Mathematical Modeling Of The Transmission And Control Of Foodborne Pathogens And Antimicrobial Resistance At Preharvest,
2011
University of Tennessee - Knoxville
Mathematical Modeling Of The Transmission And Control Of Foodborne Pathogens And Antimicrobial Resistance At Preharvest, Cristina Lanzas, Zhao Lu, Yrjo T. Grohn
Cristina Lanzas
Foodborne diseases are a significant health care and economical burden. Most foodborne pathogens are enteric pathogens harbored in the gastrointestinal tract of farm animals. Understanding the transmission of foodborne pathogens and dissemination of antimicrobial resistance at the farm level is necessary to design effective control strategies at preharvest. Mathematical models improve our understanding of pathogen dynamics by providing a theoretical framework in which factors affecting transmission and the control of the pathogens can be explicitly considered. In this review, we aim to present the principles underlying the mathematical modeling of foodborne pathogens and antimicrobial resistance at the farm level to …
Epidemiological Model For Clostridium Difficile Transmission In Healthcare Settings,
2011
University of Tennessee - Knoxville
Epidemiological Model For Clostridium Difficile Transmission In Healthcare Settings, Cristina Lanzas, Erik Dubberke, Zhao Lu, Kim Reske, Yrjo Grohn
Cristina Lanzas
Objective. Recent outbreaks of Clostridium difficile infection (CDI) have been difficult to control, and data indicate that the importance of different sources of transmission may have changed. Our objectives were to evaluate the contributions of asymptomatic and symptomatic C. difficile carriers to new colonizations and to determine the most important epidemiological factors influencing C. difficile transmission. Design, setting, and patients. Retrospective cohort study of all patients admitted to medical wards at a large tertiary care hospital in the United States in the calendar year 2008. Methods. Data from six medical wards and published literature were used to develop a compartmental …
The Cardiac Atlas Project--An Imaging Database For Computational Modeling And Statistical Atlases Of The Heart,
2011
Touro College
The Cardiac Atlas Project--An Imaging Database For Computational Modeling And Statistical Atlases Of The Heart, Carissa G. Fonseca, Michael Backhaus, David A. Bluemke, Randall D. Britten, Jae Do Chung, Brett R. Cowan, Alan H. Kadish
Office of the President Publications and Research
MOTIVATION: Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies. However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets. The Cardiac Atlas Project (CAP) has established a large-scale database of cardiac imaging examinations and associated clinical data in order to develop a shareable, web-accessible, structural and functional atlas of the normal and pathological heart for clinical, research and educational purposes. A goal of CAP is to facilitate collaborative statistical analysis of regional heart shape …
Spatio-Temporal Modelling Of Malaria Incidence For Evaluation Of Public Health Policy Interventions In Ghana, West Africa,
2011
Edith Cowan University
Spatio-Temporal Modelling Of Malaria Incidence For Evaluation Of Public Health Policy Interventions In Ghana, West Africa, Simon K. Appiah, Ute Mueller, James Cross
Research outputs 2011
Malaria is a major challenge to both the public health and the socio-economic development of Ghana. Major factors which account for this situation include poor environmental conditions and the lack of prevention services. In spite of the numerous intervention measures, the disease continues to be the most prevalent health problem in the country. The risk assessment reports for Ghana were based on household surveys which provide inadequate data for accurate analysis of incidence cases. This poses a serious threat to planning and management for the health care delivery system in Ghana. Malaria transmission varies with geographical location and time (or …
Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract,
2010
University of Texas Graduate School of Biomedical Sciences at Houston
Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract, Suzanne S. Chan
Dissertations & Theses (Open Access)
Colorectal cancer is a complex disease that is thought to arise when cells accumulate mutations that allow for uncontrolled growth. There are several recognized mechanisms for generating such mutations in sporadic colon cancer; one of which is chromosomal instability (CIN). One hypothesized driver of CIN in cancer is the improper repair of dysfunctional telomeres. Telomeres comprise the linear ends of chromosomes and play a dual role in cancer. Its length is maintained by the ribonucleoprotein, telomerase, which is not a normally expressed in somatic cells and as cells divide, telomeres continuously shorten. Critically shortened telomeres are considered dysfunctional as they …
Optimizing Vaccine Allocation At Different Points In Time During An Epidemic,
2010
University of Washington
Optimizing Vaccine Allocation At Different Points In Time During An Epidemic, Laura Matrajt, Ira M. Longini Jr.
UW Biostatistics Working Paper Series
For current pandemic influenza H1N1, vaccine production started in the early summer, and vaccination started in the fall. In most countries, by the time vaccination started, the second wave of H1N1 was already under way. With limited supplies of vaccine, it might be a good strategy to vaccinate the high-transmission groups earlier in the epidemic, but it might be a better use of resources to protect instead the high-risk groups later on. We develop a deterministic epidemic model with two age-groups (children and adults) and further subdivide each age group in low and high risk. We compare optimal vaccination strategies …
Model Or Meal? Farm Animal Populations As Models For Infectious Diseases Of Humans,
2010
Cornell
Model Or Meal? Farm Animal Populations As Models For Infectious Diseases Of Humans, Cristina Lanzas, P Ayscue, R Ivanek, Y T. Grohn
Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences
In recent decades, theory addressing the processes that underlie the dynamics of infectious diseases has progressed considerably. Unfortunately, the availability of empirical data to evaluate these theories has not grown at the same pace. Although laboratory animals have been widely used as models at the organism level, they have been less appropriate for addressing issues at the population level. However, farm animal populations can provide empirical models to study infectious diseases at the population level.
Model Or Meal? Farm Animal Populations As Models For Infectious Diseases Of Humans,
2010
University of Tennessee - Knoxville
Model Or Meal? Farm Animal Populations As Models For Infectious Diseases Of Humans, Cristina Lanzas, P Ayscue, R Ivanek, Y T. Grohn
Cristina Lanzas
In recent decades, theory addressing the processes that underlie the dynamics of infectious diseases has progressed considerably. Unfortunately, the availability of empirical data to evaluate these theories has not grown at the same pace. Although laboratory animals have been widely used as models at the organism level, they have been less appropriate for addressing issues at the population level. However, farm animal populations can provide empirical models to study infectious diseases at the population level.
Using Modeling And Simulation To Evaluate Disease Control Measures,
2010
University of Central Florida
Using Modeling And Simulation To Evaluate Disease Control Measures, Tracy Atkins
Electronic Theses and Dissertations
This dissertation introduced several issues concerning the analysis of diseases by showing how modeling and simulation could be used to assist in creating health policy by estimating the effects of such policies. The first question posed was how would education, vaccination and a combination of these two programs effect the possible outbreak of meningitis on a college campus. After creating a model representative of the transmission dynamics of meningitis and establishing parameter values characteristic of the University of Central Florida main campus, the results of a deterministic model were presented in several forms. The result of this model was the …
