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Articles 3601 - 3630 of 9758

Full-Text Articles in Veterinary Medicine

Establishment Of Cardiac Lineage From Rabbit Embryonic And Induced Pluripotent Stem Cells, Praopilas Phakdeedindan Jan 2017

Establishment Of Cardiac Lineage From Rabbit Embryonic And Induced Pluripotent Stem Cells, Praopilas Phakdeedindan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rabbit is a promising model for studying myocardial infarction as several physiological and pathological conditions are resemble to humans. However, the information on establishment of rabbit pluripotent stem cells (PSC) and differentiation potential especially cardiac differentiation in this species has been limited. This research aimed at establishing and examining in vitro cardiogenesis of rabbit embryonic stem cells (ESC) and rabbit induced pluripotent stem cells (iPSC). In experiment 1, four cell lines of ESC derived from blastocyst stage embryos were cultured and characterized for their pluripotency in terms of gene and immunohistochemistry. They exhibited normal karyotypes (n=44). Embryoid body (EB) formation …

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Development Of Inactivated Mycoplasma Gallisepticum Vaccine In Chickens, Arithat Limsatanun Jan 2017

Development Of Inactivated Mycoplasma Gallisepticum Vaccine In Chickens, Arithat Limsatanun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mycoplasma gallisepticum (MG) is the respiratory pathogen causing chronic respiratory disease (CRD) in poultry. More importantly, MG infection affects the economic losses of poultry industry due to decrease egg production and carcass quality. There are several procedures for MG monitoring and several commercial vaccines to prevent and control the MG infection. In Thailand, MG infection has been the one of major problems of poultry industry. The objectives of this study were to investigate the different molecular techniques for MG monitoring in the poultry farms and to prepare the inactivated vaccine or bacterin with Thai MG strain. There were 3 experiments …

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Comparative Study Of Urinary N-Acetyl-Beta-D-Glucosaminidase Levels, Urinary Glycosaminoglycans And Plasma Glycosaminoglycans Levels In Cats With Feline Idiopathic Cystitis, Jeeranan Benjasiriwan Jan 2017

Comparative Study Of Urinary N-Acetyl-Beta-D-Glucosaminidase Levels, Urinary Glycosaminoglycans And Plasma Glycosaminoglycans Levels In Cats With Feline Idiopathic Cystitis, Jeeranan Benjasiriwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Comparative study was conducted to measure urinary N-acetyl-β-glucosaminidase (NAG), urinary glycosaminoglycans (GAGs) and plasma glycosaminoglycans (GAGs) in cats with feline idiopathic cystitis (FIC). A standard questionnaire was designed to gather information for all cats including signalment, characteristics, environment, type of food and management of the cats’ litter box to evaluate the risk factors for developing FIC. Blood and urine samples were collected from 19 clinically normal cats and 19 aged and sex matched cats with FIC. Concentration of urinary NAG, urinary GAGs and plasma GAGs were measured by colorimetric method. NAG index and GAGs-to-creatinine ratio were calculated. The results demonstrated …

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The Role Of Triarylmethane-34 On Potassium Channel Kca3.1 In Doxorubicin-Induced Feline Kidney Cell Line, Paralee Nantarakchaikul Jan 2017

The Role Of Triarylmethane-34 On Potassium Channel Kca3.1 In Doxorubicin-Induced Feline Kidney Cell Line, Paralee Nantarakchaikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Study involved with potassium channel KCa3.1 blocker (triarylmethane-34; TRAM-34) in doxorubicin (DOX)-induced feline kidney cells was performed. The study was divided into two parts. In part I, subtoxic dose of TRAM-34 in feline kidney cell lines was studied to determine the cytotoxicity of TRAM-34 in feline kidney cells by cytotoxicity assay. In part II, feline kidney cell lines were incubated with appropriate dose and time of TRAM-34 pretreatment for 24 h or 30 min and post-treatment for 24 h condition in DOX-induced cell toxicity. Cytotoxicity assay, apoptosis and necrosis assay and KCa3.1 protein expression were measured. The cytotoxicity results indicated …

