Medicine and Health Sciences Commons^™

Finding Your Balance: An Investigation Of Recovery–Stress Balance In Vocational Dance Training, Peta Blevins, Shona Erskine, Luke Hopper, Gene Moyle

Research outputs 2014 to 2021

Professional dance careers require years of intensive training. Stress experienced during training must be balanced with adequate recovery to prevent overtraining and burnout. Little is known, however, about how dancers achieve recovery–stress balance. This study examined dancers’ recollection of stress and recovery during their vocational dance training to identify potential stressors and recovery behaviors in vocational dance training. Twelve current and ex-professional ballet (n=4) and contemporary dancers (n=8) participated in the study. Four general dimensions, based on the extant overtraining literature in athletes, were identified: dance culture, intrapersonal, interpersonal, and situational factors. Cultural norms, health factors related to injury and …

No Causal Effect Of Telomere Length On Ischemic Stroke And Its Subtypes: A Mendelian Randomization Study, Weijie Cao, Xingang Li, Xiaoyu Zhang, Jie Zhang, Qi Sun, Xizhu Xu, Ming Sun, Qiuyue Tian, Qihuan Li, Hao Wang, Jiaonan Liu, Xiaoni Meng, Lijuan Wu, Manshu Song, Haifeng Hou, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches. Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide meta-analysis including 37,684 participants of European descent. We analyzed the largest ever genome-wide association studies of stroke in Europe from …

Water Intake After Dehydration Makes Muscles More Susceptible To Cramp But Electrolytes Reverse That Effect, Wing Yin Lau, Haruyasu Kato, Kazunori Nosaka

Research outputs 2014 to 2021

Objective No previous study has compared water and oral rehydration solution (ORS) intake after dehydration induced by exercise in the heat for the effect on muscle cramps. The present study tested the hypothesis that water ingestion after dehydration would increase muscle cramp susceptibility, but this would be prevented by ORS ingestion. Methods Ten men performed two bouts of downhill running (DHR; -5%) in the heat (35°C-36 °C) until their body mass was reduced by 2%. Ten minutes after DHR, either spring water or electrolyte water similar to ORS (OS-1 ®) was ingested in a counter-balanced order on two different days …

Sero-Prevalence Of Hepatitis B And C Viral Co-Infections Among Hiv-1 Infected Art-Naïve Individuals In Kumasi, Ghana, Richard Boateng, Mohamed Mutocheluh, Albert Dompreh, Dorcas Obiri-Yeboah, Enoch Odame Anto, Michael Owusu, Patrick Williams Narkwa

Research outputs 2014 to 2021

Background

The study assessed the hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection paradigm among the human immunodeficiency virus (HIV) infected patients attending a tertiary hospital in Ghana. Also, the immunological and virological characterisation of these viruses, prior to antiretroviral therapy (ART) initiation was investigated.

Method

A total of 400 HIV infected (HIV type-1) treatment naïve subjects ≥18 years were enrolled and tested for HBsAg and anti-HCV. Hepatitis B virus serological profile was performed on samples that were HBV positive. CD4+ T-cell count and HIV-1 RNA viral loads were determined using BD FacsCalibur analyzer (USA) and COBAS AmpliPrep/COBAS …

Variable Outcomes Of Human Heart Attack Recapitulated In Genetically Diverse Mice, Ekaterina Salimova, Kristen J. Nowak, Ana C. Estrada, Milena B. Furtado, Elyshia Mcnamara, Quang Nguyen, Lois Balmer, Christoph Preuss, Jeffrey W. Holmes, Mirana Ramialison, Grant Morahan, Nadia A. Rosenthal

Research outputs 2014 to 2021

Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features were detected across 32 CC founder and recombinant inbred strains. Transcriptomic analyses revealed a plausible link between increased intrinsic cardiac oxidative phosphorylation levels and MI-induced heart failure. The emergence of significant quantitative trait loci for several post-MI traits indicates that utilizing CC …

Recurrence Of Clostridium Difficile Infection In The Western Australian Population, M. Alfayyadh, Deirdre A. Collins, S. Tempone, R. Mccann, P. K. Armstrong, Thomas V. Riley, A. Cook

Research outputs 2014 to 2021

Clostridium difficile, the most common cause of hospital-associated diarrhoea in developed countries, presents major public health challenges. The high clinical and economic burden from C. difficile infection (CDI) relates to the high frequency of recurrent infections caused by either the same or different strains of C. difficile. An interval of 8 weeks after index infection is commonly used to classify recurrent CDI episodes. We assessed strains of C. difficile in a sample of patients with recurrent CDI in Western Australia from October 2011 to July 2017. The performance of different intervals between initial and subsequent episodes of CDI was investigated. …

