Biological Psychology Commons^™

Oprm1 Rs1799971 Genotype Predicts Drinking Behavior In Males, But Not Females, Sarah Hughes Berheim, Carmen Ochoa, Grace Sullivan, Scott F. Stoltenberg

UCARE: Research Products

• The prevalence of alcohol disorders costs Americans $223.5 billion yearly due mostly from losses in workplace productivity, as well as health care and criminal justice expenses (CDC, 2016).

• Maximum number of drinks consumed in a 24 hour period is a valid indicator of dangerous drinking behavior and may reflect an increased tolerance for high levels of alcohol (Edenberg, 2016).

• Awareness of factors related to such heavy drinking is important for targeting interventions for dangerous alcohol use.

• Men drink significantly more than women, with about 4.5% of men and 2.5% of women meeting the diagnostic criteria for …

Double Dissociation Of The Anterior And Posterior Dorsomedial Caudate–Putamen In The Acquisition And Expression Of Associative Learning With The Nicotine Stimulus, Sergios Charntikov

Department of Psychology: Dissertations, Theses, and Student Research

Tobacco use is the leading cause of preventable deaths worldwide. This habit is not only debilitating to individual users but also to those around them (second-hand smoking). Nicotine is the main addictive component of tobacco products and is a moderate stimulant and a mild reinforcer. Importantly, besides its unconditional effects, nicotine also has conditioned stimulus effects that may contribute to the tenacity of the smoking habit. Because the neurobiological substrates underlying these processes are virtually unexplored, the present study investigated functional involvement of dorsomedial caudate putamen (dmCPu) in the conditioning processes with nicotine as a conditioned stimulus. Rats were trained …

Stress And Eyewitness Memory: Timing Of Stressor And Association With Cortisol Stress Responding, Timothy Ryan Robicheaux

Department of Psychology: Dissertations, Theses, and Student Research

Witnesses to and victims of criminal events can face significant stress during such encounters. Stress responding consists of a multitude of responses (e.g., anxiety, cardiovascular changes, cortisol responding). In the current study, I utilized a physiological stressor (i.e., the cold-pressor test) and a facial recognition paradigm to examine the relationship between cortisol change following stress exposure and memory accuracy. More specifically, I examined whether cortisol levels at specific memory stages (i.e., acquisition and retrieval) predicted stress responding differently.

Findings suggested that individual differences in cortisol stress responding to the cold-pressor test predicted facial recognition when peak cortisol was at a …

The Neurophysiology Of Intersensory Selective Attention And Task Switching, Jeremy W. Murphy

Dissertations, Theses, and Capstone Projects

Our ability to selectively attend to certain aspects of the world and ignore others is fundamental to our day-to-day lives. The need for selective attention stems from capacity limitations inherent in our perceptual and cognitive processing architecture. Because not every elemental piece of our environment can be fully processed in parallel, the nervous system must prioritize processing. This prioritization is generally referred to as selective attention. Meanwhile, we are faced with a world that is constantly in flux, such that we have to frequently shift our attention from one piece of the environment to another and from one task to …

Activating The Biological And Behavioral Immune Systems, Julia Christensen

Departmental Honors Projects

Psychology recognizes two distinct facets of the immune system: the biological immune system (BIO), covering all processes of the typical immune system, and the behavioral immune system (BEH), a set of cognitive, emotional, and behavioral responses to environmental stimuli. Research on this dual immune system indicates that each is capable of influencing the other (Schaller & Park, 2011). For example, perception of illness in others can activate the sympathetic nervous system (Schaller, Miller, Gervais, Yager, & Chen, 2010). Furthermore, evidence suggests that these two systems are capable of influencing moral judgment (Inbar, Pizarro, & Bloom, 2008). This study aims to …

Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li

Department of Psychology: Faculty Publications

Neurotensin is an endogenous neuropeptide closely associated with the mesolimbic dopaminergic system and shown to possess antipsychotic-like effects. In particular, acute neurotensin receptor activation can inhibit conditioned avoidance response (CAR), attenuate phencyclidine (PCP)-induced prepulse inhibition (PPI) disruptions, and reverse PCP-induced hyperlocomotion. However, few studies have examined the long term effects of repeated neurotensin receptor activation and results are inconsistent. Since clinical administration of antipsychotic therapy often requires a prolonged treatment schedule, here we assessed the effects of repeated activation of neurotensin receptors using an NTS1 receptor selective agonist, PD149163, in 3 behavioral tests of antipsychotic activity. We also investigated whether …

Spontaneous Facial Behavior Computing In Human Machine Interaction With Applications In Autism Treatment, Seyedmohammad Mavadati

