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Strengthen Research On Environmental Control Technologies And Management Policies For Emerging Contaminants In China, Ying MA, Xiang LI, Yongming LUO 2024 Chongqing Key Laboratory of Interface Process and Soil Health, College of Resources and Environment, Southwest University, Chongqing 400716, China

Strengthen Research On Environmental Control Technologies And Management Policies For Emerging Contaminants In China, Ying Ma, Xiang Li, Yongming Luo

Bulletin of Chinese Academy of Sciences (Chinese Version)

The prevention and management of emerging contaminants (ECs) have become critical measures in China’s battle against environmental pollution. This study focuses on the environmental control technologies and policy governance related to emerging contaminants (ECs), analyzing their environmental pathways and challenges to public health, and highlighting advancements and limitations in current physical, chemical, and biological control technologies. Based on a comprehensive analysis of international policies and regulations on ECs control, the study identifies existing challenges and shortcomings in domestic management. Recommendations are proposed to enhance research on environmental control technologies and policies for ECs in China, aiming to provide insights for …


Redesign And De Novo Design Of Circular Blue Bioindustry, Wei ZHANG, Shufeng ZHANG, Hantao ZHOU, Minhan DAI 2024 Flinders University, Adelaide SA 5001, Australia; Marine Bioproducts Cooperative Research Centre, Adelaide SA 5067, Australia

Redesign And De Novo Design Of Circular Blue Bioindustry, Wei Zhang, Shufeng Zhang, Hantao Zhou, Minhan Dai

Bulletin of Chinese Academy of Sciences (Chinese Version)

The future marine bioindustry, which features advanced green intelligent biomanufacturing and high-value marine bioproducts, is a strategically emerging marine industry. This study proposes a new industrial development model for the circular blue bioindustry, founded on simultaneously optimizing the sustainable utilization of marine bioresources and protecting the ecological environment. Through in-depth analysis of the current situation, challenges, and potential development opportunities of the global and Chinese marine bioindustries underpinning sustainable development, theoretical framework, approaches and implementation pathways have been established to redesign the existing marine bioindustry and de novo design of the emerging marine bioindustry. Future key development priorities are suggested …


Policy Overview (December, 2024), 2024 Chinese Academy of Sciences

Policy Overview (December, 2024)

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.


Journal Of Chinese Academy Of Sciences Was Selected Into The List Of F5000 Articles In 2023 And 2024, 2024 Chinese Academy of Sciences

Journal Of Chinese Academy Of Sciences Was Selected Into The List Of F5000 Articles In 2023 And 2024

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.


Striving For Progress, Steadily Going Forward——The Imprint Of Journal Of Chinese Academy Of Sciences In 2024, 2024 Chinese Academy of Sciences

Striving For Progress, Steadily Going Forward——The Imprint Of Journal Of Chinese Academy Of Sciences In 2024

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.


Research On Evolution And Countermeasures Of International Technology Export Controls, Defang HE, Guangjian LI, Fuqiang TANG, Fangjuan YANG 2024 China Association of Science and Technology Evaluation and Management of Scientific and Technical Achievement, Beijing 100081, China

Research On Evolution And Countermeasures Of International Technology Export Controls, Defang He, Guangjian Li, Fuqiang Tang, Fangjuan Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Imposing strict export control on technologies related to national security and interests is common international practice. In recent years, with the increasingly fierce international competition, developed countries and regions such as the United States, Europe, and Japan are adjusting their technology export control policies. On the basis of summarizing the evolution of technology export control system in major developed countries and regions, this study mainly analyzes the latest trend of technology export control of western countries such as the United States and its impact on China’s science and technology innovation. Finally, countermeasures and policy suggestions are put forward from the …


Recent Progress And Perspectives On Development Of Gene Editing Tools, Zixian LIU, Chengping LI, Gogo Jun-Jie LIU 2024 School of Life Sciences, Tsinghua University, Beijing 100084, China; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100084, China; State Key Laboratory of Membrane Biology, Tsinghua University, Beijing 100084, China; Center for Life Sciences, Tsinghua University, Beijing 100084, China