A Multi-Center Comparison Of Vo2 Peak Trainability Between Interval Training And Moderate Intensity Continuous Training, Camilla J. Williams, Brendon J. Gurd, Jacob T. Bonafiglia, Sarah Voisin, Zhixiu Li, Nicholas Harvey, Ilaria Croci, Jenna L. Taylor, Trishan Gajanand, Joyce S. Ramos, Robert G. Fassett, Jonathan P. Little, Monique E. Francois, Christopher M. Hearon, Satyam Sarma, Sylvan L. J. E. Janssen, Emeline M. Van Craenenbroeck, Paul Beckers, Véronique A. Cornelissen, Nele Pattyn, Erin J. Howden, Shelley E. Keating, Anja Bye, Dorthe Stensvold, Ulrik Wisloff, Ioannis Papadimitriou, Xu Yan, David J. Bishop, Nir Eynon, Jeff S. Coombes

Research outputs 2014 to 2021

There is heterogeneity in the observed VO_2peak response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare VO_2peak trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volumes were classified by the duration of total interval time. High-volume High Intensity Interval Training (HIIT) included studies that had participants complete more than 15 min of high intensity efforts per session. Low-volume HIIT/Sprint Interval Training (SIT) included studies using less than 15 min …

Strength Training Improves Metabolic Health Markers In Older Individual Regardless Of Training Frequency, Johanna K. Ihalainen, Alistair Inglis, Tuomas Mäkinen, Robert U. Newton, Heikki Kainulainen, Heikki Kyröläinen, Simon Walker

Research outputs 2014 to 2021

The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65–75 year). Ninety-two healthy participants were randomly assigned to one of four groups; performing strength training one- (EX1), two- (EX2), or three- (EX3) times-per-week and a non-training control (CON) group. Whole-body strength training was performed using 2–5 sets and 4–12 repetitions per exercise and 7–9 exercises per session. All training groups attended supervised resistance training for 6 months. Body composition was measured by dual …

Children Exhibit A More Comparable Neuromuscular Fatigue Profile To Endurance Athletes Than Untrained Adults, Bastien Bontemps, Enzo Piponnier, Emeric Chalchat, Anthony J. Blazevich, Valérie Julian, Olivia Bocock, Martine Duclos, Vincent Martin, Sébastien Ratel

Research outputs 2014 to 2021

The present study compared neuromuscular fatigue profiles between children, untrained adults and adult endurance athletes during repeated maximal muscle contractions. Eighteen prepubertal boys, 19 untrained men and 13 endurance male athletes performed 5-s maximal voluntary isometric knee extensor contractions (MVICs) interspersed with 5-s recovery until MVIC reached 60% of its initial value. Single and doublet magnetic stimulations were delivered to the femoral nerve to quantify the time course of potentiated twitch amplitude (T_tw,pot), high-frequency torque (T_{100 Hz}) and the low-to-high frequency torque ratio (T_{10 Hz}/T_{100 Hz}), i.e., indicators of peripheral fatigue. M-wave-normalized …

The Landscape Of Movement Control In Locomotion: Cost, Strategy, And Solution, James L. Croft, Ryan T. Schroeder, John E. A. Bertram

Research outputs 2014 to 2021

Features of gait are determined at multiple levels, from the selection of the gait itself (e.g., walk or run) through the specific parameters utilized (stride length, frequency, etc.) to the pattern of muscular excitation. The ultimate choices are determined neurally, but what is involved with deciding on the appropriate strategy? Human locomotion appears stereotyped not so much because the pattern is predetermined, but because these movement patterns are good solutions for providing movement utilizing the machinery available to the individual (the legs and their requisite components). Under different circumstances the appropriate solution may differ broadly (different gait) or subtly (different …

Neuromeasure: A Software Package For Quantification Of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation, Michael B. Gerber, Alasdair C. Mclean, Samuel J. Stephen, Alex G. Chalco, Usman M. Arshad, Gary W. Thickbroom, Josh Silverstein, K. Zoe Tsagaris, Amy Kuceyeski, Kathleen Friel, Taiza E. G. Santos, Dylan J. Edwards

