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Articles 3481 - 3510 of 30232
Full-Text Articles in Mechanical Engineering
Advanced Thermal Management Solutions For High-Powered Chips: A Comprehensive Study On Immersion Cooling And Electrochemical Additive Manufacturing-Based Cold Plates, Gautam Gupta
Mechanical and Aerospace Engineering Dissertations - Archive
This dissertation investigates advanced thermal management strategies for high-performance computing systems to address the escalating thermal challenges posed by increasing power densities and computational demands. Chapter 1 evaluates the efficacy of forced convection Single-Phase Immersion Cooling (SPIC) with a dielectric fluid (EC-110) compared to traditional air cooling for a 776 W server. Computational Fluid Dynamics (CFD) simulations demonstrate significant reductions in chip junction temperatures, maximum Dual In-line Memory Module (DIMM) temperatures, and server pressure drop with immersion cooling, highlighting its superior heat dissipation capabilities.
Chapter 2 delves into the comparative analysis of forced and natural convection Single-Phase Immersion Cooling techniques. …
Reliability Assessment Of 2.5d Heterogenous Integrated Circuits, Cu-Cu Hybrid Bonded Interconnects & Thermo-Mechanical Assessment Of Substrates In Two-Phase Immersion Cooling, Akshay Boovanahally Lakshminarayana
Reliability Assessment Of 2.5d Heterogenous Integrated Circuits, Cu-Cu Hybrid Bonded Interconnects & Thermo-Mechanical Assessment Of Substrates In Two-Phase Immersion Cooling, Akshay Boovanahally Lakshminarayana
Mechanical and Aerospace Engineering Dissertations - Archive
Moore’s law has predicted the growth of semiconductor industry for the last 50 years by providing a template for silicon scaling and homogenous system on chip integration of multiple circuits. Lately, this trend has been declining due to the increased power density and functionality and increasing chip size to accommodate this. Moving forward, heterogeneous integration of chiplets will improve the silicon yield by integrating multiple multi-functional chiplets that are of smaller area onto an interposer or a substrate in 2.5D, 3D or 3.5 D architectures. In this study, computational analysis is done on the impact of design parameters and material …
Towards The Development Of A Unified Synthesis System Framework: Advancement Of Avds Towards A Generic, Multi-Disciplinary, And Multi-Fidelity Aerospace Vehicle Design Environment, Ian Wesley Maynard
Towards The Development Of A Unified Synthesis System Framework: Advancement Of Avds Towards A Generic, Multi-Disciplinary, And Multi-Fidelity Aerospace Vehicle Design Environment, Ian Wesley Maynard
Mechanical and Aerospace Engineering Dissertations - Archive
At the start of any design program for the development of a novel aerospace vehicle, there can be millions of design, mission, and technology trades to be explored. Design software is needed that can modularly adapt itself such that it can be generically applied to a wide variety of aerospace applications. It needs to be automated such that it can ‘stitch’ together and generate synthesis codes using a wide variety of disciplinary methods including geometry, aerodynamics, propulsion, trajectory, weights, stability and control, cost, etc. It should also be able to modularly switch the multi-disciplinary synthesis execution process in the synthesis …
Characterization Of Adhesive Strength In Metal-Polymer Bonds, Oreoluwa Adeseyoju
Characterization Of Adhesive Strength In Metal-Polymer Bonds, Oreoluwa Adeseyoju
Open Access Master's Theses
Classified information has been deleted.
Investigating The Thermal Multibody Effects In Spherical Inclusions Of A Porous Matrix For Lithium-Ion Batteries, Nicholas Scholz
Investigating The Thermal Multibody Effects In Spherical Inclusions Of A Porous Matrix For Lithium-Ion Batteries, Nicholas Scholz
Open Access Master's Theses
As technology improves, there is a need for better and more efficient energy storage and lithium-ion batteries have emerged as the primary energy storage device. They have positive electrochemical properties, are easily accessible, and rechargeable. However, lithium-ion batteries have been known to fail, leading to research into the failure mechanisms. As some of these failure mechanisms, such as thermal runaway, depend on thermal interactions, this paper aims to investigates thermal multibody effects of spherical inclusions in a porous matrix to gain insight into thermal effects of a realistic lithium-ion battery microstructure. Analytical solutions to this problem, such as Maxwell’s thermal …
Propagation Of Vibro-Acoustic Energy In Ducts: Measurement, Simulation, And Attenuation Studies, Caoyang Li
Propagation Of Vibro-Acoustic Energy In Ducts: Measurement, Simulation, And Attenuation Studies, Caoyang Li
Theses and Dissertations--Mechanical and Aerospace Engineering
Vibro-acoustic energy propagates through heating, ventilating, and air conditioning (HVAC) systems through both airborne and structureborne paths. In this research, measurement and simulation studies are performed to better understand this propagation of energy and how to better attenuate the sound before it impacts building occupants.
