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Elucidating The Action Of A Regulatory Lipid Ligand Via Molecular Simulation: Cholesterol Swarms And The Inwardly Rectifying Potassium Channel, Belinda Akpa, Nicolas Barbera, Irena Levitan 2018 North Carolina State University

Elucidating The Action Of A Regulatory Lipid Ligand Via Molecular Simulation: Cholesterol Swarms And The Inwardly Rectifying Potassium Channel, Belinda Akpa, Nicolas Barbera, Irena Levitan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Sex Differences In Lower Limb Biomechanics During A Single-Leg Cut With Body Borne Load, AuraLea Carylon Fain 2018 Boise State University

Sex Differences In Lower Limb Biomechanics During A Single-Leg Cut With Body Borne Load, Auralea Carylon Fain

Boise State University Theses and Dissertations

Introduction: Musculoskeletal injuries are ever-increasing in military personnel, particularly females. These musculoskeletal injuries are attributed to adaptations in lower limb biomechanics while performing routine military tasks, such as a single-leg cut, with the addition of body borne load. However, it is unknown if females and males exhibit similar lower limb biomechanics with the addition of body borne load during these tasks. This study sought to compare the lower limb biomechanical adaptations exhibited by females and males performing a single-leg cut with body borne load. Methods: Eleven females and 17 males had lower limb biomechanics quantified during a single-leg cut with ...


The Incorporation Of Graphene To Lithium Cobalt Oxide As A Cathode To Improve The Performance Of Lithium Ion Batteries, Kenan Wang 2018 University of Arkansas, Fayetteville

The Incorporation Of Graphene To Lithium Cobalt Oxide As A Cathode To Improve The Performance Of Lithium Ion Batteries, Kenan Wang

Theses and Dissertations

One of the objectives of this thesis work was to investigate the cathode performance of lithium cobalt oxide (LiCoO2) incorporated with graphene powder in lithium ion batteries (LIBs). Graphene powder was incorporated into cathode materials to enhance the performance of LIBs. The other objective was to impede the construction of a solid electrolyte interphase (SEI) sheet using graphene sheet coating on its cathode.

The results of this work show that adding graphene powder improved the performance of LiCoO¬2 as a cathode material. With the incorporation of different weight percentages of graphene powder, the LiBs showed distinct changes in their ...


Combining Microdialysis And Electrophysiology In Cerebral Cortex To Delineate Functional Implications Of Acetylcholine Gradients, Tazima Nur 2018 University of Arkansas, Fayetteville

Combining Microdialysis And Electrophysiology In Cerebral Cortex To Delineate Functional Implications Of Acetylcholine Gradients, Tazima Nur

Theses and Dissertations

The neuronal network in cerebral cortex is a dynamic system that can undergo changes in collective neural activity as the organism changes its behavior. For example, during sleep and quiet restful awake state, many neurons tend to fire together in synchrony. In contrast, during alert awake states, firing patterns of neurons tend to be more asynchronous, firing more independently. These changes in population-level synchrony are defined as changes in cortical state. Response to sensory input is state-dependent, i.e., change in cortical state can impact the sensory information processing in cortex and introduce trial-to-trial variability in response to the same ...


Pregnancy Induced Alterations Of Reproductive Tract Collagen And Elastin In A Murine Model, Basant K. Dhital 2018 The Graduate Center, City University of New York

Pregnancy Induced Alterations Of Reproductive Tract Collagen And Elastin In A Murine Model, Basant K. Dhital

All Dissertations, Theses, and Capstone Projects

This thesis reports on structural and dynamical modifications of reproductive tract elastin and collagen as a function of parity. Pelvic floor dysfunction, including pelvic organ prolapse (POP) is a major concern affecting female health worldwide, leading to surgeries costing billions of dollars annually. Collagen, elastic fibers, and proteoglycans are major extracellular matrix (ECM) components found in connective tissues. Vaginal child birth, advancing age, and disruption or dysfunction of connective tissue are major risk factors of POP. In the female reproductive tract, the assembly of elastic fibers is crucial for the pelvic floor support. Any disturbance in the synthesis, assembly, and ...


