Dentistry Commons^™

Interactions Between Silica And Titanium Nanoparticles And Oral And Gastrointestinal Epithelia: Consequences For Inflammatory Diseases And Cancer, Cassio Luiz Coutinho Almeida-Da-Silva, Leticia Ferreira Cabido, Wei Chun Chin, Ge Wang, David M. Ojcius, Changqing Li

All Dugoni School of Dentistry Faculty Articles

Engineered nanoparticles (NPs) composed of elements such as silica and titanium, smaller than 100 nm in diameter and their aggregates, are found in consumer products such as cosmetics, food, antimicrobials and drug delivery systems, and oral health products such as toothpaste and dental materials. They may also interact accidently with epithelial tissues in the intestines and oral cavity, where they can aggregate into larger particles and induce inflammation through pathways such as inflammasome activation. Persistent inflammation can lead to precancerous lesions. Both the particles and lesions are difficult to detect in biopsies, especially in clinical settings that screen large numbers …

Trident - Spring 2023, Dugoni School Of Dentistry

Trident

The spring 2023 issue of the orthodontics alumni newsletter at University of the Pacific, Arthur A. Dugoni School of Dentistry

Pharmacology For National Board Examination, Krina Shah

Dugoni School of Dentistry Student Scholarly Works

This pharmacology study guide is designed to provide students preparing for the National Boards exam with a clear and concise visual aid in the form of systemic flow charts. Each flow chart is organized by drug class and includes information on the mechanism of action, indications, contraindications, dosages, and common adverse effects for each drug within the class. By using this study guide, students can easily navigate through the complex world of pharmacology and feel confident in their ability to succeed on the pharmacology section of the National Board exam. The study guide for pharmacology is significant in several ways. …

Medical Marijuana Knowledge And Attitudes: A Survey Of Dental And Dental Hygiene Faculty And Students, Dara Szyliowicz, Andrew Young, Yesha Golwala

Eberhardt School of Business Faculty Datasets

Background:

Medical Marijuana (MM) use is increasing, requiring healthcare professionals, such as dentists, to possess a working knowledge of MM. Previous studies have indicated that MM education is lacking in current healthcare education.

Methods:

A 50-question survey was created to assess, in detail, dental and dental hygiene faculty and students knowledge, practice, and attitudes toward MM, and to identify possible correlations between responses. The survey was modeled after a previous survey conducted amongst practicing pharmacists. All faculty dentists, faculty dental hygienists, students and residents at the Arthur A. Dugoni School of Dentistry, University of the Pacific, were invited by email …

A Flash Of Inspiration: Enhancing Dental Student Drug Recognition, Benjamin D. Zeitlin

All Dugoni School of Dentistry Faculty Articles

Students preparing for exams often retain the complexities of a subject but instant recognition and recall is something that, for most, takes time and consistent, repeated study to establish. This can happen through well-managed spaced learning (iterative study) prior to examination; given the preponderance of massed study (cramming for a subject),1 however, many students require long-term exposure in the clinic to patients’ medical histories to achieve instant recall. Understanding the applied pharmacology of common drugs is a current American Dental Association accreditation standard. Ideally, dental students should demonstrate a consistent level of basic drug recognition and the ability to retrieve …

Insight - Fall 2022, Dugoni School Of Dentistry

Insight

Welcome to the autumn 2022 issue of Insight, a newsletter celebrating the accomplishments of our community of scholars. We aim to spotlight insights from people at the Dugoni School working in all areas of scholarship, including clinical or biomedical research, the scholarship of teaching and learning, improvement of the health care system, and professional partnerships that advance the field.

Contact Point Autumn 2022, Rthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Academic Year In Review 2021-2022, Dugoni School Of Dentistry

Dugoni Academic Year in Review

The Arthur A. Dugoni School of Dentistry's annual report on the school's achievements and milestones.

Trident - Fall 2022, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Polymer Chemistry Of Dental Adhesives, Alia J. Rubaie, Karen A. Schulze

Pacific Journal of Health

Dental adhesives are water soluble, non-toxic materials that bind composite resins to dentin and enamel. Adhesive systems are dependent on a polymerization process at the interface and require different moieties to prepare the substrate to effectively interact with the tooth surface. Due to their critical role in restorative procedures, many chemists are interested in strengthening the adhesive bond strength at the interface. This review paper covers the evolution of dental adhesive systems over time and provides an extensive overview of what components make up a dental adhesive system. Additionally, this article explores the common issues found in adhesive systems, and …

Insight - Summer 2022, Dugoni School Of Dentistry

Insight

Spotlighting the work of people at the Dugoni School, including clinical and biomedical research, the scholarship of teaching and learning, improvement of the health care system, professional partnerships that advance the field and more.

