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Articles 1 - 6 of 6
Full-Text Articles in Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
11th Annual Pacific Research Day Abstracts, University Of The Pacific
11th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Pick1 Deficiency Causes Male Infertility In Mice By Disrupting Acrosome Formation, Nan (Tori) Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, Jun Xia
Pick1 Deficiency Causes Male Infertility In Mice By Disrupting Acrosome Formation, Nan (Tori) Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, Jun Xia
All Dugoni School of Dentistry Faculty Articles
Protein interacting with C kinase 1 (PICK1) is a peripheral membrane protein involved in protein trafficking, a function that has been well characterized in neurons. Here, we report that male mice deficient in PICK1 are infertile and have a phenotype resembling the human disease globozoospermia. The primary defect in the testes of Pick1-knockout mice was fragmentation of acrosomes in the early stages of spermiogenesis. This fragmentation was followed by defects in nuclear elongation and mitochondrial sheath formation, leading to round-headed sperm, reduced sperm count, and severely impaired sperm motility. We found that PICK1 interacted with Golgi-associated PDZ- and coiled-coil motif-containing …
Transferrin Lipoplex-Mediated Suicide Gene Therapy Of Oral Squamous Cell Carcinoma In An Immunocompetent Murine Model And Mechanisms Involved In The Antitumoral Response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, M. C. Pedroso De Lima
Transferrin Lipoplex-Mediated Suicide Gene Therapy Of Oral Squamous Cell Carcinoma In An Immunocompetent Murine Model And Mechanisms Involved In The Antitumoral Response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, M. C. Pedroso De Lima
All Dugoni School of Dentistry Faculty Articles
Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously the in vitro efficacy of the Herpes Simplex Virus Thymidine kinase (HSV-tk)/ganciclovir (GCV) system to mediate cytotoxicity in oral squamous cancer cells, using transferrin (Tf)-lipoplexes, prepared from cationic liposomes composed of 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP) and cholesterol. In the present study, we evaluated the antitumoral efficacy mediated by this lipoplex formulation in two suicide gene therapy strategies, HSV-tk/GCV and cytosine deaminase (CD)/5-fluorocytosine (5-FC), using a syngeneic, orthotopic murine model for head and neck squamous cell carcinoma. The cellular and molecular events associated with the …
Correlation Between The Levels Of Survivin And Survivin Promoter-Driven Gene Expression In Cancer And Non-Cancer Cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, Nejat Düzgüneş
Correlation Between The Levels Of Survivin And Survivin Promoter-Driven Gene Expression In Cancer And Non-Cancer Cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, Nejat Düzgüneş
All Dugoni School of Dentistry Faculty Articles
Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is associated with malignant transformation and is over-expressed in most human tumors. Using lipoplex-mediated transfection, we evaluated the activity of the reporter enzyme, luciferase, expressed from plasmids encoding the enzyme under the control of either the cytomegalovirus (CMV) or survivin promoters, in tumor- and non-tumor-derived human and murine cells. We also examined whether there is a correlation between the survivin promoter-driven expression of luciferase and the level of endogenous survivin. Human cancer cells (HeLa, KB, HSC-3, H357, H376, H413), oral keratinocytes, GMSM-K, and chemically immortalized human mammary cells, 184A-1, …