First, a scaled-down experiment was developed to assist in the validation of numerical simulation models. A small source room was attached to a wooden duct with variable cross-sectional area. The sound power for both untreated and treated ductwork was measured using sound intensity scanning, and the insertion loss is the difference between untreated and treated …
Artificial Intelligence Enabled Machinery Fault Detection And Diagnosis Using Vibro-Acoustic Signals, Srinivasa Rao Ippili
Artificial Intelligence Enabled Machinery Fault Detection And Diagnosis Using Vibro-Acoustic Signals, Srinivasa Rao Ippili
Theses and Dissertations--Mechanical and Aerospace Engineering
In various industries, the early detection of faults in rotating machinery is crucial to prevent system failures and ensure customer satisfaction. Typically, vibration measurement and diagnosis are employed for fault detection, but this process faces challenges in automation due to the complexity of installing and maintaining accelerometers, particularly in end-of-line quality control or pre-installed machinery health assessments. Acoustic signals, as a form of mechanical wave, offer an alternative for monitoring machinery while in operation. Unlike accelerometers, acoustic transducers are non-contact and easy to set up, enabling real-time data collection without interrupting equipment operation. However, utilizing acoustic signals in manufacturing poses …
Measurement And Simulation Of Aeroacoustic Sources Generated By Elementary Muffler Components, Seth Donkin
Measurement And Simulation Of Aeroacoustic Sources Generated By Elementary Muffler Components, Seth Donkin
Theses and Dissertations--Mechanical and Aerospace Engineering
Mufflers and silencers are commonly used to control noise from sources such as internal combustion engines and heating, ventilating, and air conditioning (HVAC) systems. In these applications, flow interacts with muffler components generating aeroacoustic noise sources. In order to measure these sources in a lab setting, specialized flow rigs are designed to isolate aeroacoustic noise sources. Flow sometimes compromises muffler performance. However, muffler performance is sometimes improved because flow can increase the attenuation of some muffler elements such as perforates. To better understand the complicated impact of flow, the University of Kentucky developed a muffler test rig to measure insertion …
Droplet Analysis Of Spray Inside A Compact Column Gas Scrubber Through Shadowgraphy, Brandon Heller
Droplet Analysis Of Spray Inside A Compact Column Gas Scrubber Through Shadowgraphy, Brandon Heller
Theses and Dissertations--Mechanical and Aerospace Engineering
The shadowgraphy imaging technique was adapted to analyze the droplet field from a spray nozzle inside the gas absorption section of a compact column gas scrubber. This technique in conjunction with a developed image processing technique was able to gain statistical size information at different distances from two types of spray nozzles. The gas scrubber then ran a parametric campaign of eight operating conditions and statistical size information was captured for each case with the goal of understanding how operating conditions affect the droplet field properties. Lastly, several simulations were completed to understand how the addition of recirculation zones would …
Microstructure-Based Modeling And Simulation Via A Nonlocal Multiphysics Discrete Approach, Donglai Liu
Microstructure-Based Modeling And Simulation Via A Nonlocal Multiphysics Discrete Approach, Donglai Liu
Theses and Dissertations--Mechanical and Aerospace Engineering
Many structures in engineering are subject to multiphysics loadings or environment. Computational modeling plays a significant role to predict or evaluate the performance of these structures, especially in the scenarios where the experimental investigation is cumbersome or prohibitively expensive. Microstructure-based modeling incorporates the information of microstructures of materials in numerical models, which can provide insights about the relationship between microstructures and mate- rial properties. This research developed a microstructure-based modeling framework for coupling diffusion-deformation simulation of solids. The model is based on a recent developed meshfree method referred to as lattice particle method in the literature. In the developed model, …
Provably Safe Control For Input-Constrained Robotic Systems, Pedram Rabiee
Provably Safe Control For Input-Constrained Robotic Systems, Pedram Rabiee
Theses and Dissertations--Mechanical and Aerospace Engineering
This dissertation addresses challenges in control design for safety-critical robotic systems with input constraints. It focuses on developing novel control barrier function (CBF) approaches to ensure safety while optimizing performance. The work is motivated by the limitations of traditional methods in handling nonlinear systems with multiple constraints and actuator limits.
