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Pleiotropic Activity Of Systemically Delivered Angiogenin In The Sod1, Martin Crivello, Saidhbhe L. O'Riordan, Ina Woods, Sarah Cannon, Luise Halang, Karen S. Coughlan, Marion C. Hogg, Sebastian A. Lewandowski, Jochen HM Prehn 2018 Royal College of Surgeons in Ireland

Pleiotropic Activity Of Systemically Delivered Angiogenin In The Sod1, Martin Crivello, Saidhbhe L. O'Riordan, Ina Woods, Sarah Cannon, Luise Halang, Karen S. Coughlan, Marion C. Hogg, Sebastian A. Lewandowski, Jochen Hm Prehn

Physiology and Medical Physics Articles

Loss-of-function mutations in the angiogenin (ANG) gene have been identified in familial and sporadic ALS patients. Previous work from our group identified human ANG (huANG) to protect motoneuronsin vitro, and provided proof-of-concept that daily intraperitoneal (i.p.) huANG injections post-symptom onset increased lifespan and delayed disease progression in SOD1G93A mice. huANG's mechanism of action remains less well understood. Here, we implemented a preclinical in vivo design to validate our previous results, provide pharmacokinetic and protein distribution data after systemic administration, and explore potential pleiotropic activities of huANG in vivo. SOD1G93A mice (n = 45) and non-transgenic controls (n = 31 ...


Investigating The Climatology Of Mesospheric And Thermospheric Gravity Waves At High Northern Latitudes, Michael Negale 2018 Utah State University

Investigating The Climatology Of Mesospheric And Thermospheric Gravity Waves At High Northern Latitudes, Michael Negale

All Graduate Theses and Dissertations

An important property of the Earth's atmosphere is its ability to support wave motions, and indeed, waves exist throughout the Earth's atmosphere at all times and all locations. What is the importance of these waves? Imagine standing on the beach as water waves come crashing into you. In this case, the waves transport energy and momentum to you, knocking you off balance. Similarly, waves in the atmosphere crash, known as breaking, but what do they crash into? They crash into the atmosphere knocking the atmosphere off balance in terms of the winds and temperatures. Although the Earth's ...


Physics 516: Electromagnetic Phenomena (Spring 2018), Philip C. Nelson 2018 University of Pennsylvania

Physics 516: Electromagnetic Phenomena (Spring 2018), Philip C. Nelson

Department of Physics Papers

These course notes are made publicly available in the hope that they will be useful. All reports of errata will be gratefully received. I will also be glad to hear from anyone who reads them, whether or not you find errors: pcn@upenn.edu.


Developing Kenya’S Educational Capacity In Nuclear Security Through Nuclear Forensics Research, Hudson Kalambuka Angeyo 2018 Department of Physics, University of Nairobi, Kenya

Developing Kenya’S Educational Capacity In Nuclear Security Through Nuclear Forensics Research, Hudson Kalambuka Angeyo

International Journal of Nuclear Security

Nuclear energy’s distinctive characteristics give rise to special educational requirements. These requirements are necessary to not only address the danger of nuclear proliferation, but also to build capacity for a secure nuclear fuel circle. In this paper, I assess the status of educational capacity in nuclear security both in response to, and in support of, Kenya’s nuclear power program. I highlight the nuclear security educational infrastructure’s key features in the context of nuclear power, noting the low capacity at Kenyan universities. I identify the steps required to ensure that the country’s dynamic nuclear regulatory infrastructural framework ...


Identifying Influentials In Directed Networks, Guillermo Gutierrez 2018 Ohio Wesleyan University

Identifying Influentials In Directed Networks, Guillermo Gutierrez

Student Symposium

Research into the identification of influential nodes specifically with regards to weighted, directed networks has been lacking throughout the lifetime of Network Theory as a whole. This research project seeks to propel the field forward through by devising an algorithm aimed at identifying influential nodes through the use of probability propagation models of information transfer through various real-world networks. The networks discussed are a developed test-network using the Price Model of citation network growth, the neuronal connectivity network of the flatworm C. elegans, and Congressional co-sponsorship networks of the USA’s 110th House and Senate. Rankings of influence of each ...