Effects Of Frankincense Compounds On Infection, Inflammation, And Oral Health, Cassio Luiz Coutinho Almeida-Da-Silva, Nallusamy Sivakumar, Homer Asadi, Anna Chang-Chien, M. Walid Qoronfleh, David M. Ojcius, Musthafa Mohamed Essa

All Dugoni School of Dentistry Faculty Articles

Boswellia trees, found throughout the Middle East and parts of Africa and Asia, are the source of frankincense oil. Since antiquity, frankincense has been traded as a precious commodity, but it has also been used for the treatment of chronic disease, inflammation, oral health, and microbial infection. More recently, the bioactive components of Boswellia trees have been identified and characterized for their effects on cancer, microbial infection (especially infection by oral pathogens), and inflammation. Most studies have focused on cell lines, but more recent research has also investigated effects in animal models of disease. As natural products are considered to …

Covid-19 Wastewater Project: Validating Sars-Cov-2 Detection Techniques, David Kim, David Vang, David Ojcius, Der Thor

Excellence Day

This research was done to validate and test the current viral RNA detection techniques and to determine sensitivity and optimal temperature of RT-qPCR technique.

Relationship Between Cervical Vertebral Maturation And Chronological Age: A Mixed Longitudinal Study, Sudhashree Lingam, Garima Shrestha, Vijaylaxmi Nag, Aditi Ghosh, Hanisha Pasupulate, Heesoo Oh

Excellence Day

The cervical vertebrae have been proposed as a method of determining skeletal maturation.This study aimed to evaluate the relationship between chronologic age and the individual skeletal maturity as assessed by means of the cervical vertebral maturation (CVM) method.

The Role Of Inflammation In Epithelial-Mesenchymal Transition In Oral Squamous Cell Carcinoma: Literature Review, Preliminary Data, And Proposal Of Experiments, Rachel Choi, Jisoo Kim, Adria Frazier, Takahiro Chino

Excellence Day

The epithelial-mesenchymal transition (EMT) is a trans-differentiation process of epithelial cells into motile mesenchymal cells. It plays an integral role in embryonic development, wound healing and cancer progression. During EMT, epithelial cells lose their cellular polarity due to the loss of intercellular adhesion and acquire migratory and invasive characteristics associated with mesenchymal cells. EMT is tightly regulated by a number of distinct molecular processes which allow its initiation and progression to completion. These processes include activation of transcription factors, expression of specific cell-surface proteins, reorganization and expression of cytoskeletal proteins, production of extracellular matrix-degrading enzymes and changes in the expression …

Sex Differences In The Immune Response To Chronic Periodontitis, John Huang, Amy Tsai, Ina Stelzer, Dorien Feyaerts, William Choi, David Vang, Edward Ganio, Dyani Gaudilliere, Brice Gaudilliere, Xiaoyuan Han

Excellence Day

Chronic Periodontitis (ChP) is an inflammatory condition that results from oral dysbiosis and host immune dysfunction. Epidemiologic evidence has shown that men are more susceptible to ChP than women. Despite gender differences in behavior and socioeconomic status influencing oral health, the biological sex-associated immunological mechanisms underlying the pathogenesis of ChP are unclear. The objective of this study is to identify sex differences in the immune responses to chronic periodontitis.

The Effects Of Cigarette Smoke On Sars-Cov-2 Infection In Human Gecs, Kaitlyn Liu, Harmony Matshik Dakafay, David Ojcius, Cassio Silva

Excellence Day

A large body of evidence shows the harmful effects of cigarette smoke to oral and systemic health. Recently, a link between smoking and susceptibility to coronavirus disease 2019 (COVID-19) was proposed. Here, we examined the effects of cigarette smoke on SARS-CoV-2 infection in human gingival epithelial cells (GECs) to better understand the mechanisms involved in SARS-CoV-2 infection in cells of the oral cavity.

Biomarkers Of Orthodontic Tooth Movement, Max Kazantcev, Kamal Thapaliya, Marie Tolarova, Miroslav Tolar

Excellence Day

Orthodontic tooth movement leads to remodeling of periodontal ligament, alveolar bone, and gingiva. Tooth movement is characterized by bone deposition at sites of tension and bone resorption at pressure sites. Due to a sterile inflammatory process in the PDL space, a flow rate of gingival crevicular fluid (GCF) is increased and its composition is modified. Various cell-signaling pathways are activated, which ultimately stimulate PDL turnover. Biochemical and cellular processes associated with orthodontic tooth movement may be better understood if we study changes of specific biomarkers in GCF during orthodontic therapy. Such information can be used clinically to choose a proper …

Assessment Of Mandibular Plane Changes Using Conventional Versus Miniscrew-Assisted Rapid Palatal Expansion In Adolescents, Michael Ricupito, Daniel Vorhees, Derek Skousen

Excellence Day

The objective of this study was to assess the cephalometric and transversal changes in growing patients (adolescents) using two different types of maxilla expanders: conventional rapid palatal expander (RPE) and miniscrew-assisted rapid palatal expander (MARPE). Our null hypothesis is that there are no significant differences between the two groups for the molar inclination, maxilla expansion amount, and mandibular plane changes.

In-Vitro Composite Surface Analysis Using Foru Polishing Systems A Sem Study, Shreya Nerli

Excellence Day

To evaluate the effect of four polishing methods on the surface gloss of a composite.