Three main contributions are presented. First, a soft-minimum barrier function is introduced, utilizing finite-time horizon predictions to create control forward invariant subsets of the safe set while respecting actuator constraints. This method is extended to multiple backup controls, which can enlarge the safe operating region.
Second, a technique for composing …
High-Fidelity Coupling For Studies Of Ablative Materials At Hypersonic Conditions, Aleksander Zibitsker
High-Fidelity Coupling For Studies Of Ablative Materials At Hypersonic Conditions, Aleksander Zibitsker
Theses and Dissertations--Mechanical and Aerospace Engineering
The development of accurate models and robust numerical tools for simulating ablative thermal protection materials (TPMs) in hypersonic flows is crucial for advancing atmospheric entry and hypersonic technologies. Traditional methods for simulating ablative materials often rely on heavy assumptions, such as equal heat and mass transfer coefficients and chemical equilibrium in the boundary layer, leading to conservative thermal protection system (TPS) designs and insufficient accuracy for certain in-flight ablation phenomena.
This work presents a high-fidelity and versatile coupled framework between hypersonic flow and material response solvers. The flow domain is modeled with an innovative overset CHAMPS NBS-Cart solver, which features …
Multiscale Fiber Remodeling In The Heart Using A Finite Element Framework, Mohammad Mehri
Multiscale Fiber Remodeling In The Heart Using A Finite Element Framework, Mohammad Mehri
Theses and Dissertations--Mechanical and Aerospace Engineering
The organization of myofibers and extra cellular matrix within the myocardium plays a significant role in defining cardiac function. When pathological events occur, such as myocardial infarction (MI) or hypertrophic cardiomyopathy (HCM), this organization can become disrupted, leading to alteration in pumping performance. The current study proposes a multiscale finite element (FE) framework to determine realistic fiber distributions in the left ventricle (LV). This is achieved by implementing a stress-based fiber reorientation law, which seeks to align the fibers with local traction vectors, such that contractile force and load bearing capabilities are maximized. By utilizing the total stress (passive and …
Optimal Tilt-Wing Evtol Takeoff Trajectory Prediction Using Regression Generative Adversarial Networks, Shuan Tai Yeh, Xiaosong Du
Optimal Tilt-Wing Evtol Takeoff Trajectory Prediction Using Regression Generative Adversarial Networks, Shuan Tai Yeh, Xiaosong Du
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Electric vertical takeoff and landing (eVTOL) aircraft have attracted tremendous attention nowadays due to their flexible maneuverability, precise control, cost efficiency, and low noise. The optimal takeoff trajectory design is a key component of cost-effective and passenger-friendly eVTOL systems. However, conventional design optimization is typically computationally prohibitive due to the adoption of high-fidelity simulation models in an iterative manner. Machine learning (ML) allows rapid decision making; however, new ML surrogate modeling architectures and strategies are still desired to address large-scale problems. Therefore, we showcase a novel regression generative adversarial network (regGAN) surrogate for fast interactive optimal takeoff trajectory predictions of …
Effect Of Bioactive Borate Glass On Printability And Physical Properties Of Hydrogels, Fateme Fayyazbakhsh, Mehedi H. Tusar, Yue-Wern Huang, Ming C. Leu
Effect Of Bioactive Borate Glass On Printability And Physical Properties Of Hydrogels, Fateme Fayyazbakhsh, Mehedi H. Tusar, Yue-Wern Huang, Ming C. Leu
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Hydrogels are a key component in bioinks and biomaterial inks for bioprinting due to their biocompatibility and printability at room temperature. The research described in the present paper contributes to the advancement of bioprinting by studying the effect of bioactive borate glass (BBG) incorporated into hydrogels on printability and physical properties. In this study, we fabricated 3D-printed hydrogel scaffolds using gelatin and alginate hydrogel mixture incorporated with various amounts of BBG, a bio ceramic rich in therapeutic ions including boron, calcium, copper, and zinc. We investigated the effect of incorporating BBG on the density, viscosity, physical interactions, chemical structure, and …
Impact Of Aging On Pim And Dc Resistance Of Fabric-Over-Foam Metallic Contacts, Kalkidan W. Anjajo, Seunghun Ryu, Shengxuan Xia, Gracie Boyer, Yuchu He, Haicheng Zhou, Hanfeng Wang, Jonghyun Park, Chulsoon Hwang
