Veterinary Medicine Commons^™

Evaluation Of The Hematological And Serum Protein Profiles Of Blood Parasite Coinfection In Naturally Infected Dogs, Sariya Asawakarn, Sirakarnt Dhitavat, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

Canine vector-borne diseases (CVBDs) are prevalent worldwide, including Thailand. Vectors can transmit more than one pathogen, and coinfections between blood parasites and/or filariae have been reported. Pathogenesis may affect the health status of infected dogs. Hematological, blood chemistry, and serum protein profile abnormalities can be used to screen for underlining causes of CVBDs. The aim of this study is to analyze the hematological and serum protein profiles as well as CRP in CVBD coinfection cases. In this study, 22 blood parasite coinfection cases are examined and classified into two groups: blood parasite coinfection (group 1: n = 16) and blood …

A Seroepidemiological Investigation On Major Viral And Bacterial Pathogens In Small-Scale Chicken Flocks In The Mekong Delta Region Of Vietnam, Nguyen Thi Bich Van, Nguyen Van Cuong, Nguyen Thi Nhung, Nguyen Thi Phuong Yen, Le Vy, Bach Tuan Kiet, Nguyen Van Hoang, Vo Be Hien, Ho Thi Viet Thu, Niwat Chansiripornchai, Guy E. Thwaites, Marc Choisy, Juan Carrique-Mas

The Thai Journal of Veterinary Medicine

Small-scale commercial chicken farming represents an important source of income to rural households in the Mekong Delta region of Vietnam. A wide range of vaccines are currently administered to flocks, but is not based on empirical knowledge on pathogen circulation. We collected serum samples and vaccination data from a random sample of 267 small-scale native chicken flocks in Dong Thap to determine serological profiles by ELISA against 8 pathogens: Avian Influenza (AI), Chicken Anaemia virus (CAV), Infectious Bursal Disease (IBD) virus, Infectious Bronchitis virus (IBV), Newcastle Disease virus (NDV), O. rhinotracheale (ORT), P. multocida (PM) and M. gallisepticum (MG). The …

Bacterial Counts And Prevalence Of Salmonella And Extended-Spectrum Β-Lactamase Producing Bacteria In Prawn And Shrimp Imported Into Japan, Yukio Morita, Su Myo Thwe, Satoshi Morita, Sumalee Boonmar

The Thai Journal of Veterinary Medicine

The prevalence of Non-typhoidal Salmonella (NTS) and extended-spectrum β-lactamase (ESBL) producing bacteria was assessed in samples of imported prawn and shrimp obtained from retail markets in Japan. The overall prevalence of NTS and ESBL producing bacteria was 4%, and 14%, respectively. We identified 4 NTS isolates, including S. enterica subspecies salamae, and 3 serovars of S. enterica subspecies enterica, including Weltevreden, Abony, and Stanley. ESBL producing bacteria were isolated from 14 of 100 samples, thirteen of which harbored Stenotrophomonas maltophilia and that harbored Chryseobacterium indologenes. Among the S. maltophilia-positive samples, six had been imported from India, five samples came from …

Activation-Induced Cell Death Of Nk Cells In Canine Atopic Dermatitis Revealed By Droplet-Sequencing Data Of Peripheral Blood Mononuclear Cells, Natthaporn Kuendee, Denis Puthier, Catherine Nguyen, Kaj Chokeshaiusaha

The Thai Journal of Veterinary Medicine

Atopic dermatitis (AD) is a mutual allergic skin disease between humans and dogs manifesting varieties of similarities in their immune responses to the disease. Recently, activation-induced cell death (AICD) of NK cells was acknowledged as a novel disrupted immunoregulation in human AD. To gain insight into its plausible commotion in canine AD, NK cell expression profiles extracted from PBMC Drop-Sequencing (Drop-Seq) data of normal and AD dogs were analyzed along with human NK cell profiles of healthy and AD patients previously reported. According to the results, a total of 2,689 differentially expressed genes (DEG) between healthy and AD conditions (P≤0.0001) …

