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Articles 6541 - 6570 of 30002

Full-Text Articles in Mechanical Engineering

Study Of The Thermodynamic Properties Absorbation Sulfur Storage Gas Of Zinc And Copper Industry, Berdiyarov Tilovkabulovich Berdiyarov Dr., Sh. T. Khojiev, S. T. Matkarimov, Sh. Munosibov Dec 2021

Study Of The Thermodynamic Properties Absorbation Sulfur Storage Gas Of Zinc And Copper Industry, Berdiyarov Tilovkabulovich Berdiyarov Dr., Sh. T. Khojiev, S. T. Matkarimov, Sh. Munosibov

Technical science and innovation

The article considers the problems of utilization of industrial gases formed in the production of copper and ore containing sulfur anhydrides. Currently, the composition of process gases entering the gas purification department is approximately 6-7% SO2, 0.2-0.3% SO3 and other gases, until sulfuric acid is obtained from these gases, the sulfate is treated in a counter-scheme with 8% sulfate acid. The aim is to first reduce the temperature of the exhaust gases and second to avoid flying components such as as As, F, Se. As a result of the studies, the amount of SO2 in the …

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Rapid Ac Electrokinetic Micromixer With Electrically Conductive Sidewalls, Fang Yang, Wei Zhao, Cuifang Kuang, Guiren Wang Dec 2021

Rapid Ac Electrokinetic Micromixer With Electrically Conductive Sidewalls, Fang Yang, Wei Zhao, Cuifang Kuang, Guiren Wang

Faculty Publications

We report a quasi T-channel electrokinetics-based micromixer with electrically conductive sidewalls, where the electric field is in the transverse direction of the flow and parallel to the conductivity gradient at the interface between two fluids to be mixed. Mixing results are first compared with another widely studied micromixer configuration, where electrodes are located at the inlet and outlet of the channel with electric field parallel to bulk flow direction but orthogonal to the conductivity gradient at the interface between the two fluids to be mixed. Faster mixing is achieved in the micromixer with conductive sidewalls. Effects of Re numbers, applied …

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Evaluation Of The Thickness Of Vacuum Metal And Semiconductor Coatings Using Computer Programs, Bahrom Igamov, Ilkhom Bekpulatov, Aleksey Kamardin, Tulkun Kamilov, Ilhom Turapov, D Igamova Dec 2021

Evaluation Of The Thickness Of Vacuum Metal And Semiconductor Coatings Using Computer Programs, Bahrom Igamov, Ilkhom Bekpulatov, Aleksey Kamardin, Tulkun Kamilov, Ilhom Turapov, D Igamova

Technical science and innovation

Comparative studies of the thickness of coatings of such metals as Cu, Ag, Cr, Co, and also Mn4 Si7 on polished substrates made of Si, Si O2 / Si structure, ST - 50 glass ceramic, mica were carried out. The coatings were deposited in vacuum using thermal evaporation and magnetron sputtering. The thickness and uniformity of deposited coatings on rotating substrates are estimated by optical measurements and computer simulation. Mathematical models for the formation of coatings on flat substrates have been developed. The possibility of the optimal position of the substrate for the formation of functional coatings uniform in thickness …

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Analysis Of Multiple Degree-Of-Freedom Oscillatory Aquatic Propulsion, Seth Alan Brooks Dec 2021

Analysis Of Multiple Degree-Of-Freedom Oscillatory Aquatic Propulsion, Seth Alan Brooks

Dissertations - ALL

Propulsive performance and flow field data were experimentally measured for a two degree-of-freedom fish platform. The fish platform was designed and constructed based on the yellowfin tuna (\textit{Thunnus albacares}) that is known to be both fast and efficient. This work extends the current understanding of oscillatory aquatic propulsion to a three-dimensional fish platform with full volume flow field data and propulsive performance. A parametric sweep of trailing-edge amplitude of the caudal fin ($A$), heave-to-pitch ratio ($h^*$), and phase offset between the two degrees-of-freedom ($\phi$) was used to explore a parameter space that encompasses and extends beyond the known biological domain. …