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Serological Status Of Pcv2-Infected Swine Herds, Cherdpong Phupolphan Jan 2017

Serological Status Of Pcv2-Infected Swine Herds, Cherdpong Phupolphan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to determine the dynamics of serological and virological profiles against Porcine Circovirus type 2 (PCV2) infection in Thai swine herds using the in-house indirect ELISA and real-time PCR techniques. A total of 10 swine herds in Thailand were divided into two groups according to their clinical history. Group A (n=5) had clinical signs of PCV2, and was routinely vaccinated by PCV2 vaccines with production loss more than 5%. Group B (n=5) had no clinical signs of PCV2 with production loss less than 5%. Group B consisted of two subgroups: PCV2-vaccinated herds (B-Vac, n=2) and non-vaccinated herds (B-non-Vac, …

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Development Of Dna Vaccine Against Porcine Epidemic Diarrhea Virus, Gun Temeeyasen Jan 2017

Development Of Dna Vaccine Against Porcine Epidemic Diarrhea Virus, Gun Temeeyasen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Porcine epidemic diarrhea (PED) is a devastating enteric disease mainly affected to the sucking piglets which causing the severe economic losses in many countries worldwide including Thailand. To date, there have no satisfied commercial vaccine for PED. The clustering system based on the spike gene demonstrated 2 variant of PEDV, classical and pandemic variant, which the difference of these variants may be affected to the protective immunity between them. The objectives of this study were to investigate the genetic diversity of S gene of PEDV in Thailand and evaluate the efficacy of DNA vaccine which developed from Thai PEDV isolate. …

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Development Of Multiplex Rt-Pcr And Metagenomic Analyses Of Canine Infectious Respiratory Disease Complex Associated Viruses In Dogs, Chutchai Piewbang Jan 2017

Development Of Multiplex Rt-Pcr And Metagenomic Analyses Of Canine Infectious Respiratory Disease Complex Associated Viruses In Dogs, Chutchai Piewbang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Canine infectious respiratory disease complex (CIRDC) viruses have been detected in dogs with respiratory illness. The CIRDC is associated with multiple factors depending on host susceptibility, environment and pathogens. Canine influenza virus (CIV), canine parainfluenza virus (CPIV), canine distemper virus (CDV), canine respiratory coronavirus (CRCoV), canine adenovirus type 2 (CAdV-2) and canine herpesvirus 1 (CaHV-1), are all associated with the CIRDC. Environmental factors serve as the one key point for infection. The transmission route can be via community-acquired infection (CAI) or hospital-associated infection (HAI), but the variable factors within these two routes are not well described. Moreover, novel pathogens that …

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Detection And Distribution Of Enterotoxin And Adhesin Genes Of Staphylococcus Pseudintermedius Isolated From Dog, Human, And Environment, Nathita Phumthanakorn Jan 2017

Detection And Distribution Of Enterotoxin And Adhesin Genes Of Staphylococcus Pseudintermedius Isolated From Dog, Human, And Environment, Nathita Phumthanakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

To obtain the information of virulence factors associated with Staphylococcus pseudintermedius pathogenicity, host survival and adaptation, the study of staphylococcal enterotoxin (SE) genes and cell wall-associated (CWA) protein genes in S. pseudintermedius isolates from dogs, humans, and environment were performed. Human methicillin-resistant Staphylococcus pseudintermedius (MRSP) harbored the hightes number of SE genes at 12 out of 17 genes compared to those from dogs at 5 and environmental isolates at 3 gene types. For CWA protein genes or S. pseudintermedius surface proteins (sps), there was no an easy and fast method to detect them. Therefore, this study develop the multiplex PCR …

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Dual Infection Between A Thai Isolate Highly Pathogenic Porcine Reproductive And Respiratory Syndrome Virus And Pandemic H1n1swine Influenza Virus In Weanling Pigs, Nattaphong Sangpratum Jan 2017

Dual Infection Between A Thai Isolate Highly Pathogenic Porcine Reproductive And Respiratory Syndrome Virus And Pandemic H1n1swine Influenza Virus In Weanling Pigs, Nattaphong Sangpratum