Estimation Of Percentage Of Morbidity And Mortality Due To Avian Influenza (H9) At Commercial Poultry Layer Farms Of Lahore, Afeefa Shafiq, Aisha Arshad, Zafar-Ul-Ahsan Qurashi, Zain Khalid, Noor Ul Huda, Muhammad Noman, Muhammad Ilyas, Hamad Bin Rashid, Asim Khalid Mehmood, Saima Hasan, Quratul Ain, Sobia Amir, Sheraz Shahid, Shakera Sadiq, Mamoona Chaudhry

The Thai Journal of Veterinary Medicine

The current study was aimed at the estimation of the percentage of morbidity, mortality and potential risk factors associated with the avian influenza virus (AIV) H9 at commercial layer farms of District Lahore, Pakistan. Samples collected included blood samples and tracheal/oropharyngeal swabs from sick birds and tissue samples (trachea & lungs) of dead birds. Sera were tested by Hemagglutination Inhibition Test (HI) using the positive control antigen of H9. Tracheal/oropharyngeal swabs and tissue samples were processed by real-time RT-PCR (rRT-PCR). Out of 50 layer farms, 16 farms were positive for antibody titer against the AIV H9. Out of a total …

Subtyping Of Blastocystis Infection In Common Quails (Coturnix Coturnix) In Xinxiang City Of China, Xuehan Liu, Xuefeng Yang, Zhixing An, Yaming Ge, Rongjun Wang, Haiju Dong, Huili Zhu

The Thai Journal of Veterinary Medicine

Blastocystis is a unicellular anaerobic intestinal protist primarily of various animal species worldwide, and has been reported to inhabit humans as well. Blastocystis infections and subtype identification have been documented in China, although infections by the protist in quail remain unknown. Herein, a total of 128 fecal samples were collected from captive quails (Coturnix coturnix) in Xinxiang city, central China, and tested for the prevalence and genetic characteristics of Blastocystis. Ten (7.8%) samples were positive by PCR amplification and sequencing the barcode regeion of the SSU rRNA gene. Sequence analysis showed that ST7 was the predominant subtype with max identity …

Successful Management Of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia With Mycophenolate Mofetil And Prednisolone Following Surgical Resection In A Cat, Min-Soo Kim, Keon Kim, Gwang-Hyun Lee, Cheol-Hyun Kim, Seo-Lin Jang, Guk-Hyun Suh, Chang-Min Lee

The Thai Journal of Veterinary Medicine

A 1-year-old castrated male Ragdoll who showed a series of vomiting and had reduced appetite presented to a local animal hospital. Hyperthermia and tachypnea were observed in physical examination, and leukocytosis was detected in hematological examination. Abdominal ultrasonography revealed an intramural mass with irregular echogenicity extending from the pylorus to the duodenum and loss of intestinal wall layer with regional lymph node enlargement. After exploratory laparotomy for biopsy and symptomatic alleviation, histopathological evaluation revealed densely infiltrated eosinophils within the branching and anastomosing trabecular pattern of collagen by several spindle-shaped cells. Finally, the patient was diagnosed with feline gastrointestinal eosinophilic sclerosing …

A Case Of Acquired Idiopathic Megaoesophagus In A Dog: The Use Of Sildenafil As Treatment, Yeremia Yobelanno Sitompul, Willy Moris Nainggolan, Bradley O’Hagan

The Thai Journal of Veterinary Medicine

Acquired idiopathic megaoesophagus in dogs is rarely found in Indonesia. In this case report, a dachshund dog was presented with a history of vomiting after eating. Clinical examination, complete blood count, kidney, and liver tests identified only minor dehydration. On observation of the dog after eating, the sign reported as vomiting was confirmed as regurgitation. Radiography and contrast studies identified a significantly dilated oesophagus. With an absence of other clinical abnormalities, the dog was diagnosed with idiopathic megaoesophagus and prescribed treatment with sildenafil twice daily at 0.75mg/kg for five days, along with postural management of feeding. Treatment resulted in cessation …

