Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors,
2016
Northern Michigan University
Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura Wise, Alan L. Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter
Journal Articles
The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. The adverse effects of clozapine, including agranulocytosis, make finding a safe clozapine-like a drug a goal for drug developers. The drug dis- crimination paradigm is a model of interoceptive stimulus that has been used in an effort to screen experimental drugs for clozapine-like atypical antipsychotic effects. The present study was conducted to elucidate the receptor-mediated stimulus properties that form this clozapine discriminative cue by testing selective receptor ligands …
The Relationship Between Physical Fitness And School Performance In Middle School Girls,
2016
Walden University
The Relationship Between Physical Fitness And School Performance In Middle School Girls, Jamie Anne Donnelly
Walden Dissertations and Doctoral Studies
Past research has indicated a significant relationship between physical fitness and standardized test scores; however, the relationship between physical fitness and other aspects of school performance has yet to be empirically examined in a population specifically composed of middle school girls. This study examined several factors that contribute to school success, such as classroom behavior, attendance, and grades, in relation to physical fitness among a group of adolescent girls. It was specifically designed to examine the statistical relationship between physical fitness, as measured by the Fitnessgram, and quantitative data on school performance including grades, standardized test scores, school behavior, and …
Understanding Mental Toughness And Stress: The Role Of Cortisol,
2016
Rollins College
Understanding Mental Toughness And Stress: The Role Of Cortisol, Alexis K. Satterwhite Ms.
Honors Program Theses
Mental toughness research aims to understand how two people of the same skill level, experience, and background react to pressure and stress, with one succumbing to the pressure while another succeeds (Clough & Strycharczyk, 2012). This study used Clough, Earle, and Sewell’s (2002) four C’s of mental toughness (commitment, challenge, control, and confidence) as a theoretical framework. The current study aims to explore physiological aspects of mental toughness through cortisol, a stress hormone that is released as an internal reaction to some type of threat occurring externally to the body (Kottler & Chen, 2011). The relationships between mental toughness and …
An Event-Related Potential Study Of Social Information Processing In Adolescents,
2016
CUNY John Jay College
An Event-Related Potential Study Of Social Information Processing In Adolescents, Danielle Difilipo, Jillian Grose-Fifer
Publications and Research
Increased social awareness is a hallmark of adolescence. The primary aim of this eventrelated potential study was to investigate whether adolescents, in comparison to adults, would show relatively enhanced early neural processing of complex pictures containing socially-relevant information. A secondary aim was to investigate whether there are also gender and age differences in the ways adolescents and adults process social and nonsocial information. We recorded EEGs from 12–17 year-olds and 25–37 year-olds (N = 59) while they viewed pleasant pictures from the International Affective Picture System. We found age-related amplitude differences in the N1 and the LPP, and gender-related differences …
Cognitive Phenotypes And The Evolution Of Animal Decisions,
2016
University of Maryland - Baltimore County
Cognitive Phenotypes And The Evolution Of Animal Decisions, Tamra C. Mendelson, Courtney L. Fitzpatrick, Mark E. Hauber, Charles H. Pence, Rafael L. Rodríguez, Rebecca J. Safran, Caitlin A. Stern, Jeffrey R. Stevens
Faculty Publications
Despite the clear fitness consequences of animal decisions, the science of animal decision making in evolutionary biology is underdeveloped compared with decision science in human psychology. Specifically, the field lacks a conceptual framework that defines and describes the relevant components of a decision, leading to imprecise language and concepts. The ‘judgment and decision-making’ (JDM) framework in human psychology is a powerful tool for framing and understanding human decisions, and we apply it here to components of animal decisions, which we refer to as ‘cognitive phenotypes’. We distinguish multiple cognitive phenotypes in the context of a JDM framework and highlight empirical …
Initiation And Retention In Couples Outpatient Treatment For Parents With Drug And Alcohol Use Disorders,
2016
Old Dominion University
Initiation And Retention In Couples Outpatient Treatment For Parents With Drug And Alcohol Use Disorders, Abbly L. Braitman, Michelle L. Kelley
Psychology Faculty Publications
The focus of the current study was to identity mental health, relationship factors, substance use related problems, and individual factors as predictors of couples-based substance abuse treatment initiation and attendance. Heterosexual couples with children that met study criteria were invited to attend 12 sessions of outpatient behavioral couples therapy. Men were more likely to initiate treatment if they had a higher income, had greater relationship satisfaction, were initiating treatment for alcohol use disorder only, were younger when they first suspected a problem, and had higher depression but lower hostility or phobic anxiety. Men attended more treatment sessions if they reported …
Acute And Chronic Effects Of Inhalants In Intracranial Self-Stimulation,
2016
Student
Acute And Chronic Effects Of Inhalants In Intracranial Self-Stimulation, Matthew Tracy
Theses and Dissertations
Inhalants are a loosely defined diverse group of volatile substances which people abuse. Despite widespread misuse of inhalants, there are limited preclinical methods available to study the reinforcement-like properties of inhalants. One procedure which has demonstrated substantial promise as a tool to investigate inhalant pharmacology is the intracranial self-stimulation (ICSS) procedure. ICSS utilizes pulses of electrical stimulation to the mesolimbic reward pathway to serve as a temporally defined and controlled operant reinforcer with a highly adjustable efficacy. The first aim of the project was to characterize the effects of commonly abused inhalants: including toluene, trichloroethane, nitrous oxide, isoflurane and R134a …