Chulalongkorn University Theses and Dissertations (Chula ETD)

After an introduction of pandemic H1N1 swine influenza virus (pdmH1N1 SIV) in the Thai swine farms, mild clinical outcome is observed and its role in porcine respiratory disease complex (PRDC) is questionable. A highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has become endemic in the Thai swine farms. This study was conducted to determine the pathogenicity of the pdmH1N1 SIV when co-infected with a HP-PRRSV. Thirty-two weanling pigs from a free PRRSV, SIV, porcine circovirus type 2 (PCV-2) and Mycoplasma spp. commercial farm were randomly divided into 4 groups: Negative, PRRSV, SIV and Co-infection groups. Pigs in PRRSV …

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Monitoring Of Antibiogram And Resistance Gene Profiles Among Escherichia Coli In Pig Production System, Kittitat Lugsomya Jan 2017

Monitoring Of Antibiogram And Resistance Gene Profiles Among Escherichia Coli In Pig Production System, Kittitat Lugsomya

Chulalongkorn University Theses and Dissertations (Chula ETD)

The antimicrobial resistant (AMR) bacteria in pig farms have been believed as an important source in food chain with public health concern. While some studies suggested transmission of AMR from pigs to humans may occur, but there was still needing to combine high resolution genomic data analysis with systematically collected epidemiological evidence to reconstruct patterns of AMR transmission between pigs and humans. The objectives of this study were to determine the occurrence and characterization the AMR phenotypes against 18 antimicrobials in pig producing system in both cross-sectional from fattening and longitudinal studies from newborn to slaughtering pigs and to evaluate …

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Identification Of Porcine Circovirus Type 3 (Pcv3) In Thailand And Its Associated Syndrome, Roongtham Kedkovid Jan 2017

Identification Of Porcine Circovirus Type 3 (Pcv3) In Thailand And Its Associated Syndrome, Roongtham Kedkovid

Chulalongkorn University Theses and Dissertations (Chula ETD)

Porcine circovirus type 3 (PCV3) is a recently identified swine virus with currently unknown pathogenesis. To date, PCV3 has been found in many countries, indicating the wide spread of the virus. Therefore, there is an urgent need to clarify the detrimental role of PCV3. To better understand how PCV3 might influence the pig industry, various perspectives in swine production cycle should be considered. In this study, firstly, PCV3 was identified for the first time in Thailand. The study also showed that PCV3 has existed in the Thai pig population as early as 2005, suggesting that the virus might have long …

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Immunophenotype, Molecular Diagnosis, Minimal Residual Disease, And Multidrug Resistance Protein Expression In Modified Cop, Modified Chop And Rescue Protocols Of Treated Canine Lymphomas, Sirintra Sirivisoot Jan 2017

Immunophenotype, Molecular Diagnosis, Minimal Residual Disease, And Multidrug Resistance Protein Expression In Modified Cop, Modified Chop And Rescue Protocols Of Treated Canine Lymphomas, Sirintra Sirivisoot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Multicentric lymphoma is the most common hematopoietic tumors in dogs. Both B- or T-lymphocyte clones can originate to lymphoma. A gold standard method to differentiate each lymphocyte lineage is immunohistochemistry (IHC) by detecting specific proteins of B and T cell. A protein marker for T and B cells is CD3 and CD79a, respectively. However, another pan pre B-cell marker is Pax5 or B-cell specific activator protein. It is more specific and sensitive than CD79a because it expresses only in B-cell lymphoma cases. The first purpose of this research was to 1) determine Pax5 expression in canine lymphomas by IHC and …

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Oral Fluid Samples Used For Prrs Diagnosis And Management, Yonlayong Woonwong Jan 2017