Impact Of Aging On Pim And Dc Resistance Of Fabric-Over-Foam Metallic Contacts, Kalkidan W. Anjajo, Seunghun Ryu, Shengxuan Xia, Gracie Boyer, Yuchu He, Haicheng Zhou, Hanfeng Wang, Jonghyun Park, Chulsoon Hwang
Mechanical and Aerospace Engineering Faculty Research & Creative Works
In this paper the impact of aging on the level of passive intermodulation (PIM) and DC resistance of fabric-over-foam metallic contacts is presented. These contacts are widely used to maintain metallic connections between modules and chassis in electronic devices. The PIM caused by the loose metallic contact of these materials mainly affects a receiver's RF sensitivity in mobile devices. This aging test under elevated temperature and relative humidity conditions offers an experiment-based approach with respect to various metallic contact cases. Energy dispersive spectroscopy and scanning electron microscopy are used to characterize the change in material composition and the contact surface …
Phenolic Polymer Infiltration And Pyrolysis Process For Additively Manufactured Carbon/Peek Composites To Produce Carbon–Carbon Composites, S. Weiler, H. A. Haffner, K. Chandrashekhara, J. Watts, G. E. Hilmas, J. Bayldon, L. M. Rueschhoff
Phenolic Polymer Infiltration And Pyrolysis Process For Additively Manufactured Carbon/Peek Composites To Produce Carbon–Carbon Composites, S. Weiler, H. A. Haffner, K. Chandrashekhara, J. Watts, G. E. Hilmas, J. Bayldon, L. M. Rueschhoff
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Carbon–carbon composites are carbon fibers reinforced with carbon matrix and are classified as advanced materials well suited for high-temperature structural applications. Carbon–carbon composites are characterized by maintaining excellent mechanical properties and structural stability at high temperatures and have been used in aerospace application as nozzles, heatshields, and leading edge. However, conventional methods to manufacture carbon–carbon composites are costly and time-consuming. the aim of this work is to develop a method for creating additively manufactured (AM) carbon–carbon composites using a high-pressure re-infiltration process. in doing so, less infiltration cycles are required compared to a low-pressure re-infiltration, reducing the total manufacture time. …
New Testing Capabilities Of The Missouri University Of Science And Technology Supersonic Wind Tunnel, Joshua Gary, Davide Viganò
New Testing Capabilities Of The Missouri University Of Science And Technology Supersonic Wind Tunnel, Joshua Gary, Davide Viganò
Mechanical and Aerospace Engineering Faculty Research & Creative Works
The development of non-intrusive, laser-based diagnostic techniques has significantly enhanced supersonic experimental aerodynamics, enabling the measurement of many parameters in complex flow fields. Among these techniques, Tomographic Particle Image Velocimetry, capable of measuring 3 components of velocity in 3-dimensional volumes, is now available at the Aerodynamics Research Laboratory of the Missouri University of Science and Technology. To integrate this new system into the university's supersonic wind tunnel, a redesigned nozzle, test section, and diffuser have been implemented. The upgraded modular test section features 4 large ports which can be configured with windows for optical diagnostics or lead plates for model …
Sensor Tasking For Low Earth Orbit Objects: Leveraging Space Sensor Data For Ground-Based Optical Observations, Smriti Nandan Paul, Hang Woon Lee
Sensor Tasking For Low Earth Orbit Objects: Leveraging Space Sensor Data For Ground-Based Optical Observations, Smriti Nandan Paul, Hang Woon Lee
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Because of recent advancements in space technologies, easier and more economical access to space, and an increase in commercial interests, the near-Earth space environment has witnessed an exploding number of objects being put into orbit. In particular, the low Earth orbit (LEO) region is at an increased risk of orbital collisions from large satellite constellation projects. Thus, monitoring LEO objects for space situational awareness and space traffic management has become increasingly imperative. In this paper, we use the concept of limited-CDF (cumulative distribution function) surface and mutual information for designing sensor tasking algorithms focusing on regular observation of known catalog …
Tractor Test #2294: Kubota M7-154, Nebraska Tractor Test Lab
Tractor Test #2294: Kubota M7-154, Nebraska Tractor Test Lab
Nebraska Tractor Tests
ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …
Stable Energy-Efficient Macro-Scale Partial Flow-Boiling Operations Using Microstructured Surfaces And Ultrasonics, Divya Kamlesh Pandya