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Exploiting Building Demand Flexibility Through Machine Learning For Building-To-Grid Integration, Hannah Charlene Fontenot Dec 2021

Exploiting Building Demand Flexibility Through Machine Learning For Building-To-Grid Integration, Hannah Charlene Fontenot

Dissertations - ALL

Demand flexibility – the ability to adjust a building's load profile across different timescales – is a key aspect of the ongoing effort to increase interconnectivity between buildings and the power grid. By harnessing their demand flexibility, buildings can provide significant benefits to the grid and bolster grid resilience and reliability. To facilitate the transition toward the "smart grid", new and intelligent control approaches are required that can seamlessly integrate building, occupant, and grid data and effectively control multiple building assets to provide grid services while maintaining occupants' required thermal comfort levels and reducing the building's overall energy consumption and …

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Temperature-Immune Self-Referencing Fabry–Pérot Cavity Sensors, Hengky Chandrahalim, Jonathan W. Smith Dec 2021

Temperature-Immune Self-Referencing Fabry–Pérot Cavity Sensors, Hengky Chandrahalim, Jonathan W. Smith

AFIT Patents

A passive microscopic Fabry-Pérot Interferometer (FPI) sensor an optical fiber a three-dimensional microscopic optical structure formed on a cleaved tip of an optical fighter that reflects a light signal back through the optical fiber. The reflected light is altered by refractive index changes in the three-dimensional structure that is subject to at least one of: (i) thermal radiation; and (ii) volatile organic compounds.

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Droplet-Based Fuel Property Measurements, Wanjun Dang Dec 2021

Droplet-Based Fuel Property Measurements, Wanjun Dang

LSU Doctoral Dissertations

Ongoing work to find renewable biofuels to function as drop-in replacements or blending components with gasoline has identified a large number of fuel candidates. Given the vast number of potential biomass-derived fuel molecules and limited sample sizes, screening tools are required to down-select candidate fuels having desired physical properties to ensure good engine performance. This work investigates approaches for rapid screening of candidate fuels using micro-liter sample sizes targeting four properties -- surface tension, viscosity, heat of vaporization (HOV), and vapor pressure. Measurement techniques for fuel properties are developed based on unit phenomena for liquid fuel droplets including droplet oscillation …

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Investigation Of An Optimized Occupancy-Driven Hvac Control Strategy And Development Of A Scalable House/Grid Simulation, Kaleb Pattawi Dec 2021

Investigation Of An Optimized Occupancy-Driven Hvac Control Strategy And Development Of A Scalable House/Grid Simulation, Kaleb Pattawi

Mechanical Engineering Master's Theses

Energy consumption in buildings is projected to increase more than 50% by 2050. Renewable energy sources are expected to increase and will help alleviate some of the energy demand; however, the intermittent nature of renewables makes it tough to effectively use energy in buildings. Various pricing schemes, including time of use electricity pricing, are used to encourage users to shift loads. Buildings need to be able to proactively react to changing energy sources and electricity prices in order to reduce over-generation of electricity and save money. This work demonstrates an optimized Heating Ventilation and Air Conditioning (HVAC) control strategy that …

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Active Membrane Energy Exchanger For Air Cooling And Dehumidification, Songhao Wu, Andrew Fix, David M. Warsinger, James E. Braun Dec 2021

Active Membrane Energy Exchanger For Air Cooling And Dehumidification, Songhao Wu, Andrew Fix, David M. Warsinger, James E. Braun