Oral Fluid Samples Used For Prrs Diagnosis And Management, Yonlayong Woonwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Porcine reproductive and respiratory syndrome (PRRS) is an economically significant swine disease having a negative impact to the swine industry worldwide. Appropriate management strategies and diagnostic tests are crucial to successfully control PRRS virus (PRRSV). However, the application for oral fluid-based diagnosis has not been evaluated in the Thai farms previously. In this study, pre-extraction methods of oral fluids were evaluated to improve the PCR product yielded. Moreover, the oral fluids utilization for PRRSV monitoring during the gilt acclimatization and farrowing to nursery period was investigated. The results demonstrated that increasing sample volume might be a suitable simple method for …

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Quantitative Microbial Risk Assessment Of Streptococcus Suis Serotype 2 From Pork Consumption, Phrutsamon Wongnak Jan 2017

Quantitative Microbial Risk Assessment Of Streptococcus Suis Serotype 2 From Pork Consumption, Phrutsamon Wongnak

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed at determine prevalence and concentration of Streptococcus suis contamination in pork production chains as well as evaluate the health risk attributable to S. suis serotype 2 from pork consumption in Thailand. In total, 492 pig-to-pork and 480 environmental samples were collected from 4 pork production chains in Bangkok. Besides, total 1,036 pork samples were also collected from traditional and modern trades in Chiangmai, Phayao, Nan, Khonkaen, Mukdahan, Saraburi, Nakhonpathom, and Phang-nga provinces. All samples were enumerated using plate count method. S. suis isolates were confirmed by detecting cps2-j gene, followed by Quellung reaction. A stochastic risk assessment …

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Quantitative Microbial Risk Assessment Of Klebsiella Pneumoniae To Ciprofloxacin From Pork In Bangkok, Rodjana Namkratok Jan 2017

Quantitative Microbial Risk Assessment Of Klebsiella Pneumoniae To Ciprofloxacin From Pork In Bangkok, Rodjana Namkratok

Chulalongkorn University Theses and Dissertations (Chula ETD)

Risk estimates are evaluated by using quantitative microbial risk assessment (QMRA) which is a scientific tool. The methodology can be applied to model of human adverse health effect associated with K. pneumoniae and ciprofloxacin-resistant K. pneumoniae (CRKP) from pork consumption in Bangkok. This study had four phases which were 1) sample collection, 2) bacterial isolation and enumeration, 3) antimicrobial susceptibility test and 4) risk assessment. A total of 378 pork samples from fresh markets were collected from six Bangkok areas which contained Central Bangkok, Eastern Bangkok, Northern Bangkok, Southern Bangkok, Upper Thonburi and Lower Thonburi. The mean prevalence of K. …

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Application Of Autologous Blood-Derived Platelet-Rich Fibrin For Periodontitis Treatment In Dogs, Chatvadee Kornsuthisopon Jan 2017

Application Of Autologous Blood-Derived Platelet-Rich Fibrin For Periodontitis Treatment In Dogs, Chatvadee Kornsuthisopon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Periodontitis is one of the most prevalent inflammatory oral diseases in dog. Non-surgical managements are conventionally performed to obtain healthy oral status. With progressive periodontitis, advanced periodontal surgery and also dental extraction become warranted with major disadvantages of trauma, bleeding, prolonged anesthetic time and hospitalization, and wound healing impairment. Hence, use of platelet-rich fibrin has been studied and considered one of the novel approaches to augment in periodontitis management. This study aimed to evaluate the efficacy of autologous blood-derived platelet-rich fibrin in an aspect of periodontitis treatment in a canine models. In this study, the experiment was done at maxillary …

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The Effect Of Dexmedetomidine In Combination With Pethidine On Isoflurane Minimum Alveolar Concentration For Canine Antinociception, Kanjana Vinyunantakul Jan 2017

The Effect Of Dexmedetomidine In Combination With Pethidine On Isoflurane Minimum Alveolar Concentration For Canine Antinociception, Kanjana Vinyunantakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The effects of dexmedetomidine combined with pethidine on the minimum alveolar concentration (MAC) of isoflurane and cardiorespiratory variables in dogs were evaluated in thirty client-owned, healthy adult male dogs scheduled for castration at the Small Animal Teaching Hospital, Faculty of Veterinary Science, Chulalongkorn University. The dogs were allocated into Group 1 (n=6) receiving sterilized water for injections (placebo) as a negative control group, Group 2 (n=12) receiving 5 µg kg-1 of dexmedetomidine IM as a positive control group, and, Group 3 (n=12) receiving 5 µg kg-1 of dexmedetomidine and 5 mg kg-1 of pethidine IM. At 15 minutes after injection …