Recent Progress And Perspectives On Development Of Gene Editing Tools, Zixian Liu, Chengping Li, Gogo Jun-Jie Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The gene editing field has witnessed remarkable advancements in recent years, leading to the establishment and refinement of multidimensional gene editing platforms. These innovations have enabled precise targeted gene knockout, repair, and insertion. These tools have stimulated significant progress in fundamental research, therapeutics, agriculture, environment protection, and industrial applications. In this review, we provide a comprehensive overview of the milestones in gene editing tool development and offer perspectives on potential future directions for this rapidly evolving field.


Microbial Production Of Feed Amino Acids Promotes Reduction And Replacement Of Soybean Meal, Jia LIU, Qi SHENG, Kaifang LIU, Liming LIU 2024 Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China

Microbial Production Of Feed Amino Acids Promotes Reduction And Replacement Of Soybean Meal, Jia Liu, Qi Sheng, Kaifang Liu, Liming Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

With the promotion of soybean meal reduction and substitution as well as lower-protein diet technologies, China has become a leading global producer of feed amino acids. However, the amino acid industry faces significant challenges due to its relatively late start in independently developing industrial strains, resulting in relatively lagging key economic and technical parameters and a less robust intellectual property framework. The rapid progress of synthetic biology has provided promising avenues for the design and optimization of industrial amino acid-producing strains, offering new opportunities for the amino acid fermentation industry to enhance the global competitiveness. This study offers an in-depth …


Current Status And Prospect Of Industrial Filamentous Fungi In Biomanufacturing, Zhiqiang DU, Ping MEN, Yu ZHOU, Xuan ZHANG, Xuenian HUANG, Xuefeng LYU 2024 Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China

Current Status And Prospect Of Industrial Filamentous Fungi In Biomanufacturing, Zhiqiang Du, Ping Men, Yu Zhou, Xuan Zhang, Xuenian Huang, Xuefeng Lyu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Filamentous fungi, a critical class of industrial microorganisms pivotal to the biomanufacturing industry, has extensive applications in various fields such as pharmaceuticals, food, agriculture, and chemical materials, which are playing a vital role in human life. Recently, innovations in synthetic biology have further driven the application of industrial filamentous fungi in biomanufacturing, highlighting their critical role in this field. This article presents a comprehensive review of the recent progress in the field, covering the latest developments in genetic modification techniques for industrial filamentous fungi, successful cases of rational strain improvement strategies aimed to enhance the quality and efficiency of current …


Digitalized Design Of Cell Factory Enables Green Biomanufacturing, Fanze MENG, Rui CAO, Bing HU, Lei QIN, Chun LI 2024 Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China

Digitalized Design Of Cell Factory Enables Green Biomanufacturing, Fanze Meng, Rui Cao, Bing Hu, Lei Qin, Chun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Green manufacturing is a modern manufacturing mode in the consideration of both environmental impact and efficiency of resource utilization, it represents a significant component of the “new productive force”. Centered on cell factories, green biomanufacturing leverages renewable resources to efficiently produce products that conform to the concepts of low-carbon, green, and sustainable development. The design of high-performance cell factories is pivotal for achieving efficient green biomanufacturing. Nevertheless, traditional cell factory design processes are complex, time-consuming, and labor-intensive. With advancements in artificial intelligence, digital-assisted cell factory design has emerged as a solution to save time and reduce costs. By integrating technologies …


Microsphere Core Technology Boosts Innovation Of Biopharmaceutical Industry Chain, Jie WU, Weiqing ZHOU, Lan ZHAO, Guanghui MA 2024 State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Microsphere Core Technology Boosts Innovation Of Biopharmaceutical Industry Chain, Jie Wu, Weiqing Zhou, Lan Zhao, Guanghui Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

Advancements in life science and biotechnology have boosted the evolution of the biopharmaceutical industry with the continual emergence of biomedical products for disease prevention, diagnosis, and treatment. Microspheres, as crucial functional materials, play a significant role in the discovery, preparation, separation, and delivery of biological drugs due to their flexible size, morphology, structure, and function. This study reviews recent significant advancements in microspheres and their applications in cell culture, chromatographic separation, drug delivery, and as vaccine adjuvants. Additionally, it proposes future trends for the development of microspheres.