Discovery Undergraduate Interdisciplinary Research Internship

Heating, ventilation and air conditioning (HVAC) equipment consume 35% of total building energy use in the US, among which a large share is used for cooling and dehumidification. The majority of air dehumidification systems take the conventional approach of moisture condensation removal. It requires air to be cooled below its dew point temperature and is an energy-intensive process, especially for areas with hot and humid climates. Vapor selective membrane systems are promising alternatives for air dehumidification as they do not require cooling energy for latent (humidity) heat removal. It allows water vapor transport through the membrane while blocking air. Previous …

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State-Of-The-Art Of Thermal Control Solutions To Establish A Modular, Multi-Orbit Capable Spacecraft Thermal Management System Design Methodology, Robert C. Consolo Jr Dec 2021

State-Of-The-Art Of Thermal Control Solutions To Establish A Modular, Multi-Orbit Capable Spacecraft Thermal Management System Design Methodology, Robert C. Consolo Jr

Doctoral Dissertations and Master's Theses

Today, the exploration and exploitation of space continues to become a more common occurrence. All types of spacecraft (S/C) utilize various types of thermal management solutions to mitigate the effects of thermal loading from the unforgiving vacuum of space. Without an appropriately designed thermal system, components on-board the S/C can experience failure or malfunction due to fluctuations in temperatures either beyond the designed operational parameters or unstable oscillating temperatures. The purpose of this study is to perform a comprehensive review of technologies available today that are being used for thermal management onboard S/C in addition to investigating the means to …

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Numerical Simulation Of A Cryogenic Spray, Neel Kishorkumar Shah Dec 2021

Numerical Simulation Of A Cryogenic Spray, Neel Kishorkumar Shah

Doctoral Dissertations and Master's Theses

Cryogenic sprays have many applications in modern engineering. Cooling of electronic equipment subject to high heat flows, surgical ablation of gastrointestinal mucosae or orbital maneuvering are a few examples of their versatility. However, the atomization of a cryogenic liquid is a complex process. During such an event, aerodynamic effects associated with secondary atomization are further affected by thermodynamic flashing. A better understanding of the characteristics of cryogenic sprays is then necessary to allow for improved design and optimization in applications. The overarching objective of this study is to document such characteristics. The numerical simulation was performed over cryogenic nitrogen spray …

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Development And Application Of A Novel Acoustic Microfluidic Technology For Single Cell Per Well Trapping And High-Resolution Analysis Of Cilia Motion In Chlamydomonas Reinhardtii, Mingyang Cui Dec 2021

Development And Application Of A Novel Acoustic Microfluidic Technology For Single Cell Per Well Trapping And High-Resolution Analysis Of Cilia Motion In Chlamydomonas Reinhardtii, Mingyang Cui

McKelvey School of Engineering Graduate Student Theses & Dissertations

Acoustic manipulation of cells and microorganisms is a label-free and contact-free technique with promise for biological and biomedical applications. When exposed to an ultrasonic standing wave field, particles suspended in microfluidic channels will be moved to pressure minima (nodes) or maxima (antinodes) due to the acoustic impedance mismatch between particles and the suspension medium. Cilia motion is fundamental to understanding biological and biomedical problems related to dysfunctional human cilia, including primary ciliary dyskinesia, blindness, and male infertility. However, in vivo and ex vivo mammalian ciliated cell research is laborious and time-consuming due to difficulty in growing, maintaining, and imaging these …

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Acoustic Radiation Force And Its Application For Cell Manipulation And Ion Channels Activation, Xiangjun Peng Dec 2021

Acoustic Radiation Force And Its Application For Cell Manipulation And Ion Channels Activation, Xiangjun Peng

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sound is a stress wave that carries energy and momentum flux. Scattered sound waves can generate acoustic radiation force that can be used to manipulate particles or cells. This dissertation demonstrates the physics behind cell manipulation by ultrasound. The work begins with a detailed analysis of the mechanics of using standing surface acoustic waves to fabricate acoustic tweezers for contactless particle manipulation using acoustic radiation force. Models to design and analyze acoustic radiation force have traditionally relied on plane wave theories that cannot predict how standing surface acoustic waves can levitate cells in the direction perpendicular to the substrate. We …

