Dentistry Commons^™

Does Covid-19 Contribute To Development Of Neurological Disease?, Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Abid Bhat, Shasthara Paneyala, Duraisamy Patteswari, Meena K. Sakharkar, Hamdan Hamdan, David M. Ojcius, Srinivasa R. Bolla, Musthafa M. Essa, Saravana B. Chidambaram, M. Walid Qoronfleh

All Dugoni School of Dentistry Faculty Articles

Background: Although coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID-19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and the brain. Thus, there is evidence showing possible retrograde transmission of the virus from the olfactory epithelium to regions of the brain stem. Methods: This is a literature review article. The research design method is an evidence-based rapid review. The present discourse aim is first to scrutinize and assess the available literature on …

Noninvasive Temporal Detection Of Early Retinal Vascular Changes During Diabetes, Mohammad A. Saghiri, Andrew Suscha, Shoujian Wang, Ali M. Saghiri, Christine M. Sorenson, Nader Sheibani

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Diabetes associated complications, including diabetic retinopathy and loss of vision, are major health concerns. Detecting early retinal vascular changes during diabetes is not well documented, and only few studies have addressed this domain. The purpose of this study was to noninvasively evaluate temporal changes in retinal vasculature at very early stages of diabetes using fundus images from preclinical models of diabetes.Non-diabetic and Akita/+ male mice with different duration of diabetes were subjected to fundus imaging using a Micron III imaging system. The images were obtained from 4 weeks- (onset of diabetes), 8 weeks-, 16 weeks-, and 24 weeks-old male Akita/+ …

Dugoni School Of Dentistry Year In Review 2019-20, Dugoni School Of Dentistry

Dugoni Academic Year in Review

Highlights of academic programs, clinical services, research, community outreach and other areas of University of the Pacific's Arthur A. Dugoni School of Dentistry.

Contact Point Autumn 2020, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

Oropharyngeal Airway Changes Following Orthodontic Treatment Of Anterior Open Bite In Growing Vs Non-Growing Patients, Mona Awadi, Heeyeon Suh, Joorok Park, Heesoo Oh

Orthodontics and Endodontics Theses

Introduction: Orthodontic treatment of anterior open bite can result in a counter-clockwise rotation of the mandible and a more ideal forward position of the tongue. Usually this movement is thought to increase the oropharyngeal airway. The primary aim of the present study was to evaluate changes in vertical dimension and airway in AOB patients following orthodontic treatment. Methods: 52 subjects were included in this retrospective study of anterior open bite malocclusion treated in the graduate orthodontics clinic at the University of the Pacific, Arthur A. Dugoni School of Dentistry between 2006 – 2019. Cephalometric and airway measurements were done by …

Association Of Type And Severity Of Nonsyndromic Orofacial Clefts With Combined Genotypes Of Rfc1 80 Ga, Mthfr 677 Ct, Irf6 (Rs642961) And Irf6 (Rs2235371) Gene Polymorphisms In An Indian Population, Chantal Hakim Dds, Msd, Marie M. Tolarová Md, Phd, Drsc, Miroslav Tolar Md, Phd

Orthodontics and Endodontics Theses

Association of type and severity of nonsyndromic OROFACIAL CLEFTS with combined genotypes of RFC1 80 GA, MTHFR 677 CT, IRF6 rs642961 and rs2235371 gene polymorphisms in an Indian population Abstract By Chantal Hakim University of the Pacific. Arthur Dugoni School of Dentistry 2020 Introduction. Genetic etiology of nonsyndromic orofacial clefts comprises many genes acting together. However, little is known about their interactions. The purpose of our study was to analyze associations of phenotypic subtypes of nonsyndromic orofacial clefts with combinations of four genotypes involving candidate gene polymorphisms. Materials and Methods. We analyzed a large dataset of cases and controls collected …

Comparison Of Skeletal And Dental Differences Between Class I And Class Ii Sides And Their Relationship With Asymmetric Molar Relationships In Class Ii Subdivision Malocclusions – A Cbct Study, Ivan Lo, Heeyeon Suh, Joorok Park, Heesoo Oh

Orthodontics and Endodontics Theses

Introduction: The purpose of this study is to compare dental and skeletal differences between Class I and Class II sides and their contributions to the degree of asymmetric molar relationship in Class II subdivision malocclusions using CBCT.