Research outputs 2014 to 2021

The recent enhanced sophistication of non-invasive mapping of the human motor cortex using MRI-guided Transcranial Magnetic Stimulation (TMS) techniques, has not been matched by refinement of methods for generating maps from motor evoked potential (MEP) data, or in quantifying map features. This is despite continued interest in understanding cortical reorganization for natural adaptive processes such as skill learning, or in the case of motor recovery, such as after lesion affecting the corticospinal system. With the observation that TMS-MEP map calculation and quantification methods vary, and that no readily available commercial or free software exists, we sought to establish and make …

Geographical Variations In Prostate Cancer Outcomes: A Systematic Review Of International Evidence, Paramita Dasgupta, Peter D. Baade, Joanne F. Aitken, Nicholas Ralph, Suzanne K. Chambers, Jeff Dunn

Research outputs 2014 to 2021

Background: Previous reviews of geographical disparities in the prostate cancer continuum from diagnosis to mortality have identified a consistent pattern of poorer outcomes with increasing residential disadvantage and for rural residents. However, there are no contemporary, systematic reviews summarizing the latest available evidence. Our objective was to systematically review the published international evidence for geographical variations in prostate cancer indicators by residential rurality and disadvantage.

Methods: Systematic searches of peer-reviewed articles in English published from 1/1/1998 to 30/06/2018 using PubMed, EMBASE, CINAHL, and Informit databases. Inclusion criteria were: population was adult prostate cancer patients; outcome measure was PSA testing, prostate …

The Incidence, Prevalence, Nature, Severity And Mechanisms Of Injury In Elite Female Cricketers: A Prospective Cohort Study, Nirmala Kanthi Panagodage Perera, Alex Kountouris, Joanne L. Kemp, Corey Joseph, Caroline F. Finch

Research outputs 2014 to 2021

Objectives

Incidence, prevalence, nature, severity and mechanisms of injury in elite female cricketers over two seasons from March 2014 to March 2016, inclusive.

Design

Prospective cohort study.

Methods

Injury data collected via Cricket Australia’s Athlete Management System on all elite female players over two seasons were analysed. Profiles of the nature, anatomical location and mechanism of injuries were presented according to dominant player position. Injury incidence rates were calculated based on match playing hours.

Results

There were 600 medical-attention injuries; with 77.7% players reporting ≥1 injury. There were 79.5% acute injuries compared to gradual onset injuries. Of the all medical-attention …

Measuring Food Provision In Western Australian Long Day Care (Ldc) Services: A Weighed Food Record Method/Protocol At A Service Level, Ros Sambell, Ruth Wallace, Leesa Costello, Amanda Devine

Research outputs 2014 to 2021

Background

There are currently 1.3 million children utilising Early Childhood Education and Care (ECEC) services in Australia. Long day care (LDC), family day care and out of school hours care currently provide this service in different environments. This research reports findings from a LDC perspective. Children can consume 40–67% of their food intake whilst at LDC services, this highlights the importance of monitoring food provision at a service level. There are several methods to measure food provision which typically focus on intake at an individual level. There is limited evidence of measuring food provision accurately at a service level and …

Evaluation Of Dyslipidaemia Using An Algorithm Of Lipid Profile Measures Among Newly Diagnosed Type Ii Diabetes Mellitus Patients: A Cross-Sectional Study At Dormaa Presbyterian Hospital, Ghana, Enoch Odame Anto, Christian Obirikorang, Max Efui Annani-Akollor, Eric Adua, Sampson Donkor, Emmanuel Acheampong, Evans Adu Asamoah

Research outputs 2014 to 2021

Background and Objectives: Dyslipidaemia and its associated complications have been reported to increase mortality among type 2 diabetes mellitus (T2DM) patients. However, there is a dearth of data on the incidence of dyslipidemia among Ghanaian patients with T2DM. This study evaluated dyslipidemia among newly diagnosed T2DM patients at Dormaa Presbyterian Hospital, Ghana. Materials and Methods: This cross-sectional study recruited a total of 215 participants at the Presbyterian Hospital, Dormaa-Ghana. A well-structured questionnaire was administered to collect demographic data. Predisposing factors of dyslipidemia such as BMI, hypertension, and family history of diabetes were also obtained. Lipid profile was performed on the …

Neuromuscular Factors Contributing To Reductions In Muscle Force After Repeated, High-Intensity Muscular Efforts [Journal Article], Benjamin J. C. Kirk, Gabriel S. Trajano, Timothy S. Pulverenti, Grant Rowe, Anthony J. Blazevich