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Defining The Role Of Elastic Fibers In Tendon Mechanics, Jeremy D. Eekhoff Dec 2021

Defining The Role Of Elastic Fibers In Tendon Mechanics, Jeremy D. Eekhoff

McKelvey School of Engineering Graduate Student Theses & Dissertations

Tendons serve as a linking component of the musculoskeletal system by transferring forces between muscle and bone. As such, the structural proteins of the tendon extracellular matrix are of vital importance for the tissue to function properly and maintain its mechanical integrity. Collagen is the principal constituent of tendon and makes up its aligned hierarchical organization. Other structural proteins, such as elastin, are in comparison understudied and not well understood in relation to tendon function. Elastin, the main component of elastic fibers, has unique mechanical properties including high extensibility, fatigue resistance, and elasticity; these properties are important for elastin-rich tissues …

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Hydrogen Peroxide Vapor Decontamination Of Polylactic Acid Fibers, Alexandra Craig Dec 2021

Hydrogen Peroxide Vapor Decontamination Of Polylactic Acid Fibers, Alexandra Craig

Mechanical Engineering Theses

Electrospun fibers have attracted attentions in topical drug delivery due to the ability to modulate drug release at high drug loading. While the pharmaceutical properties of these drug-eluting fibers were reported elsewhere, the compatibility of these fibers with hydrogen peroxide vapor, an effective decontaminant, is not fully established. In this work, polylactic acid (PLA) microfibers loaded with acetylsalicylic acid (ASA) were electrospun to examine their compatibility with hydrogen peroxide vapor. Results suggested a strengthening effect of the PLA/ASA fibers due to intermolecular interactions of ASA with PLA, which modulated the in vitro drug release rates. After exposing PLA/ASA fibers to …

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The NTh-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Response-Coupled Forward/Adjoint Linear Systems (NTh-Casam-L): Ii. Illustrative Application, Dan Gabriel Cacuci Dec 2021

The NTh-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Response-Coupled Forward/Adjoint Linear Systems (NTh-Casam-L): Ii. Illustrative Application, Dan Gabriel Cacuci

Faculty Publications

This work illustrates the application of the nth-order comprehensive adjoint sensitivity analysis methodology for response-coupled forward/adjoint linear systems (abbreviated as “nth-CASAM-L”) to a paradigm model that describes the transmission of particles (neutrons and/or photons) through homogenized materials, as encountered in radiation protection and shielding. The first-, second-, and third-order sensitivities of responses that depend on both the forward and adjoint particle fluxes are obtained exactly, in closed-form, underscoring the principles and methodology underlying the nth-CASAM-L. The results presented in this work underscore the fundamentally important role of the nth-CASAM-L in the quest …

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The NTh-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Response-Coupled Forward/Adjoint Linear Systems (NTh-Casam-L): I. Mathematical Framework, Dan Gabriel Cacuci Dec 2021

The NTh-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Response-Coupled Forward/Adjoint Linear Systems (NTh-Casam-L): I. Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work presents the mathematical framework of the nth-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Response-Coupled Forward/Adjoint Linear Systems (abbreviated as “nth-CASAM-L”), which is conceived for obtaining the exact expressions of arbitrarily-high-order (nth-order) sensitivities of a generic system response with respect to all of the parameters (including boundary and initial conditions) underlying the respective forward/adjoint systems. Since many of the most important responses for linear systems involve the solutions of both the forward and the adjoint linear models that correspond to the respective physical system, the sensitivity analysis of such responses makes it necessary …

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The NTh-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Response-Coupled Forward/Adjoint Linear Systems (NTh-Casam-L): I. Mathematical Framework, Dan Gabriel Cacuci Dec 2021