Surgical Correction Of Bilateral Soft Palate Hypoplasia Using Soft Palate Hinged-Flap And Bilateral Buccal Mucosal Rotation Flaps In A Dog, Wongsuda Yala, Chaiyasit Suksawakhon, Wanchart Yippaditr, Julaluk Kruafu

The Thai Journal of Veterinary Medicine

A 3-month-old 13 kg intact female American pit bull dog was presented with a history of chronic sneezing, nasal discharge, oronasal reflux, and aspiration with food and water. Oral examination under general anesthesia revealed a shortened soft palate extended caudally from the hard palate. As a result, bilateral soft palate hypoplasia was diagnosed. The dog was operated upon by using soft palate hinged-flap combined with bilateral buccal mucosal rotation flaps techniques. Ten days after surgery, the dog was eating well and the nasal discharge was resolved. Oral examination showed that the new soft palate had healed well. A follow-up after …

Successful Treatment Of Demodicosis Due To Demodex Cati In A Cat Using Spot – On Formulation Of Fluralaner, Piyarat Chansiripornchai, Niwat Chansiripornchai

The Thai Journal of Veterinary Medicine

This case report describes the successful use of fluralaner in treating demodicosis caused by Demodex cati in a cat. A 4.2 kg 10 – year – old spayed female Siamese short – haired cat was presented with a 5 – month history of severe dermatitis. The cat had been treated at previous animal hospitals with a variety of drugs such as antimicrobials, glucocorticoids and ectoparasiticides on separate occasions but the clinical signs remained severe. Microscopic examination of skin samples revealed the presence of D. cati. The cat was treated with a single dose of spot – on formulation of fluralaner …

Diagnosis Of Toothpick-Induced Chronic Intramuscular Abscess Using Fistulography In A Dog, Pei-Chun Hsieh, Kuan-Sheng Chen, Wei-Ming Lee, Wei-Yau Shia

The Thai Journal of Veterinary Medicine

A ten-year-old, 16.7 kg mixed-breed dog presented with chronic lameness and delayed healing of discharging wounds in the right pelvic limb following a puncture injury for approximately 6 months. Debridement surgery had been performed, but the tissue infection was persistent. Plain radiographic examination showed neither increased soft tissue opacity nor foreign body (FB) existence near the discharging wound of the right pelvic limb. After the second debridement surgery, closed drainage tubes were placed, and susceptible antibiotic therapy was prescribed in an attempt to control the persistent infection, but the fluid draining from the wound was still purulent. Therefore, fistulography was …

Calcinosis Circumscripta Associated With Surgical Site Of The Right Femur In A Belgian Sheepdog: Imaging Diagnosis And Surgical Treatment, Naparee Srisowanna, Kanittha Darawiroj, Somporn Techangamsuwan, Nan Choisunirachon

The Thai Journal of Veterinary Medicine

A nine-month, intact male, Belgian Sheepdog was presented to the hospital due to a history of rapidly progressive growth of a solitary calcified mass at the right hip area. The dog has a history of an internal implant fixation for the right femoral fracture at 5 months ago. Physical examination revealed a dome shape, hard consistency, non-movable, painless, subcutaneous mass with size 5x6 cm. Radiography and ultrasonography showed a well-circumscribed, calcified soft tissue mass at craniolateral aspect of the right proximal femur without cortical bone reaction. Computed tomography (CT) scan was not performed in this case because metal fixation was …

Antifungal Activity Of Green Sulfur Nanoparticles Synthesized Using Catharanthus Roseus Extract Against Microsporum Canis, Akarapon Chantongsri, Patchara Phuektes, Glenn N. Borlace, Jareerat Aiemsaard

