa and the correlation between aging and disease remain poorly understood. Here, we show that, relative to young (8-12 weeks) mice, the urothelium of aged (18-24 months) female mice accumulates large lysosomes with reduced acid phosphatase activity and decreased overall autophagic flux in the aged urothelium, indicative of compromised cellular homeostasis. …
A Conceptual Analysis Of Sbirt Implementation Alongside The Continuum Of Prep Awareness: Domains Of Fit And Feasibility.,
2024
University of Louisville, Kent School of Social Work
A Conceptual Analysis Of Sbirt Implementation Alongside The Continuum Of Prep Awareness: Domains Of Fit And Feasibility., Lesley M. Harris, Kerr C. Jelani, Blake D. Skidmore, Smita Ghare, Andrea Reyes-Vega, Vania Remenik-Zarauz, Harideep Samanapally, Rana U. Anwar, Rishikesh Rijal, Kendall Bryant, Martin T. Hall, Shirish Barve
Faculty and Staff Scholarship
Screening, Brief Intervention, and Referral to Treatment (SBIRT) is a supplementary intervention that can be incorporated into the Pre-Exposure Prophylaxis (PrEP) Care Continuum, complementing initiatives and endeavors focused on Human Immunodeficiency Virus (HIV) prevention in clinical care and community-based work. Referencing the Transtheoretical Model of Change and the PrEP Awareness Continuum, this conceptual analysis highlights how SBIRT amplifies ongoing HIV prevention initiatives and presents a distinct chance to address identified gaps. SBIRT's mechanisms show promise of fit and feasibility through (a) implementing universal Screening (S), (b) administering a Brief Intervention (BI) grounded in motivational interviewing aimed at assisting individuals in …
Features Of Acute Covid-19 Associated With Post-Acute Sequelae Of Sars-Cov-2 Phenotypes: Results From The Impacc Study,
2024
The Texas Medical Center Library
Features Of Acute Covid-19 Associated With Post-Acute Sequelae Of Sars-Cov-2 Phenotypes: Results From The Impacc Study, Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E Milliren, Jingjing Qi, Linda N Geng, Grace A Mccomsey, Charles B Cairns, Lindsey R Baden, Joanna Schaenman, Albert C Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P Shannon, Rafick P Sekaly, Lauren I R Ehrlich, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Harm Van Bakel, Seunghee Kim-Schulze, David A Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K Haddad, Carolyn S Calfee, David J Erle, Charles R Langelier, Walter Eckalbar, Steven E Bosinger, Bjoern Peters, Steven H Kleinstein, Elaine F Reed, Alison D Augustine, Joann Diray-Arce, Holden T Maecker, Matthew C Altman, Ruth R Montgomery, Patrice M Becker, Nadine Rouphael
Faculty, Staff and Students Publications
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B …
Investigating The Link Between Vitamin D Levels And Glucocorticoid Usage In Systemic Lupus Erythematosus,
2024
HCA Healthcare
Investigating The Link Between Vitamin D Levels And Glucocorticoid Usage In Systemic Lupus Erythematosus, Ellen Yos, Jayden Navarro, Mohamed Faris
South Atlantic Division GME Research Day 2024
No abstract provided.
Secondary Cold Agglutinin Hemolytic Anemia And Unconventional Treatment With Rituximab,
2024
HCA Healthcare
Secondary Cold Agglutinin Hemolytic Anemia And Unconventional Treatment With Rituximab, Jacob Trimble, Roy Dennis, Zachary Bondranko, Mary Therese Thomas, Thomas Bumbalo
South Atlantic Division GME Research Day 2024
No abstract provided.
Analysis Of Temporal Artery Biopsy By Provider Across A Large Multi-State Healthcare Network,
2024
HCA Healthcare
Analysis Of Temporal Artery Biopsy By Provider Across A Large Multi-State Healthcare Network, Karling Gravenstein, Mikalah Maury, Priya Arya, Robert Liebman
South Atlantic Division GME Research Day 2024
No abstract provided.
