Medicine and Health Sciences Commons^™

Cerebrospinal Fluid Neurofilament Light Concentration Predicts Brain Atrophy And Cognition In Alzheimer's Disease, Kunal Dhiman, Veer Bala Gupta, Victor L. Villemagne, Dhamidhu Eratne, Petra L. Graham, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Ashley I. Bush, Christopher C. Rowe, Colin L. Masters, David Ames, Eugene Hone, Kaj Blennow, Henrik Zetterberg, Ralph N. Martins

Research outputs 2014 to 2021

Introduction
This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology, as well as its potential to predict brain atrophy, cognition, and amyloid accumulation.
Methods
CSF NfL concentration was measured in 221 participants from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL).
Results
CSF NfL levels as well as NfL/amyloid β (Aβ42) were significantly elevated in AD compared to healthy controls (HC; P < .001), and in mild cognitive impairment (MCI) compared to HC (P = .008 NfL; P< .001 NfL/Aβ42). CSF NfL and NfL/Aβ42 differentiated AD from HC with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.84 and 0.90, respectively. CSF NfL and NfL/Aβ42 predicted cortical amyloid load, brain atrophy, and cognition.
Discussion
CSF NfL is a biomarker of neurodegeneration, correlating with cognitive impairment and brain neuropathology.

A Broad Autism Phenotype Expressed In Facial Morphology, Diana Weiting Tan, Murray T. Maybery, Syed Zulqarnain Gilani, Gail A. Alvares, Ajmal Mian, David Suter, Andrew J. O. Whitehouse

Research outputs 2014 to 2021

Autism spectrum disorder is a heritable neurodevelopmental condition diagnosed based on social and communication differences. There is strong evidence that cognitive and behavioural changes associated with clinical autism aggregate with biological relatives but in milder form, commonly referred to as the ‘broad autism phenotype’. The present study builds on our previous findings of increased facial masculinity in autistic children (Sci. Rep., 7:9348, 2017) by examining whether facial masculinity represents as a broad autism phenotype in 55 non-autistic siblings (25 girls) of autistic children. Using 3D facial photogrammetry and age-matched control groups of children without a family history of ASD, we …

The Potential Of Ultraviolet Radiation Meters In Secondary Schools As A Sun Protection Intervention Mechanism For Adolescents, Simone Pettigrew, Ashleigh Parnell, Mark Strickland, Rachel Neale, Robyn Lucas

Research outputs 2014 to 2021

The aim of this pilot study was to assess whether the installation of ultraviolet radiation (UVR) meters in secondary schools has the potential to improve adolescents’ sun protection‐related knowledge, attitudes, and behaviours and reduce their exposure to UVR during school hours. Data were collected from students at two schools via online pre‐ and post‐intervention surveys, measurement of sunscreen usage, polysulfone UVR exposure badges, and photographs of the schoolyards to assess hat and shade use. Several operational issues limited the quantity and quality of data that could be collected, and findings were mixed. While there were no significant changes in either …

Release: A Protocol For A Systematic Review Based, Individual Participant Data, Meta- And Network Meta-Analysis, Of Complex Speech-Language Therapy Interventions For Stroke-Related Aphasia, Marian C. Brady, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Louise R. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M. T. Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M. Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann Charlotte Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca Shisler Marshall, Flavia Mattioli, Ilknur Mavis, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright

Research outputs 2014 to 2021

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies …

Stratified Analyses Of Genome Wide Association Study Data Reveal Haplotypes For A Candidate Gene On Chromosome 2 (Kiaa1211l) Is Associated With Opioid Use In Patients Of Arabian Descent, Hiba Alblooshi, Habiba Al Safar, Ahmed El Kashef, Hamad Al Ghaferi, Mansour Shawky, Gary K. Hulse, Guan K. Tay

Research outputs 2014 to 2021

Background: Genome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved in development of opioid use disorder. This study extends the first GWAS of substance use disorder (SUD) patients from the United Arab Emirates (UAE) by stratifying the study group based on opioid use, which is the most common substance of use in this cohort. Methods: The GWAS cohort consisted of 512 (262 case, 250 controls) male participants from the UAE. The samples were genotyped using the Illumina Omni5 Exome system. Data was stratified according to opioid use using PLINK. Haplotype analysis was conducted using Haploview …

Whole-Fat Or Reduced-Fat Dairy Product Intake, Adiposity, And Cardiometabolic Health In Children: A Systematic Review, Therese O'Sullivan, Kelsey A. Schmidt, Mario Kratz