Stable Energy-Efficient Macro-Scale Partial Flow-Boiling Operations Using Microstructured Surfaces And Ultrasonics, Divya Kamlesh Pandya
Dissertations, Master's Theses and Master's Reports
Controlled but explosive growth in vaporization rates is made feasible by ultrasonic acoustothermal heating of the microlayers associated with micro-scale nucleating bubbles within the microstructured boiling surface/region of a millimeter-scale single-channel heat exchanger (HX) – part of a typically multi-channel heat-sink. The experiments illustrate the achievement of a remarkably high stable heat flux (10 – 80 W/cm2) for a partial flow-boiling-based cooling approach and exceptional efficiency through active/passive enhancement in the vaporization rates into the heterogeneously nucleated micro-bubbles (through acoustothermal heating of their microlayers) and their removal rates (typically within the passive microstructured region of boiling). A controlled …
Directional Dependent Fracture Characteristics Of 3d Printed Mechanical Metamaterials, Thomas Draper
Directional Dependent Fracture Characteristics Of 3d Printed Mechanical Metamaterials, Thomas Draper
Dissertations, Master's Theses and Master's Reports
Structural metamaterials, such as lattice metamaterials, are engineered cellular structures designed to achieve properties not achievable by natural materials. They enable mechanical properties unattainable by homogeneous solid materials and offer optimal properties for these materials tunable for specific applications in industries such as automotive, medical, and aerospace. Recent findings have revealed unique tunable mechanical properties such as negative Poisson's ratio, high strength-to-weight ratio, anisotropic stiffness, and much more. While the elastic and wave propogation properties of many lattice metamaterials are well investigated, the fracture properties are not well explored. However, their low fracture toughness is a bottleneck for their use …
Wave Energy Converter Wave Force Prediction Using A Neural Network, Morgan Kline
Wave Energy Converter Wave Force Prediction Using A Neural Network, Morgan Kline
Dissertations, Master's Theses and Master's Reports
Due to the unpredictable nature of large bodies of water, wave energy can be a difficult renewable resource to rely on. One way to make Wave Energy Converters (WECs) more efficient is to apply a control strategy. In many control solutions, it is assumed that the wave excitation force is known into the future. In many instances, especially with complex waveforms, this is simply not the case. Simulation studies have shown the promise of wave force prediction using neural networks. This study demonstrates this experimentally and aims to characterize the important factors when designing such a network. Several wave elevation …
Fatigue Resistant Cast Steel Railcar Couplers Produced By Wire-Arc Additive Manufacturing (Waam), Samuel Vellequette
Fatigue Resistant Cast Steel Railcar Couplers Produced By Wire-Arc Additive Manufacturing (Waam), Samuel Vellequette
Dissertations, Master's Theses and Master's Reports
Every year, approximately 90,000 cast steel railcar coupler knuckles are replaced preemptively to avoid fatigue failure. The coupler geometry has been in service since the early 1930s, so geometry changes are restricted to maintain compatibility with the existing fleet. Defects from the casting process, decarburization during heat treatment, and in-service exposure to corrosive environments combine to promote fatigue crack nucleation in high-stress regions of the knuckle. Wire-arc additive manufacturing (WAAM), which uses traditional welding techniques to build material to near-net shapes, was employed to deposit higher-strength materials in critical regions. By replacing the cast steel in the high-stress region of …
Pulse-Width Modulation Spray System Performance And Development Of A Novel System To Optimize Spray Use Efficacy, Prashanta Pokharel
Pulse-Width Modulation Spray System Performance And Development Of A Novel System To Optimize Spray Use Efficacy, Prashanta Pokharel
Theses and Dissertations--Biosystems and Agricultural Engineering
The overarching objective of this research was to enhance our understanding of pulse width modulation (PWM) based nozzle control system and develop an intelligent nozzle control system for agricultural spray applications. This dissertation focused on measuring and analyzing the transient nozzle pressure characteristics and performance under PWM control. Additionally, it explored the development of an innovative multi-degree-of-freedom (DOF) nozzle control system for precise chemical applications in specialty crop systems.
