Biological Psychology Commons^™

Measuring The Effects Of Lobinaline-N-Bioxide (419) On Alcohol Consumption, Nicotine Locomotor Sensitization, And Conditioned Place Preference In Mice And Rats, Cocanut M. Suhail

Theses and Dissertations--Medical Sciences

Objective: Novel drug 419 was examined to see the effect it has in vivo mice and rats on alcohol consumption, nicotine locomotor sensitization, and conditioned place preference (CPP) models regarding behavioral tests on dopamine transporter activity.

Methods: Mice and rats were used to see how they react to the drug 419 and control vehicle, in each of the models. The animals were assessed to pre- and post- drug administration of novel drug 419. We examined each model to see the association between how drug 419 will help with treating drug abuse.

Results: We found that in alcohol consumption model the …

Covid-19, Evolution, Brains And Psychology, Frederick Toates

Animal Sentience

Attention needs to be directed to the processes that control behavior in humans and the adaptive problems that they solved in our early evolutionary environment. The evolutionary mismatch between the current environment and the human brain can yield important insights into the problems that beset us in the context of environmental degradation and nonhuman animal welfare.

Intrasexual Competition: Effects Of Hormonal Contraceptives, Hannah Fergusson

Cal Poly Humboldt theses and projects

Women’s intrasexual competition has been shown to fluctuate with fertility status, and in particular, with testosterone. It’s increasingly common that women take some form of hormonal contraceptives, especially the combined oral contraceptive (COC) pill which has been shown to decrease testosterone levels. Progesterone-only methods such as the implant or shot have been shown to have higher levels of free testosterone compared to the pill. The current study investigates the differences in intrasexual competition between pill users and progesterone-only users. 773 women took several surveys that obtained their information regarding menstrual cycle, contraceptive use, relationship status, and also took the Scale …

Does Testosterone Affect Sexist Attitudes In Men? A Simulated Analysis, Steven R. Bowman

Cal Poly Humboldt theses and projects

Sexism continues to negatively affect the lives of women across many cultures and modern societies. Although sexism has a damaging effect on people overall, women are disproportionately affected. Previous research on the topic generally explores attitudes, culture, socioeconomic status, sexual and violent crime census data, and developmental factors, but there is a lack of research investigating potential links among biological factors, such as hormone levels, and sexist attitudes. The present study used simulated data to simulate a study investigating the relationship between endogenous testosterone, cognitive aggression, and sexist attitudes. Using the faux, pwr2ppl, and ProcessR packages in R Studio open-source …

The Impact Of Socio-Economic Status, Life History, And Biological Sex On Affective Empathy In Adults, Shadow R. Love

Master's Theses or Doctor of Nursing Practice

ABSTRACT

A discussion of affective (or emotional) empathy as it is impacted by socioeconomic status (SES), life history, and biological sex is presented. The current study examined a gap in prior research by examining the interaction between these three variables and affective empathy. Participants were 504 adults between the ages of 18-68, with average age of 37 and primarily biological sex male (64%). Ethnicity varied with the majority as White/Caucasian (68.8%) followed in descending response rate by Hispanic or Latino/a, Black or African American, Asian, Native American or American Indian, and Native Hawaiian or Pacific Islander and 1.6% as two …

Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic Brain Injury (TBI) is defined as an impact to the head, penetration of the skull, or rapid deceleration of the skull, resulting in an alteration of brain function or neurological deficit. Cognitive deficits are common following TBI and often go unresolved due to a lack of effective treatments. These deficits often perseverate into the chronic post injury phase, so the development of rehabilitative strategies is imperative. Behavioral flexibility, impulse control, and attention are a few cognitive processes that are commonly affected by TBI. The current research compares these processes between rats with and without a severe frontal brain injury …

Enhancing The Rewarding Effects And Subsequent Self-Administration Of Nicotine Through Appetitive Interoceptive Conditioning, Allissa Flynn

Honors Program: Senior Projects (Public)

Nicotine is commonly considered to be the primary addictive constituent in tobacco products. Therefore, research focused on nicotine and its effects is necessary for understanding nicotine dependency and in developing potential cessation treatments. Research has confirmed the relevance of learning processes associated with nicotine and their influence on the development of addiction. Conditioning involving interoceptive stimuli is increasingly cited as playing a role in many diseases, psychopathologies, and drug addiction. The internal stimulus effects of nicotine can form associations with other reinforcing stimuli through a process of Pavlovian conditioning where nicotine is the conditioned stimulus. In this way, nicotine acquires …

Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia

Open Access Theses & Dissertations

Preclinical work indicates that exposure to traditional antidepressant medications, in adolescent and adult female subjects, alters reward-related behavior later in life. In recent years, the anesthetic ketamine (KET), now used as a fast-acting antidepressant, has shown promising therapeutic efficacy for the management of depression. However, the potential long-term behavioral consequences of KET exposure across development have not been thoroughly assessed. Thus, to address this issue, we examined if KET exposure, during adolescence or early adulthood, results in enduring alterations in responsivity to the rewarding properties of sucrose and cocaine later in life. Specifically, female C57BL/6 mice were randomly assigned to …

Mechanisms Of Value-Biased Prioritization In Fast Sensorimotor Decision Making, Kivilcim Afacan-Seref

Dissertations and Theses

In dynamic environments, split-second sensorimotor decisions must be prioritized according to potential payoffs to maximize overall rewards. The impact of relative value on deliberative perceptual judgments has been examined extensively, but relatively little is known about value-biasing mechanisms in the common situation where physical evidence is strong but the time to act is severely limited. This research examines the behavioral and electrophysiological indices of how value biases split-second perceptual decisions and the possible mechanisms underlying the process. In prominent decision models, a noisy but statistically stationary representation of sensory evidence is integrated over time to an action-triggering bound, and value-biases …

The Role Of High-Fat Diets In Exacerbating Cognitive Deficits After Traumatic Brain Injury, Michelle A. Frankot

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic brain injury (TBI) can cause chronic psychiatric-like impairments that may be driven by inflammation in the brain. In the current study, inflammation was upregulated using a high-fat diet (HFD) to assess the role of inflammation in TBI-induced deficits. Rats were randomly assigned to receive an HFD or calorie-matched low-fat diet (LFD) for the duration of the experiment. After two weeks of free access to their respective diets, rats began behavioral training on the Rodent Gambling Task (RGT), during which they were allowed to freely choose to nosepoke in one of four holes in a standard operant chamber. Responses in …

Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic brain injury (TBI) impacts millions worldwide and can cause lasting psychiatric symptoms. Chronic neuroinflammation is a characteristic of post-injury pathology and is positively associated with psychiatric conditions such as ADHD and bipolar disorder. Therefore, the current study sought to treat TBI-induced impulsivity and inattention using minocycline, an antibiotic with anti-inflammatory properties. Rats were trained on the five-choice serial reaction time task (5CSRT), a measure of motor impulsivity and attention. After behavior was stable on the 5CSRT, rats received either a bilateral frontal TBI or sham procedure. Minocycline was given at either 1 h post-injury or beginning at 8 weeks …

How Does Eye Movement Desensitization And Reprocessing (Emdr) Work? An Examination Of The Potential Mechanisms Of Action, Sara Forster

Theses and Dissertations

A mounting body of evidence suggests that Eye Movement Desensitization and Reprocessing therapy (EMDR) is successful in reducing the impact of posttraumatic symptoms. Although the exact mechanisms of action remain unknown, theories from the psychological to the neuroscientific continue to emerge, expand, and evolve. This study will examine four of the most prominent theories to date and weigh the evidence for and against each one. It will also review, compare, and contrast the theories, evaluate the research supporting each one, and propose the most likely explanation for EMDR's success given the state of the research. Neurobiological mechanisms and correlates as …

Construct Validity Of The Teate Depression Inventory: Convergent And Discriminant Validity And Equivalence For Black/African American And White/Caucasian Samples, Dylin Coons

Masters Theses

The purpose of this study was to replicate the construct validity of a new measure of depression, the Teate Depression Inventory (TDI; Balsamo & Saggino, 2013), with the primary focus on Black/African American participants. Research has purported that Black/African Americans experience inequality in obtaining mental health care for internalizing disorders. This may partially be caused by errors in diagnosing these individuals with symptoms. Correctly diagnosing internalizing disorders is a critical step in obtaining appropriate treatment. More research on depression and anxiety is needed to enhance mental health practices by addressing the need for professionals to be culturally competent and conscious …

Does Pregnancy Enhance Sensitivity To Emotional Displays Of Threat?, Lauren E. Larsen

