Neurosciences Commons^™

Safety And Efficacy Of L5-S1 Inclusion In Multi-Level Oblique Lumbar Interbody Fusions, Danyal Quraishi, Shahed Elhamdani, Chen Xu, Alexander Yu

Tower Health Research Day

No abstract provided.

The Role Of Computational Methods In Cardiovascular Medicine: A Narrative Review, Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Gerard E Francisco, Franco Molteni, Jörg Wissel, Andrea Santamato

Faculty, Staff and Student Publications

Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. A search was conducted in the Web of Science database for articles focused on the use of BoNT-A in spasticity published between 2000 and 2022. We extracted various metrics, including counts of publications and contributions from different countries, institutions, authors, and journals. Analytical methods in CiteSpace were employed for the examination of co-citations, collaborations, and the co-occurrence …

Apigenin Alleviates Autistic-Like Stereotyped Repetitive Behaviors And Mitigates Brain Oxidative Stress In Mice, Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sadek

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed in its pharmacological action as a positive allosteric modulator of α7-nAChRs. However, there is no research describing the pharmacological potential of APG in ASD. The aim of this study was to evaluate the effects of the subchronic systemic treatment of APG (10–30 mg/kg) on ASD-like repetitive and compulsive-like behaviors and oxidative stress status in the hippocampus and cerebellum in BTBR mice, utilizing the reference drug aripiprazole (ARP, 1 …

The Role Of Spreading Depolarizations In Mild Traumatic Brain Injuries, Natalie J. Pinkowski

Biomedical Sciences ETDs

Mild traumatic brain injuries (mTBIs) often lead to acute symptoms like disorientation and discoordination, but the underlying mechanisms are unknown. Although most patients recover quickly from a single mTBI, repeated injuries can be debilitating. After an mTBI, a neurometabolic cascade produces metabolic burden and vulnerability. Spreading depolarizations (SDs) have been observed after mTBIs. Here we investigated SDs’ role in short-term motor behavioral deficits post-mTBI. We hypothesized that SDs contribute to the deficits, and exacerbated symptoms after repeated mTBIs. To test this, we used acute motor behavioral tests and long-term behavioral and cognitive tests after initiating SDs by mTBI, chemical, or …

The Effects Of Acute Hypoxia Exposure On Cognitive Function, John W. Sepko, Zakary Patrick, Parker Wilkerson, Madison Hulsey, Paul D. Loprizini

Neuroscience Research Showcase

Introduction: There is conflicting literature as to the effects of varying levels of hypoxia on cognition. Recent work by Loprinzi et al. (2019) demonstrated that moderate levels of hypoxia exposure increased memory (cognitive) performance. However, research investigating severe hypoxic exposure has shown immediate cognitive impairments (Nation, 2017). To reconcile these mixed findings, the present study aimed to investigate the extent to which varying levels of hypoxia affect cognition. Methods: Eighty-seven participants were recruited using convenience sampling at the University of Mississippi and completed a within-subject study design. The first lab visit was conducted for familiarizing the participant to the lab …

Novel Tests For Motor And Spatial Deficits In Zebra Finches Verify A Role For Aromatase And Estradiol In Improving Spatial But Not Motor Outcomes Post-Cerebellar Lesion, Simran Patel, Lainy B. Day, Mathew Thibodeaux, Demetria Tolbert, Chyna-Rae Dearman, Gerald W. Stinson, Joshua Hamer, John C. Garner, Dwight Waddell

Neuroscience Research Showcase

Objective: Test the role of Arom and E2 in recovery of zebra finch posture and spatial learning post-CB lesion.

