Age-Dependent Effects Of Eedq On Cocaine-Induced Locomotor Activity And D2 Receptor Supersensitivity,
2019
California State University, San Bernardino
Age-Dependent Effects Of Eedq On Cocaine-Induced Locomotor Activity And D2 Receptor Supersensitivity, Angie Teran
Electronic Theses, Projects, and Dissertations
The neurochemical changes occurring between the preweanling period and adolescence could be crucial for understanding the role development plays in the manifestation of psychotic behaviors. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) fully attenuates the DA agonist-induced behaviors of adult rats, while potentiating the DA agonist-induced locomotor activity of preweanling rats. My specific hypotheses were as follows: (1) Systemically administered EEDQ would block the cocaine-induced locomotor activity of adult rats. (2) Systemically administered EEDQ would potentiate the cocaine-induced locomotion of preweanling rats. (3) EEDQ would increase the Emax values (a measure of D2 receptor sensitivity) of preweanling rats, but not adolescent or adult rats. …
Mouse Performance On A Novel Touchscreen Continuous Performance Task Is Dependent On Signaling In The Prelimbic Cortex,
2019
Western University
Mouse Performance On A Novel Touchscreen Continuous Performance Task Is Dependent On Signaling In The Prelimbic Cortex, Tyler D. Dexter, Daniel Palmer, Amy C. Reichelt, Anita Taksokhan, Lisa M. Saksida, Tim J. Bussey
Western Research Forum
Attention is the cognitive processing that facilitates the ability to target and attend to relevant environmental stimuli, while filtering out irrelevant or distracting stimuli. Control over selective attention is theorized to be dependent on organized neural communication that stems from the medial prefrontal cortex (mPFC). To evaluate selective and sustained attention, mice were trained on the novel touchscreen rodent continuous performance task (rCPT), a task designed to emulate the human CPT. In the rodent version, images are continuously presented on a touchscreen, where mice have been trained to selectively respond to one image type while suppressing responses to all others. …
Blood, Meth, And Tears: The Super Soldiers Of World War Ii,
2019
James Madison University
Blood, Meth, And Tears: The Super Soldiers Of World War Ii, Nicholas Racine
MAD-RUSH Undergraduate Research Conference
Day and night, soldiers in World War II were physically and mentally strained by fatigue and psychiatric distress. Consequently, many soldiers were left exhausted and demoralized. War efforts hinged on soldiers succeeding in missions, thus a fast-acting solution was needed. Development of the psychostimulant drugs Benzedrine and Pervitin in the 1920s and 30s spurred enthusiasm among scientists, the media, the public, and various governments. Potent and powerful, these drugs exert effects that promote wakefulness, elevated mood, and improved field performance. Governments quickly began researching use of stimulants to improve their war efforts. By the early 40s, both drugs had millions …
Laboratory Induced Cortisol Reactivity Predicts Greater Rates Of Treatment Success In Affective Disorders.,
2019
Southern Methodist University
Laboratory Induced Cortisol Reactivity Predicts Greater Rates Of Treatment Success In Affective Disorders., Andres David Roque
Psychology Theses and Dissertations
Response rates to first line treatments for affective disorders remain unsatisfactory (Loerinc et al., 2015). Identification of moderators and mediators that can facilitate treatment success is of great scientific and clinical interest. One such candidate could be stress-induced cortisol reactivity. For instance, higher cortisol reactivity to a pretreatment presentation of combat-related stimuli related to significantly worse outcome at post-treatment following 6-sessions of virtual reality exposure therapy in individuals with PTSD (Norrholm et al., 2016). By contrast, greater cortisol reactivity to an acute stressor predicted greater treatment response in not only depressive symptoms (Dieleman et al., 2016) but also anxiety symptoms …
Quantitative Reasoning: Individual Differences In Heart Rate And Response Latency,
2019
Missouri State University
Quantitative Reasoning: Individual Differences In Heart Rate And Response Latency, Abigail L. Van Nuland
Graduate Theses/Dissertations
Math is something that all students are required to use at some point during their academic careers. Then they must use it again in the real world. Unfortunately, many students struggle with quantitative processing. In the current study, participants answered first grade level math problems in order to assess cognitive effort when solving math problem. Participants were then assigned randomly to one of two conditions; Answer or Equation. In the Answer Condition participants were asked to solve a series of math problems, whereby they were given a math equation and then they were asked to choose an answer. In the …
An Erp Investigation Of Reward Signals For Differing Classes Of Reinforcing Stimuli,