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Computed Tomography Appearance Of Intra-Thoracic Lymph Nodes In Normal Cats, Ninlawan Thammasiri Jan 2017

Computed Tomography Appearance Of Intra-Thoracic Lymph Nodes In Normal Cats, Ninlawan Thammasiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study of the appearance of intra-thoracic lymph nodes in the cat observed on the computed tomography which divided into 3 parts as following; the feline soft cadaver, clinically normal cats and the retrospective study of the feline patients. The result showed that the computed tomographic images of feline soft tissue cadavers could not detected any intra-thoracic lymph nodes. However, based on the study on 30 clinically normal cats which were mixed breed, age ranging from 4 months to 11 years old, body weight between 1.5 to 5.7 kilogram, 12 male cats (6 castrated) and 18 female cats (10 spayed) …

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Intra-Articular Characteristics Of Dogs With Medial Patellar Luxation, Sethapong Jahrupatrakorn Jan 2017

Intra-Articular Characteristics Of Dogs With Medial Patellar Luxation, Sethapong Jahrupatrakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study investigated the relationship of degree of patellar luxation of dogs with joint radiography, intra-articular degenerative change of the stifle with medial patellar luxation (MPL), histopathologic change, and biomarker index. Thirty-eight stifles were divided into four groups: normal stifle joints (4), grades 2 (13), 3 (12), and 4 (9) MPL. Demographic data, lameness score, and degree of patellar luxation of all dogs were assessed and recorded. Radiographs were taken to assess osteophyte formation. Synovial tissue was collected for microscopic evaluation differential cell counts, and cytokines measurement. Stifle joints with MPL were scored during surgical correction. All observed data were …

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Comparative Surgical Treatment Of Elongated Soft Palate In Brachycephalic Dogs Using The Ultrasonic Scalpel And The Conventional Incisional Techniques, Sunisa Thunyodom Jan 2017

Comparative Surgical Treatment Of Elongated Soft Palate In Brachycephalic Dogs Using The Ultrasonic Scalpel And The Conventional Incisional Techniques, Sunisa Thunyodom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Brachycephalic airway obstruction syndrome (BAOS) is life threatening condition in brachycephalic dogs. Surgical correction of primary disorders including elongated soft palate and stenotic nares is indicated in all cases. Aim of this study was to compare the use of the ultrasonic scalpel with the conventional incision technique for staphylectomy. Twenty dogs with BAOS enrolled in this study were randomly assigned into conventional (N=10) or ultrasonic group (N=10). Respiratory score was evaluated and recorded prior to surgery. Staphylectomy time and bleeding were recorded. Respiratory, postoperative complication and pain scores were evaluated and recorded at days 1, 3, 7, 14 and 28 …

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การประเมินทางพันธุกรรมของลักษณะการอยู่รอดของลูกสุกรที่สัมพันธ์กับขนาดครอกและน้ำหนักแรกเกิดรายตัว, ทิตยา วรวัฒนธรรม Jan 2017

การประเมินทางพันธุกรรมของลักษณะการอยู่รอดของลูกสุกรที่สัมพันธ์กับขนาดครอกและน้ำหนักแรกเกิดรายตัว, ทิตยา วรวัฒนธรรม

Chulalongkorn University Theses and Dissertations (Chula ETD)