Simran Patel^1,2, Lainy B. Day¹, Mathew Thibodeaux¹, Demetria Tolbert^1,2, Chyna-Rae Dearman¹, Gerald W. Stinson¹, Joshua Hamer¹, John C. Garner³, Dwight Waddell ⁴ (¹ Department of Biology, University of Mississippi, University MS; ² Mississippi INBRE Research Scholar, University of Southern Mississippi, Hattiesburg MS; ³ Department of Kinesiology and Health Promotion, Troy University, Troy, AL 36082; ⁴ Department of Biomedical Engineering, University of Mississippi, University, MS …

Influences Of Dietary Enrichment In Juvenile And Adult Male Zebra Finch (Taeniopygia Castanotis) On Cheek Patch Growth And Color, Carley Craig, Mathew Thibodeaux, Mary Tharp, Gabrielle Morris, Woodward Young, Belinda Bagwandeen, Lainy B. Day

Neuroscience Research Showcase

Zebra finches (ZF) are sexually dimorphic. In captive ZFs, enriched diets increase cheek area and alter color, increasing adult male attractiveness. In the wild, breeding and brooding occur when proteinaceous seeds available. Our experiment tests whether supplemental egg food benefits captive non-breeding adults and juveniles.Pre-experiment, adults fed eggs, cuttlebone & bread 2x week. Other facets of our experiment showed enriched diet led to decreased reactive CORT levels and increased body mass, with the largest increase in females.

All authors are affiliated with the University of Mississippi Department of Biology and Neuroscience Minor.

The Effects Of Estradiol And Genistein On Cerebellar Neuroprotection In Zebra Finches, Grace Thompson, Renee E. Breaux, Emily Mcfatridge, Sarah Chong, Ethan Zadronzy, Estelle Blair, Lainy B. Day

Neuroscience Research Showcase

Introduction:

• Brain damage causes a secondary wave of degeneration
• Aromatase is upregulated in glia post-injury
• Aromatase (AROM) converts testosterone to estradiol (E₂) E₂ is neuroprotective and limits cell death
• E₂ is linked to cancer, stroke, and male infertility Genistein (GEN) is a soybean phytoestrogen with strong estrogen receptor beta (ERβ) affinity
• Genistein could be used clinically for neuroprotection
• ERβ receptors are abundant in the cerebellum AROM expression in the cerebellum is constitutively low
• Zebra Finch (ZF) brains have high neuroplasticity
• The ZF cerebellum is ideal for neuroplasticity research

All authors are affiliated with the University of …

Sex Differences In The Role Of Estradiol On Recovery After Cerebellar Lesion In The Zebra Finch (Taeniopygia Castanotis), Mathew Thibodeaux, Chyna-Rae Dearman, Lainy B. Day

Neuroscience Research Showcase

Purpose:

• Test sex differences in a spatial (Escape Maze) and motor task (Log Roll)
• Manipulate E2 and aromatase levels in order to differentiate roles of E2 and aromatase in recovery post-CB lesion
• Confirm steroids aid recovery in spatial but not motor tasks post-CB lesion
• Determine whether steroids differentially influence male and female recovery in cognitive and motor tasks

Mathew Thibodeaux¹, Chyna-Rae Dearman¹, Lainy B. Day^1,2 (¹Department of Biology & ²Interdisciplinary Neuroscience Minor, University of Mississippi)

Identifying The Distribution Of Peptide Hormones Regulating Adrenal And Gonadal Steroids In The Brains Of Diploid And Polypoid Treefrogs, Jordan Jackson, Chris J. Leary, Lainy B. Day

Neuroscience Research Showcase

Hypothesis: polyploidization altered the relative expression levels of hormone receptors > altered regulation of circulating hormone levels and influence hormone interactions, or mutation of duplicated receptor coding genes. RNAseq - expression levels and sequences of receptors in the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitaryadrenal/ interrenal (HPA/I) axes

All authors are affiliated with the University of Mississippi Department of Biology.