The Thai Journal of Veterinary Medicine

Elemental sulfur has been used for a long time to treat superficial mycoses in both medical and veterinary practices, but effective treatment requires high concentrations of sulfur. Encapsulation of sulfur in nanoparticles can potentially allow the delivery of high concentrations of sulfur to infections. Sulfur nanoparticles were synthesized from Catharanthus roseus extract and sodium sulfide at various pH conditions (4, 6, and 7). Particle identification and characterizations were performed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), and dynamic light scattering analysis. Broth microdilution and time-kill assays were used to determine the antifungal effect against Microsporum canis DMST29297. The …

Effects Of Senktide On Kisspeptin/Neurokinin B/Dynorphin Peptide Mrna Expression And Luteinizing Hormone Secretion In Fasted Female Goats: A Pilot Study, Pongpak Intaravichai, Somchai Sajapitak, Sittipoj Krasaesub, Tatchapon Mongkonwattanaporn, Theera Rukkwamsuk

The Thai Journal of Veterinary Medicine

This pilot study aimed to examine KNDy peptide mRNA (Kiss1/Tac3/Pdyn) expression and to determine the effects of peripheral neurokinin 3 receptor agonist (senktide) administration on the ARC Kiss1 mRNA expression and LH secretion that was affected by fasting condition in intact female goats during the luteal phase of the estrus cycle. During the mid to late luteal phase of the estrus cycle, the goats were randomly divided into three groups; the fed group (n = 2), which was fed ad libitum throughout the experimental period, the fasted group (n = 2) and the fasted + senktide group (n = 2) …

Computed Tomographic Appearance Of Bladder And Vaginal Leiomyoma In Dog: Case Report, Sirirat Phantharangsi, Sukanya Maneein, Sekkarin Ploypetch

The Thai Journal of Veterinary Medicine

An 18-year-old, female Shih Tzu dog was presented at Prasu-Arthorn Animal Hospital, Faculty of Veterinary Science, Mahidol University with the clinical signs of abdominal enlargement, constipation and urine incontinence. The survey abdominal radiographs demonstrated only a caudal large oval soft tissue abdominal mass and abdominal ultrasonography was suggested to indicate the mass origin. However, ultrasonographic finding did not identify the mass location and tissue invasiveness so computed tomography (CT) was requested. The CT result revealed that the mass was a mixed heterogenous attenuating and fluid attenuating mass (8.56 x 5.47 x 6.72 cm) at the uterine body and involved the …

Deterring Non-Target Birds From Toxic Bait Sites For Wild Pigs, Nathan P. Snow, Joseph M. Halseth, Justin A. Foster, Michael J. Lavelle, Justin W. Fischer, Michael P. Glow, Ingrid A. Messer, Seth M. Cook, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Toxic baiting of wild pigs (Sus scrofa) is a potential new tool for population control and damage reduction in the US. Field trials testing a prototype toxic bait (HOGGONE 2 containing 5% sodium nitrite [SN]), though, revealed that wild pigs spilled small particles of toxic bait outside of bait stations which subsequently created hazards for non-target species that consumed those particles, primarily passerine birds. To deter non-target birds from consuming particles of spilled bait, we tested four deterrents at mock bait sites (i.e., baited with bird seed) in north-central Colorado, USA during April–May 2020. We found a programable, inflatable deterrent …

Towards A More Comprehensive Understanding Of Wild Pig (Sus Scrofa) Impacts On Agricultural Producers: Insights From A Texas Case Study, Keith M. Carlisle, Nicole Didero, Sophie Mckee, Julie Elser, Stephanie A. Shwiff

United States Department of Agriculture Wildlife Services: Staff Publications

This research investigates the impacts of invasive wild pigs (Sus scrofa Linneaus) on agricultural producers in Texas, with the aim of identifying and describing all categories of wild pig impacts and quantifying the extent of producers’ over- or underestimation of their total wild pig-related costs in 2018, as compared to calculations based upon data subsequently provided by the producers about individual wild pig-related costs and losses. Based on interviews with 23 producers in 16 Texas counties, we identified more than 20 discrete categories of negative impacts and negligible positive impacts associated with wild pigs. Among them were categories that have …