Methods: One hundred and eight patients presenting with Angle Class II subdivision malocclusions (mean age =21.05 years) were assessed with 3-dimensional cone-beam computed tomography scans. Paired t-tests were used to compare linear skeletal, angular and dental measurement differences between Class I and Class II sides. Correlations of linear skeletal, angular and dental measurement differences between Class I and Class II sides were made …

Invisalign First: A Qualitative Study On The Perceived Benefits And Drawbacks Of Invisalign First As A Treatment Modality For Mixed Dentition Patients, Erin Walker, James Chen

Orthodontics and Endodontics Theses

Given the recent implementation of Invisalign First for early interceptive orthodontic treatment, a limited number of orthodontists have had experience with this treatment modality and there currently are no published studies on the topic. The present study aims to use a qualitative survey to identify common themes in providers’ perceptions of Invisalign First as a new treatment option for early interceptive orthodontics. Twenty-three orthodontists in the private practice sector voluntarily participated in an open-ended survey via email. The results of the survey indicate the following common themes in regards to benefits of Invisalign First: fewer emergencies, patient comfort, patient experience, …

Prediction Of Class Iii Treatment Need And Success, Andrew Levin, James Chen

Orthodontics and Endodontics Theses

Objective: The purpose of the present study is to develop prognostic models for surgical need and treatment success for class III malocclusions. Material and Methods: This is a retrospective cohort study that evaluated treatment outcomes of consecutively treated patients at UCSF from Jan 1st 2007-Jan 1st 2012 and UoP from May 1st, 2014 – May 1st 2019. Receiver operator curves were used to develop prognostic models for surgical need and treatment success for class III malocclusions. Predictor variables were selected a priori (Class III-WITS, U1-PP, IMPA). The prognostic models were validated first using a UCSF validation cohort to show consistency …

Patient And Parent Perceptions On Outcomes In Early Orthodontic Treatment, Joseph Phillips, James Chen

Orthodontics and Endodontics Theses

Introduction: Orthodontics has clinical benefits, however, the psychosocial outcomes are not well understood. These soft benefits are often classified as aesthetic, functional, and psychosocial, however, there is limited work understanding these outcomes as reported directly from the patient. By better understanding the patient’s perspectives, we can continually refine our clinical model to be patient-centric and more appropriately manage the patient’s expectations and experiences. Materials and Methods: This is a cross-sectional qualitative study of 20 parents of 24 children ages 8-11 years. Participants were remotely interviewed using a semi-structured chronologically based line of questioning to elucidate their perceived outcomes of early …

Prevalence Of Short Root Anomaly In Patients Seeking Orthodontic Treatment, Tim Howarth, James Chen, Heesoo Oh

Orthodontics and Endodontics Theses

Introduction: The purpose of this study was to investigate variance in prevalence and severity of short root anomaly (SRA) in patients seeking orthodontic treatment, stratified by ethnicity and sex. Materials and Methods: In this retrospective cross-sectional study, we evaluated 896 patients who had initial cone-beam computed tomographies (CBCTs) taken from July 1, 2014 to May 30, 2019. Panoramic radiographs and images from the CBCTs of each patient were extracted and placed in a database. The crown-to-root ratio of maxillary central incisors, lateral incisors, canines, and all pre-molars were evaluated to determine the presence, severity and associations of SRA. A Chi-square …

Soft Tissue Effects From Maxillomandibular Advancement With Counterclockwise Rotation, Timothy Yu, Audrey Yoon, Stanley Yung Chuan Liu, Heeyeon Suh, Joorok Park, Heesoo Oh