Research outputs 2014 to 2021

Multiple neuromuscular processes contribute to the loss of force production following repeated, high-intensity muscular efforts; however, the relative contribution of each process is unclear. In Experiment 1, 16 resistance trained men performed six sets of unilateral isometric plantar flexor contractions of the right leg (3 s contraction/2 s rest; 85% maximal voluntary contraction torque; 90-s inter-set rest) until failure with and without caffeine ingestion (3 mg kg^-1) on two separate days. Corticospinal excitability and cortical silent period (cSP) were assessed before and immediately, 10 and 20 min after the exercise. In Experiment 2, electrically evoked tetanic force and …

Chemical Profile And In Vivo Toxicity Evaluation Of Unripe Citrus Aurantifolia Essential Oil, Christian K. Adokoh, Du-Bois Asante, Desmond O. Acheampong, Yohei Kotsuchibashi, Francis A. Armah, Ignatius H. Sirikyi, Keisuke Kimura, Edward Gmakame, Sey Abdul-Rauf

Research outputs 2014 to 2021

Citrus aurantifolia (Christm.) Swingle (syn. C. MEDICA var. ACIDA Brandis) (family: Rutaceae) essential oil is one of the cheapest oils found in local markets. Although, it is generally accepted as non-toxic to vital organs and cells, majority of people are cynical about it usage. Herein, the present study reports the chemical composition and in vivo oral toxicity study of unripe C. aurantifolia essential oil found in Ghana. The toxicity of C. aurantifolia essential oil extract was investigated via oral administration using two methods: The acute toxicity single dose study (SDS) and the repeated dose method. The oil exhibited no acute …

Cross-Sectional Changes In Weight Status And Weight Related Behaviors Among Australian Children And Australian Indigenous Children Between 2010 And 2015, Louise L. Hardy, Rona Macniven, Tuguy Esgin, Seema Mihrshahi

Research outputs 2014 to 2021

BACKGROUND: Since 2006 there has been substantial long-term investment in school-based child obesity prevention programs in New South Wales (Australia). Whether these programs have led to population level improvements in children's weight status and weight-related behaviors are yet to be determined. The purpose of this study was to describe changes in children's weight status and weight-related behaviors, including Indigenous children, who are at greater risk of poorer health outcomes than non-Indigenous children.

METHODS: Representative cross-sectional population surveys conducted in 2010 and 2015 among children age 5-16 years (n = 15,613). Objective measurements included height, weight, waist circumference, cardiorespiratory fitness, and …

Foam Rolling As A Recovery Tool Following Eccentric Exercise: Potential Mechanisms Underpinning Changes In Jump Performance, Eric J. Drinkwater, Christopher Latella, Christopher Wilsmore, Stephen P. Bird, Melissa Skein

Research outputs 2014 to 2021

Purpose: Recovery from exercise-induced muscle damage (EIMD) is paramount in sports performance. Foam rolling (FR) has been suggested to improve acute performance; however, the ability to facilitate recovery from eccentric (ECC) exercise remains unclear.

Methods: Eleven males undertook 6 × 25 ECC knee extensions to induce muscular damage. Immediately, 24, 48, and 72 h post-training countermovement jump (CMJ), maximal voluntary isometric contraction (MVIC), pressure-pain threshold (PPT), knee flexion range of motion (ROM), and mid-thigh circumference (MTC) were assessed. Neurophysiological measures included voluntary activation (VA), peak twitch torque (PTT), time to peak twitch (PTT_time), and rate of twitch torque …

The Capacity Of The Fecal Microbiota From Malawian Infants To Ferment Resistant Starch, Yanan Wang, Elissa K. Mortimer, Kondwani G. H. Katundu, Noel Kalanga, Lex E. X. Leong, Geetha L. Gopalsamy, Claus T. Christophersen, Alyson C. Richard, Aravind Shivasami, Guy C. J. Abell, Graeme P. Young, Geraint B. Rogers

Research outputs 2014 to 2021

In Low and Middle-Income Countries (LMIC), weaning is associated with environmentally acquired and inflammation-associated enteric disorders. Dietary intake of high amylose maize starch (HAMS) can promote commensal fermentative bacteria and drive the production of short chain fatty acids (SCFAs). By stabilizing commensal gut microbiology, and stimulating the production of anti-inflammatory metabolites, HAMS supplementation might therefore influence enteric health. However, the extent to which the gut microbiota of LMIC infants are capable of fermenting HAMS is unclear. We assessed the capacity of the fecal microbiota from pre-weaning and weaning Malawian infants to ferment HAMS and produce SCFAs using an in vitro …