Landscape Transformations Produce Favorable Roosting Conditions For Turkey Vultures And Black Vultures, Jacob E. Hill, Kenneth F. Kellner, Bryan M. Kluever, Michael L. Avery, John S. Humphrey, Eric A. Tillman, Travis L. Devault, Jerrold L. Belant

United States Department of Agriculture Wildlife Services: Staff Publications

Recent increases in turkey vulture (Cathartes aura) and black vulture (Coragyps atratus) populations in North America have been attributed in part to their success adapting to human-modified landscapes. However, the capacity for such landscapes to generate favorable roosting conditions for these species has not been thoroughly investigated. We assessed the role of anthropogenic and natural landscape elements on roosting habitat selection of 11 black and 7 turkey vultures in coastal South Carolina, USA using a GPS satellite transmitter dataset derived from previous research. Our dataset spanned 2006–2012 and contained data from 7916 nights of roosting. Landscape …

Reproductive Success Of Captive-Reared Allegheny Woodrats (Neotoma Magister) Released Into Genetically Depauperate Populations, Miracle M. Davis, Timothy J. Smyser, Scott A. Johnson, Joseph Duchamp, Jeffery L. Larkin, Robert K. Swihart, Jacqueline M. Doyle

United States Department of Agriculture Wildlife Services: Staff Publications

Habitat fragmentation and degradation have led to a proliferation of small and isolated populations that are vulnerable to genetic erosion. Reduction in habitat and concomitant declines in population connectivity can expediate the collapse of species that exist as natural metapopulations. In recent years, Allegheny woodrats (Neotoma magister) have experienced local extirpations and declines in genetic diversity across their range due to disease-related mortality, reduced food availability, and disruption of connectivity among subpopulations. In response, we developed a captive-breeding program to facilitate genetic management of isolated woodrat populations in Indiana. Between 2010 and 2012, 27 captive-reared individuals were released to four …

Economic Estimates Of Wild Hog (Sus Scrofa) Damage And Control Among Young Forest Plantations In Alabama, Micah Fern, Rebecca Barlow, Chris Slootmaker, John Kush, Stephanie Shwiff, Larry Teeter, Jim Armstrong

United States Department of Agriculture Wildlife Services: Staff Publications

Operating as ecological engineers, the increased distribution and abundance of wild hogs (Sus scrofa) has caused considerable socio-economic impacts. The international scope of economic research providing wild hog damage estimates are often confined to agricultural crops, while damage estimates among forest plantations are lacking. In Alabama, private landowners hold the majority of timberland acreage and are less equipped to absorb financial losses from wild hog damage than their industrial counterparts. A survey was conducted to estimate the economic impact of wild hogs, namely costs of damage and control, to privately owned forestlands. The survey was distributed in the …

Sex And Nest Type Influence Avian Blood Parasite Prevalence In A High-Elevation Bird Community, Marina D. Rodriguez, Paul F. Doherty, Antoinette J. Piaggio, Kathryn P. Huyvaert

United States Department of Agriculture Wildlife Services: Staff Publications

Background: The prevalence of avian haemosporidian parasites and the factors influencing infection in the Colorado Rocky Mountains are largely unknown. With climate change expected to promote the expansion of vector and avian blood parasite distributions, baseline knowledge and continued monitoring of the prevalence and diversity of these parasites is needed.

Methods: Using an occupancy modeling framework, we conducted a survey of haemosporidian parasite species infecting an avian community in the Colorado Rocky Mountains in order to estimate the prevalence and diversity of blood parasites and to investigate species-level and individual-level characteristics that may influence infection.