Case Report: Unilateral Internuclear Ophthalmoplegia As First Manifestation In Multiple Sclerosis,
2024
HCA Healthcare
Case Report: Unilateral Internuclear Ophthalmoplegia As First Manifestation In Multiple Sclerosis, Imaad Zaman, Tyler Adame, Steven Do, Kien Nham, Azeem Muhammad
North Texas GME Research Forum 2024
Multiple Sclerosis is an inflammatory disorder of the central nervous system secondary to myelin degeneration. The disease is mediated by reactive lymphocytes where the spinal cord, brain and optic nerves are attacked. Diagnosis of MS is made clinically and confirmed via MRI with T2 hyperintensities. On presentation, a 26-year-old female with no significant past medical history presented with frequent headaches and blurry vision. There was right eye nystagmus on L lateral gaze with CN III deficits with absent medial rotation. MRI Head presented with a classic presentation of T2 hyperintensities in the subcortical and deep white matter. Further confirmed with …
Evaluating The Effect Of Vitamin D Supplementation On Long Term Prednisone Dosage In Systemic Lupus Erythematosus,
2024
HCA Healthcare
Evaluating The Effect Of Vitamin D Supplementation On Long Term Prednisone Dosage In Systemic Lupus Erythematosus, Ellen Yos, Mohamed Faris
South Atlantic Division GME Research Day 2024
No abstract provided.
Drug Reaction With Eosinophilia And Systemic Symptoms (Dress) Syndrome: Lamotrigine Associated,
2024
HCA Healthcare
Drug Reaction With Eosinophilia And Systemic Symptoms (Dress) Syndrome: Lamotrigine Associated, Kendal Allen, Jordan Steelquist, Renee Delos Angeles, He Wang, Andrew Chen
Far West Division GME Research Day 2024
No abstract provided.
Case Report: A 28-Year-Old Male With Bilateral Lower Extremities Paresthesias, Characteristic Presentation Of Guillain-Barre Syndrome And Innovative Treatments,
2024
HCA Healthcare
Case Report: A 28-Year-Old Male With Bilateral Lower Extremities Paresthesias, Characteristic Presentation Of Guillain-Barre Syndrome And Innovative Treatments, Petros Keoseyan, Ricky Oshakuade, Danielle Genov, Derek Draper, Nick Duff, Anna Belits, Dmitriy Scherbak
Continental, MidAmerica, & Mountain Divisions GME Research Day 2024
No abstract provided.
A Case Report Of Marburg Multiple Sclerosis Responding To Mitoxantrone,
2024
HCA Healthcare
A Case Report Of Marburg Multiple Sclerosis Responding To Mitoxantrone, Aruna Souri, Athena Dao, Russell Bartt
Continental, MidAmerica, & Mountain Divisions GME Research Day 2024
No abstract provided.
A Bullous Eruption In An 81-Year-Old Male,
2024
HCA Healthcare
A Bullous Eruption In An 81-Year-Old Male, Garrett S. Furth, Christian J. Scheufele, Carlos S. Bahrami, Stephen E. Weis
North Texas GME Research Forum 2024
INTRODUCTION: When a patient presents with a blistering rash arriving at the diagnosis can seem overwhelming. Bullous Pemphigoid (BP) is the most common autoimmune blistering disease and tends to affect older individuals, with a mean age of presentation of eighty. It is caused by antibodies targeting the basement membrane zone, the structure between epidermis and dermis, specifically affecting the BP180 (Type-XVII collagen) and BP230 (a plakin) proteins. Antibody-antigen complexes lead to complement activation and destruction of these transmembrane proteins, causing separation of the epidermis and dermis, and formation of tense, subepidermal blisters and bullae. Identification of key clinical features and …
Recurrent Pleural Effusion, An Extraarticular Manifestation Of Seronegative Rheumatoid Arthritis,
2024
HCA Healthcare
Recurrent Pleural Effusion, An Extraarticular Manifestation Of Seronegative Rheumatoid Arthritis, Ronald Spinelle, Jeffin Cherian, Luke Rogers, Domenick Sorresso
West Florida Division GME Research Day 2024
No abstract provided.