Bioprocess Engineering And Intelligent Biomanufacturing, Guan WANG, Yingping ZHUANG 2024 State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Qingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China

Bioprocess Engineering And Intelligent Biomanufacturing, Guan Wang, Yingping Zhuang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the era of rapid development of synthetic biology, biomanufacturing, as a bridge between life sciences and engineering technologies, is gradually demonstrating its extraordinary potential to reshape industrial landscapes. However, challenges such as production efficiency, cost control, and process monitoring still hinder the smooth transition from laboratory innovations to industrial-scale implementation. Intelligent biomanufacturing has emerged as a new form of productive force, offering innovative solutions to these problems. This study reviews the latest advances in bioprocess engineering and intelligent biomanufacturing, focusing on three key technological systems: intelligent sensing, intelligent analysis, and intelligent control. Intelligent sensing technology acts as the “eyes” …


Artificial Intelligence Driven Information Technology System Restructuring And Reconstruction—Review Of Information Science & Technology In China: A Roadmap To 2050, Xuehai HONG 2024 Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China

Artificial Intelligence Driven Information Technology System Restructuring And Reconstruction—Review Of Information Science & Technology In China: A Roadmap To 2050, Xuehai Hong

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Information Science & Technology in China: A Roadmap to 2050 and Information Technology: Accelerating the Integration of Human Machine Things have predicted the long-term development of China’s information technology field. This study reviews the development and changes in the field of information technology in the past 15 years, and compares them with the initial predictions, pointing out that some important judgments made at the beginning were in line with expectations. In recent years, the global development of information technology has entered a slow period, while the rapid evolution of the new generation of artificial intelligence will bring new opportunities …


Scientific Approach To Building A Highland Of Ecological Civilization In Xizang Of China, Xiaodan WANG, Jianxin ZHANG, Da WEI, Hui ZHAO, Jiangtao HONG, Yuling LIANG, Yahui QI, Zhengrong YUAN 2024 Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610299, China

Scientific Approach To Building A Highland Of Ecological Civilization In Xizang Of China, Xiaodan Wang, Jianxin Zhang, Da Wei, Hui Zhao, Jiangtao Hong, Yuling Liang, Yahui Qi, Zhengrong Yuan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Xizang, which plays an important barrier role in maintaining national ecological security, is a unique region that ensures China’s sustainable development and leads the construction of national ecological civilization. The Seventh Central Conference on the Work of Xizang has set clear goals and specific requirements for building an ecological civilization highland on the Qinghai-Xizang Plateau, which were identified as a new mission and task of Xizang government for environmental protection and sustainable development in the new era. Based on the previous research achievements about national ecological security barrier, this work further carried out the systematic study of ecological civilization highland …


Development And Utilization Of Mineral Resources In The Arctic And China’S Strategic Countermeasures, Yina SU 2024 Chinese Academy of Natural Resources Economics, Beijing 101149, China

Development And Utilization Of Mineral Resources In The Arctic And China’S Strategic Countermeasures, Yina Su

Bulletin of Chinese Academy of Sciences (Chinese Version)

There are abundant strategic mineral resources as oil, gas, iron ore, copper, and nickel in the Arctic region. If the Arctic routes can be opened in the future, they will become another important transportation channels connecting the Pacific and Atlantic Oceans, following the Panama Canal and the Suez Canal, which may reshape the world’s maritime trade and transportation pattern. With the development of science and technology, increase in mineral resources consumption and changes in the international environment, the strategic position of the Arctic region is increasingly elevated, and the United States, Russia and some other countries of the European Union …