ประเมินค่าพารามิเตอร์ทางพันธุกรรมของลักษณะการอยู่รอดของลูกสุกรแรกเกิด (PSB) และการอยู่รอดของลูกสุกรก่อนหย่านม (PSW) ร่วมกับลักษณะน้ำหนักแรกเกิดรายตัว (IBW) และลักษณะขนาดครอก (LS) จากข้อมูลการอยู่รอดของลูกสุกรจำนวน 14,389 บันทึก (1,413 ครอก) จากแม่สุกร 705 ตัว ข้อมูลการอยู่รอดของลูกสุกรพันธุ์แลนด์เรซ ยอร์กเชียร์ และดูร็อก บันทึกในฟาร์มที่เลี้ยงสุกรในโรงเรือนเปิดที่ไม่มีระบบระบายความร้อน เป็นข้อมูลของลูกสุกรที่เกิดระหว่างปี พ.ศ. 2549 ถึง 2560 ประมาณค่าองค์ประกอบความแปรปรวนด้วยวิธี Gibbs sampling สำหรับลักษณะแบบไบนารี่และวิธี Average Information Restricted Maximum Likelihood (AIREML) สำหรับลักษณะแบบต่อเนื่อง ผลการศึกษาพบว่า ลำดับท้อง ระยะเวลาการอุ้มท้องของแม่สุกร และกลุ่มของโรงเรือน-ปี-เดือนที่ลูกสุกรเกิด มีอิทธิพลต่อ PSB, PSW และ IBW อย่างมีนัยสำคัญทางสถิติ (p<0.05) นอกจากนี้ PSW และ IBW ยังได้รับอิทธิพลจากพันธุ์ และเพศของสุกร (p<0.05) สำหรับ LS พบว่าขึ้นอยู่กับอิทธิพลของพันธุ์ของลูกสุกร และกลุ่มของโรงเรือน-ปี-เดือนที่ลูกสุกรเกิด (p<0.05) ค่าอัตราพันธุกรรมของ PSB, PSW, IBW และ LS มีค่าเท่ากับ 0.23 ± 0.02, 0.36 ± 0.03, 0.38 ± 0.03 และ 0.22 ± 0.01 ตามลำดับ ค่าสหสัมพันธ์ทางพันธุกรรมระหว่าง IBW กับ PSB และ PSW มีค่าสูงเท่ากับ 0.77 ± 0.05 และ 0.85 ± 0.05 ตามลำดับ ในขณะที่ค่าสหสัมพันธ์ทางพันธุกรรมระหว่าง PSB กับ PSW มีค่าปานกลางเท่ากับ 0.69 ± 0.14 สำหรับลักษณะรายครอกพบว่าค่าสหสัมพันธ์ทางพันธุกรรมระหว่าง LS กับลักษณะเปอร์เซ็นต์การอยู่รอดของลูกสุกรแรกเกิด (%PSB) เปอร์เซ็นต์การอยู่รอดของลูกสุกรก่อนหย่านม (%PSW) และน้ำหนักแรกเกิดเฉลี่ย (ABW) มีค่าเป็นลบเท่ากับ -0.16 ± 0.03 -0.64 ± 0.02 และ -0.99 ± 0.001 ตามลำดับ จากค่าสหสัมพันธ์ทางพันธุกรรมแสดงให้เห็นว่า การคัดเลือกเพื่อเพิ่มน้ำหนักแรกเกิดของลูกสุกรอาจมีผลทำให้ PSB และ PSW เพิ่มขึ้น แต่หากคัดเลือกเพื่อเพิ่ม LS จะมีผลทำให้ %PSB, %PSW และ ABW ลดลง

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Development Of Mouse Models For The Study Of Zika Virus Pathogenesis And Antibody Response, Anna Beatriz Kawiecki Jan 2017

Development Of Mouse Models For The Study Of Zika Virus Pathogenesis And Antibody Response, Anna Beatriz Kawiecki

LSU Master's Theses

After the emergence of Zika virus (ZIKV) in the Americas in 2015, ZIKV infection was associated for the first time since its discovery with severe symptoms in both adults and congenital cases, including neurological, ocular, and developmental manifestations. Previous ZIKV circulation in Africa and Southeast Asia has been characterized by mild symptoms and small-scale case-counts. It is unclear whether the unprecedented size and severity of the ZIKV outbreak in the Americas are the consequence of a change in the virus, different background flaviviral immunity in the population, or a reporting issue. In addition, ZIKV has been shown to be transmitted …

