Medicine and Health Sciences Commons^™

The Detection Of Cmv In Saliva Can Mark A Systemic Infection With Cmv In Renal Transplant Recipients, Shelley Waters, Silvia Lee, Megan Lloyd, Ashley Irish, Patricia Price

Research outputs 2014 to 2021

Human cytomegalovirus (CMV) is often transmitted through saliva. The salivary gland is a site of CMV replication and saliva can be used to diagnose congenital CMV infections. CMV replication is monitored in whole blood or plasma in renal transplant recipients (RTR) and associates with clinical disease. However, these assays may not detect replication in the salivary gland and there is little data linking detection in saliva with systemic infection and clinical sequelae. RTR (n = 82) were recruited > 2 years after transplantation. An in-house quantitative PCR assay was used to detect CMV UL54 in saliva samples. CMV DNA was …

Steroid Therapy And Outcome Of Parapneumonic Pleural Effusions (Stoppe): Study Protocol For A Multicenter, Double-Blinded, Placebo-Controlled Randomized Clinical Trial, Deirdre B. Fitzgerald, Grant W. Waterer, Catherine A. Read, Edward T. Fysh, Ranjan Shrestha, Christopher Stanley, Sanjeevan Muruganandan, Norris S. H. Lan, Natalia D. Popowicz, Carolyn J. Peddle-Mcintyre, Najib M. Rahman, Seng Khee Gan, Kevin Murray, Yun Chor Gary Lee

Research outputs 2014 to 2021

BACKGROUND: Community-acquired pneumonia (CAP) is a major global disease. Parapneumonic effusions often complicate CAP and range from uninfected (simple) to infected (complicated) parapneumonic effusions and empyema (pus). CAP patients who have a pleural effusion at presentation are more likely to require hospitalization, have a longer length of stay and higher mortality than those without an effusion. Conventional management of pleural infection, with antibiotics and chest tube drainage, fails in about 30% of cases. Several randomized controlled trials (RCT) have evaluated the use of corticosteroids in CAP and demonstrated some potential benefits. Importantly, steroid use in pneumonia has an acceptable safety …

Prevalence Of Coexistent Plantaris Tendon Pathology In Patients With Mid-Portion Achilles Pathology: A Retrospective Mri Study, Sachin Khullar, Prasanna Gamage, Peter Malliaras, Leesa Huguenin, Ashutosh Prakash, David Connell

Research outputs 2014 to 2021

Co-existence of Plantaris tendinopathy (PT) in patients with mid-Achilles tendinopathy (Mid-AT) is of clinical significance. This study aims to describe the MRI-based pathological characteristics of co-existing PT and Mid-AT. One-hundred MRI studies of patients diagnosed with Mid-AT were retrospectively analysed by an experienced musculoskeletal radiologist. Presence or absence of a Plantaris tendon, co-existing PT with Mid-AT, insertional characteristics of Plantaris tendon, and maximum anteroposterior thickness of the tendon in Mid-AT (axial images) were evaluated. When PT co-existed with Mid-AT, the location of the tendon pathologies in relation to calcaneal insertion was assessed (sagittal images) and their association was analysed using …

Occupational Exposure Of Benzene, Toluene, Ethylbenzene And Xylene (Btex) To Pump Attendants In Ghana: Implications For Policy Guidance, Francis Atta Kuranchie, Prosper Naah Angnunavuri, Francis Attiogbe, Esi Nana Nerquaye-Tetteh

Research outputs 2014 to 2021

Gasoline plays an important role as fuel for engines, but its use is replete with a high probability of adverse health to persons along the distribution chain, especially pump attendants. This study is a systematic review of the literature on gasoline exposure and the specific risks of adverse health on pump attendants by benzene, ethylbenzene, toluene and xylene (BTEX) to instigate policy in Ghana. A careful review of the literature indicates that pump attendants are at risk of developing cancer and non-cancer health hazards. This is particularly so in Ghana due to poor safe work practices and controls at pump …

Nurse Practitioner Leadership And Research Activity [Slides], Mary Ryder, Elisabeth Jacob, Joyce Hendricks

Research outputs 2014 to 2021

Conclusion:

• Nurse Practitioners in both Ireland and Australia identify themselves as leaders of the nursing profession.
• NP work practices are primarily focused on provision of direct patient care.
• Research activity is lacking among NPs.
• Leadership ability influences research outcomes for NPs in both Ireland and Australia.