Analysis On Development Status And Characteristics Of Non-Governmental Bio-Safety And Bio-Security Think Tanks In The United States, Wenbing MA, Qiang SONG, Lei WANG 2024 Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China

Analysis On Development Status And Characteristics Of Non-Governmental Bio-Safety And Bio-Security Think Tanks In The United States, Wenbing Ma, Qiang Song, Lei Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

At present, the complexity of bio-safety governance is becoming increasingly prominent, and complex issues such as security and development in the bio-economy, preparedness and response to infectious disease pandemics, the interweaving and integration of bio-security and other security factors, and the integration of scientific and technological factors and security factors urgently require think tanks to conduct systematic, comprehensive and forward-looking assessments and provide professional solutions. Rooted in the relatively mature experience in the construction of think tanks in the United States, a number of bio-safety and bio-security think tanks with greater influence have been developed, which have acted as an …


Outstanding Articles In 2023 Of Journal Of Chinese Academy Of Sciences, 2024 Chinese Academy of Sciences

Outstanding Articles In 2023 Of Journal Of Chinese Academy Of Sciences

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.


Ai Helps To Establish A New Paradigm For Scientific Research, Weinan E 2024 Perking University, Beijing 100871, China AI for Science Institute, Beijing, Beijing 100084, China

Ai Helps To Establish A New Paradigm For Scientific Research, Weinan E

Bulletin of Chinese Academy of Sciences (Chinese Version)

The main purpose of scientific research is to discover fundamental principles and solve practical problems. Although tremendous progress has been made on both fronts, the lack of effective tools and efficient organizational structure still stands as the main bottleneck for scientific progress. The rapid development of artificial intelligence (AI) offers a new possibility. In recent years, deep learning has had an impressive performance, both in helping to solve fundamental scientific problems and in improving the effectiveness of scientific research tools. A new set of infrastructure is emerging, leading us to a new paradigm, the“Android paradigm”, for doing scientific research.


Computing System For Simulation Intelligence, Guangming TAN, Weile JIA, Zhan WANG, Guojun YUAN, En SHAO, Ninghui SUN 2024 Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China

Computing System For Simulation Intelligence, Guangming Tan, Weile Jia, Zhan Wang, Guojun Yuan, En Shao, Ninghui Sun

Bulletin of Chinese Academy of Sciences (Chinese Version)

This study refers computer simulation in scientific research to as scientific simulation. Based on its narrow and broad definitions, this study divides scientific simulation into three stages: numerical computation, simulation intelligence, and science brain. Now, scientific simulation is entering the era of simulation intelligence, i. e., driven by scientific big data and artificial intelligence technology, scientific simulation is shifting from traditional numerical simulation to simulation integrated with artificial intelligence. In order to understand what the right computing system for simulation intelligence is, the design guidelines, basic methods, and key technical problems are discussed.


Digital Scientists And Parallel Sciences: The Origin And Goal Of Ai For Science And Science For Ai, Feiyue WANG, Yutong WANG 2024 State Key Laboratory for Management and Control of Complex Systems, Chinese Academy of Sciences, Beijing 100190, China Faculty of Innovation Engineering, Macau University of Science and Technology, Macao 999078, China

Digital Scientists And Parallel Sciences: The Origin And Goal Of Ai For Science And Science For Ai, Feiyue Wang, Yutong Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on recent development in foundation model, parallel intelligence, decentralized science (DeSci), and other artificial intelligence (AI) technologies, from AI for Science (AI4S) to Science for AI (S4AI), this study discusses parallel sciences and digital scientists, and their impact and significance in paradigm shift for research and development as well as Industry 5.0 and intelligent industry, which demonstrate that paradigm shift is emerging and accelerating, and we must be prepared.


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