Research outputs 2014 to 2021

Dietary guidelines commonly recommend that children aged > 2 y consume reduced-fat dairy products rather than regular- or whole-fat dairy. In adults, most studies have not found the consumption of whole-fat dairy products to be associated with increased cardiometabolic or adiposity risk. Associations in children could differ due to growth and development. We systematically reviewed the literature in indexed, peer-reviewed journals to summarize pediatric studies (children aged from 2 to 18 y) assessing associations between whole- and reduced-fat dairy intake and measures of adiposity as well as biomarkers of cardiometabolic disease risk, including the serum lipid profile, blood pressure, low-grade chronic …

Sustaining Dancer Wellbeing Through Independent Professional Dance Careers, Luke S. Hopper, Peta Blevins, Shona Erskine, Danica Hendry, Raewyn Hill, Richard Longbottom

Research outputs 2014 to 2021

Dancers dedicate their lives to their art. The lucky few dancers who reach professional careers, must navigate a casualised industry, balance financial pressures and maintain performance fitness. This research aimed to provide practical considerations for dancers to support their health and wellbeing through independent, professional dance careers. Dancers from Australian contemporary dance company Co3 participated in a training program involving psychological and physiotherapy assessments and fitness training in conjunction with a major performance season. Focus groups with company dancers and staff investigated the perceived efficacy of the training program within the company schedule and in supporting dancer wellbeing. Dancers were …

Prkag2 Gene Expression Is Elevated And Its Protein Levels Are Associated With Increased Amyloid-Β Accumulation In The Alzheimer’S Disease Brain, Prashant Bharadwaj, Ralph Martins

Research outputs 2014 to 2021

Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in Alzheimer’s disease (AD) brain. Recent studies have identified PRKAG2 and TIPRL genes that control nutrient kinase regulated autophagy, and here we determined if their expression is altered in postmortem AD brains. Gene and protein expression of TIPRL were unchanged. However, gene expression of PRKAG2 was increased 3-fold and its protein levels positively correlated with Aβ accumulation in the AD brain. In summary, our findings suggest that increased PRKAG2 is an important contributing factor to Aβ accumulation in the AD brain.

Sex And Apoe Ε4 Genotype Modify The Alzheimer’S Disease Serum Metabolome, Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak Mahmoudian Dehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Colette, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmuller

Research outputs 2014 to 2021

Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified association analyses of 139 serum metabolites in 1,517 individuals from the AD Neuroimaging Initiative with AD biomarkers. We observed substantial sex differences in effects of 15 metabolites with partially overlapping differences for APOE ε4 status groups. Several group-specific metabolic alterations were not observed in unstratified analyses using sex and APOE ε4 as covariates. Combined stratification revealed further …

Investigation Of The Association Between Dietary Fibre, Protein And Fat With Manganese Content In Food, Madhura Jayasinghe, Binosha Fernando, Subhashinie Senadheera, Pubudu Gunawardene, Somathilaka Ranaweera

Research outputs 2014 to 2021

Manganese deficiency may cause severe health disorders and is becoming prevalent in societies that are rapidly urbanising. Determining the Manganese contents and its relationship with the intake of protein, fibre and fats is important; which may allow people to select Manganese rich foods based on their major macronutrients. A cross-sectional study including detailed dietary assessment for two weeks, followed by proximate analysis of regularly consumed diets was conducted using 1200 adults from three different social segments as; lecturers/teachers (400), managerial employees in the private sector (400), and houses wives (400). Each social segment was assumed to elicit different lifestyles and …

Clarifying Workforce Flexibility From A Division Of Labor Perspective: A Mixed Methods Study Of An Emergency Department Team, Sarah Wise, Christine Duffield, Margaret Fry, Michael Roche

Research outputs 2014 to 2021

Background: The need for greater flexibility is often used to justify reforms that redistribute tasks through the workforce. However, "flexibility" is never defined or empirically examined. This study explores the nature of flexibility in a team of emergency doctors, nurse practitioners (NPs), and registered nurses (RNs), with the aim of clarifying the concept of workforce flexibility. Taking a holistic perspective on the team's division of labor, it measures task distribution to establish the extent of multiskilling and role overlap, and explores the behaviors and organizational conditions that drive flexibly.