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Evaluation Of Broad Anti-Herpesviral Activity With Α-Hydroxytropolones, Shannon David Dehghanpir Jan 2017

Evaluation Of Broad Anti-Herpesviral Activity With Α-Hydroxytropolones, Shannon David Dehghanpir

LSU Master's Theses

Herpesviruses are ubiquitous in animals and cause economic losses concomitant with many diseases, including upper respiratory disease, keratitis, abortion, neonatal death, and neurologic disease. The majority of the domestic animal herpesviruses are within the subfamily Alphaherpesvirinae, along with the prototypical human herpes simplex virus 1 (HSV-1). Suppression of HSV-1 replication has been reported with α-hydroxytropolones (αHTs), which are aromatic ring compounds that have broad bioactivity due to potent chelating activity. It is postulated that αHTs inhibit enzymes within the nucleotidyltransferase superfamily (NTS), similarly structured enzymes that require divalent cations for nucleic acid cleavage activity. One potential herpesviral target includes the …

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The Lowdown Of Out-Of-Competition Testing: What The Rmtc Isn't Telling Us About Its Proposed Regulations, Clara Fenger, Tanya Boulmetis, Kim Brewer, Thomas Tobin Dec 2016

The Lowdown Of Out-Of-Competition Testing: What The Rmtc Isn't Telling Us About Its Proposed Regulations, Clara Fenger, Tanya Boulmetis, Kim Brewer, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

No abstract provided.

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Allelic Variation In Cxcl16 Determines Cd3+ T Lymphocyte Susceptibility To Equine Arteritis Virus Infection And Establishment Of Long-Term Carrier State In The Stallion, Sanjay Sarkar, Ernest Bailey, Yun Young Go, R. Frank Cook, Ted Kalbfleisch, John E. Eberth, R. Lakshman Chelvarajan, Kathleen M. Shuck, Sergey Artiushin, Peter J. Timoney, Udeni B. R. Balasuriya Dec 2016

Allelic Variation In Cxcl16 Determines Cd3+ T Lymphocyte Susceptibility To Equine Arteritis Virus Infection And Establishment Of Long-Term Carrier State In The Stallion, Sanjay Sarkar, Ernest Bailey, Yun Young Go, R. Frank Cook, Ted Kalbfleisch, John E. Eberth, R. Lakshman Chelvarajan, Kathleen M. Shuck, Sergey Artiushin, Peter J. Timoney, Udeni B. R. Balasuriya

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of horses and other equid species. Following natural infection, 10–70% of the infected stallions can become persistently infected and continue to shed EAV in their semen for periods ranging from several months to life. Recently, we reported that some stallions possess a subpopulation(s) of CD3+ T lymphocytes that are susceptible to in vitro EAV infection and that this phenotypic trait is associated with long-term carrier status following exposure to the virus. In contrast, stallions not possessing the CD3+ T …

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Assessing Readiness For Clinical Practice: Students’ Perspectives Of Their Veterinary Curriculum, L. Chris Sanchez, Alison Kwiatkowski, Jeff Abbott, Dana N. Zimmel, Linda S. Behar-Horenstein Dec 2016

Assessing Readiness For Clinical Practice: Students’ Perspectives Of Their Veterinary Curriculum, L. Chris Sanchez, Alison Kwiatkowski, Jeff Abbott, Dana N. Zimmel, Linda S. Behar-Horenstein

The Qualitative Report

Studies describing the effectiveness of a veterinary curriculum from the student perspective are currently sparse. The overall purpose of this investigation was to describe students’ perceived preparedness for clinical practice. Three focus group meetings with fourth year veterinary students were conducted. Data were open-coded and categorized to identify themes. Four main themes emerged: Challenging communications, Un/appreciating curricular experiences, Documenting demands impede case involvement, and Hungering for timely, effective feedback. Overall students felt comfortable talking to clients about medicine but less comfortable discussing euthanasia or money; they appreciated the split clinical curriculum but questioned the value of the 1st/2nd year courses; …

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Animal Health Matters, Jane Hennings, Larry Holler, Russ Daly, Linda Fawcett Dec 2016