2019
University of New Mexico - Main Campus
An Erp Investigation Of Reward Signals For Differing Classes Of Reinforcing Stimuli, Darin R. Brown
Psychology ETDs
In order to successfully traverse an actively complex environment, an agent is required to learn from the consequences of their actions. For over a century, models of behavior have been developed demonstrating these consequence-based learning systems. More recently, underlying biological systems have been found to adhere to these constructs of learning. The electroencephalographic signal known as the Reward Positivity (RewP) is thought to reflect a dopamine-dependent cortical signal specific to reward receipt. Importantly, this signal has been shown to adhere to an axiomatic (rule-like) positive reward prediction error, whereby it is evoked following outcomes that are better than expected. These …
Developing Sensory Behavioral Assays For Zebrafish Autism Model,
2019
Georgia Southern University
Developing Sensory Behavioral Assays For Zebrafish Autism Model, Shannon Wagner
Honors College Theses
Individuals of all ages can suffer from a wide variety of symptoms and disabilities that could be diagnosed as Autism Spectrum Disorder (ASD). Due to new methods and technology, individuals are now being diagnosed in the first two years of their life, which is when the signs of ASD are initially exhibited. Individuals diagnosed with ASD share many similar disabilities and symptoms such as hyperactivity to social, visual, and auditory stimuli, as well as hyposensitivity to olfactory stimuli. Neural circuit-based alterations are widely considered as a cause for these behavioral aberrations. We have created behavioral assays using zebrafish larvae to …
Ptsd Precipitating From Sexual Abuse And Combat War Exposure And Co-Morbid Disorders Of Chronic Pain, Substance Abuse And Immune Systems,
2019
Bridgewater State University
Ptsd Precipitating From Sexual Abuse And Combat War Exposure And Co-Morbid Disorders Of Chronic Pain, Substance Abuse And Immune Systems, Jessica Anzalone
Honors Program Theses and Projects
Posttraumatic stress disorder (PTSD) is a trauma and stress related disorder that some people develop after exposure to a traumatic life altering event. The person must witness the traumatic event, have the traumatic event occur to a loved one, or experience a traumatic event first hand. According to the publication of the American Psychiatric Association, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the diagnostic criteria for the identity of PTSD must include behavioral symptoms that accompany PTSD in four diagnostic clusters; re-experiencing, avoidance, negative cognitions and mood, and arousal (American Psychological Association, 2018). Two …
The Effects Of Adenosine Antagonists On Vigilant Attention In Sleep Restricted Rats,
2019
James Madison University
The Effects Of Adenosine Antagonists On Vigilant Attention In Sleep Restricted Rats, Morgan Crewe
Masters Theses, 2010-2019
The relation between chronic sleep restriction and performance on the Psychomotor Vigilance Task (PVT) have been well documented in the human literature, with chronic sleep restriction as little as 7 hours per night resulting in significant impairment in sustained attention performance measured via the PVT. Recently, an analogous version of the human PVT has been developed for use with rodent models (rPVT). Recent studies have measured the effects of sleep restriction on rPVT performance, citing similar results found in the human literature. However, few studies to date have directly examined the role of adenosine accumulation during sleep deprivation in producing …
“Flowing Along The Wall”: Anarcha-Feminist Bioethics And Resistance In Octavia E. Butler’S Dawn 2019.,
2019
SUNY College Cortland
“Flowing Along The Wall”: Anarcha-Feminist Bioethics And Resistance In Octavia E. Butler’S Dawn 2019., Theresa Mendez
Master's Theses
Science fiction (sf) texts conversant with the temporal play between past, present, and future push readers to imagine the extremes of human and environmental existence, interaction, and potential. Simultaneously, despite the sf genre’s tendency to traffic in extremes, these texts provoke readers to consider the ways in which these imagined worlds are grounded in history as well as in the contemporary social moment. As Donna Haraway has argued, “the boundary between science fiction and social reality is an optical illusion” (306). This illusory boundary must continue to be traversed in order to consider how sf literatures, particularly those which imagine …
The Effects Of Two Novel Anti-Inflammatory Compounds On Prepulse Inhibition And Neural Microglia Cell Activation In A Rodent Model Of Schizophrenia,
2019
East Tennessee State University
The Effects Of Two Novel Anti-Inflammatory Compounds On Prepulse Inhibition And Neural Microglia Cell Activation In A Rodent Model Of Schizophrenia, Heath W. Shelton
Electronic Theses and Dissertations
