Dentistry Commons^™

Orofacial Pain And Menstrually Related Migraine, Chisa Nishihara, Keisuke Hatori, Yung-Chu Hsu, Kana Ozasa, Andrew L. Young, Yoshiki Imamura, Noboru Noma

All Dugoni School of Dentistry Faculty Articles

PURPOSE: Migraine is a common, debilitating, primary headache disorder that can cause and be affected by odontalgia.

CASE REPORT: A 49-year-old woman(Patient 1) presented with pulsating pain in the left maxillary molar area, and a history of unsuccessful root canal treatment. She was ultimately diagnosed with menstrually related migraine without aura and zolmitriptan was prescribed, which reduced her headache and toothache together. A 45-year-old woman (Patient 2) presented with throbbing pain in the right maxillary molar and cheek area. Past repeated endodontic therapy had been unsuccessful. She was then diagnosed with menstrually related migraine without aura, and sumatriptan significantly reduced …

Insight - December 2019, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Dugoni School Year In Review 2018-2019, Dugoni School Of Dentistry

Dugoni Academic Year in Review

Highlights of academic programs, clinical services, research, community outreach and other areas of University of the Pacific's Arthur A. Dugoni School of Dentistry.

Contact Point Autumn 2019, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Facial Tissue Changes With Microimplant Assisted Rapid Palatal Expanders, Kevin Shimizu

Orthodontics and Endodontics Theses

Introduction: Skeletal expansion has been a treatment modality in orthodontics and orthopedics to correct skeletal transverse discrepancies with maxillary constriction. The utilization of microimplants in conjunction with these palatal expanders offers a higher degree of pure skeletal expansion and minimizes the dental side effects. The purpose of this study is to evaluate the changes of the hard and soft tissues of the face after skeletal expansion for orthodontics. Methods: 36 patients who had received successful expansion with a microimplant assisted rapid palatal expander were compared to their pre-expansion records. All patients received CBCTs from which a 3-D analysis configuration was …

Hiv-1 Envelope Overcomes Nlrp3-Mediated Inhibition Of F-Actin Polymerization For Viral Entry, Audrey Paoletti, Awatef Allouch, Marina Caillet, Hela Saïdi, Frédéric Subra, Roberta Nardacci, Qiuji Wu, Zeinaf Muradova, Laurent Voisin, Syed Qasim Raza, Frédéric Law, Maxime Thoreau, Haithem Dakhli, Olivier Delelis, Béatrice Poirier-Beaudouin, Nathalie Dereuddre-Bosquet, Roger Le Grand, Olivier Lambotte, Asier Saez-Cirion, Gianfranco Pancino, David M. Ojcius, Eric Solary, Eric Deutsch, Mauro Piacentini, Marie Lise Gougeon, Guido Kroemer, Jean Luc Perfettini

All Dugoni School of Dentistry Faculty Articles

© 2019 The Author(s) Purinergic receptors and nucleotide-binding domain leucine-rich repeat containing (NLR) proteins have been shown to control viral infection. Here, we show that the NLR family member NLRP3 and the purinergic receptor P2Y2 constitutively interact and regulate susceptibility to HIV-1 infection. We found that NLRP3 acts as an inhibitory factor of viral entry that represses F-actin remodeling. The binding of the HIV-1 envelope to its host cell receptors (CD4, CXCR4, and/or CCR5) overcomes this restriction by stimulating P2Y2. Once activated, P2Y2 enhances its interaction with NLRP3 and stimulates the recruitment of the E3 ubiquitin ligase CBL to NLRP3, …

Trident - September 2019, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

In Vivo Effectiveness And Safety Of Probiotics On Prophylaxis And Treatment Of Oral Candidiasis: A Systematic Review And Meta-Analysis, Lijun Hu, Mimi Zhou, Andrew L. Young, Weiwei Zhao, Zhimin Yan

All Dugoni School of Dentistry Faculty Articles

BACKGROUND: To systematically review and assess the in vivo effectiveness and safety of probiotics for prophylaxis and treating oral candidiasis.

METHODS: A literature search for studies published in English until August 1, 2018 was conducted in the following databases: PubMed, EMBASE, Cochrane Library, and Web of Science. Randomized controlled clinical trials and experimental mouse animal model studies comparing probiotics (at any dosage and in any form) with control groups (placebo, blank control or other agents) and reporting outcomes of the prophylactic and therapeutic effects were considered for inclusion. A descriptive study and, potentially, a meta-analysis were planned.