Shared Decision Making In Scaling And Root Planing, José Verdugo, Lory Laughter, David W. Chambers

Excellence Day

Estimate the patient participation in decisions commonly arising in scaling and root planing as functions of the professionals’ preferences of dental hygienists, typical situations in this procedure, common approaches to patient interaction, and the interaction of these factors.

Diabetes, Periodontitis And The Oral Microbiome, Madison West, Kaitlin Liautaud, Charles Hunter Pitts, Michael Ricupito, Joshua Cho

Excellence Day

The association between diabetes mellitus and periodontitis has been studied thoroughly. However, the role of the oral microbiome in linking these two diseases still is not clear. The objective of this literature review is to search the current studies on oral dysbiosis in the two diseases and find out whether the oral microbiome could be a possible biomarker indicating diabetes in periodontal patients.

Cbct Analysis Of Root Resorption In Orthodontic Patients With Short Root Anomaly, Sani Zaidi, Kaiyuan Xu, Heesoo Oh, Jonas Bianchi

Excellence Day

The objective of this study was to evaluate the amount of root resorption after orthodontic treatment in patients with Short Root Anomaly (SRA) in comparison with control patients using Cone Beam Computed Tomography (CBCT). We hypothesized that patients with SRA present more susceptibility to root resorption during orthodontic treatment when compared to the normal population.

Contact Point Spring 2022, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Trident - Spring 2022, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Insight - Winter 2022, Dugoni School Of Dentistry

Insight

The winter 2022 issue of Insight is out now. In this issue we spotlight a case study of a new oral appliance that can help reduce oral damage to patients with a neurological disorder. As always, we also include a list of recent published scholarship in peer-reviewed journals.

Creating A Case-Based Exam To Assess Student Progress In A Health Professional Program, Terry Hoover, Parvati Iyer, Meixun Zheng

Pacific Journal of Health

Student-centered education requires timely identification of professional students not progressing appropriately in their chosen discipline. However, many institutions in the United States have been slow to develop “progress” exams designed to assess to test individual student progress towards graduation. Literature review found scant evidence of schools reporting design and implementation of such assessments. This paper shares the process piloted at one U.S. dental school to develop a case-based written exam, map test items to concepts/knowledge expected of students and evaluate the validity and effectiveness of the exam as a useful measure of learning progress. It also analyzes the correlation between …

Differential Involvement Of The Canonical And Noncanonical Inflammasomes In The Immune Response Against Infection By The Periodontal Bacteria Porphyromonas Gingivalis And Fusobacterium Nucleatum, Kívia Queiroz De Andrade, Cassio Luiz Coutinho Almeida-Da-Silva, David M. Ojcius, Robson Coutinho-Silva

All Dugoni School of Dentistry Faculty Articles

We examined the involvement of the P2 × 7 receptor and the canonical and noncanonical inflammasomes in the control of single-species or dual-species infection by the periodontal bacteria Porphyromonas gingivalis and Fusobacterium nucleatum in cells and mice. Stimulation of the P2 × 7 receptor leads to activation of the canonical NLRP3 inflammasome and activation of caspase-1, which leads to cleavage of pro-IL-1β to IL-1β, a key cytokine in the host inflammatory response in periodontal disease. The non-canonical inflammasome pathway involves caspase-11. Thus, wildtype (WT), P2 × 7^−/−, caspase-11^−/− and caspase-1/11^−/− mice were co-infected with both bacterial …

Online Learning During Covid-19 Produced Equivalent Or Better Student Course Performance As Compared With Pre-Pandemic: Empirical Evidence From A School-Wide Comparative Study, Meixun S. Zheng, Daniel Bender, Cindy Lyon

All Dugoni School of Dentistry Faculty Articles

Background: The COVID-19 pandemic forced dental schools to close their campuses and move didactic instruction online. The abrupt transition to online learning, however, has raised several issues that have not been resolved. While several studies have investigated dental students’ attitude towards online learning during the pandemic, mixed results have been reported. Additionally, little research has been conducted to identify and understand factors, especially pedagogical factors, that impacted students’ acceptance of online learning during campus closure. Furthermore, how online learning during the pandemic impacted students’ learning performance has not been empirically investigated. In March 2020, the dental school studied here moved …

Evaluation Of Usage-Induced Degradation Of Different Endodontic File Systems, Shekhar Bhatia, Venkateshbabu Nagendrababu, Ove A. Peters, Amr Fawzy, Umer Daood

All Dugoni School of Dentistry Faculty Articles

To evaluate structural profiles and mechanical behaviour of WaveOne Gold (WOG), Twisted File Adaptive (TFA) and XP-endo shaper (XPS) instruments after root canal preparation. Standardized in vitro shaping was performed in presence of 5.25% sodium hypochlorite. File morphology was analyzed using scanning electron microscopy; X-ray diffraction analysis was performed before and after use along with Raman spectroscopy. Nanoindentation was carried out to characterize surface topography. Ni2+ release was measured at 1, 3, 5 and 7 days. X-ray photoelectron spectroscopy (XPS) analysis was done before and after use. After allocating scan line shifts like in WOG, mechanical deformation was shown using …