The Not-So-Sterile Womb: Evidence That The Human Fetus Is Exposed To Bacteria Prior To Birth, Lisa F. Stinson, Mary C. Boyce, Matthew S. Payne, Jeffrey A. Keelan

Research outputs 2014 to 2021

The human microbiome includes trillions of bacteria, many of which play a vital role in host physiology. Numerous studies have now detected bacterial DNA in first-pass meconium and amniotic fluid samples, suggesting that the human microbiome may commence in utero. However, these data have remained contentious due to underlying contamination issues. Here, we have used a previously described method for reducing contamination in microbiome workflows to determine if there is a fetal bacterial microbiome beyond the level of background contamination. We recruited 50 women undergoing non-emergency cesarean section deliveries with no evidence of intra-uterine infection and collected first-pass meconium …

Is The Blood An Alternative For Programmed Cell Death Ligand 1 Assessment In Non-Small Cell Lung Cancer?, Emmanuel Acheampong, Isaac Spencer, Weitao Lin, Melanie Ziman, Michael Millward, Elin Gray

Research outputs 2014 to 2021

Anti-programmed cell death (PD)-1/PD-ligand 1 (L1) therapies have significantly improved the outcomes for non-small cell lung cancer (NSCLC) patients in recent years. These therapies work by reactivating the immune system and enabling it to target cancer cells once more. There is a general agreement that expression of PD-L1 on tumour cells predicts the therapeutic response to PD-1/PD-L1 inhibitors in NSCLC. Hence, immunohistochemical staining of tumour tissue biopsies from NSCLC patients with PD-L1 antibodies is the current standard used to aid selection of patients for treatment with anti-PD-1 as first line therapy. However, issues of small tissue samples, tissue heterogeneity, the …

Comparison Of Subsequent Injury Categorisation (Sic) Models And Their Application In A Sporting Population, Liam A. Toohey, Michael K. Drew, Lauren V. Fortington, Miranda J. Menaspa, Caroline F. Finch, Jill L. Cook

Research outputs 2014 to 2021

Background: The original subsequent injury categorisation (SIC-1.0) model aimed to classify relationships between chronological injury sequences to provide insight into the complexity and causation of subsequent injury occurrence. An updated model has recently been published. Comparison of the data coded according to the original and revised subsequent injury categorisation (SIC-1.0 and SIC-2.0) models has yet been formally compared.

Methods: Medical attention injury data was prospectively collected for 42 elite water polo players over an 8 month surveillance period. The SIC-1.0 and SIC-2.0 models were retrospectively applied to the injury data. The injury categorisation from the two models was compared using …

Fractional Anisotropy Of Thalamic Nuclei Is Associated With Verticality Misperception After Extra-Thalamic Stroke, Taiza E. G. Santos, Jussara A. O. Baggio, Carlo Rondinoni, Laura Machado, Karina T. Weber, Luiz H. Stefano, Antonio C. Santos, Octavio M. Pontes-Neto, Joao P. Leite, Dylan J. Edwards

Research outputs 2014 to 2021

Verticality misperception after stroke is a frequent neurological deficit that leads to postural imbalance and a higher risk of falls. The posterior thalamic nuclei are described to be involved with verticality perception, but it is unknown if extra-thalamic lesions can have the same effect via diaschisis and degeneration of thalamic nuclei. We investigated the relationship between thalamic fractional anisotropy (FA, a proxy of structural integrity), and verticality perception, in patients after stroke with diverse encephalic extra-thalamic lesions. We included 11 first time post-stroke patients with extra-thalamic primary lesions, and compared their region-based FA to a group of 25 age-matched healthy …

Association Between Aortic Calcification, Cardiovascular Events, And Mortality In Kidney And Pancreas-Kidney Transplant Recipients, Joshua R. Lewis, Germaine Wong, Anne Taverniti, Mirna Vucak-Dzumhur, Grahame J. Elder

Research outputs 2014 to 2021

BACKGROUND: Cardiovascular (CV) disease is the leading cause of death in kidney and simultaneous pancreas-kidney (SPK) transplant recipients. Assessing abdominal aortic calcification (AAC), using lateral spine x-rays and the Kaupilla 24-point AAC (0-24) score, may identify transplant recipients at higher CV risk.