Recent studies have shown elevated neuroinflammation in a large subset of individuals diagnosed with schizophrenia. A pro-inflammatory cytokine, tumor necrosis factor-alpha (TNFα), has been directly linked to this neuroinflammation. This study examined the effects of two TNFα modulators (PD2024 and PD340) produced by our collaborators at P2D Bioscience, Inc., to alleviate auditory sensorimotor gating deficits and reduce microglial cell activation present in the polyinosinic:polycytidylic (Poly I:C) rodent model of schizophrenia. Auditory sensorimotor gating was assessed using prepulse inhibition and microglial activation was examined and quantified using immunohistochemistry and confocal microscopy, respectively. Both PD2024 and PD340 alleviated auditory sensorimotor gating deficits …
The Effects Of Ambient Temperature And Lighting Intensity On Wheel-Running Behavior In A Diurnal Rodent, The Nile Grass Rat (Arvicanthis Niloticus),
2019
Hope College
The Effects Of Ambient Temperature And Lighting Intensity On Wheel-Running Behavior In A Diurnal Rodent, The Nile Grass Rat (Arvicanthis Niloticus), Garrett M. Fogo, Alyssa M. Goodwin, Ohanes S. Khacherian, Brandi J. Ledbetter, Andrew J. Gall
Faculty Publications
Environmental conditions, such as the light-dark cycle and temperature, affect the display of circadian rhythmicity and locomotor activity patterns in mammals. Here, we tested the hypothesis that manipulating these environmental conditions would affect wheel-running activity patterns in a diurnal rodent, the Nile grass rat (Arvicanthis niloticus). Grass rats are diurnal in the field, however, a subset switch from a day-active pattern to a night-active pattern of activity after the introduction of a running wheel. The mechanism of this chronotype switch remains largely unknown. In the present study, grass rats were presented with running wheels in 12:12 light-dark conditions. First, subjects …
First Thirty Days Of Life: Examining Calf Behavioral Development In Beluga Whales (Delphinapterus Leucas) And Pacific White-Sided Dolphins (Lagenorhyncus Obliquidens) At One Zoological Facility,
2019
University of Southern Mississippi
First Thirty Days Of Life: Examining Calf Behavioral Development In Beluga Whales (Delphinapterus Leucas) And Pacific White-Sided Dolphins (Lagenorhyncus Obliquidens) At One Zoological Facility, Kendal Smith
Master's Theses
Cetacean development is important for general comparative understanding and the implementation of informed husbandry policies. Due to the inaccessibility of many of these species in the wild, researchers can study managed care populations to better understand basic developmental patterns of cetaceans, as well as to improve husbandry policies for facility animals. However, no previous studies have attempted to observe the behavioral development of Pacific white-sided dolphins (Lagenorhyncus obliquidens). Eight beluga whale calves and four Pacific white-sided dolphin calves were observed for the first 30 days of life to determine the developmental trajectory of several typically monitored behaviors. The …
Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise,
2019
University of Southern Mississippi
Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise, Maria Zapetis
Dissertations
As human populations rise, the level of man-made noise increases globally. Naval sonar and boat traffic are underwater sound sources of particular concern to marine mammal welfare. To better understand the impact of these noise increases on cetaceans, studies can explore animals’ behavioral changes in response to noise. Studies have investigated the ‘dose-response’ relationship between the received sound pressure level of sonar signals and the behavior of cetaceans in the wild, but exposure studies in controlled environments are limited. The studies in this dissertation examined bottlenose dolphin vocal modifications during various experimental noise treatments. Acoustic recordings previously obtained for bottlenose …
The Development Of Socio-Sexual Behavior In Beluga Whales (Delphinapterus Leucas),
2019
University of Southern Mississippi
The Development Of Socio-Sexual Behavior In Beluga Whales (Delphinapterus Leucas), Malin K. Lilley
Dissertations
The reproductive success of the beluga whale is critical for a species facing extinction in its endangered Cook Inlet, Alaska population. To date, little is known about the mating behavior of these whales in wild populations. On the other hand, observations of beluga whales in human care allow researchers to better understand many aspects of their daily lives and life histories that are difficult to assess in wild populations. Thus far, a catalog of socio-sexual behavior has been established based on observations of belugas; however, the developmental trajectory of socio-sexual behavior is not well-understood. The present study explored how socio-sexual …
The Relationship Between Aggression And Depression: Testing The Moderating Effects Of Age And Gender,
2019
Boise State University
The Relationship Between Aggression And Depression: Testing The Moderating Effects Of Age And Gender, Benjamin P. Comer