Orthodontics and Endodontics Theses

Introduction: The purpose of the study was to evaluate the effects of maxillomandibular advancement (MMA) surgery with counterclockwise rotation on soft tissue oral and nasal structures. Materials and Methods: This retrospective study included 34 subjects diagnosed with OSA who underwent MMA at the Stanford Sleep Clinic. Initial (T1) and Final (T2) CBCTs were evaluated and compared for 10 hard tissue and 15 soft tissue measurements. Additionally, the external nasal valve surface area was measured and compared between the two time points. A 3D superimposition was performed and used to evaluate the relative hard and soft tissue movements. Results: There was …

Efficiency And Effectiveness Of Arch Expansion With Corticotomy-Assisted Clear Aligner Therapy, Thomas Roblee, Robert R. Boyd, James Chen, Heesoo Oh

Orthodontics and Endodontics Theses

Introduction: Surgically Facilitated Orthodontic Therapy (SFOT) has been utilized for years to overcome the limitations encountered with traditional orthodontic treatment of dentoalveolar and alveoloskeletal malocclusions. The procedure, which consists of full flap corticotomies and bone grafting, has many proposed benefits including increased speed and range of tooth movement. The purpose of this study is to evaluate arch expansion in patients treated with SFOT and clear aligners. Materials and Methods: A retrospective cohort study design was used to evaluate 51 consecutive adult patients that were treatment planned for significant arch expansion with corticotomies, bone grafting, and clear aligners. 17 of the …

Epidemiology, Outcome, And Prognostic Factors Of Oropharyngeal Lymphoepithelial Carcinoma: A Population-Based Analysis Using The Seer Database, Serena Lee

Orthodontics and Endodontics Theses

Introduction: Lymphoepithelial carcinoma (LEC) in the oropharynx is rare. Current understanding of the disease is derived mainly from case reports and small case series, prompting further elucidation of its epidemiology and prognostic factors that affect outcome. The aim of this retrospective cohort study was to examine demographic characteristics, clinicopathologic features, and prognostic factors in patients with oropharyngeal LEC. Methods: The U.S. National Cancer Institute’s SEER registry was queried to obtain data on patients with primary oropharyngeal LEC from 1975 to 2016. Variables examined include age at diagnosis, sex, race, year of diagnosis, primary site of tumor origin, tumor size, extent, …

Trident - Fall 2020, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Is There An Association Between Oral Health And Severity Of Covid-19 Complications?, Nathalie Botros, Parvati Iyer, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Most patients with severe complications from COVID-19 have underlying conditions such as obesity, diabetes, and hypertension. In parallel, there is growing evidence for a link between periodontitis and non-oral systemic diseases. The oral cavity is also a reservoir for respiratory pathogens, and patients with periodontal disease are more likely to develop hospital-acquired pneumonia than healthy individuals. We therefore hypothesize that improving oral health could decrease the severity of COVID-19 symptoms and reduce the associated morbidity.

Insight - Summer 2020, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Plant And Fungal Products That Extend Lifespan In Caenorhabditis Elegans, Jan Martel, Cheng Yeu Wu, Hsin Hsin Peng, Yun Fei Ko, Hung Chi Yang, John D. Young, David M. Ojcius

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The nematode Caenorhabditis elegans is a useful model to study aging due to its short lifespan, ease of manipulation, and available genetic tools. Several molecules and extracts derived from plants and fungi extend the lifespan of C. elegans by modulating aging-related pathways that are conserved in more complex organisms. Modulation of aging pathways leads to activation of autophagy, mitochondrial biogenesis and expression of antioxidant and detoxifying enzymes in a manner similar to caloric restriction. Low and moderate concentrations of plant and fungal molecules usually extend lifespan, while high concentrations are detrimental, consistent with a lifespan-modulating mechanism involving hormesis. We review …

Antibacterial Efficacy Of Novel Eastern Medicine-Inspired Toothpastes Compared To Commercial Formulations, Joshua S. Goldfaden