METHODS: Between the years 2000 and 2015, 413 kidney and 213 SPK first transplant recipients were scored for AAC at time of transplant and then followed for CV events (coronary heart, cerebrovascular, or peripheral vascular disease), graft-loss, and all-cause mortality.

RESULTS: The mean age was 44 ± 12 years (SD) with 275 (44%) having AAC (26% moderate: 1-7 …

The Exercise And Sports Science Australia Position Statement: Exercise Medicine In Cancer Management, Sandra C. Hayes, Robert U. Newton, Rosalind R. Spence, Daniel A. Galvao

Research outputs 2014 to 2021

Objectives: Since Exercise and Sports Science Australia (ESSA) first published its position statement on exercise guidelines for people with cancer, there has been exponential growth in research evaluating the role of exercise pre-, during and post-cancer treatment.

Design and Methods: The purpose of this report is to use the current scientific evidence, alongside clinical experience and exercise science principles to update ESSA’s position statement on cancer-specific exercise prescription.

Results: Reported in this position statement is a summary of the benefits accrued through exercise following a cancer diagnosis and the strengths and limitations of this evidence-base. An exercise prescription framework is …

Effects Of Different Combinations Of Concentric And Eccentric Resistance Training Programs On Traditional And Alternative Hamstrings-To-Quadriceps Ratios, Cassio V. Ruas, Ronei S. Pinto, Guy G. Haff, Camila D. Lima, Lee E. Brown

Research outputs 2014 to 2021

Resistance training is often recommended for combined increases in traditional and alternative hamstrings-to-quadriceps (H:Q) ratios in order to reduce knee strength imbalance and associated hamstrings and knee ligament injury risk. The aim of this study was to investigate the effect of different concentric and eccentric resistance training programs on traditional and alternative H:Q ratios. Forty male volunteers were assigned to one of 4 groups: concentric quadriceps and concentric hamstrings (CON/CON, n = 10), eccentric quadriceps and eccentric hamstrings (ECC/ECC, n = 10), concentric quadriceps and eccentric hamstrings (CON/ECC, n = 10), or no training (control (CNTRL), n = 10). Traditional …

Verifying Head Impacts Recorded By A Wearable Sensor Using Video Footage In Rugby League: A Preliminary Study, Lauchlan Carey, Peter Stanwell, Douglas P. Terry, Andrew S. Mcintosh, Shane V. Caswell, Grant L. Iverson, Andrew J. Gardner

Research outputs 2014 to 2021

Background: Rugby league is a full-contact collision sport with an inherent risk of concussion. Wearable instrumented technology was used to observe and characterize the level of exposure to head impacts during game play.

Purpose: To verify the impacts recorded by the x-patch™ with video analysis.

Study design: Observational case series.

Methods: The x-patch™ was used on eight men’s semi-professional rugby league players during the 2016 Newcastle Rugby League competition (five forwards and three backs). Game day footage was recorded by a trained videographer using a single camera located at the highest midfield location to verify the impact recorded by the …

Weight Management Among School-Aged Children And Adolescents: A Quantitative Assessment In A Ghanaian Municipality, Daniel Gyamfi, Christian Obirikorang, Emmanuel Acheampong, Evans A. Asamoah, Bernard Berko Sampong, Emmanuella Nsenbah Batu, Enoch O. Anto

Research outputs 2014 to 2021

BACKGROUND: Childhood and adolescent overweight, obesity and underweight have become an issue of grave concern to both the developed and developing countries in context of global burden of non-communicable diseases. Unhealthy weight status is a significant public health issue for developing countries, of which Ghana is not excluded. This study evaluated the prevalence of overweight, obesity and underweight and its related factors among school-aged children and adolescents.

METHODS: A total of 1004 participants were randomly selected from six schools. A structured questionnaire on demography and socioeconomic status of students' parents/guardians was completed by the selected students. Anthropometric parameters were measured, …

Plasma Neurofilament Light Chain And Amyloid-Β Are Associated With The Kynurenine Pathway Metabolites In Preclinical Alzheimer's Disease, Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins

Research outputs 2014 to 2021

BACKGROUND: Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer's disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in neurodegenerative diseases. However, the association of these markers of neurodegeneration and AD pathology with neuroinflammation has not been investigated previously. Therefore, the current study examined whether NFL and Aβ correlate with KP metabolites in elderly individuals to provide insight on the association between blood indicators of neurodegeneration and neuroinflammation.

METHODS: Correlations between KP metabolites, measured using liquid chromatography and gas chromatography coupled with mass spectrometry, and plasma NFL and Aβ concentrations, measured using …