Electronic Theses and Dissertations

Digital devices and computing machines such as computers, hand-held devices and robots are becoming an important part of our daily life. To have affect-aware intelligent Human-Machine Interaction (HMI) systems, scientists and engineers have aimed to design interfaces which can emulate face-to-face communication. Such HMI systems are capable of detecting and responding upon users' emotions and affective states. One of the main challenges for producing such intelligent system is to design a machine, which can automatically compute spontaneous behaviors of humans in real-life settings. Since humans' facial behaviors contain important non-verbal cues, this dissertation studies facial actions and behaviors in HMI …

A Mixed Methods Evaluation Of The Effectiveness Of A Group Yoga Intervention As An Adjunctive Trauma Therapy For Adolescent Girls, Melissa Eileen Houser

Electronic Theses and Dissertations

Neuroscience findings support the need for trauma treatments that work from the lowest levels of the brain up to the highest levels of the brain (Perry, 2009) due to evidence that the inverse relationship between amygdala and medial prefrontal cortex is not as strong in individuals who have experienced trauma, leading to difficulty in inhibiting fear responses through cognition (McRae, Ochsner, & Gross 2011). Difficulties associating language with traumatic events have also been found (van der Kolk, 2006). The integration of mindfulness practices and the popularization of yoga in the West have led to use of yoga to address trauma …

Psychophysiological Markers Of Cognitive Reactions To Depictions Of Corporal Punishment, Hope Reuschel

Online Theses and Dissertations

The following study assessed cognitive mechanisms, via physiological measures, in reaction to photos depicting conditions of corporal punishment, nonphysical punishment, and a neutral control. Detections in skin conductance (SCR) were used to examine autonomic stress response. The current study examined executive working memory (WM) processes as influenced by cognitive and psychophysiological response to viewing depictions of various punishments being implemented. Results of this study found that while participants reacted differently, autonomically and cognitively, to photo conditions, these differences were unrelated to other anticipated moderators such as tendency to internalize shame or greater personal exposure to corporal punishment. Subsequent analyses, however, …

Cannabinoid Modulation Of Cisplatin Induced Neuropathy, Hannah Marie Harris

Electronic Theses and Dissertations

Endocannabinoid modulation of cancer-related pain is well-documented. Sativex, a cannabinoid extract with a 1:1 ratio of tetrahydrocannabinol (thc) and cannabidiol (cbd) has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether thc or cbd alone is effective in attenuating or preventing tactile allodynia associated with cisplatin-administration. Mice (c57bl/6) were given eight doses of 2.3 mg/kg cisplatin or saline solution ip every second day to induce tactile allodynia (ringers on alternate days). Tactile responses to hind-paws were quantified in g of force using an electric von frey (evf) prior to (baseline) and after the cisplatin administration protocol. …

Behavioral Effects Of Fluoxetine On Aggression And Associative Learning In Betta Splendens, Benjamin Eisenreich

Graduate Student Theses, Dissertations, & Professional Papers

While the link between serotonin and the behaviors of aggression and learning has been elucidated, few studies have examined the impact serotonin has on learning for aggressive rewards. In particular, the SSRI fluoxetine has been demonstrated to reduce aggression as well the acquisition of instrumental responding for rewards indicating that this drugs behavioral effect may be related to motivational processes important for learning. To examine the relationship between fluoxetine and motivational process important for learning, two experiments were conducted using Betta splendens, a species well known for their robust aggressive response and drive to engage in aggressive behaviors, to examine …

Examining Memory Consolidation And Reconsolidation In An Appetitive Pavlovian Task, Jonathan J. Chow

Theses and Dissertations--Psychology

Memory plays an important role in defining how one behaves. The neurobiological mechanisms of memory have been studied extensively in animal models and the NMDA glutamate receptor has been identified to play an important role in the consolidation and reconsolidation of appetitive memories. Certain memories, depending on what was learned, can function differently and can be more difficult to disrupt based on a number of factors. Currently, no study has examined whether or not a reward-predictive stimulus attributed with incentive value is more difficult to disrupt than a stimulus that functions as a general reward-predictor. To determine the role of …

Effects Of Repeated Cue Exposure On Cannabis Craving, Jessica S. Fogel

Theses and Dissertations--Psychology

Craving is a key element of the cannabis withdrawal syndrome that has been associated with continued use and relapse. Although cue-induced cannabis craving has been established in single laboratory sessions, procedures to sustain craving over multiple sessions are needed. The purpose of the present study was to determine if cue-induced craving responses could be elicited in the same subjects across multiple sessions. It was hypothesized that exposure to cannabis cues would produce more robust craving responses than exposure to neutral cues and that elicited craving responses will be sustained across multiple cue exposures. Five experimental cue exposure sessions (1 neutral …

Differences In Stress Biomarkers In Women With High And Low Stress Appraisal, Clarissa Sara Gomez