Cal Poly Humboldt theses and projects

The human face provides us with an abundant amount of social and biological information. It is important for us to be able to recognize emotions quickly and accurately, some emotions may be more important and therefore draw more of our attention than others, specifically “threat-relevant” emotions (fear, disgust, anger). To date few studies have investigated how pregnancy impacts emotion recognition abilities. These studies have shown that women have higher accuracy in encoding emotional expressions signaling threat or harm. To determine if pregnancy increases attentional bias to threat, 43 pregnant women and 45 non-pregnant women (controls) performed an emotion recognition task. …

Attentional Control In Infancy: The Role Of Sociodemographic Risk, Cortisol, And The Home Environment, Hannah B. White

Theses and Dissertations--Psychology

Infants’ ability to channel their cognitive resources by controlling their visual attention allows them to be active agents in their learning and development. Individual differences in attentional control have been linked to a wide variety of developmental outcomes including disparities between social classes in cognitive functioning. However, it is yet unknown when in development differences in attentional control related to sociodemographic factors emerge, or how factors of the home environment and the infant’s stress response relate to this effect. Accordingly, Experiment 1 examined whether certain sociodemographic factors, such as socioeconomic and minority status, predict 3.5-month-old infants’ (N = 102) …

Ethanol Sustains Phosphorylated Tau Protein Immunofluorescence In The Cultured Neonatal Rat Hippocampus: Implications For Fetal Alcohol Spectrum Disorders, Caleb Seth Bailey

Theses and Dissertations--Psychology

Fetal Alcohol Spectrum Disorders (FASDs) are comprised of developmental, behavioral, and cognitive abnormalities caused by prenatal alcohol exposure, affecting an estimated 2%-5% of childrenand costing up to $4 billion annually in the United States alone. Although some behavioral therapies can help, the biochemical mechanisms that underpin FASDs need further elucidation for development of more efficacious therapeutics. The tau protein modulates cytoskeletal structure in neurons, and thereby plays an integral role in proper development and function of the central nervous system, but its function is altered by its phosphorylation state, such that increased phosphorylation reduces tau protein function. The tau protein …

Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze

Theses and Dissertations (Comprehensive)

Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …

Age, Access, And Sweets-Motivation, Gehan Senthinathan

Theses and Dissertations (Comprehensive)

Availability can have profound influence on the consumption of foods and drinks. The 2-phase intermittent-continuous protocol (ICP) examines sucrose solution intake in two groups of rats and finds intermittent access significantly increases intake. In Phase I, rats receive intermittent or continuous access to a 4% sucrose solution, and with adults this results in a long-term elevation (a doubling) in the intermittent group. In Phase II, when rats are shifted to common sucrose schedule, this difference is maintained. Adult rats given 16% sucrose in Phase I do not differ in consumption, but in Phase II with 4% sucrose, an unexpressed elevation …

Working Memory Deficits Are Associated With Altered Regional Brain Volume And Structural Connectivity In Children With Chromosome 22q11.2 Deletion Syndrome., Diana Hobbs

LSU New Orleans Theses and Dissertations

Background: Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit nonverbal learning disability that may manifest in part because of working memory (WM) deficits. 22q11.2DS is a complex developmental disorder with serious physical, learning, cognitive, and psychiatric symptoms including a risk of developing schizophrenia 30 times that of the general population. WM impairment likely contributes to and exacerbates learning difficulties, school problems, existing neuropsychological disorders such as attention deficit hyperactivity disorder (ADHD); and a poor WM may be a biological risk marker for future mental illness. WM impairment is established in this population, but less is known about its neurological origins. …

Structural Connectivity And Immunological Correlates Of Emotion Processing In Children With Chromosome 22q11.2 Deletion Syndrome, Ashley F. P. Sanders

LSU New Orleans Theses and Dissertations

Neurological abnormalities are associated with emotion processing deficits seen in children with neurodevelopmental disorders. Research suggests that inflammatory mechanisms can negatively impact brain structure and function and are thought to play a role in these processing atypicalities. Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit emotion processing impairments and associated neural abnormalities. We investigated the roles of inflammatory factors and structural connectivity in relation to emotion processing deficits in 28 children with 22q11.2DS and 33 typically developing children (M = 11.12 years old; SD = 2.17). Results indicate poorer social skills and significantly lower emotion recognition scores in children …