Animal Health Matters, Jane Hennings, Larry Holler, Russ Daly, Linda Fawcett

Animal Health MATTERS Newsletter

[Page] 1 SDSU and SHIC Study on Senecavirus Offers Keen Insights
[Page] 2 Director's Message: Innovation in the Laboratory and Being Proactive in the Protection of Animal Health
[Page] 2 Bovine Abortion-Sample Submission Guidelines
[Page] 3 South Dakota One Health Meeting Covers Bacterial Zoonotic Disease
[Page] 3 Small Ruminant, Poultry Serology Offerings Expanded at the ADRDL
[Page] 4 Molecular Diagnostics Section Evolves, Adds New Tests
[Page] 5 Recent PCR tests Added by ADRDL
[Page] 6 New Employees
[Page] 7 ADRDL Continues Their Critical Role Supporting Animal Exports

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Evaluation Of Several Pre-Clinical Tools For Identifying Characteristics Associated With Limb Bone Fracture In Thoroughbred Racehorses, Anthony Nicholas Corsten Dec 2016

Evaluation Of Several Pre-Clinical Tools For Identifying Characteristics Associated With Limb Bone Fracture In Thoroughbred Racehorses, Anthony Nicholas Corsten

Open Access Theses

Catastrophic skeletal fractures in racehorses are devastating not only to the animals, owners and trainers, but also to the perception of the sport in the public eye. The majority of these fatal accidents are unlikely to be due to chance, but are rather an end result failure from stress fractures. Stress fractures are overuse injuries resulting from an accumulation of bone tissue damage over time. Because stress fractures are pathological, it is possible that overt fractures can be predicted and prevented. In this study, third metacarpals (MC3) from 33 thoroughbred racehorse comprised of 8 non-fractured controls and 25 horses that …

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2016 Study Of Current Conditions Of Kentucky County Animal Shelters And Degree Of Compliance With Kentucky Animal Shelter Laws, Cynthia L. Gaskill, Rachel Cullman-Clark, Liane Lachiewicz, Matt Lamarre, Brad Rohleder, Kristin Sadler, Rachel Sparling, Craig N. Carter Dec 2016

2016 Study Of Current Conditions Of Kentucky County Animal Shelters And Degree Of Compliance With Kentucky Animal Shelter Laws, Cynthia L. Gaskill, Rachel Cullman-Clark, Liane Lachiewicz, Matt Lamarre, Brad Rohleder, Kristin Sadler, Rachel Sparling, Craig N. Carter

Veterinary Science Reports

Kentucky’s county animal shelter conditions have not been studied for over 20 years. Major goals of this study were to assess current conditions in Kentucky’s county shelters and determine the degree of compliance with Kentucky shelter laws. Additional information was gathered to determine the major problems and needs identified by shelter personnel and researchers. Data was used to determine if additional state funds or refinements and additions to current laws are warranted to ensure humane care of animals in Kentucky’s county shelters. Researchers consisted of a group of 6 veterinary students who traveled to all Kentucky county animal shelters. Ninety …

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Chikungunya Virus Infection In Balb/C And Icr Mouse Models, Sonthaya Tiawsirisup, Ranida Tuanudom, Nichapat Yurayart Dec 2016

Chikungunya Virus Infection In Balb/C And Icr Mouse Models, Sonthaya Tiawsirisup, Ranida Tuanudom, Nichapat Yurayart

The Thai Journal of Veterinary Medicine

Chikungunya virus (CHIKV) infection is an emerging or re-emerging infectious disease found in several countries. The ecology of this virus involves humans, reservoir animals, and mosquito vectors. Two experiments were conducted in this study. Blood samples were collected and tested for CHIKV infection by using immunocytochemistry (ICC) staining and reverse transcription polymerase chain reaction (RT-PCR). For the first experiment, BALB/c mice were inoculated with 106.3 CID50/mouse. Mean CHIKV titers in the BALB/c mice were 103.3, 101.5, 102.3, and 102.3 CID50/ml of serum on day 1 to day 4 post inoculation (PI), respectively. For the second experiment, there were two groups …

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