The NTh-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Response-Coupled Forward/Adjoint Linear Systems (NTh-Casam-L): I. Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work presents the mathematical framework of the nth-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Response-Coupled Forward/Adjoint Linear Systems (abbreviated as “nth-CASAM-L”), which is conceived for obtaining the exact expressions of arbitrarily-high-order (nth-order) sensitivities of a generic system response with respect to all of the parameters (including boundary and initial conditions) underlying the respective forward/adjoint systems. Since many of the most important responses for linear systems involve the solutions of both the forward and the adjoint linear models that correspond to the respective physical system, the sensitivity analysis of such responses makes it necessary …

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A Parametric Computational Fluid Dynamics (Cfd) Study Of In-Line Horizontal Axis Wind Turbines (Hawts) With Yaw, North Alyster Yates Dec 2021

A Parametric Computational Fluid Dynamics (Cfd) Study Of In-Line Horizontal Axis Wind Turbines (Hawts) With Yaw, North Alyster Yates

Masters Theses

Because of the constant use of non-renewable fossil fuels, and the enormous impact they have on global warming and pollution, there has been a push to use more eco-friendly and renewable sources for power. One such form is wind power via turbines. The most common form, Horizontal Axis Wind Turbines (HAWTs), can generate massive amounts of power. However, they also have a serious flaw in their design. As the wind passes through the swept area of the blades and past the tower, it creates massive disturbances in the airflow. These disturbances are called a ‘wake’. When trying to create a …

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Predictive Computational Materials Modeling With Machine Learning: Creating The Next Generation Of Atomistic Potential Using Neural Networks, Mashroor Shafat Nitol Dec 2021

Predictive Computational Materials Modeling With Machine Learning: Creating The Next Generation Of Atomistic Potential Using Neural Networks, Mashroor Shafat Nitol

Theses and Dissertations

Machine learning techniques using artificial neural networks (ANNs) have proven to be effective tools to rapidly mimic first principles calculations. These tools are capable of sub meV/atom accuracy while operating with linear scaling with respect to the system size. Here novel interatomic potentials are constructed based on the rapid artificial neural network (RANN) formalism. This approach generates precise force fields for various metals that have historically been difficult to describe at the atomic scale. These force fields can be utilized in molecular dynamics simulations to provide new physical insights. The RANN formalism, which is incorporated into a LAMMPS molecular dynamics …

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Torque Vectoring To Maximize Straight-Line Efficiency In An All-Electric Vehicle With Independent Rear Motor Control, William Blake Brown Dec 2021

Torque Vectoring To Maximize Straight-Line Efficiency In An All-Electric Vehicle With Independent Rear Motor Control, William Blake Brown

Theses and Dissertations

BEVs are a critical pathway towards achieving energy independence and meeting greenhouse and pollutant gas reduction goals in the current and future transportation sector [1]. Automotive manufacturers are increasingly investing in the refinement of electric vehicles as they are becoming an increasingly popular response to the global need for reduced transportation emissions. Therefore, there is a desire to extract the most fuel economy from a vehicle as possible. Some areas that manufacturers spend much effort on include minimizing the vehicle’s mass, body drag coefficient, and drag within the powertrain. When these values are defined or unchangeable, interest is driven to …

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A Data-Driven Approach For The Investigation Of Microstructural Effects On The Effective Piezoelectric Responses Of Additively Manufactured Triply Periodic Bi-Continuous Piezocomposite, Wenhua Yang Dec 2021

A Data-Driven Approach For The Investigation Of Microstructural Effects On The Effective Piezoelectric Responses Of Additively Manufactured Triply Periodic Bi-Continuous Piezocomposite, Wenhua Yang