Physics 516: Electromagnetic Phenomena (Spring 2018), Philip C. Nelson 2018 University of Pennsylvania

Physics 516: Electromagnetic Phenomena (Spring 2018), Philip C. Nelson

Department of Physics Papers

These course notes are made publicly available in the hope that they will be useful. All reports of errata will be gratefully received. I will also be glad to hear from anyone who reads them, whether or not you find errors: pcn@upenn.edu.


Vibration Response: Mapping The Behavioral Response Of Fruit Fly Larvae To Mechanical Stimuli, Alexander Berne 2018 University of Miami

Vibration Response: Mapping The Behavioral Response Of Fruit Fly Larvae To Mechanical Stimuli, Alexander Berne

2018 Entries

Drosophila larvae are capable of a wide array of simple, quantifiable behavioral responses to stimuli, which makes the organism a useful tool for deconstructing biotic behavior for wider application. To this end, an understanding of the response to mechanical stimulation remains relatively unexplored in this organism, and warrants investigation. This research aims to map the fruit fly’s behavior as a function of a generalized mechanical stimulus, namely, vibration.

Fruit fly larvae are placed in a light and temperature controlled environment, and observed crawling on vibrating agar plates with CCD cameras controlled through LabVIEW. Larvae are monitored for their instantaneous ...


Evolving Specialization In An Agent-Based Model Without Task-Switching Costs, Shane Meyer 2018 University of Missouri, St. Louis

Evolving Specialization In An Agent-Based Model Without Task-Switching Costs, Shane Meyer

Dissertations

This work examines the possibility of evolving the phenotypic specialization associated with division of labor in an agent-based model without task-switching costs. The model examines two groups competing for vital resources, where members of one group are capable of sharing resources with other agents in their group. Agents attempt to collect resources which allow them to reproduce, with more resources leading to a greater number of offspring by asexual reproduction. Four variants of the model are examined, with combinations of one or two resources and the presence of a foraging risk. The presence of the foraging risk can lead to ...


Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh 2018 Marquette University

Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh

Master's Theses (2009 -)

NADPH-cytochrome p450 oxidoreductase (CYPOR) is a membrane-bound protein in living cells. CYPOR delivers electrons to cytochrome p450 proteins (CYPs) to catalyze metabolism of drugs and synthesis of steroids. Extraction and solubilization of CYPOR from the membrane is typically done with the TritonX-100 detergent. The amount of the solubilized protein by this detergent, however, remains relatively low to structurally analyze CYPOR with NMR spectroscopy. The goal of the first project in this thesis was to optimize the amount of the extracted CYPOR from the E. coli membrane using various detergents and additives. To this aim, non-ionic detergents with variable hydrophobicity (TritonX-100 ...


Liquid-Like Thermal Conduction In Intercalated Layered Crystalline Solids, B. Li, H. Wang, Y. Kawakita, Q. Zhang, M. Feygenson, H. L. Yu, D. Wu, K. Ohara, T. Kikuchi, K. Shibata, T. Yamada, X. K. Ning, Y. Chen, J. Q. He, David Vaknin, R. Q. Wu, K. Nakajima, M. G. Kanatzidis 2018 Japan Atomic Energy Agency

Liquid-Like Thermal Conduction In Intercalated Layered Crystalline Solids, B. Li, H. Wang, Y. Kawakita, Q. Zhang, M. Feygenson, H. L. Yu, D. Wu, K. Ohara, T. Kikuchi, K. Shibata, T. Yamada, X. K. Ning, Y. Chen, J. Q. He, David Vaknin, R. Q. Wu, K. Nakajima, M. G. Kanatzidis

Ames Laboratory Accepted Manuscripts

As a generic property, all substances transfer heat through microscopic collisions of constituent particles1. A solid conducts heat through both transverse and longitudinal acoustic phonons, but a liquid employs only longitudinal vibrations2,3. As a result, a solid is usually thermally more conductive than a liquid. In canonical viewpoints, such a difference also serves as the dynamic signature distinguishing a solid from a liquid. Here, we report liquid-like thermal conduction observed in the crystalline AgCrSe2. The transverse acoustic phonons are completely suppressed by the ultrafast dynamic disorder while the longitudinal acoustic phonons are strongly scattered but survive, and are thus ...