Issue 1. Shielding Of Ionic Radiation . Vol 1 . April 2018, Journal port Science Research 2018 Bryant University

Issue 1. Shielding Of Ionic Radiation . Vol 1 . April 2018, Journal Port Science Research

Journal port Science Research

A selection of scientific values in the field of ionic radiation and radiation attenuation on various materials. Be useful to researchers for this exact field


Spatially-Resolved Study Of The Meissner Effect In Superconductors Using Nv-Centers-In-Diamond Optical Magnetometry, Naufer Nusran, Kamal R. Joshi, Kyuil Cho, Makariy A. Tanatar, William R. Meier, Sergey Bud’ko, Paul C. Canfield, Yong Liu, Thomas A. Lograsso, Ruslan Prozorov 2018 Iowa State University and Ames Laboratory

Spatially-Resolved Study Of The Meissner Effect In Superconductors Using Nv-Centers-In-Diamond Optical Magnetometry, Naufer Nusran, Kamal R. Joshi, Kyuil Cho, Makariy A. Tanatar, William R. Meier, Sergey Bud’Ko, Paul C. Canfield, Yong Liu, Thomas A. Lograsso, Ruslan Prozorov

Ames Laboratory Accepted Manuscripts

Non-invasive magnetic field sensing using optically-detected magnetic resonance of nitrogen-vacancy centers in diamond was used to study spatial distribution of the magnetic induction upon penetration and expulsion of weak magnetic fields in several representative superconductors. Vector magnetic fields were measured on the surface of conventional, elemental Pb and Nb, and compound LuNi2B2C and unconventional iron-based superconductors Ba1−x KxFe2As2 (x=0.34 optimal hole doping), Ba(Fe1−x Cox)2As2 (x=0.07 optimal electron doping), and stoichiometric CaKFe4As4, using variable-temperature confocal system with diffraction-limited spatial resolution. Magnetic induction profiles across the crystal edges were measured in zero-field-cooled and field-cooled ...


The Subject Librarian Newsletter, Physics, Spring 2017, Sandy Avila 2018 University of California, Irvine School of Law

The Subject Librarian Newsletter, Physics, Spring 2017, Sandy Avila

Sandy Avila

No abstract provided.


The Subject Librarian Newsletter, Physics, Fall 2016, Sandy Avila 2018 University of Central Florida

The Subject Librarian Newsletter, Physics, Fall 2016, Sandy Avila

Sandy Avila

No abstract provided.


Beyond Triplet: Unconventional Superconductivity In A Spin-3/2 Topological Semimetal, Hyunsoo Kim, Kefeng Wang, Yasuyuki Nakajima, Rongwei Hu, Steven Ziemak, Paul Syers, Limin Wang, Halyna Hodovanets, Jonathan D. Denlinger, Philip M. R. Brydon, Daniel F. Agterberg, Makariy A. Tanatar, Ruslan Prozorov, Johnpierre Paglione 2018 University of Maryland, College Park and Ames Laboratory

Beyond Triplet: Unconventional Superconductivity In A Spin-3/2 Topological Semimetal, Hyunsoo Kim, Kefeng Wang, Yasuyuki Nakajima, Rongwei Hu, Steven Ziemak, Paul Syers, Limin Wang, Halyna Hodovanets, Jonathan D. Denlinger, Philip M. R. Brydon, Daniel F. Agterberg, Makariy A. Tanatar, Ruslan Prozorov, Johnpierre Paglione

Ames Laboratory Accepted Manuscripts

In all known fermionic superfluids, Cooper pairs are composed of spin-1/2 quasi-particles that pair to form either spin-singlet or spin-triplet bound states. The “spin” of a Bloch electron, however, is fixed by the symmetries of the crystal and the atomic orbitals from which it is derived and, in some cases, can behave as if it were a spin-3/2 particle. The superconducting state of such a system allows pairing beyond spin-triplet, with higher spin quasi-particles combining to form quintet or septet pairs. We report evidence of unconventional superconductivity emerging from a spin-3/2 quasi-particle electronic structure in the half-Heusler ...