RESULTS: Six randomized …

Eradication Of Human Immunodeficiency Virus Type-1 (Hiv-1)-Infected Cells, Nejat Düzgüneş, Krystyna Konopka

All Dugoni School of Dentistry Faculty Articles

Predictions made soon after the introduction of human immunodeficiency virus type-1 (HIV-1) protease inhibitors about potentially eradicating the cellular reservoirs of HIV-1 in infected individuals were too optimistic. The ability of the HIV-1 genome to remain in the chromosomes of resting CD4+ T cells and macrophages without being expressed (HIV-1 latency) has prompted studies to activate the cells in the hopes that the immune system can recognize and clear these cells. The absence of natural clearance of latently infected cells has led to the recognition that additional interventions are necessary. Here, we review the potential of utilizing suicide gene therapy …

Contact Point Spring 2019, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Insight - April 2019, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Antrodia Cinnamomea Induces Anti-Tumor Activity By Inhibiting The Stat3 Signaling Pathway In Lung Cancer Cells, Tsung-Teng Huang, Ying-Wei Lan, Chuan-Mu Chen, Yun-Fei Ko, David M. Ojcius, Jan Martel, John D. Young, Kowit-Yu Chong

All Dugoni School of Dentistry Faculty Articles

We examined the effects of an Antrodia cinnamomea ethanol extract (ACEE) on lung cancer cells in vitro and tumor growth in vivo. ACEE produced dose-dependent cytotoxic effects and induced apoptosis in Lewis lung carcinoma (LLC) cells. ACEE treatment increased expression of p53 and Bax, as well as cleavage of caspase-3 and PARP, while reducing expression of survivin and Bcl-2. ACEE also reduced the levels of JAK2 and phosphorylated STAT3 in LLC cells. In a murine allograft tumor model, oral administration of ACEE significantly inhibited LLC tumor growth and metastasis without affecting serum biological parameters or body weight. ACEE increased cleavage …

Chlamydia Pneumoniae Is Present In The Dental Plaque Of Periodontitis Patients And Stimulates An Inflammatory Response In Gingival Epithelial Cells, Cássio Luiz Coutinho Almeida-Da-Silva, Tamer Alpagot, Ye Zhu, Sonho Sierra Lee, Brian P. Roberts, Shu-Chen Hung, Norina Tang, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Chlamydia pneumoniae is an airborne, Gram-negative, obligate intracellular bacterium which causes human respiratory infections and has been associated with atherosclerosis. Because individuals with periodontitis are at greater risk for atherosclerosis as well as respiratory infections, we in-vestigated the role of C. pneumoniae in inflammation and periodontal dis-ease. We found that C. pneumoniae was more frequently found in subgingival dental plaque obtained from periodontally diseased sites of the mouth versus healthy sites. The known periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, were also found in the plaque. In addition, C. pneumoniae could efficiently invade human gingival epithelial cells (GECs) in …

Pretreatment With A Heat-Killed Probiotic Modulates The Nlrp3 Inflammasome And Attenuates Colitis-Associated Colorectal Cancer In Mice, I. Che Chung, Chun Nan Ouyang, Sheng Ning Yuan, Hsin Chung Lin, Kuo Yang Huang, Pao Shu Wu, Chia Yuan Liu, Kuen Jou Tsai, Lai Keng Loi, Yu Jen Chen, An Ko Chung, David M. Ojcius, Yu Sun Chang, Lih Chyang Chen

All Dugoni School of Dentistry Faculty Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Colorectal cancer (CRC) is one of the most common malignancies worldwide. Inflammation contributes to cancer development and inflammatory bowel disease is an important risk factor for CRC. The aim of this study is to assess whether a widely used probiotic Enterococcus faecalis can modulate the NLRP3 inflammasome and protect against colitis and colitis-associated CRC. We studied the effect of heat-killed cells of E. faecalis on NLRP3 inflammasome activation in THP-1-derived macrophages. Pretreatment of E. faecalis or NLRP3 siRNA can inhibit NLRP3 inflammasome activation in macrophages in response to fecal content or …

Trident - March 2019, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Introduction To The Field Actions Science Reports Special Issue 19 (2019): Reinventing Plastics, David M. Ojcius, Nicolas Renard

All Dugoni School of Dentistry Faculty Articles

No abstract provided.