Relation Between Harsh Parenting Exposure In Childhood And Adult Externalizing Symptoms : Moderating Role Of The Autonomic Nervous System,
2016
University at Albany, State University of New York
Relation Between Harsh Parenting Exposure In Childhood And Adult Externalizing Symptoms : Moderating Role Of The Autonomic Nervous System, Samantha Aldea Barry
Legacy Theses & Dissertations (2009 - 2024)
Though literature suggests that many individuals with childhood attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) report having symptoms of the respective disorder as adults, little is known about potential predictors of adulthood externalizing symptoms. The proposed study examines the impact of the parasympathetic nervous system (PNS), as measured by respiratory sinus arrhythmia (RSA), and the sympathetic nervous system (SNS), as measured by skin conductance levels (SCL), on the link between harsh parenting experienced during childhood and ADHD and ODD symptoms during young adulthood. Results yielded a significant two-way interaction between harsh parenting and resting RSA, which significantly accounted for …
Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala,
2016
Wayne State University
Analgesia Followed By Long-Term Hyperalgesia Generated By Disinhibition Of The Basolateral Amygdala, Derek Atchley
Wayne State University Theses
Stress produces bimodal effects on pain peception. During exposure to a stressor pain responses are inibited (i.e. stress-induced analgesia). However, following long-term exposure to a stressor increases in responsiveness to painful stimuli may develop (i.e. stress-induced hyperalgesia). Here I evaluated how a key component of the subcortical defense circuit and target of stress hormones contributes to the development of both stress-induced analgesia and hyperalgesia. Bicuculline methiodide, a GABAA antagonist, injected into the basolateral amygdala was used to mimic the neural effects of a stressor or threat exposure. Immediately following injection pain responsiveness was decreased as measured by vocalizations after discharge …
Age-Related Changes In Hippocampal Arc Expression Following Minimal Behavioural Induction,
2016
Wilfrid Laurier University
Age-Related Changes In Hippocampal Arc Expression Following Minimal Behavioural Induction, Irina V. Odintsova
Theses and Dissertations (Comprehensive)
Normal ageing is associated with significant changes in cognitive function, including the decline of some forms of memory. The hippocampal formation is critical to learning and memory function, and plasticity in this region declines with age. Additionally, age-related differences in plasticity are greatest at lower levels of stimulation, thus peri-threshold plasticity may be of the greatest relevance for age-related changes in cognition. Moreover, the hippocampus is prone to changes in the expression of gene products that mediate plasticity with age. The current thesis attempts to link these observations by measuring hippocampal expression of Arc, an immediate-early gene that is critical …
Political Neuroscience,
2016
University of Nebraska-Lincoln
Political Neuroscience, Ingrid J. Haas
Department of Political Science: Faculty Publications
The field of political science has traditionally had close ties to disciplines like economics, history, and sociology. While political science has always been somewhat interdisciplinary in nature, in recent years this interdisciplinary approach has expanded to include biology, psychology, and neuroscience. This interest in the human sciences has led to the development of new subfields within political science, including biopolitics, political psychology, and political neuroscience (also called neuropolitics). What these new subfields have in common is an interest in individual human behavior and decision-making as an approach to understanding political behavior. While political science has traditionally focused on understanding politics …
Effect Of Prior Trauma Exposure On Alpha Amplitude, Heart Rate, And Self-Reported Negative Affect,
2016
Central Washington University
Effect Of Prior Trauma Exposure On Alpha Amplitude, Heart Rate, And Self-Reported Negative Affect, Gina L. Denoble
All Master's Theses
This study was conducted to investigate whether the number of traumatic events an individual has previously experienced influences that individual’s physiological and psychological reactions when exposed to a negative affective stimulus followed by a mindfulness-based stress reduction (MBSR) intervention. Twenty-eight participants were placed into intact quasi-experimental groups based on their scores on the Traumatic Life Events Questionnaire (TLEQ). The negative affective stimulus consisted of a series of photos bearing negative affective valence. The photos were selected from the International Affective Picture System (IAPS), and paralleled the areas of trauma exposure evaluated by the TLEQ. All participants were exposed to the …
Evidence For Animal Grief?,
2016
Currently Unaffiliated
Evidence For Animal Grief?, Carolyn Ristau
Animal Sentience
The nature of evidence appropriate to the study of animal emotion (and cognition) is discussed in this review with reference to Barbara King’s book. How Animals Grieve is beautifully written, but it intermixes examples meeting King’s criteria for evidence of grief with other poignant but far less convincing examples. Yet, as noted earlier by Griffin (1958/1974), “Excessive caution can sometimes lead one as far astray as rash enthusiasm.” King cites strong evidence from long-term scientific field studies, often involving known individuals; from videotapes; from convergent evidence in neurophysiological studies; and, notwithstanding possible emotional bias, from animals living closely with humans. …
In The Light Of Evolution: Human Nature, Political Behavior, And Making Sense Of Our Social Identity,
2016
DePauw University
In The Light Of Evolution: Human Nature, Political Behavior, And Making Sense Of Our Social Identity, Corby F. Burger 16
Honor Scholar Theses
No abstract provided.