Open Access Theses & Dissertations

Measures of physiological biomarkers have been widely used in the field of stress research to explain how stress negatively impacts health outcomes. Women in particular have been shown to be more at risk for developing physiological and psychological stress-induced conditions (e.g., hypertension, depression) due to hormonal differences (Kirschbaum et al., 1992), but more importantly, because of their appraisal of stressful events (Schamus et al., 2008). Few studies however have examined whether womenâ??s stress appraisal is predictive of stress reactivity, as measured by stress biomarkers, during stressful events. The goal of this study was to examine whether stress appraisal predicted stress …

Losing Robin Williams: An Analysis Of User-Generated Twitter Content Following The Sudden Death Of A Celebrity, Samantha Mallow

Honors Program Theses

The purpose of my thesis is to examine how people use social media, in this case Twitter, to share content that reflects their attitudes toward the loss of a celebrity and the issue of mental illness. To complete my research, I examined how users of Twitter created content expressing their reactions to the sudden passing of comedian and actor Robin Williams on August 11, 2014. Williams’ death raised mental illness issues that he had faced during his life. After analyzing the data I created a short survey with eight tweets that referred to mental illness. The survey was administered to …

Developing A Neuroplasticity-Based Treatment Program For Psychopathy: Treatment Foci And Options, Mariah Villanueva

Undergraduate Research Posters

Psychopathy is a neurodevelopmental disorder that is commonly misunderstood as the condition of criminals, and many people believe the best cure is simple confinement for those who ignore society’s laws. Psychopathy, though, is a genuine condition with a genetic basis that manifests itself through neurotransmitter system disruption and hormone imbalances. Psychopathy has a serious neurological impact on an individual, with impairments largely focused in the prefrontal cortex and amygdala, as well as overall negatively affecting the limbic system of the brain. Together, the total impact causes issues with that individual’s ability to empathize, to experience emotions normally, to develop a …

Cocaine-Induced Behavioral Sensitization And Conditioned Place Preference In Japanese Quail (Coturnix Japonica): A Focus On Sex Differences And Dopaminergic Mechanisms, Karin E. Gill

Theses and Dissertations--Psychology

Research has indicated that gonadal hormones may mediate behavioral and biological responses to cocaine. Estrogen, in particular, has been shown to increase behavioral responding to cocaine in female rats relative to male rats. The use of Japanese quail may add to our knowledge of sex differences in drug abuse because of their advanced visual system and the ability to control their gonadal hormones via alterations in photoperiod. In three experiments, cocaine-induced behaviors were examined using this avian model.

In Experiment 1, I investigated the potential sex differences in cocaine-induced locomotor activity between male and female Japanese quail and I examined …

Individual Differences In The Dopaminergic Reward System: The Effect Of Genetic Risk On Neural Reward Sensitivity And Risky Choice, Heather E. Soder

USF Tampa Graduate Theses and Dissertations

When making decisions, individuals evaluate several possible outcomes of their choice; however, some display heightened reward sensitivity, despite the potential for future negative consequences, which can lead one to make risky choices. Rewards are processed in the mesolimbic dopamine reward system, and this system is in part modulated by genetic polymorphisms that are associated with dopamine transmission. The current study tested if genetic polymorphisms that are associated with enhanced dopamine neurotransmission will be more neurally reward sensitive, score higher on self-reported impulsivity, and make riskier choices. In a sample of 85 participants, five genetic polymorphisms were genotyped and used to …

Genetic Moderation Of Phenotypic And Neural Indicators Of Peer Influenced Risk-Taking Behavior: An Experimental Investigation, Troy Alan Webber

USF Tampa Graduate Theses and Dissertations

Risk-taking behavior (RTB) is defined as behavior involving the probability of reward with concurrent probability of some negative outcome. Peer influence is among the most robust predictors of RTB, such that greater peer influence, particularly deviant or delinquent peer influence, is associated with increased RTB. Evidence suggests that those with genetic predispositions for RTB may also be more susceptible to peer influence as a function of genotype. Given that genetic polymorphisms within the dopaminergic system have evidenced associations with various forms of RTB and delinquent peer affiliation, it is possible that these genes may interact with peer influence to predict …

The Role Of Neurotensin Receptors On Visceral Pain And Activity Levels In Mice., Christopher J. Walker

UNF Graduate Theses and Dissertations

This study examines the effects of neurotensin (NT) receptor sites on the sensation of visceral pain. Previous work by researchers has found, through the use of NT analogs, that visceral pain is closely associated with NT receptor 2 (NTSR2). This study tested 70 genetically modified mice. The mice were either missing NTSR1, NTSR2, or were wild-type (WT) mice that were not missing any NT receptors. The mice were injected intraperitoneally with either saline or acetic acid then observed for a 60 minute period and writhing behavior was recorded. Twenty four hours later activity levels were recorded in the open field …