Hemic and Lymphatic Diseases Commons^™

Confusion, Pruritus, And Purple Skin: A Case Of Hypereosinophilic Syndrome, Blane Alost, Asha Kurian

Central & West Texas GME Research Day 2023

No abstract provided.

Unusual Presentation Of B-Cell Acute Lymphocytic Leukemia (All) With Skin Manifestations, Muhammad Bilal, Victoria Brown, Uma Iyer

North Florida Division GME Research Day 2023

No abstract provided.

A Case Of Amiodarone Induced Thyrotoxicosis Presenting With Methimazole Induced Agranulocytosis, Suhail Saadomer, Moises Matos, Mustafa Kinaan

North Florida Division GME Research Day 2023

No abstract provided.

Kikuchi Disease: A Rare Recurrence, R Levi Sundermeyer, Jessica Bautista

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Multiple Myeloma Diagnosed In A 23-Year-Old Male Presenting With Pathologic Compression Fracture, Kyle Combe, Tristan Myers, Michelle Levy, Greg Schlessinger

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Spur Cell Hemolytic Anemia: An Uncommon Etiology Of Anemia In Liver Cirrhosis, Hanan Gruhonjic, Austin Van Vliet, Maxwell Tague, Masi Javeed

West Florida Division GME Research Day 2023

No abstract provided.

Pancytopenia, Enterovirus Infection, And Pcr Testing, Stephen Mock, Salome Herzstein, Andrea Horbey

East Florida Division GME Research Day 2023

Introduction: This is a case of a patient presenting with fever, rash, and vomiting. Upon further studies, patient was found to have pancytopenia which started an extensive hospital work up.

Case Description: A previously healthy 9- year-old female presented to the emergency department with 3 days of tactile fever, 2 days of rash, and 1 day of nonbilious nonbloody emesis. The rash initially appeared on the trunk and by the day of admission, had begun to spread peripherally to the extremities. The rash on the abdomen was described as mild, generalized, blanchable and maculopapular. The rash on the extremities was …

Paraneoplastic Leukemoid Reaction In Uterus Carcinosarcoma, Xiaolan Tang, Ashali Jain, Uma Iyer, Jennifer Reppucci

North Florida Division GME Research Day 2023

No abstract provided.

Atypical Hemolytic Uremic Syndrome: A Diagnostic Conundrum, Rebecca Kurian, William Zvagelsky, Suleiman A. Daifallah

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Hairy Cell Leukemia Presenting As Group B Streptococcus Cellulitis And Abscesses, Hannah Berrett, Mattias D'Anna, Ajay Iyer, Zachary Hancock, Meg Laures, Muzaffar Iqbal

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Atypical Lymphoma And Monospot Testing: Malignant Deception, Jacob Keeling, Kavanya Feustel, Changlee Pang, Kevin Ky, Jennifer Griffith, Alexander Enurah

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

A Case Of Hemophagocytic Lymphohistiocytosis(Hlh) Secondary To Cytomegalovirus Infection In An Immunocompetent Patient, Marcarthur Limpiado, Simerun Singh, Ajay Iyer, William Zvagelsky, Shruti Verma, Minar Rane, Emadeldeen Elgwairi

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Opioid-Induced Intrathecal Catheter Tip Granuloma Via Pain Pump In A Patient With Chronic Pain Syndrome: A Case Report, Katherine David, R Blake Kline, Jon Halling

South Atlantic Division GME Research Day 2023

No abstract provided.

Monoclonal Gammopathy Of Renal Significance: A Likely Underrecognized Problem, Ajay Iyer, Angad Singh, Thomas Pritchard, Manoj Khamuani, Minar Rane, Joseph Stilwill, Max Glaser

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Follicular Lymphoma Presenting As A Small Bowel Obstruction: A Case Report, Erica Roma, Kelsey Staudinger, Emmett Mcguire, Katrina Lancaster Shorts

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Acute Myeloid Leukemia With Concurrent Npm1 And Runx1 Mutations, Zhuang Zuo, L Jeffrey Medeiros, C Cameron Yin

Faculty, Staff and Student Publications

NPM1 mutation, as a founding genetic event, cooperates with other gene mutations, such as DNMT3A and FLT3, to promote the development of acute myeloid leukemia. NPM1 mutation, however, has been reported to be mutually exclusive with RUNX1 mutation in acute myeloid leukemia cases. In this study, we analyzed mutation panel testing data from a relatively large cohort of rare AML cases with both NPM1 and RUNX1 mutations. We describe the dynamic process of the emergence of these mutations, as well as molecular genetic features and clinical outcome of these patients. We show that concurrence of both mutations in acute …

Integrated Clinical Genotype-Phenotype Characteristics Of Early T-Cell Precursor Acute Lymphoblastic Leukemia, Matthew T Ye, Yi Wang, Zhuang Zuo, Steliana Calin, Hua He, Zhenya Tang, Elias J Jabbour, Gautam Borthakur, Yizhuo Zhang, Yaling Yang, M James You

Faculty, Staff and Student Publications

Background: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T-ALL with a unique immunophenotype and high treatment failure rate. The molecular genetic abnormalities and their prognostic impact in ETP-ALL patients are poorly understood.

Methods: The authors performed systematic analyses of the clinicopathologic features with an emphasis on molecular genetic aspects of 32 patients with ETP-ALL.

Results: The median age was 43 years (range, 16-71). The blasts were positive for cytoplasmic CD3 and CD7 and negative for CD1a and CD8. Other markers expressed included CD34 (88%), CD33 (72%), CD117 (68%), CD13 (58%), CD5 (partial, 56%), CD2 (38%), …

Membranous Nephropathy In Chronic Lymphocytic Leukemia Responsive To Ibrutinib: A Case Report, Anna-Eve Turcotte, William F Glass, Jamie S Lin, Jan A Burger

Faculty, Staff and Student Publications

Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment involving alkylating agents and fludarabine. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.

Induction Of Thrombotic Thrombocytopenic Purpura By Dengue Virus Infection In A Critical Patient: Role Of Therapeutic Plasma Exchange, Rathindra Nath Biswas, Sudipta Sekhar Das, Anupam Chakrapani, Subrata Sen

Faculty, Staff and Student Publications

Thrombotic thrombocytopenic purpura (TTP) secondary to dengue fever is a very unusual occurrence. Both conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, we present a young lady who suffered dengue fever followed by microangiopathic anemia, thrombocytopenic purpura, and altered sensorium. Investigations revealed microangiopathic hemolysis; there was no evidence of disseminated intravascular coagulation. As soon as, we diagnosed the patient as having TTP, we treated her with serial plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms …

Improved Outcomes With “7+3” Induction Chemotherapy For Acute Myeloid Leukemia Over The Past Four Decades: Analysis Of Swog Trial Data, Megan Othus, Guillermo Garcia-Manero, John E Godwin, James K Weick, Frederick R Appelbaum, Harry P Erba, Elihu H Estey

Faculty, Staff and Student Publications

We have previously shown that complete response (CR) rates and overall survival of patients with acute myeloid leukemia have improved since the 1980s. However, we have not previously evaluated how the length of first CR (CR1) has changed over this time period. To address this, we analyzed 1,247 patients aged 65 or younger randomized to "7+3" arms from five SWOG studies: S8600 (n=530), S9031 (n=98), S9333 (n=57), S0106 (n=301), and S1203 (n=261). We evaluated length of CR1 and survival after relapse from CR1 over the four decades that these studies represent. Both length of CR1 and survival after relapse from …