Does The Pain Of Rejection Promote The Pleasure Of Revenge? A Neural Investigation Of Cingulo-Striatal Contributions To Violence,
2016
University of Kentucky
Does The Pain Of Rejection Promote The Pleasure Of Revenge? A Neural Investigation Of Cingulo-Striatal Contributions To Violence, David Chester
Theses and Dissertations--Psychology
Aggression is a dynamic and costly feature of human behavior. One reliable cause of aggression is social rejection, though the underlying mechanisms of this effect remain to be fully understood. Previous research has identified two psychological processes that are independently linked to aggressive retaliation: pain and pleasure. Given recent findings that pain magnifies the experience of pleasure, I predicted that the pain of rejection would promote the pleasure of aggression and thus, aggression itself. I also expected that this indirect effect of aggressive pleasure would only be observed among individuals with weaker self-regulatory abilities that are necessary to cope with …
Slam Poetry: An Online Intervention For Treating Depression,
2016
University of Montana
Slam Poetry: An Online Intervention For Treating Depression, Spencer J. Ruchti, Mercedes Becker, Cara Mckee, Austin Herron, Alex Swalling
Undergraduate Theses, Professional Papers, and Capstone Artifacts
Given that depression is the “leading cause of disability worldwide,” and that less than 50% of people suffering from depression receive treatment, this study aims to provide support for a globally accessible depression treatment (WHO, 2012). The study conducted implemented an internet-based treatment for depression in which users were provided an opportunity to watch slam poetry videos related to mental health issues and write free responses regarding the content of the videos and their subjective experience of depression. Numerous studies provide support for the effectiveness of expressive writing, online mental health interventions, and slam poetry in particular for reducing symptoms …
Behavioral Phenotyping Of Vmat1 Knockout Mice: Relevance To Neuropsychiatric Disorders,
2016
Virginia Commonwealth University
Behavioral Phenotyping Of Vmat1 Knockout Mice: Relevance To Neuropsychiatric Disorders, Kevin A. Webster Ph.D.
Theses and Dissertations
Schizophrenia is a debilitating mental disorder that causes a large economic burden and is prevalent across all cultures and countries around the world. Although both environmental factors and genetics are known to play an important role in the etiology of schizophrenia, the exact role of genetics and its interaction with environmental factors in an individual’s predisposition to develop schizophrenia is poorly understood. Schizophrenia is characterized by symptoms that include positive symptoms (e.g. delusions, hallucinations, disorganized thinking and speech), negative symptoms (e.g. avolition, anhedonia, depressive-like behavior), and cognitive dysfunctions (e.g. executive functioning deficits in learning and memory, attention, and vigilance). Genomic …
The Effect Of Inversion And Motor Expertise On Body Compatibility,
2016
Pomona College
The Effect Of Inversion And Motor Expertise On Body Compatibility, Harrison M. Goodall Iii
Pomona Senior Theses
Previous studies have established that when a subject’s attention is directed to a specific body part, the subject is able to move that body part faster than a body part their attention was not drawn to. This is known as the body compatibility effect, and it has been shown that this effect only occurs when viewing upright images of the human body. In this study, we presented control subjects and expert acrobats with inverted and upright stimuli. We hypothesized that the amount of time the acrobats spent inverted would result in the acrobats exhibiting body compatibility effects for both upright …
The Effects Of Pet Ownership On Anxiety And Depression Among Trauma-Exposed College Students,
2016
Virginia Commonwealth University
The Effects Of Pet Ownership On Anxiety And Depression Among Trauma-Exposed College Students, Dung N. Nguyentran, Marlene A. Michniak, James J. Jung, Christine Q. Do
Undergraduate Research Posters
Rates of anxiety and depression are prevalent in college students and can be attributed in part to stress and trauma-related events. However, studies suggest that pet ownership has the possibility of alleviating symptoms of anxiety, depression, negative emotions, and suicide. The purpose of this study was to determine the relationship between pet ownership and levels of anxiety and depression among those who have experienced a traumatic event. The sample was comprised of five hundred and forty-seven VCU students who completed an online survey from Spit for Science during their junior year. Linear regressions were performed to determine the nature and …
Devaluation As A Strategy To Address Behaviourally Whether Fish Feel,
2016
Indiana University Bloomington
Devaluation As A Strategy To Address Behaviourally Whether Fish Feel, Robert Ian Bowers
Animal Sentience
Failures of behavioural studies to address the question of whether fish feel pain have left scientists arguing on the basis of other criteria, including anatomy. I draw an analogy with a debate concerning the breadth of stimulus-response learning among nonhuman animals and propose an experiment that harks back to one solution to that debate: the devaluation paradigm. By changing the value of a noxious stimulus after training, one can differentiate a directly evoked response from a response to an intermediate representation, the pain.