Theses and Dissertations

A two-scale model consisting of ceramic grain scale and composite scale are developed to systematically evaluate the effects of microstructures (e.g., residual pores, grain size, texture) and geometry on the piezoelectric responses of the polarized triply periodic bi-continuous (TPC) piezocomposites. These TPC piezocomposites were fabricated by a recently developed additive manufacturing (AM) process named suspension-enclosing projection-stereolithography (SEPS) under different process conditions. In the model, the Fourier spectral iterative perturbation method (FSIPM) and the finite element method will be adopted for the calculation at the grain and composite scale, respectively. On the grain scale, a DL approach based on stacked generative …

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The Development Of A Finite Element Model For Ballistic Impact Predictions, Richard Allen Perkins Dec 2021

The Development Of A Finite Element Model For Ballistic Impact Predictions, Richard Allen Perkins

Theses and Dissertations

Concrete is a widely used product and is an important application throughout industry due to its inexpensive cost and wide range of applications. This work focuses on understanding the behavior of high strength concrete in high strain rate ballistic impact loading scenarios. A finite element analysis was created with the implementation of the Concrete Damage and Plasticity Model 2 (CDPM2) to represent the material behavior. The model’s parameters were calibrated to existing literature and the results were analyzed by a comparison of the impact velocity to residual velocity and a qualitative assessment of the impact crater. The model captured the …

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Effects Of Bonding Pressure And Lamina Thickness On Mechanical Properties Of Clt Composed Of Southern Yellow Pine, Cody S. Bates Dec 2021

Effects Of Bonding Pressure And Lamina Thickness On Mechanical Properties Of Clt Composed Of Southern Yellow Pine, Cody S. Bates

Theses and Dissertations

This study produced cross-laminated timber panels at a range of four lamina thickness (5/8, 1, 1 1/8, and 1 1/4 inch) and three bonding pressures (50, 125, 200 psi), producing a total of 12 panels for mechanical testing. The goal of this study is to observe how the thickness and pressure trends affect the mechanical properties of CLT. Tests include flatwise bending, flatwise shear, internal-bond, and delamination. Results showed that bending MOE decreases as the panel thickness increases while bonding pressure had no significance. Bending MOR was less significant for the thickness and more significant for pressure compared to the …

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Modeling The Ballistic Limit Of Fragment Simulating Projectiles Impacting A36 Mild Steel Spaced Armor Configurations, Daniel H. Rios-Estremera Dec 2021

Modeling The Ballistic Limit Of Fragment Simulating Projectiles Impacting A36 Mild Steel Spaced Armor Configurations, Daniel H. Rios-Estremera

Theses and Dissertations

Terminal ballistics study multivariate behavior and aftermath of projectile and target interactions. Tests and models are often based on monolithic armors, however, layered and spaced armors are common in real world applications. Such configurations add complexities that require research to understand their effects on terminal ballistics. The ballistic limit velocity (V50) represents the speed where armor perforation probability is 50%. It is used for quantitative comparison of protection capabilities for different armors. This research studied the V50 of spaced and layered A36 steel armors against fragment simulating projectiles (FSPs). Four methods for estimating armor V50 were evaluated and compared to …

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Uncertainty-Aware Deep Learning For Prediction Of Remaining Useful Life Of Mechanical Systems, Samuel J. Cornelius Dec 2021

Uncertainty-Aware Deep Learning For Prediction Of Remaining Useful Life Of Mechanical Systems, Samuel J. Cornelius

Theses and Dissertations

Remaining useful life (RUL) prediction is a problem that researchers in the prognostics and health management (PHM) community have been studying for decades. Both physics-based and data-driven methods have been investigated, and in recent years, deep learning has gained significant attention. When sufficiently large and diverse datasets are available, deep neural networks can achieve state-of-the-art performance in RUL prediction for a variety of systems. However, for end users to trust the results of these models, especially as they are integrated into safety-critical systems, RUL prediction uncertainty must be captured. This work explores an approach for estimating both epistemic and heteroscedastic …

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Study Of Alloy And Process Modifications To Design Hydrogen Resilient High Hardness Steels, William R. Williams Dec 2021