Pacific Journal of Health

Toothpaste is an oral health care agent that dates back to the 5^th Century B.C. in East Asia. Following the conception of dentistry in the 7^th Century B.C. and the field’s subsequent growth, the embodiment of toothpaste has evolved from containing natural substances such as tea leaves to abrasive chemicals, particularly: fluoride, triclosan, and sodium lauryl sulfate (SLS). Regarding how each respective reagent functions, fluoride forms a complex with calcium ions in the teeth to prevent erosion of the protective enamel coating. This ion also disrupts metabolic activities of Streptococcus mutans (S. mutans), which are the …

Cbl Negatively Regulates Nlrp3 Inflammasome Activation Through Glut1-Dependent Glycolysis Inhibition, Hsin Chung Lin, Yu Jen Chen, Yau Huei Wei, Yu Ting Chuang, Su Heng Hsieh, Jing Yu Hsieh, Yi Lin Hsieh, David M. Ojcius, Kuo Yang Huang, I. Che Chung, Sheng Ning Yuan, Yu Sun Chang, Lih Chyang Chen

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Activation of the nod-like receptor 3 (NLRP3) inflammasomes is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Cbl plays a pivotal role in suppressing NLRP3 inflammasome activation by inhibiting Pyk2-mediated apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization. Here, we showed that Cbl dampened NLRP3 inflammasome activation by inhibiting glycolysis, as demonstrated with Cbl knockout cells and treatment with the Cbl inhibitor hydrocotarnine. We revealed that the inhibition of Cbl promoted caspase-1 cleavage and interleukin (IL)-1β secretion through a glycolysis-dependent mechanism. Inhibiting Cbl increased cellular glucose uptake, glycolytic capacity, and mitochondrial oxidative …

Impact Of Covid-19 On Dental Education In The United States, Parvati Iyer, Kalid Aziz, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

© 2020 American Dental Education Association Dental institutions in the United States are reeling from the consequences of the novel SARS-CoV2 coronavirus, the causative agent of CODIV-19. As oral health care providers, we have been trained on prevention of aerosol transmissible diseases, but we are still grappling with many unknown factors regarding COVID-19. While the Centers for Disease Control and Prevention (CDC), American Dental Association (ADA), and local state agencies are releasing updates on guidelines for dentists and patients, no official information exists for dental institutions on how to effectively follow the recommended guidelines including “shelter in place” with social …

The Three-Dimensional Stable Mandibular Landmarks In Patients Between The Ages Of 12.5 And 17.1 Years, Gui Chen, Mona Al Awadi, David W. Chambers, Manuel O. Lagravère-Vich, Tianmin Xu, Heesoo Oh

All Dugoni School of Dentistry Faculty Articles

Background: With the aid of implants, Björk identified two-dimensional mandibular stable structures in cephalograms during facial growth. However, we do not know what the three-dimensional stable structures are with certainty. The purpose of this study was to identify the most stable mandibular landmarks in growing patients using three-dimensional images. Methods: The sample was comprised of two cone-beam computed tomography (CBCT) scans taken about 4.6 years apart in 20 growing patients between the ages of 12.5 (T1) and 17.1 years (T2). After head orientation, landmarks were located on the chin (Pog), internal symphysis (Points C, D and E), and mandibular canals, …

The History Of The Dental Profession - From Ancient Origins To Modern Day, Steven A. Kezian

Pacific Journal of Health

Abstract:

This research paper explores some of the earliest known evidences of dental treatment and traveled through time discussing important figures who made vital contributions toward the development of this profession.

Dentistry is one of the oldest professions to be developed. Ever since there have been humans, there have been problems with our teeth, and we have been figuring out ways to alleviate them. The idea that there were people specializing in the healing of the teeth and oral diseases has roots to ancient pre-history and a long and fascinating saga.