Nurse Practitioners Perceptions On Leadership And Research [Slides], Mary Ryder, Elisabeth Jacob, Joyce Hendricks

Research outputs 2014 to 2021

Conclusion:

• Participants identified themselves as clinical leaders focused on direct patient care
• The NP role was misunderstood
• Support from nursing academics and management was identified as a research opportunity
• Confidence in research abilities was a barrier to research
• The NP role was similar in Ireland and Australia

Socioeconomic Correlates Of Overweight And Obesity Among Ever-Married Urban Women In Bangladesh, Tania Sultana Tanwi, Sayan Chakrabarty, Syed Hasanuzzaman, Sue Saltmarsh, Stephen Winn

Research outputs 2014 to 2021

Background

The escalating prevalence of overweight and obesity globally is reflected amongst urban women in many low-to-middle income countries. Evidence also shows that overweight and obesity is an increasing trend in Bangladesh. The present study assessed the prevalence and socioeconomic determinants of overweight and obesity among urban women in Bangladesh.

Methods

Data were extracted from Bangladesh Demographic and Health Survey (BDHS) 2014. A two-stage stratified sampling technique has been used for data collection in this cross-sectional survey. A sample of 1701 ever-married non-pregnant urban women aged 15–49 years was selected for statistical analysis. Descriptive analysis, multiple binomial logistic regression analysis …

Implementing Automated External Defibrillators Into Community Sports Clubs/Facilities: A Cross-Sectional Survey Of Community Club Member Preparedness For Medical Emergencies, Lauren Victoria Fortington, Liam West, Damian Morgan, Caroline F. Finch

Research outputs 2014 to 2021

Objective There is a growing focus on ensuring the availability of automated external defibrillators (AED) in sport settings to assist in preventing sudden cardiac death. For the AED to be most effective, understanding how best to integrate it with wider risk management and emergency action plans (EAP) is needed. The aim of this survey was to identify sports club/facility member knowledge of AED use and club EAPs, 6 months following participation in a government-funded AED provision and cardiopulmonary resuscitation training programme.

Methods Cross-sectional survey of community sports clubs and facilities in Victoria, Australia. Included participants were members of sports club/facilities …

Correction: Relationship Between Serum Osteocalcin/Undercarboxylated Osteocalcin And Type 2 Diabetes: A Systematic Review/Meta-Analysis Study Protocol, Yihui Liu, Xiaoying Liu, Joshua R. Lewis, Kaye Brock, Tara C. Brennan-Speranza, Armando Teixeira-Pinto

Research outputs 2014 to 2021

The affiliations for the third author, Joshua R Lewis, were incomplete in the previous version of this manuscript...

'Mini-Interval Gait' Switching: Understanding The Positive Implications Of A Novel Training Regime, James L. Croft, John E. A. Bertram

Research outputs 2014 to 2021

The neuromechanical reorganization required to change gaits imposes an energetic cost 75% greater than either a walking or running step at the same speed. By combining walking and running with the requisite gait switching transition steps, an exercise protocol can be generated with virtually any desired metabolic output even at relatively slow treadmill speed. Gait switching increases metabolic demand through discrete events, which can be tolerated more easily by individuals recovering from health problems, just as interval training allows greater work production for healthy individuals. In addition to cardio-respiratory benefits, ‘mini-intervals’ with frequent gait switching also provides positive effects and …