Drug Rash With Eosinophilia And Systemic Symptoms (Dress),
2024
HCA Healthcare
Drug Rash With Eosinophilia And Systemic Symptoms (Dress), Grace M. Yedlicka, Jonah Warwick, Ryan Spilman
Continental, MidAmerica, & Mountain Divisions GME Research Day 2024
No abstract provided.
Bridging The Gap For Hiv Education In Primary Care Setting,
2024
HCA Healthcare
Bridging The Gap For Hiv Education In Primary Care Setting, Oregon Mcdiarmid, Lindsay Porter
North Texas GME Research Forum 2024
No abstract provided.
Relationship Between Genotype And Disease Phenotype For Gluten-Related Disorders,
2024
Linfield University
Relationship Between Genotype And Disease Phenotype For Gluten-Related Disorders, Michael Roberts, Nadine Grzeskowiak, Stephen Bricher
Faculty Publications
We investigated gluten-related disorders (GRD) in intestinal biopsy-proven subjects to determine the relation between genotype (i.e., Human Leukocyte Antigen (HLA) DQ alleles) and phenotype (i.e., antibody levels and clearly defined symptoms). Subjects had known DQ genotypes, information on IgA anti-Endomysial antibodies (EMA) and/or anti-tissue Trans Glutaminase (tTG) antibodies (tTGA). Subjects also answered a survey characterizing gastrointestinal, skin, and neural symptoms. Though all were biopsy-proven, HLA genotypes included all combinations of DQ2.5, DQ2.2, DQ8, DQ7.5, DQ5, and DQ6. Subject antibody levels were proportional to the number of DQ2.5 haplotypes, and subjects with non-CD-associated haplotypes did not have positive antibody scores (despite …
Characterization Of Pain In Lipedema: Reliability And Validity Of Pain Pressure Thresholds And Hand-Held Sphygmomanometer Assessments In People With Lipedema,
2024
Edith Cowan University
Characterization Of Pain In Lipedema: Reliability And Validity Of Pain Pressure Thresholds And Hand-Held Sphygmomanometer Assessments In People With Lipedema, Francesco Bettariga, Luca Fumagalli, Daniele Aloisi, Luca Maestroni, Sara Mantovani
Research outputs 2022 to 2026
Background: Lipedema is a chronic condition characterized by abnormal deposition of subcutaneous adipose tissue, leading to pain. The lack of internationally recognized diagnostic criteria complicates the characterization of pain. Physiological parameters such as pain pressure threshold (PPT) represent promising prognostic markers for diagnosing lipedema, yet they remain understudied. This study aimed to evaluate the reliability and validity of two pain pressure measurements, PPT and the hand-held sphygmomanometer (HHS) in lipedema. Methods: A total of 28 adult females diagnosed with lipedema were recruited. Both PPT, using a digital algometer, and HHS, using a manual aneroid HHS, were performed to assess pain …
Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs),
2024
Old Dominion University
Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper
Chemistry & Biochemistry Faculty Publications
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent quantitative analysis of small molecules. While evaporatively prepared samples yield significant SERS enhancement resulting in lower detection limits, the distribution of these enhancements along the SERS surface is inherently stochastic. Acquiring spatially resolved SERS spectra of these dried surfaces, we have shown that this enhancement is governed by a power law as a function of analyte concentration. Consequently, by definition, …
Acyclovir As A Novel Treatment For Severe Chronic Active Epstein-Barr Virus,
2024
HCA Healthcare
Acyclovir As A Novel Treatment For Severe Chronic Active Epstein-Barr Virus, Mary Therese Thomas, Philip Mardock, Amanda Wright, Kedar Arukala
South Atlantic Division GME Research Day 2024
No abstract provided.
Systemic Lupus Erythematosus Presenting As Aseptic Meningitis And Pancytopenia,
2024
HCA Healthcare
Systemic Lupus Erythematosus Presenting As Aseptic Meningitis And Pancytopenia, Julia Collins, Roy Escobar, Vishnu Halthore, Ali Abu-Alya, Tanvir Khosla, Hamza Hansoti, Janita Sidhu, Elia Barraza, Zachary Charif, Azaam Mamoor, Ann Wierman, Venkatachalam Veerappan
Far West Division GME Research Day 2024
No abstract provided.