Study Of Alloy And Process Modifications To Design Hydrogen Resilient High Hardness Steels, William R. Williams

Theses and Dissertations

High hardness steels (HHS) are vulnerable to hydrogen embrittlement, which can lead to rapid degradation of mechanical properties. Improved resistance to hydrogen embrittlement would be beneficial to many industries including construction, automotive, and military. A comparison study was performed to assess the hydrogen susceptibility of select commercially available and in-house designed HHS alloys. Slow strain rate tensile tests, performed with specimens charged with various levels of hydrogen, provided a macroscopic view of the onset of hydrogen embrittlement. Hydrogen permeation and thermal desorption spectroscopy tests determined the uptake and diffusivity of hydrogen through the material. The evaluation of hydrogen susceptibility for …

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Airfoil Flow Optimized Control With An Upstream Cylinder, Nicole Steiner Dec 2021

Airfoil Flow Optimized Control With An Upstream Cylinder, Nicole Steiner

Fall Student Research Symposium 2021

The purpose of this research is to optimize the aerodynamic performance of an airfoil with an upstream cylinder by neural network artificial intelligence. The effects of an upstream oscillating cylinder on the aerodynamic performance of an airfoil are also studied. This paper reports the effects oscillating frequency of the cylinder and the Reynolds number on the lift/drag ratio of the airfoil. The frequency has a complicated correlation with the lift/drag ratio, while the Reynolds number is found to have a positive correlation with the lift/drag ratio. The optimized case is found to have a lift/drag ratio of 1.7319, which is …

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Smooth Muscle Cells Affect Differential Nanoparticle Accumulation In Disturbed Blood Flow-Induced Murine Atherosclerosis, Hunter Miller, Morgan A. Schake, Badrul Alam Bony, Evan T. Curtis, Conner C. Gee, Ian Mccue, Thomas J. Ripperda Jr., Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi Dec 2021

Smooth Muscle Cells Affect Differential Nanoparticle Accumulation In Disturbed Blood Flow-Induced Murine Atherosclerosis, Hunter Miller, Morgan A. Schake, Badrul Alam Bony, Evan T. Curtis, Conner C. Gee, Ian Mccue, Thomas J. Ripperda Jr., Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Atherosclerosis is a lipid-driven chronic inflammatory disease that leads to the formation of plaques in the inner lining of arteries. Plaques form over a range of phenotypes, the most severe of which is vulnerable to rupture and causes most of the clinically significant events. In this study, we evaluated the efficacy of nanoparticles (NPs) to differentiate between two plaque phenotypes based on accumulation kinetics in a mouse model of atherosclerosis. This model uses a perivascular cuff to induce two regions of disturbed wall shear stress (WSS) on the inner lining of the instrumented artery, low (upstream) and multidirectional (downstream), which, …

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Microfabricated Platforms To Investigate Cell Mechanical Properties, Amir M. Esfahani, Grayson Minnick, Jordan Rosenbohm, Haiwei Zhai, Xiaowei Jin, Bahareh Tajvidi Safa, Justin Brooks, Ruiguo Yang Dec 2021

Microfabricated Platforms To Investigate Cell Mechanical Properties, Amir M. Esfahani, Grayson Minnick, Jordan Rosenbohm, Haiwei Zhai, Xiaowei Jin, Bahareh Tajvidi Safa, Justin Brooks, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Mechanical stimulation has been imposed on living cells using several approaches. Most early investigations were conducted on groups of cells, utilizing techniques such as substrate deformation and flow-induced shear. To investigate the properties of cells individually, many conventional techniques were utilized, such as AFM, optical traps/optical tweezers, magnetic beads, and micropipette aspiration. In specific mechanical interrogations, microelectro- mechanical systems (MEMS) have been designed to probe single cells in different interrogation modes. To exert loads on the cells, these devices often comprise piezo-electric driven actuators that attach directly to the cell or move a structure on which cells are attached. Uniaxial …

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