Clostridium Difficile Ribotype 017–Characterization, Evolution And Epidemiology Of The Dominant Strain In Asia, Korakrit Imwattana, Daniel R. Knight, Brian Kullin, Deirdre A. Collins, Papanin Putsathit, Pattarachai Kiratisin, Thomas V. Riley

Research outputs 2014 to 2021

Clostridium difficile ribotype (RT) 017 is an important toxigenic C. difficile RT which, due to a deletion in the repetitive region of the tcdA gene, only produces functional toxin B. Strains belonging to this RT were initially dismissed as nonpathogenic and circulated largely undetected for almost two decades until they rose to prominence following a series of outbreaks in the early 2000s. Despite lacking a functional toxin A, C. difficile RT 017 strains have been shown subsequently to be capable of causing disease as severe as that caused by strains producing both toxins A and B. While C. difficile RT …

Genomic Delineation Of Zoonotic Origins Of Clostridium Difficile, Daniel R. Knight, Thomas V. Riley

Research outputs 2014 to 2021

Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen historically associated with diarrhea and pseudomembranous colitis in hospitalized patients. In recent years, there have been dramatic increases in the incidence and severity of C. difficile infection (CDI), and associated morbidity and mortality, in both healthcare and community settings. C. difficile is an ancient and diverse species that displays a sympatric lifestyle, establishing itself in a range of ecological niches external to the healthcare system. These sources/reservoirs include food, water, soil, and over a dozen animal species, in particular, livestock such as pigs and cattle. In a manner analogous to human infection, …

Rates Of Age- And Amyloid Β-Associated Cortical Atrophy In Older Adults With Superior Memory Performance, Christa Dang, Nawaf Yassi, Karra D. Harrington, Ying Xia, Yen Ying Lim, David Ames, Simon M. Laws, Martha Hickey, Stephanie Rainey-Smith, Hamid R. Sohrabi, James D. Doecke, Jurgen Fripp, Olivier Salvado, Peter J. Snyder, Michael Weinborn, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Paul Maruff

Research outputs 2014 to 2021

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid b (Ab) deposition (Ab1) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Ab-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n 5 172) and cognitively normal for age (n 5 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Ab status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Ab1. …

Cannabis Teratology Explains Current Patterns Of Coloradan Congenital Defects: The Contribution Of Increased Cannabinoid Exposure To Rising Teratological Trends, Albert S. Reece, Gary K. Hulse

Research outputs 2014 to 2021

Rising Δ9-tetrahydrocannabinol concentrations in modern cannabis invites investigation of the teratological implications of prenatal cannabis exposure. Data from Colorado Responds to Children with Special Needs (CRCSN), National Survey of Drug Use and Health, and Drug Enforcement Agency was analyzed. Seven, 40, and 2 defects were rising, flat, and falling, respectively, and 10/12 summary indices rose. Atrial septal defect, spina bifida, microcephalus, Down’s syndrome, ventricular septal defect, and patent ductus arteriosus rose, and along with central nervous system, cardiovascular, genitourinary, respiratory, chromosomal, and musculoskeletal defects rose 5 to 37 times faster than the birth rate (3.3%) to generate an excess of …

Patient-Defined Meaningfulness Within Chronic Pain Rehabilitation: A Concept Analysis, Katrina Liddiard, Annette J. Raynor, Annette M. Rivard, Cary A. Brown

Research outputs 2014 to 2021

Background: As the problem of chronic pain grows worldwide, rehabilitation is critical to improved patient well-being. There is thus a need for rehabilitation-focused research. It appears that outcomes are improved when patients perceive the rehabilitation process to be meaningful. However, there is no empirical evidence determining how this would be achieved. An important first step is to identify and describe the concept of meaningfulness as it is used in the chronic pain rehabilitation literature. Objective: This paper reports the findings of a structured concept analysis to define meaningfulness from the patient perspective in chronic pain rehabilitation. Methodology: In consultation with …