Pretreatment With A Heat-Killed Probiotic Modulates The Nlrp3 Inflammasome And Attenuates Colitis-Associated Colorectal Cancer In Mice., I-Che Chung, Chun-Nan Ouyang, Sheng-Ning Yuan, Hsin-Chung Lin, Kuo-Yang Huang, Pao-Shu Wu, Chia-Yuan Liu, Kuen-Jou Tsai, Lai-Keng Loi, Yu-Jen Chen, An-Ko Chung, David M. Ojcius, Yu-Sun Chang, Lih-Chyang Chen

All Dugoni School of Dentistry Faculty Articles

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Inflammation contributes to cancer development and inflammatory bowel disease is an important risk factor for CRC. The aim of this study is to assess whether a widely used probiotic Enterococcus faecalis can modulate the NLRP3 inflammasome and protect against colitis and colitis-associated CRC. We studied the effect of heat-killed cells of E. faecalis on NLRP3 inflammasome activation in THP-1-derived macrophages. Pretreatment of E. faecalis or NLRP3 siRNA can inhibit NLRP3 inflammasome activation in macrophages in response to fecal content or commensal microbes, P. mirabilis or E. coli, according …

Association Between Periodontal Pathogens And Systemic Disease, Fiona Q. Bui, Cássio Luiz Coutinho Almeida-Da-Silva, Brandon Huynh, Alston Trinh, Jessica Liu, Jacob Woodward, Homer Asadi, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the …

Insight - January 2019, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Dicer Regulates Activation Of The Nlrp3 Inflammasome, David M. Ojcius, Ardavan Jafari, Laxmi Yeruva, Christian W. Schindler, Ali A. Abdul-Sater

All Dugoni School of Dentistry Faculty Articles

Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1β is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the assembly of a macromolecular protein complex, termed the inflammasome. Aberrant activation of the inflammasome has been linked to debilitating human diseases including chronic inflammatory and autoimmune diseases. Thus, there is a great interest in understanding how inflammasomes are regulated. Here we show that Dicer, an enzyme necessary for the production of mature micro-RNAs (miRNAs), is required for optimal activation of NLRP3 inflammasomes in bone marrow macrophages. Our …

Immunological Pathways Triggered By Porphyromonas Gingivalis And Fusobacterium Nucleatum: Therapeutic Possibilities?, Kívia Queiroz De Andrade, Cassio Luiz Coutinho Almeida-Da-Silva, Robson Coutinho-Silva

All Dugoni School of Dentistry Faculty Articles

Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are Gram-negative anaerobic bacteria possessing several virulence factors that make them potential pathogens associated with periodontal disease. Periodontal diseases are chronic inflammatory diseases of the oral cavity, including gingivitis and periodontitis. Periodontitis can lead to tooth loss and is considered one of the most prevalent diseases worldwide. P. gingivalis and F. nucleatum possess virulence factors that allow them to survive in hostile environments by selectively modulating the host's immune-inflammatory response, thereby creating major challenges to host cell survival. Studies have demonstrated that bacterial infection and the host immune responses are involved …

Saudi Arabian Students In Postgraduate Dental Programs: Investigating Factors Associated With Burnout, Asiri Amal

University of the Pacific Theses and Dissertations

Burnout related to emotional and physical study or work demands affects an individual’s performance and well being. This study focused on Saudi Arabian dental residents studying in the United States and the United Kingdom who are faced with many challenges in pursuit of a higher education degree. A survey including demographic and MBI questions was distributed to assess this population’s level of burnout. The Maslach Burnout inventory (MBI) was has been widely used in the literature to assess three components of burnout: emotional exhaustion (EE), depersonalization (DEP), and (diminished) personal accomplishment (PA). Potential predictors of burnout level, tested for statistical …

Oral Health Care: An Autoethnography Reflecting On Dentistry's Collective Neglect And Changes In Professional Education Resulting In The Dental Hygienist Being The Prevention-Focused Primary Oral Health Care Provider, Maureen Patricia Mcweeney Harrington

University of the Pacific Theses and Dissertations

Many factors influence poor oral health among disadvantaged populations including socioeconomic circumstances, knowledge of disease prevention strategies and ability to implement those strategies, public policies, insurance status, insurance policies, dental providers and other challenges to accessing dental care. Often these issues converge and result in early disadvantages to achieving good oral health (Horton & Barker, 2010). Addressing even some of the factors that contribute to poor oral health may provide ways to change the dental health status of historically underserved populations. The purpose of this research is to explore my role as a practitioner and researcher in the creation of …