Results: We estimated the prevalence …

Responses Of Turkey Vultures To Unmanned Aircraft Systems Vary By Platform, Morgan B. Pfeiffer, Bradley F. Blackwell, Thomas W. Seamans, Bruce N. Buckingham, Joshua L. Hoblet, Patrice E. Baumhardt

United States Department of Agriculture Wildlife Services: Staff Publications

A challenge that conservation practitioners face is manipulating behavior of nuisance species. The turkey vulture (Cathartes aura) can cause substantial damage to aircraft if struck. The goal of this study was to assess vulture responses to unmanned aircraft systems (UAS) for use as a possible dispersal tool. Our treatments included three platforms (fixed-wing, multirotor, and a predator-like ornithopter [powered by flapping flight]) and two approach types (30 m overhead or targeted towards a vulture) in an operational context. We evaluated perceived risk as probability of reaction, reaction time, flight-initiation distance (FID), vulture remaining index, and latency to return. …

Potential Use For Serosurveillance Of Feral Swine To Map Risk For Anthrax Exposure, Texas, Usa, Rachel M. Maison, Courtney F. Pierce, Izabela K. Ragan, Vienna R. Brown, Michael J. Bodenchuk, Richard A. Bowen, Angela M. Bosco-Lauth

United States Department of Agriculture Wildlife Services: Staff Publications

Anthrax is a disease of concern in many mammals, including humans. Management primarily consists of prevention through vaccination and tracking clinical-level observations because environmental isolation is laborious and bacterial distribution across large geographic areas diffi cult to confi rm. Feral swine (Sus scrofa) are an invasive species with an extensive range in the southern United States that rarely succumbs to anthrax. We present evidence that feral swine might serve as biosentinels based on comparative seroprevalence in swine from historically defi ned anthrax-endemic and non–anthraxendemic regions of Texas. Overall seropositivity was 43.7% (n = 478), and logistic regression revealed county endemicity …

Dietary Supplementation Of Bacillus-Based Probiotics On The Growth Performance, Gut Morphology, Intestinal Microbiota And Immune Response In Low Biosecurity Broiler Chickens, Bidhan Chandra Das

Faculty, Staff and Student Publications

A feeding trial was conducted to evaluate the effects of Bacillus-based probiotics on growth performance, intestinal histo-morphology, gut microbial population and immune response in broilers. A total of 2000 Hubbard Classic day-old chicks were randomly enrolled in four experimental groups and 4 replicates of 500 birds in each group, and reared for 35 days under a low- level of biosecurity measures. The trial groups were assigned treatment-1 (T1): basal diet(control), treatment-2 (T2): basal diet plus Bacillus licheniformis (DSM17236), treatment-3 (T3): basal diet plus Bacillus subtilis (PB6), and treatment-4 (T4) basal diet plus 4% Flavomycin. All four groups were fed …

How Do Genetic Relatedness And Spatial Proximity Shape African Swine Fever Infections In Wild Boar?, Tomasz Podgórski, Kim M. Pepin, Anna Radko, Angelika Podbielska, Magdalena Łyjak, Grzegorz Woźniakowski, Tomasz Borowik

United States Department of Agriculture Wildlife Services: Staff Publications

The importance of social and spatial structuring of wildlife populations for disease spread, though widely recognized, is still poorly understood in many host-pathogen systems. In particular, system-specific kin relationships among hosts can create contact heterogeneities and differential disease transmission rates. Here, we investigate how distance-dependent infection risk is influenced by genetic relatedness in a novel host-pathogen system: wild boar (Sus scrofa) and African swine fever (ASF).We hypothesized that infection risk would correlate positively with proximity and relatedness to ASF-infected individuals but expected those relationships to weaken with the distance between individuals due to decay in contact rates and …

Guidance For Management Of Free-Roaming Community Cats: A Bioeconomic Analysis, Valeria A. Benka, John D. Boone, Philip S. Miller, Joyce R. Briggs, Aaron M. Anderson, Christopher Slootmaker, Margaret Slater, Julie K. Levy, Felicia B. Nutter, Stephen Zawistowski

Publications and Research

Objectives This study used computer simulation modeling to estimate and compare costs of different free-roaming cat (FRC) management options (lethal and non-lethal removal, trap–neuter–return, combinations of these options and no action) and their ability to reduce FRC population abundance in open demographic settings. The findings provide a resource for selecting management approaches that are well matched for specific communities, goals and timelines, and they represent use of best available science to address FRC issues.

