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Efficacies Of Liposome-Encapsulated Streptomycin And Ciprofloxacin Against Mycobacterium Avium-M. Intracellulare Complex Infections In Human Peripheral Blood Monocyte/Macrophages, S. Majumdar, Diana L. Flasher, Daniel S. Friend, P. Nassos, D. Yajko, W. K. Hadley, Nejat Düzgüneş
Efficacies Of Liposome-Encapsulated Streptomycin And Ciprofloxacin Against Mycobacterium Avium-M. Intracellulare Complex Infections In Human Peripheral Blood Monocyte/Macrophages, S. Majumdar, Diana L. Flasher, Daniel S. Friend, P. Nassos, D. Yajko, W. K. Hadley, Nejat Düzgüneş
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Current treatments of disseminated infection caused by the Mycobacterium avium-M. intracellulare complex (MAC) are generally ineffective. Liposome- mediated delivery of antibiotics to MAC-infected tissues in vivo can enhance the efficacy of the drugs (N. Duzgunes, V. K. Perumal, L. Kesavalu, J. A. Goldstein, R. J. Debs, and P. R. J. Gangadharam, Antimicrob. Agents Chemother. 32:1404-1411, 1988; N. Duzgunes, D. A. Ashtekar, D. L. Flasher, N. Ghori, R. J. Debs, D. S. Friend, and P. R. J. Gangadharam, J. Infect. Dis. 164:143-151, 1991). We investigated the therapeutic efficacies of liposome- encapsulated streptomycin and ciprofloxacin against growth of the MAC inside human …
Fusion Activity And Inactivation Of Influenza Virus: Kinetics Of Low Ph-Induced Fusion With Cultured Cells, Nejat Düzgüneş, Maria C. Pedroso De Lima, L. Stamatatos, D. Flasher, D. R. Alford, Daniel S. Friend, S. Nir
Fusion Activity And Inactivation Of Influenza Virus: Kinetics Of Low Ph-Induced Fusion With Cultured Cells, Nejat Düzgüneş, Maria C. Pedroso De Lima, L. Stamatatos, D. Flasher, D. R. Alford, Daniel S. Friend, S. Nir
All Dugoni School of Dentistry Faculty Articles
The kinetics of fusion of influenza virus (A/PR/8/34) with human promyelocytic leukaemia (HL-60), human T lymphocytic leukaemia (CEM) and murine lymphoma (S49) cells were investigated. Fusion was demonstrated by electron microscopy, and monitored by fluorescence dequenching of octadecylrhodamine incorporated in the virus membrane. Rapid fusion was induced upon mild acidification of the medium. At pH 5, all virus particles were capable of fusing with the cells. The initial rate and the extent of fusion were maximal between pH 4.9 and 5.2 and declined sharply below and above this range. The rate constants of adhesion of influenza virus to cells or …