The pressure dynamics of a PWM system were studied by developing an instrumentation system capable of operating a solenoid valve and recording pressure signals. A nozzle body and two manifolds of …
Control Of Flow Instabilities With Acoustic Metamaterials, Jensen E. Mctighe
Control Of Flow Instabilities With Acoustic Metamaterials, Jensen E. Mctighe
Open Access Master's Theses
Acoustic metamaterials (AMs) have been proposed for uses in flow control, as they offer a passive control method and can be engineered independently, without needing complex fluid structure interactions simulations. For example, AMs embedded into flat plate surfaces have been demonstrated to delay (or speed up) the onset of laminar-to-turbulent boundary layer transition by attenuating (or strengthening) Tollmein-Schlicting waves through numerical simulation. However, as of present, no experimental research has been conducted to study or demonstrate the behaviors of AMs designed to interact with flow structures. An experiment was performed in which an AM was embedded into a flat plate …
Observability-Aware Path Planning For Autonomous Navigation, Raymond Brink Neistat
Observability-Aware Path Planning For Autonomous Navigation, Raymond Brink Neistat
Open Access Master's Theses
Terrain-Aided Navigation (TAN) is a popular method of localization for GPS-denied vehicles, particularly in the marine domain. There are many ways to perform TAN in a marine setting, such as Bathymetric SLAM (BSLAM) and Bayesian Filtering with the aid of an a priori map. These techniques have been studied extensively, but show an overall lack of rigorous observability analyses. Without nonlinear observability analyses, TAN practitioners do not have an analytical indicator to know which areas of terrain will provide opportunities for the best localization performance. This thesis reviews current developments in the endeavors of nonlinear observability analyses as well as …
1d Granular Chains Of Closed-Cell Pvc Foams Under Low And Medium Velocity Impacts, Vikranth Kumar Reddy Madhirala
1d Granular Chains Of Closed-Cell Pvc Foams Under Low And Medium Velocity Impacts, Vikranth Kumar Reddy Madhirala
Open Access Dissertations
Chapter 1: This study experimentally analyses the deformation and energy retention behavior often closed-cell PVC foam disks constituting a one-dimensional granular chain subjected to low-velocity impacts. A pressure-driven impactor loads disk chains of two densities, each at 1 and 10 m/s. The deformations of the disks are captured using high-speed cameras, and the chain’s input and output forces are recorded during the impact. Energy retained by the chain and the disks is calculated using the deformations of the disks, input, output, and contact forces. The results show that the energy retained by the chain of H130 foam is 3 …
A Strategic Framework For Estimating International Container Flows: An Empirical Study, Dung-Ying Lin, Hsin-Chun Huang, Steven Travis Waller, Xiang Zhang
A Strategic Framework For Estimating International Container Flows: An Empirical Study, Dung-Ying Lin, Hsin-Chun Huang, Steven Travis Waller, Xiang Zhang
Journal of Marine Science and Technology–Taiwan
Maritime transportation is a highly complex transportation system that plays a pivotal role in international trade. Its low-cost and high-volume advantages have enabled it to cover most of the world’s cargo transportation. However, with the trend of global trade volume increasing almost every year and the recent congestion of ports due to the COVID-19 pandemic, the chaos in global supply chains not only increases operating costs for shippers but also makes it difficult for countries that rely heavily on port trade to plan for their ports’ future. To develop a strategic analytic tool to estimate container flow in liner shipping, …
An Application Of Cfd To Support The Development Of Treatment Strategies And Technology For The Management Of Cystic Fibrosis In Pediatric Patients, Morgan L. Thomas
An Application Of Cfd To Support The Development Of Treatment Strategies And Technology For The Management Of Cystic Fibrosis In Pediatric Patients, Morgan L. Thomas
Theses and Dissertations
Inhaled medications are a key treatment modality in multiple lung-related diseases and disorders. Considering children with cystic fibrosis (CF), improvements in the delivery of aerosol antibiotics have the potential to better eradicate bacterial lung infections, preserve lung function and thereby further extend lifespans and quality of life. The overall objective of this dissertation was to expand and validate CFD models for predicting the deposition of pharmaceutical aerosols throughout the airways and apply these models to understand the targeted delivery of inhaled antibiotics to children with CF. To accomplish this goal, three contributions were made. First, CFD methodologies for modeling aerosol …