Boise State University Theses and Dissertations
The purpose of this thesis is to a) explore the research related to aggression and depression and b) test hypotheses that focus on the relationship between aggression and depression in relation to age and gender over time. Aggression and depression are discussed extensively by examining a broad range of literature that points to environmental, social, individual, psychological, and biophysiological influences. First, aggression and depression are discussed separately in terms of their underlying theory, biosocial perspectives, typologies, behavioral and personality abnormalities, brain structures related to each, and neurochemical/neurological influences. The final sections of the literature review discuss how aggression and depression …
The Role Of Head Trauma In Emotion Dysregulation Among Victims Of Partner Violence,
2019
University of Rhode Island
The Role Of Head Trauma In Emotion Dysregulation Among Victims Of Partner Violence, Aleksandra Fryc
Senior Honors Projects
The project I completed explores the relationship between head trauma and emotion dysregulation, or the inability to modulate the intensity and/or duration of emotional responses in a flexible manner in order to meet individual goals and situational demands (Gratz & Roemer, 2004), among victims of domestic violence. The rationale and importance of the project included the possibility that the findings of this study can inform future research in topics including head trauma, emotion dysregulation, and domestic violence. Despite evidence linking emotion dysregulation to both domestic violence and head trauma, no investigations to date have examined whether head trauma stemming from …
Redefining Burnout: Exploring Common Conceptualizations And The Neurophysiology Of Chronic Stress To Establish An Integrated Allostatic Model,
2019
Florida School of Professional Psychology at National Louis University
Redefining Burnout: Exploring Common Conceptualizations And The Neurophysiology Of Chronic Stress To Establish An Integrated Allostatic Model, Danny A. Guzzi
Dissertations
Burnout is a widely researched stress-related phenomenon associated with numerous adverse outcomes for employees and organizations. Unfortunately, burnout is not well understood and research to this point has been flawed due to a lack of consensus on the definition, dimensionality, and context of the construct. Prevalent conceptualizations of burnout have been criticized for being arbitrarily developed without solid theoretical foundation and for failing to clearly distinguish burnout from depression or other work-related conditions such as compassion fatigue, secondary traumatization, and vicarious traumatization. The current project first examines relevant literature to identify commonalities among prevalent burnout conceptualizations. Then relevant stress research …
Estimating Cognitive Workload In An Interactive Virtual Reality Environment Using Electrophysiological And Kinematic Activity,
2019
Old Dominion University
Estimating Cognitive Workload In An Interactive Virtual Reality Environment Using Electrophysiological And Kinematic Activity, Christoph Tremmel
Biomedical Engineering Theses & Dissertations
As virtual reality (VR) technology continues to gain prominence in commercial, educational, recreational and research applications, there is increasing interest in incorporating physiological sensors in VR devices for passive user-state monitoring to eventually increase the sense of immersion. By recording physiological signals such as the electroencephalogram (EEG), electromyography (EMG) or kinematic parameters during the use of a VR device, the user’s interactions in the virtual environment could be adapted in real time based on the user’s cognitive state. This dissertation evaluates the feasibility of passively monitoring cognitive workload via electrophysiological and kinematic activity while performing a classical n-back task in …
What Makes A Good Therapy Dog? Identifying Factors Associated With Calm Behavior In Therapy Dogs,
2019
University of Nebraska at Omaha
What Makes A Good Therapy Dog? Identifying Factors Associated With Calm Behavior In Therapy Dogs, Kristen Cunningham, Zachary L. Darwish, Rosemary Strasser
UNO Student Research and Creative Activity Fair
Dogs offer a variety of benefits to society, including the use of therapy dogs to provide therapeutic and physiological benefits, enhancing the lives of a wide range of recipients. Unlike service or emotional support animals, therapy dogs provide support to a multitude of individuals, often in hospitals, schools, nursing homes, or other venues. While many studies have examined behavioral assessments of service dog programs, little research has investigated the factors that make a good therapy dog. Therapy dogs must undergo strategic training before becoming certified. The present study seeks to illuminate what factors might distinguish therapy dogs from pet dogs …