Real-Time Spatial Frequency Domain Imaging By Single Snapshot Multiple Frequency Demodulation Technique, Zili Cao, Weihao Lin, Xinlin Chen, Bixin Zeng, Min Xu 2018 Fairfield University

Real-Time Spatial Frequency Domain Imaging By Single Snapshot Multiple Frequency Demodulation Technique, Zili Cao, Weihao Lin, Xinlin Chen, Bixin Zeng, Min Xu

Min Xu

We have presented a novel Single Snapshot Multiple Frequency Demodulation (SSMD) method enabling single snapshot wide field imaging of optical properties of turbid media in the Spatial Frequency Domain. SSMD makes use of the orthogonality of harmonic functions and extracts the modulation transfer function (MTF) at multiple modulation frequencies and of arbitrary orientations and amplitudes simultaneously from a single structured-illuminated image at once. SSMD not only increases significantly the data acquisition speed and reduces motion artifacts but also exhibits excellent noise suppression in imaging as well. The performance of SSMD-SFDI is demonstrated with experiments on both tissue mimicking phantoms and ...


Mapping Absolute Tissue Endogenous Fluorophore Concentrations With Chemometric Wide-Field Fluorescence Microscopy, Zhang Xu, Michael Reilley, Run Li, Min Xu 2018 Fairfield University

Mapping Absolute Tissue Endogenous Fluorophore Concentrations With Chemometric Wide-Field Fluorescence Microscopy, Zhang Xu, Michael Reilley, Run Li, Min Xu

Min Xu

We report chemometric wide-field fluorescence microscopy for imaging the spatial distribution and concentration of endogenous fluorophores in thin tissue sections. Nonnegative factorization aided by spatial diversity is used to learn both the spectral signature and the spatial distribution of endogenous fluorophores from microscopic fluorescence color images obtained under broadband excitation and detection. The absolute concentration map of individual fluorophores is derived by comparing the fluorescence from “pure” fluorophores under the identical imaging condition following the identification of the fluorescence species by its spectral signature. This method is then demonstrated by characterizing the concentration map of endogenous fluorophores (including tryptophan, elastin ...


Lung Cancer Diagnosis With Quantitative Dic Microscopy And Support Vector Machine, Longfei Zheng, Shuangshuang Cai, Bixin Zeng, Min Xu 2018 Fairfield University

Lung Cancer Diagnosis With Quantitative Dic Microscopy And Support Vector Machine, Longfei Zheng, Shuangshuang Cai, Bixin Zeng, Min Xu

Min Xu

We report the study of lung squamous cell carcinoma diagnosis using the TI-DIC microscopy and the scattering-phase theorem. The spatially resolved optical properties of tissue are computed from the 2D phase map via the scattering-phase theorem. The scattering coefficient, the reduced scattering coefficient, and the anisotropy factor are all found to increase with the grade of lung cancer. The retrieved optical parameters are shown to distinguish cancer cases from the normal cases with high accuracy. This label-free microscopic approach applicable to fresh tissues may be promising for in situ rapid cancer diagnosis. © (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE ...


Characterization Of Magnetic Thin Films Using The Magneto Optic Kerr Effect, Nicholas J. Savino 2018 Lynchburg College

Characterization Of Magnetic Thin Films Using The Magneto Optic Kerr Effect, Nicholas J. Savino

Student Scholar Showcase

Understanding magnetic properties of materials allows for advances in applications such as data storage. The Magneto-Optic Kerr Effect (MOKE) displays the reflective response a magnetic material has to a magnetic field. When polarized light reflects off of a magnetic material, the polarization orientation can change. The application of an external magnetic field can affect how much this polarization changes in a non-linear manner. Hysteresis loops are created when examining the relationship between intensity of the reflected light to the applied magnetic field provide information about magnetic properties of that material, such as the coercive field and field retention. Preliminary measurements ...


Principles Of Physics I & Ii (Vsu), Francis Flaherty, Dereth Drake, Michael Holt 2018 Valdosta State University

Principles Of Physics I & Ii (Vsu), Francis Flaherty, Dereth Drake, Michael Holt

Physics and Astronomy Grants Collections

This Grants Collection for Principles of Physics I & II was created under a Round Six ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

  • Linked Syllabus
  • Initial Proposal
  • Final Report


An Integration Setup If The In-Situ Mass And Spectroscopic Analysis For Volatile Liquids Or Solids, Kolton K. Jones 2018 Western Kentucky University

An Integration Setup If The In-Situ Mass And Spectroscopic Analysis For Volatile Liquids Or Solids, Kolton K. Jones

Masters Theses & Specialist Projects

To help address the growing need for more and better sensors, an attempt was made to produce an in-situ mass and spectroscopic analysis of liquid and solid samples, to characterize samples and sensors. Spectroscopic analysis consisted of Raman and FTIR where mass measurements were carried out. The sample or sensor’s holder would allow for spectroscopic analysis as well as expose the sample to high temperatures and various chemicals. While Raman and FTIR were successful in producing reliable and consistent data, the constructed watt balance was not. This failure was a result of eliminate vibrational noise.