Magnetic Interaction And Electronic Transport In La0.4bi0.6mn0.5ti0.5o3 Manganite, Vijaylakshmi Dayal, Punith Kumar V., Ravi L. Hadimani, E. A. Balfour, H. Fu, David C. Jiles 2018 Maharaja Institute of Technology Mysore

Magnetic Interaction And Electronic Transport In La0.4bi0.6mn0.5ti0.5o3 Manganite, Vijaylakshmi Dayal, Punith Kumar V., Ravi L. Hadimani, E. A. Balfour, H. Fu, David C. Jiles

Ravi L. Hadimani

We report magnetic interactions and electronic transport properties in La0.4Bi0.6Mn0.5Ti0.5O3 perovskite manganite synthesized using solid-state route. After characterizing the samples structurally, the systematic investigations of magnetic and electrical transport behaviors have been undertaken. It has been observed that at low temperatures near TC, the sample is magnetically frustrated leading to the second-order magnetic transition. A justification for the observed magnetic behavior has been explained based on Arrott's plot study. The resistivity as a function of temperature in the absence and the presence of applied magnetic field suggests semiconducting nature of the sample. The conduction of ...


Hyperthermia As A Cancer Treatment- From Theory To Practice, Graham Fullerton 2018 Claremont McKenna College

Hyperthermia As A Cancer Treatment- From Theory To Practice, Graham Fullerton

CMC Senior Theses

Using iron super-paramagnetic and ferromagnetic nanoparticles composed of Fe3O4 molecules, scientists analyze the effectiveness and practicality of this new treatment theory, hyperthermia. The problems of magnetic particle density, isothermal barriers/cellular cooling thresholds, and nanoparticle specific targeting are addressed in this review.

Iron magnetic nanoparticles were chosen due to their relatively low biological reactivates and lack of subsequent cellular toxicity. However, there are significant heating problems associated with these magnetic nanoparticles due to their relative size and short thermal time constants or thermal half-lives. Effectively, these aforementioned issues create a phenomenon where cancerous cells, surrounded by unheated ...


Can A Comprehensive Transition Plan To Barefoot Running Be The Solution To The Injury Epidemic In American Endurance Runners?, Michael A. Scarlett 2018 Claremont McKenna College

Can A Comprehensive Transition Plan To Barefoot Running Be The Solution To The Injury Epidemic In American Endurance Runners?, Michael A. Scarlett

CMC Senior Theses

Fossils belonging to the genus Homo, dating as far back as two million years ago, exhibit uniquely efficient features suggesting that early humans had evolved to become exceptional endurance runners. Although they did not have the cushion or stability-control features provided in our modern day running shoes, our early human ancestors experienced far less of the running-related injuries we experience today. The injury rate has been estimated as high as 90% annually for Americans training for a marathon and as high as 79% annually for all American endurance runners. There is an injury epidemic in conventionally shod populations that does ...


Modulation Of The Navigational Strategy Of Insects In Controlled Temperature Environments, Joseph Shomar, Anggie Ferrer, Josh Forer, Tom Zhang, Mason Klein 2018 University of Miami

Modulation Of The Navigational Strategy Of Insects In Controlled Temperature Environments, Joseph Shomar, Anggie Ferrer, Josh Forer, Tom Zhang, Mason Klein

2018 Entries

With its small size and limited motor tool set, the Drosophila larva is a good system to study how animals alter specific elements of their behavior to search and reach optimal environmental conditions. We aim to understand the larva’s response to temperature across development, in sensory gradients, and to distinguish behavioral modulations based on physical changes from those due to sensory input. PID-controlled instruments drive temporal or spatial temperature gradients; combined with a moat system to replenish gels at high temperature, we can explore the larva’s full behavioral profile. Many larvae are simultaneously observed during free navigation in ...


Phase Characterization Of Microtubule-Motor Active Nematic Liquid Crystals, Garrek Stemo 2018 University of Colorado, Boulder

Phase Characterization Of Microtubule-Motor Active Nematic Liquid Crystals, Garrek Stemo

Undergraduate Honors Theses

Active nematic liquid crystals have remarkable properties that are only now starting to be understood. These non-equilibrium systems self-organize in solutions. We study a type of solu- tion consisting of microtubule filaments and motor proteins. Microtubules give structure to the cell, while motor proteins facilitate transport of molecules along microtubules. We compose sim- ulations and extract data to quantify stresses, pressure, filament distribution, and the order of two-dimensional active nematic liquid crystals. We identify and quantify phases and phase transi- tions, and seek to describe the physical properties of steady-state configurations. By characterizing these systems, we contribute to the developing ...