Implementing Eccentric Resistance Training—Part 2: Practical Recommendations, Timothy J. Suchomel, John P. Wagle, Jamie Douglas, Christopher B. Taber, Mellissa Harden, G. Gregory Haff

Research outputs 2014 to 2021

The purpose of this review is to provide strength and conditioning practitioners with recommendations on how best to implement tempo eccentric training (TEMPO), flywheel inertial training (FIT), accentuated eccentric loading (AEL), and plyometric training (PT) into resistance training programs that seek to improve an athlete’s hypertrophy, strength, and power output. Based on the existing literature, TEMPO may be best implemented with weaker athletes to benefit positional strength and hypertrophy due to the time under tension. FIT may provide an effective hypertrophy, strength, and power stimulus for untrained and weaker individuals; however, stronger individuals may not receive the same eccentric (ECC) …

Monitoring Melanoma Recurrence With Circulating Tumor Dna: A Proof Of Concept From Three Case Studies, Ashleigh C. Mcevoy, Michelle R. Pereira, Anna Reid, Robert Pearce, Lester Cowell, Zeyad Al-Ogaili, Muhammad A. Khattak, Michael Millward, Tarek M. Meniawy, Elin S. Gray, Melanie R. Ziman

Research outputs 2014 to 2021

Background: A significant number of melanoma patients experience recurrence to distant sites, despite having had surgical treatment of the primary lesion, with curative intent. Monitoring of patients for early evidence of disease recurrence would significantly improve management of the disease, allowing timely therapeutic intervention. Circulating tumor DNA (ctDNA) is becoming a well-recognized biomarker for monitoring malignancies and has, in a few studies, been shown to signify disease recurrence earlier than conventional methods.

Methods: We performed a retrospective analysis of plasma ctDNA using droplet digital PCR (ddPCR) in 30 primary melanoma patients with tumors harboring BRAF, NRAS or TERT promoter mutations. …

Applications Of The Reflective Practice Questionnaire In Medical Education, Shane L. Rogers, Lynn E. Priddis, Nicole Michels, Michael Tieman, Lon J. Van Winkle

Research outputs 2014 to 2021

Background: We sought to determine whether the Reflective Practice Questionnaire (RPQ) is a reliable measure of reflective capacity and related characteristics in medical students. We also planned to learn how the RPQ could be used in medical education. Methods: The RPQ is a 40 item self-report questionnaire that includes a multi-faceted approach to measuring reflective capacity. It also includes sub-scales on several other theoretically relevant constructs such as desire for improvement, confidence, stress, and job satisfaction. The reliabilities of reflective capacity and other sub-scales were determined by calculating their Cronbach alpha reliability values. In the present study, the RPQ was …

Perceptions And Experiences Of Emergency Department Staff During The Implementation Of The Four-Hour Rule/National Emergency Access Target Policy In Australia: A Qualitative Social Dynamic Perspective, Roberto Forero, Shizar Nahidi, Josephine De Costa, Daniel Fatovich, Gerry Fitzgerald, Sam Toloo, Sally Mccarthy, David Mountain, Nick Gibson, Mohammed Mohsin, Wing Nicola Man

Research outputs 2014 to 2021

Background: The Four-Hour Rule or National Emergency Access Target policy (4HR/NEAT) was implemented by Australian State and Federal Governments between 2009 and 2014 to address increased demand, overcrowding and access block (boarding) in Emergency Departments (EDs). This qualitative study aimed to assess the impact of 4HR/NEAT on ED staff attitudes and perceptions. This article is part of a series of manuscripts reporting the results of this project. Methods: The methodology has been published in this journal. As discussed in the methods paper, we interviewed 119 participants from 16 EDs across New South Wales (NSW), Queensland (QLD), Western Australia (WA) and …

Summary Of Aboriginal And Torres Strait Islander Health Status 2018, Australian Indigenous Healthinfonet, Millie Harford-Mills, Andrea Macrae, Neil Drew

Research outputs 2014 to 2021

This latest Summary of Aboriginal and Torres Strait Islander health provides an up-to-date, plain language summary of the health of Aboriginal and Torres Strait Islander people. It includes Aboriginal and Torres Strait Islander-specific information on:

• population
• births
• deaths
• common health conditions
• key health risk and protective factors.