Influence Of Multiband Sign-Changing Superconductivity On Vortex Cores And Vortex Pinning In Stoichiometric High-Tc Cakfe4 As4, Antón Fente, William R. Meier, Tai Kong, Vladimir G. Kogan, Sergey Bud’ko, Paul C. Canfield, Isabel Guillamón, Hermann Suderow 2018 Universidad Autónoma de Madrid

Influence Of Multiband Sign-Changing Superconductivity On Vortex Cores And Vortex Pinning In Stoichiometric High-Tc Cakfe4 As4, Antón Fente, William R. Meier, Tai Kong, Vladimir G. Kogan, Sergey Bud’Ko, Paul C. Canfield, Isabel Guillamón, Hermann Suderow

Ames Laboratory Accepted Manuscripts

We use a scanning tunneling microscope to study the superconducting density of states and vortex lattice of single crystals of CaKFe 4 As 4 . This material has a critical temperature of T c = 35 K, one of the highest among stoichiometric iron based superconductors (FeBSCs), and is comparable to T c found near optimal doping in other FeBSCs. We observe quasiparticle scattering from defects with a pattern related to interband scattering between zone centered hole sheets. We measure the tunneling conductance in vortex cores and find a peak due to Caroli–de Gennes–Matricon bound states. The peak is located ...


Thorium And Molten Salt Reactors: Essential Questions For Classroom Discussions, Gregory A. DiLisi, Allison Hirsch*, Meredith Murray*, Richard Rarick 2018 John Carroll University

Thorium And Molten Salt Reactors: Essential Questions For Classroom Discussions, Gregory A. Dilisi, Allison Hirsch*, Meredith Murray*, Richard Rarick

2018 Faculty Bibliography

No abstract provided.


A Comparison Of The Diel Cycle Of Modeled And Measured Latent Heat Flux During The Warm Season In A Colorado Subalpine Forest, Sean P. Burns, Sean C. Swenson, William R. Wieder, David M. Lawrence, Gordon B. Bonan, John F. Knowles, Peter D. Blanken 2018 CU + NCAR

A Comparison Of The Diel Cycle Of Modeled And Measured Latent Heat Flux During The Warm Season In A Colorado Subalpine Forest, Sean P. Burns, Sean C. Swenson, William R. Wieder, David M. Lawrence, Gordon B. Bonan, John F. Knowles, Peter D. Blanken

University Libraries Open Access Fund Supported Publications

Precipitation changes the physiological characteristics of an ecosystem. Because land-surface models are often used to project changes in the hydrological cycle, modeling the effect of precipitation on the latent heat flux E is an important aspect of land-surface models. Here we contrast conditionally sampled diel composites of the eddy-covariance fluxes from the Niwot Ridge Subalpine Forest AmeriFlux tower with the Community Land Model (CLM, version 4.5). With respect to measured E during the warm season: for the day following above-average precipitation, E was enhanced at midday by ≈40 W m−2 (relative to dry conditions), and nocturnal E increased ...


Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh 2018 Marquette University

Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh

Master's Theses (2009 -)

NADPH-cytochrome p450 oxidoreductase (CYPOR) is a membrane-bound protein in living cells. CYPOR delivers electrons to cytochrome p450 proteins (CYPs) to catalyze metabolism of drugs and synthesis of steroids. Extraction and solubilization of CYPOR from the membrane is typically done with the TritonX-100 detergent. The amount of the solubilized protein by this detergent, however, remains relatively low to structurally analyze CYPOR with NMR spectroscopy. The goal of the first project in this thesis was to optimize the amount of the extracted CYPOR from the E. coli membrane using various detergents and additives. To this aim, non-ionic detergents with variable hydrophobicity (TritonX-100 ...


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