Call For Abstracts - Resrb 2018, June 18-20, Brussels, Belgium, Wojciech M. Budzianowski 2017 Wojciech Budzianowski Consulting Services

Call For Abstracts - Resrb 2018, June 18-20, Brussels, Belgium, Wojciech M. Budzianowski

Wojciech Budzianowski

No abstract provided.


Comparative Study Of Magnetic Properties Of Nanoparticles By High-Frequency Heat Dissipation And Conventional Magnetometry, V. Malik, J. Goodwill, Surya K. Mallapragada, Tanya Prozorov, Ruslan Prozorov 2017 Ames Laboratory

Comparative Study Of Magnetic Properties Of Nanoparticles By High-Frequency Heat Dissipation And Conventional Magnetometry, V. Malik, J. Goodwill, Surya K. Mallapragada, Tanya Prozorov, Ruslan Prozorov

Surya K. Mallapragada

The rate of heating of 15 nm uniformly-sized magnetic aqueous nanoparticles suspension by high-amplitude and high-frequency ac magnetic field induced by the resonating LC circuit was measured. The results are analyzed in terms of specific energy absorption rate (SAR). Fitting field amplitude and frequency dependences of SAR to the linear response theory, magnetic moment per particles was extracted. The value of magnetic moment was independently evaluated from dc magnetization measurements of a frozen colloid by fitting field-dependent magnetization to a Langevin function. The two methods produced similar results, which are compared to the theoretical expectation for this particle size. Additionally ...


Statistical Biophysics Blog: Let’S Stop Being Sloppy About Uncertainty, Daniel M. Zuckerman 2017 Oregon Health & Science University

Statistical Biophysics Blog: Let’S Stop Being Sloppy About Uncertainty, Daniel M. Zuckerman

Scholar Archive

Molecular dynamics simulations often fail to reach timescales characteristic of equilibrum sampling, so great care must be taken in computing and reporting statistical uncertainty.


The Transition From The Open Minimum To The Ring Minimum On The Ground State And On The Lowest Excited State Of Like Symmetry In Ozone: A Configuration Interaction Study, Theresa Lynn Windus, Daniel Theis, Joseph Ivanic, Klaus Ruedenberg 2017 Iowa State University

The Transition From The Open Minimum To The Ring Minimum On The Ground State And On The Lowest Excited State Of Like Symmetry In Ozone: A Configuration Interaction Study, Theresa Lynn Windus, Daniel Theis, Joseph Ivanic, Klaus Ruedenberg

Theresa Windus

The metastable ring structure of the ozone 11A1 ground state, which theoretical calculations have shown to exist, has so far eluded experimental detection. An accurate prediction for the energy difference between this isomer and the lower open structure is therefore of interest, as is a prediction for the isomerization barrier between them, which results from interactions between the lowest two 1A1 states. In the present work, valence correlated energies of the 11A1 state and the 21A1 state were calculated at the 11A1 open minimum, the 11A1 ring minimum, the transition state between these two minima, the minimum of the 21A1 ...


Characterization Of Sheared Colloidal Aggregation Using Langevin Dynamics Simulation, Sergiy Markutsya, Rodney O. Fox, Shankar Subramaniam 2017 Iowa State University

Characterization Of Sheared Colloidal Aggregation Using Langevin Dynamics Simulation, Sergiy Markutsya, Rodney O. Fox, Shankar Subramaniam

Rodney O. Fox

Aggregation of colloidal particles under shear is studied in model systems using a Langevin dynamics model with an improved interparticle interaction potential. In the absence of shear, aggregates that form are characterized by compact structure at small scales and ramified structure at larger scales. This confirms the structural crossover mechanism previously suggested by Sorensen and coworkers, that colloidal aggregation occurs due to monomer addition at small scales and due to cluster-cluster aggregation at large scales. The fractal dimension of nonsheared aggregates is scale-dependent. Smaller aggregates have a higher fractal dimension than larger ones, but the radius of gyration where this ...


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