Storytelling Heals The Wounded Mind, Liliana Whitaker

Classical Conversations

Humans are storytelling creatures. We use stories to communicate ideas in a memorable and engaging way, inspire people to believe in the best version of themselves, find truth in our legal system, empathize with experiences different than our own, and entertain ourselves for hours on end. Recent neuroscience proposes that the human mind thinks through stories. Narrative is the technical and broad term for story, defined as a series of actions and events that unfold over time according to proper cause and effect. Narrative practice is an emerging field comprising of storytelling treatments in therapy and medicine, usually focusing on …

Icnirp Statement On Short Wavelength Light Exposure From Indoor Artificial Sources And Human Health, Sharon Miller, Christian Cajochen, Adele Green, John Hanifin, Anke Huss, Ken Karipidis, Sarah Loughran, Gunnhild Oftedal, John O'Hagan, David H Sliney, Rodney Croft, Eric Van Rongen, Nigel Cridland, Guglielmo D'Inzeo, Akimasa Hirata, Carmela Marino, Martin Röösli, Soichi Watanabe

Department of Neuroscience Faculty Papers

Concerns have been raised about the possibility of effects from exposure to short wavelength light (SWL), defined here as 380-550 nm, on human health. The spectral sensitivity of the human circadian timing system peaks at around 480 nm, much shorter than the peak sensitivity of daytime vision (i.e., 555 nm). Some experimental studies have demonstrated effects on the circadian timing system and on sleep from SWL exposure, especially when SWL exposure occurs in the evening or at night. The International Commission on Non-Ionizing Radiation Protection (ICNIRP) has identified a lack of consensus among public health officials regarding whether SWL from …

Winners And Losers: Emotional Shifts Across Elections Are Conveyed By A Politician’S Smile, Carl Senior, Patrick A. Stewart, Erik Bucy, Nick Lee

Political Science Faculty Publications and Presentations

The human smile can convey both rewarding and affiliative social intent and thus has significant utility in politics, where the ability to bond with and reassure voters is vital to electoral success. We examine experimental evidence from the 2019 UK general election to investigate the influence of a politician’s reward or affiliative smile on voter emotions. It was hypothesised that the winner’s affiliative smile would engender positive affect across all partisan groups compared to the winner’s reward smile display. Participants from a nationally representative sample were shown campaign footage containing both types of smiles from the leaders of the main …

Glial Lipid Droplets Resolve Ros During Sleep, Lindsey D Goodman, Matthew J Moulton, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The Sehgal lab presents data showing that the non-cell autonomous pathway of glial lipid droplet formation occurs during sleep and helps to resolve neuronal reactive oxygen species (ROS). This promotes neuronal function after an active day. Hence, this pathway has an important physiological function beyond its previously described role in ROS-associated diseases, including Alzheimer’s disease.

Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen

Dissertations (1934 -)

Glutamatergic signaling is fundamental to human behavior and its dysfunction is implicated in a wide range of neurological and neurodegenerative disorders. Excitatory amino-acid transporters (EAATs) – of which four primary subtypes (EAAT1, EAAT2, EAAT3, and EAAT4) exist in the human brain – are primary regulators of glutamate signaling. Endogenously-expressed at either low (EAAT4-low) or high (EAAT4-high) concentration in cerebellar Purkinje cells, EAAT4 has been shown to regulate Purkinje cell activity in the cerebellar molecular layer. However, differences in glutamatergic signaling at the circuit and single-synaptic levels in EAAT4-low and EAAT4-high regions are poorly understood. To characterize EAAT4-specific effects on excitatory …

No, You Can't Just Peek In Their Brain To See Their Future, Alia Barcus

Tredway Library Prize for First-Year Research

This paper argues against the use of predictive cognitive neuroscience research in judicial processes. Barcus argues that, because predictive models do not adequately address the “whys” of behavior and are better suited to macro-scale processes rather than individual-level predictions, they can only provide “a crude idea of future behavior” at best and will be bias-laden and inaccurate at worst. Meanwhile, neuroscience brain imaging is a newly-developing field and relies on small-scale studies, a combination that creates little replicability and presents deeply-flawed outcomes when this research is used as a basis for criminal prosecution. Barcus concludes that this scholarship, while holding …