This history is divided into five stages:

-Ancient pre-history …

Commentary: Phytocannabinoids As Therapeutic Agents To Combat Chronic Gingival Disease., Nick Narek Ohanian

Pacific Journal of Health

The therapeutic potential of cannabis has been harnessed for thousands of years yet the United States Food and Drug Administration (FDA) has still not approved cannabis as a safe or effective drug. The FDA has, however, approved the manufacturing of pharmaceutical drugs, which contain a “synthetic version of a substance that is present in the marijuana” and other compounds that mimic its action. A search of the US National Library of Medicine and National Institute of Health for keywords “CBD” and “Periodontitis” together yields only 2 publications. Although the current State and Federal regulations on the use of cannabis for …

Contact Point Spring 2020, Arthur A. Dugoni School Of Dentistry

Contact Point

No abstract provided.

S-Seco-Porphyrazine As A New Member Of The Seco-Porphyrazine Family – Synthesis, Characterization And Photocytotoxicity Against Cancer Cells, Dariusz T. Mlynarczyk, Jaroslaw Piskorz, Lukasz Popenda, Magdalena Stolarska, Wojciech Szczolko, Krystyna Konopka, Stefan Jurga, Lukasz Sobotta, Jadwiga Mielcarek, Nejat Düzgüneş, Tomasz Goslinski

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An important subgroup within the porphyrazine (Pz) family constitutes seco-porphyrazines, in the chemical structure of which one pyrrole unit is opened in the oxidative process. So far, there are only limited data on N-seco- and C-seco-Pzs. Here, the synthesis of a novel member of the Pzs seco-family, represented by an S-seco-tribenzoporphyrazine analogue, 22,23-bis(4-(3,5-dibutoxycarbonylphenoxy)butylsulfanyl)tribenzo[b,g,l]-22,23-dioxo-22,23-seco-porphyrazinato magnesium(II), is reported, with moderate 34% yield. The new derivative was characterized using NMR spectroscopy, UV–Vis spectroscopy, and mass spectrometry. In the photochemical study performed following the indirect chemical method with 1,3-diphenylisobenzofuran, S-seco-Pz revealed a high singlet oxygen quantum yield of 0.27 in DMF. Potential photocytotoxicity of …

The Role Of Glial Cell Derived Neurotrophic Factor In Head And Neck Cancer, Hongbin Cao, Qian He, Rie Von Eyben, Joshua Bloomstein, Dhanya K. Nambiar, Vignesh Viswanathan, Sonya Aggarwal, Shirley Kwok, Rachel Liang, Amanda J. Koong, James S. Lewis Jr., Christina Kong, Nan Xiao, Quynh-Thu Le

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Glial cell-derived neurotrophic factor (GDNF) is reported to promote the survival of neurons and salivary gland regeneration after radiation damage. This study investigated the effect of GDNF on cell migration, growth, and response to radiation in preclinical models of head and neck squamous cell carcinoma (HNSCC) and correlated GDNF expression to treatment outcomes in HNSCC patients. Our ultimate goal is to determine whether systemic administration of GDNF at high dose is safe for the management of hyposalivation or xerostomia in HNSCC patients. Three HPV-positive and three HPV-negative cell lines were examined for cell migration, growth, and clonogenic survival in vitro …

Trident - Spring 2020, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Insight - February 2020, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Impact Of Access Cavity Design On Peri-Cervical Dentin Removal In 3d Printed Tooth Models, James A. Mcintosh, Ove A. Peters, Christine Peters, Craig Dunlap

Orthodontics and Endodontics Theses

Aims Preservation of peri-cervical dentin during the preparation of endodontic access is important to prevent fractures and improve the long-term prognosis. The purpose of this study was to evaluate the impact of rotary file instrumentation (TruNatomy and XP-Endo Shaper) on peri-cervical dentin removal, depending on access size. Materials and Methods Forty 3D printed mandibular first molars, with either a small or large access design, were instrumented using TruNatomy or XP-endo Shaper file systems. Canal volumes were calculated based on micro-computed tomography data obtained pre- and post-operatively. Digital sectioning of each reconstructed volume was performed 90-degrees to the long axis at …