The Summary has been prepared by the HealthInfoNet as part of its effort to help 'close the gap' by providing the evidence base to inform practice and policy in Aboriginal and Torres Strait Islander health. The Summary aims to make this information available to all people, including those without a specialised knowledge …

Overview Of Aboriginal And Torres Strait Islander Health Status 2018, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Overview of Aboriginal and Torres Strait Islander health status (Overview) aims to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander people. The initial sections of the Overview provide information about the context of Aboriginal and Torres Strait Islander health, population, and various measures of population health status. The remaining sections are about selected health conditions and risk and protective factors that contribute to the overall health of Aboriginal and Torres Strait Islander people. These sections comprise an introduction and evidence of the extent of …

The Chest Australia Trial: A Randomised Controlled Trial Of An Intervention To Increase Consultation Rates In Smokers At Risk Of Lung Cancer, Jon D. Emery, Sonya R. Murray, Fiona M. Walter, Andrew Martin, Stephen Goodall, Danielle Mazza, Emily Habgood, Yvonne Kutzer, David John Barnes, Peter Murchie

Research outputs 2014 to 2021

Background: International research has focused on screening and mass media campaigns to promote earlier patient presentation and detect lung cancer earlier. This trial tested the effect of a behavioural intervention in people at increased risk of lung cancer on help-seeking for respiratory symptoms.

Methods: Parallel, individually randomised controlled trial. Eligible participants were long-term smokers with at least 20 pack-years, aged 55 and above. The CHEST intervention entailed a consultation to discuss and implement a self-help manual, followed by self-monitoring reminders to encourage help-seeking for respiratory symptoms. The control group received a brief discussion about lung health. Both groups had baseline …

Immunomagnetic-Enriched Subpopulations Of Melanoma Circulating Tumour Cells (Ctcs) Exhibit Distinct Transcriptome Profiles, Carlos Aya-Bonilla, Elin S. Gray, Jayapal Manikandan, James B. Freeman, Pauline Zaenker, Anna L. Reid, Muhammad A. Khattak, Markus H. Frank, Michael Millward, Mel Ziman

Research outputs 2014 to 2021

Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic-captured by targeting either the melanoma-associated marker, MCSP, or the melanoma-initiating marker, ABCB5. Firstly, the expression of a subset of melanoma genes was investigated by RT-PCR in MCSP-enriched and ABCB5-enriched CTCs isolated from a total of 59 blood draws from 39 melanoma cases. Of these, 6 MCSP-and 6 ABCB5-enriched CTC fractions were further analysed using a genome-wide gene expression microarray. The transcriptional programs of both CTC subtypes included cell survival maintenance, cell proliferation, and migration pathways. ABCB5-enriched CTCs were specifically characterised …

Real-Time Classification Of Multivariate Olfaction Data Using Spiking Neural Networks, Arnup Vanarse, Adam Osseiran, Alexander Rassau, Therese O'Sullivan, Jonny Lo, Amanda Devine

Research outputs 2014 to 2021

Recent studies in bioinspired artificial olfaction, especially those detailing the application of spike-based neuromorphic methods, have led to promising developments towards overcoming the limitations of traditional approaches, such as complexity in handling multivariate data, computational and power requirements, poor accuracy, and substantial delay for processing and classification of odors. Rank-order-based olfactory systems provide an interesting approach for detection of target gases by encoding multi-variate data generated by artificial olfactory systems into temporal signatures. However, the utilization of traditional pattern-matching methods and unpredictable shuffling of spikes in the rank-order impedes the performance of the system. In this paper, we present an …

Grandparental Childcare, Health And Well-Being In Europe: A Within-Individual Investigation Of Longitudinal Data, Mirkka Danielsbacka, Antti O. Tanskanen, David A. Coall, Markus Jokela