Population Coding Of Strategic Variables During Foraging In Freely Moving Macaques, Neda Shahidi, Melissa Franch, Arun Parajuli, Paul Schrater, Anthony Wright, Xaq Pitkow, Valentin Dragoi

Faculty, Staff and Student Publications

Until now, it has been difficult to examine the neural bases of foraging in naturalistic environments because previous approaches have relied on restrained animals performing trial-based foraging tasks. Here we allowed unrestrained monkeys to freely interact with concurrent reward options while we wirelessly recorded population activity in the dorsolateral prefrontal cortex. The animals decided when and where to forage based on whether their prediction of reward was fulfilled or violated. This prediction was not solely based on a history of reward delivery, but also on the understanding that waiting longer improves the chance of reward. The task variables were continuously …

It's About Time! Timing In Epilepsy Evaluation And Treatment, Heather Ravvin Mckee, Jorge Vidaurre, Dave Clarke, Janelle Wagner, Jeffrey W Britton, Linda Laux, Eugen Trinka, Clio Rubinos, Tanya J W Mcdonald, Fred A Lado, Martina Bebin, Christos Papadelis, Aaron F Struck, Carolina B Maciel, Ana L Velasco, Arjun Chandran, Sandipan Pati, Nitin Tandon, Guadalupe Fernandez-Baca Vaca, Madison M Berl, Ahsan N Moosa

Faculty, Staff and Student Publications

The 2023 American Epilepsy Society Annual Course "It's About Time" addressed timing in epilepsy evaluation and treatment with respect to health disparity and vulnerable populations and diagnostic, clinical, and epilepsy surgery evaluation. This comprehensive course included topics on gaps in epilepsy care and optimization of behavioral health for patients with epilepsy. The summary details current knowledge in areas of seizure forecasting and epileptogenesis. Intricacies and controversies over timing were discussed for treatment of nonconvulsive seizures and ictal-interictal patterns, acute symptomatic seizures, neuromodulation versus surgery, and epilepsy surgery in status epilepticus. Timing regarding clinical care in autoimmune-associated epilepsy, developmental and epileptic …

4r-Cembranoid Suppresses Glial Cells Inflammatory Phenotypes And Prevents Hippocampal Neuronal Loss In Lps-Treated Mice, Luis A Rojas-Colón, John B Redell, Pramod K Dash, Pedro E Vegas, Wanda Vélez-Torres

Faculty, Staff and Student Publications

Chronic neuroinflammation has been implicated in neurodegenerative disease pathogenesis. A key feature of neuroinflammation is neuronal loss and glial activation, including microglia and astrocytes. 4R-cembranoid (4R) is a natural compound that inhibits hippocampal pro-inflammatory cytokines and increases memory function in mice. We used the lipopolysaccharide (LPS) injection model to study the effect of 4R on neuronal density and microglia and astrocyte activation. C57BL/6J wild-type mice were injected with LPS (5 mg/kg) and 2 h later received either 4R (6 mg/kg) or vehicle. Mice were sacrificed after 72 h for analysis of brain pathology. Confocal images of brain sections immunostained for …

Consensus On Best Practices In Neuroscience-Informed Treatment Of Combat-Related Posttraumatic Stress In Military Veterans: A Delphi Study Of Experts In The Field Of Mental Health, Danielle Lauren Winters

Counseling & Human Services Theses & Dissertations

The purpose of this study was to capture consensus among mental health professionals who work with combat trauma-afflicted veterans and/or utilize a neuroscience-informed counseling approach, about a set of best practices for uniting neuroscience-informed treatment modalities with the treatment of veterans who present with Post Traumatic Stress (PTS). A multi-round Delphi study was used to elicit information from mental health professionals, which led to the proposition of ways in which mental health professionals may more efficiently work with combat veterans while utilizing neuroscience-informed treatments such as Prolonged Exposure Therapy, Eye Movement Desensitization and Reprocessing (EMDR) neuro-informed Cognitive Behavioral therapy (nCBT), …