Methods Multiple FRC management approaches were simulated at varying intensities using a stochastic individual- based model in the software package Vortex. Itemized costs were obtained from …

Chemical And Biological Characterization Of The Anticancer Potency Of Salvia Fruticosa In A Model Of Human Malignant Melanoma, Sotiris Kyriakou, Venetia Tragkola, Michael Plioukas, Ioannis Anestopoulos, Paschalina S. Chatzopoulou, Eirini Sarrou, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi

School of Veterinary and Biomedical Sciences: Faculty Publications

Malignant melanoma is one of the most aggressive types of skin cancer with an increasing incidence worldwide. Thus, the development of innovative therapeutic approaches is of great importance. Salvia fruticosa (SF) is known for its anticancer properties and in this context, we aimed to investigate its potential anti-melanoma activity in an in vitro model of human malignant melanoma. Cytotoxicity was assessed through a colorimetric-based sulforhodamine-B (SRB) assay in primary malignant melanoma (A375), non-malignant melanoma epidermoid carcinoma (A431) and non-tumorigenic melanocyte neighbouring keratinocyte (HaCaT) cells. Among eight (8) different fractions of S. fruticosa extracts (SF1-SF8) tested, SF3 was found to possess …

Investigation Of Bovine Herpesvirus-1 Determinants Of Neuronal Infectivity In Novel Bovine Neuronal Cell Systems For Development Of A Safer Viral Vaccine Vector, Jared Rudd

LSU Doctoral Dissertations

Bovine herpesvirus-1 (BoHV-1) is the causative agent of infectious bovine rhinotracheitis and a component of the bovine respiratory disease complex. BoHV-1 is a significant burden on the cattle industry in the United States causing severe respiratory disease, abortions, loss of calves (“shipping fever”). BoHV-1 belongs to the alphaherpesvirus subfamily of Herpesviridae. Alphaherpesviruses enter axons of sensory nerves and establish life-long latency in trigeminal and dorsal root ganglionic neurons after primary infection of the oronasal or genital epithelium respectively. Modified live attenuated vaccines for BoHV-1 are commercially available but are limited in their protection while retaining the ability to establish latency …

Mt10-Cvb3 Vaccine Virus Protects Against Cvb4 Infection By Inducing Cross-Reactive, Antigen-Specific Immune Responses, Ninaad Lasrado, Rajkumar Arumugam, Mahima T. Rasquinha, Meghna Sur, David Steffen, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Group B coxsackieviruses (CVB) containing six serotypes, B1–B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis and pancreatitis. Yet, no vaccines are currently available to prevent these infections. Translationally, the derivation of vaccines that offer protection against multiple serotypes is highly desired. In that direction, we recently reported the generation of an attenuated strain of CVB3, termed Mt10, which completely protects against both myocarditis and pancreatitis induced by the homologous wild-type CVB3 strain. Here, we report that the Mt10 vaccine can induce cross-protection against multiple CVB serotypes as demonstrated with CVB4. We note that the …

Estrogens Regulate Placental Angiogenesis In Horses, Shingo Haneda, Pouya Dini, Alejandro Esteller-Vico, Kirsten E. Scoggin, Edward L. Squires, Mats H. T. Troedsson, Peter Daels, Yasuo Nambo, Barry A. Ball

Maxwell H. Gluck Equine Research Center Faculty Publications

A sufficient vascular network within the feto-maternal interface is necessary for placental function. Several pregnancy abnormalities have been associated with abnormal vascular formations in the placenta. We hypothesized that growth and expansion of the placental vascular network in the equine (Equus caballus) placenta is regulated by estrogens (estrogen family hormones), a hormone with a high circulating concentration during equine gestation. Administration of letrozole, a potent and specific inhibitor of aromatase, during the first trimester (D30 to D118), decreased circulatory estrone sulfate concentrations, increased circulatory testosterone and androstenedione concentrations, and tended to reduce the weight of the fetus ( …