Research outputs 2014 to 2021

Previous studies suggest grandparental childcare is associated with improved health and well-being of grandparents but limited information on the causal nature of this association exists. Here, we use the longitudinal Survey of Health, Ageing and Retirement in Europe (SHARE) of people aged 50 and above across 11 countries including follow-up waves between 2004 and 2015 (n = 41,713 person-observations from 24,787 unique persons of whom 11,102 had two or more measurement times). Between-person and within-person (or fixed-effect) regressions were applied, where between-person models show associations across participants and within-person models focus on each participant's variation over time. Health and well-being …

Utilising A Multi‐Item Questionnaire To Assess Household Food Security In Australia, Lucy M. Butcher, Therese A. O'Sullivan, Maria M. Ryan, Johnny Lo, Amanda Devine

Research outputs 2014 to 2021

Issue addressed: Currently, two food sufficiency questions are utilised as a proxy measure of national food security status in Australia. These questions do not capture all dimensions of food security and have been attributed to underreporting of the problem. The purpose of this study was to investigate food security using the short form of the US Household Food Security Survey Module (HFSSM) within an Australian context; and explore the relationship between food security status and multiple socio-demographic variables.

Methods: Two online surveys were completed by 2334 Australian participants from November 2014 to February 2015. Surveys contained the short form of …

Editorial: Insights Into Biomarkers, Cytokines, And Chemokines In Skin Cancer, Lucy W. Barrett, Elin S. Gray, James W. Wells, Jason Waithman

Research outputs 2014 to 2021

No abstract provided.

New Graduate Nurses' Clinical Safety Knowledge By The Numbers, Melanie Murray, Deborah Sundin, Vicki Cope

Research outputs 2014 to 2021

AIM: To explore new graduate registered nurses' knowledge and attitudes concerning medical error and patient safety, during their first 6 months of professional practice.

BACKGROUND: New graduate registered nurses demonstrate basic skills and levels of performance due to limited exposure and experience in actual situations. There is a concern held for their clinical reasoning skills required to recognize patient deterioration, posing a threat to patient safety.

METHODS: An online questionnaire was used to survey new graduate registered nurses at three time points during graduate nurse programmes between August 2016 and February 2018.

RESULTS: A decrease in self-reported knowledge and attitudes …

Entropy Analysis Of High-Definition Transcranial Electric Stimulation Effects On Eeg Dynamics, Diego C. Nascimento, Gabriela Depetri, Luiz H. Stefano, Osvaldo Anacleto, Joao P. Leite, Dylan J. Edwards, Taiza E. G. Santos, Francisco Louzada Neto

Research outputs 2014 to 2021

A foundation of medical research is time series analysis—the behavior of variables of interest with respect to time. Time series data are often analyzed using the mean, with statistical tests applied to mean differences, and has the assumption that data are stationary. Although widely practiced, this method has limitations. Here we present an alternative statistical approach with sample analysis that provides a summary statistic accounting for the non-stationary nature of time series data. This work discusses the use of entropy as a measurement of the complexity of time series, in the context of Neuroscience, due to the non-stationary characteristic of …

The Experiences Of Migrants To Australia Who Stutter, Charn Nang, Victoria Reynolds, Deborah Hersh, Clare Andrews, Oswell Humphries

Research outputs 2014 to 2021

Purpose: Migration is a contemporary, global matter. With the number of international migrants doubling over the past four decades, speech-language pathologists will likely work with migrants who have childhood-onset stuttering. However, combined migration and stuttering experiences have never been investigated specifically. This study is the first to investigate the experiences of migrants to Australia who stutter. Methods: Three women and six men, aged 23 to 66 years old, participated. Data from individual interviews were analysed using Interpretative Phenomenological Analysis to examine the ‘lived experience’ of participants, as well as with NVivo 12 software for the management of coding. Participants also …