Methods: The explanatory sequential mixed methods study was set in the …

Association Between The Triglyceride To High-Density Lipoprotein Cholesterol Ratio And The Risk Of Type 2 Diabetes Mellitus Among Chinese Elderly: The Beijing Longitudinal Study Of Aging, Dequiang Zheng, Haibin Li, Feiling Ai, Fei Sun, Manjot Singh, Xue Cao, Jiajia Jiang, Yan He, Zhe Tang, Xiuhua Guo

Research outputs 2014 to 2021

Objective: Time-dependent covariates are generally available as longitudinal data were collected periodically in the cohort study. To examine whether time-dependent triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio could predict the future risk of type 2 diabetes mellitus (T2DM) and assess its potential impact on the risk of T2DM incidence. Research design and methods: This study enrolled 1460 participants without T2DM aged 55 or above in 1992 in the Beijing Longitudinal Study of Aging during 25 years. The questionnaire data were collected in nine surveys from 1992 to 2017. Physical examination and blood laboratory tests including TG and HDL-C concentrations were …

Exploring The Association Between Recent Concussion, Subconcussive Impacts And Depressive Symptoms In Male Australian Football Players, Sarah Ann Harris, Paola T. Chivers, Fleur L. Mcintyre, Ben Piggott, Max Bulsara, Fiona H. Farringdon

Research outputs 2014 to 2021

Objectives: To explore the association between depressive symptoms and recent head-related trauma (diagnosed concussion, subconcussive impacts) in semiprofessional male Australian Football (AF) players.

Methods: Sixty-nine semiprofessional male players from a West Australian Football League (WAFL) club participated in the study (M age =21.81, SD=2.91 years). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression Scale. Injuries and potential confounding variables (eg, pre-existing mental health condition; alcohol or drug hangovers; experiencing a stressful event) were self-reported anonymously using the WAFL Injury Report Survey. Both tools were administered every 2-weeks over the first 22-weeks of the WAFL season. Controlling for …

Ador2a C Allele Carriers Exhibit Ergogenic Responses To Caffeine Supplementation, Jozo Grgic, Craig Pickering, David J. Bishop, Juan Del Coso, Brad Schoenfeld, Grant M. Tinsley, Zeljko Pedisic

Research outputs 2014 to 2021

Caffeine’s ergogenic effects on exercise performance are generally explained by its ability to bind to adenosine receptors. ADORA2A is the gene that encodes A2A subtypes of adenosine receptors. It has been suggested that ADORA2A gene polymorphisms may be responsible for the inter-individual variations in the effects of caffeine on exercise performance. In the only study that explored the influence of variation in ADORA2A—in this case, a common polymorphism (rs5751876)—on the ergogenic effects of caffeine on exercise performance, C allele carriers were identified as “non-responders” to caffeine. To explore if C allele carriers are true “non-responders” to the ergogenic effects of …

A Sensorimotor Control Framework For Understanding Emotional Communication And Regulation, Justin H.G. Williams, Charlotte F. Huggins, Barbra Zupan, Megan Willis, Tamsyn E. Van Rheenen, Wataru Sato, Romina Palermo, Catherine Ortner, Martin Krippl, Mariska Kret, Joanne M. Dickson, Chiang-Shan R. Li, Leroy Lowe

Research outputs 2014 to 2021

Our research team was asked to consider the relationship of the neuroscience of sensorimotor control to the language of emotions and feelings. Actions are the principal means for the communication of emotions and feelings in both humans and other animals, and the allostatic mechanisms controlling action also apply to the regulation of emotional states by the self and others. We consider how motor control of hierarchically organised, feedback-based, goal-directed action has evolved in humans, within a context of consciousness, appraisal and cultural learning, to serve emotions and feelings. In our linguistic analysis, we found that many emotion and feelings words …

Medical-Attention Injuries In Community Cricket: A Systematic Review, Geordie Mcleod, Siobhan O'Connor, Damian Morgan, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

Objectives: The aim was to identify and describe outcomes from original published studies that present the number, nature, mechanism and severity of medically treated injuries sustained in community-level cricket. Design: Systematic review. Methods: Nine databases were systematically searched to December 2019 using terms "cricket∗" and "injur∗". Original, peer-reviewed studies reporting injury for at least one injury descriptor (body region, nature of injury and/or mechanism of injury) in community-level cricketers of all ages were included. Qualitative synthesis, critical appraisal and descriptive summary results are reported within the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results: Six studies were …

Correction To: Bilingualism Is Associated With A Delayed Onset Of Dementia But Not With A Lower Risk Of Developing It: A Systematic Review With Meta-Analyses, Stefano Brini, Hamid R. Sohrabi, Jeffrey J. Hebert, Mitchell R. L. Forrest, Matti Laine, Heikki Hämäläinen, Mira Karrasch, Jeremiah J. Peiffer, Ralph N. Martins, Timothy J. Fairchild

Research outputs 2014 to 2021

The original version of this article unfortunately contained the following mistakes. 1. In the Results section under the paragraph Disease Severity, the sentence “The PIs ranged between -0.47 and 0.57 MMSE points” should read -0.49 and 0.59 MMSE points. 2. In Figs. 3, 5, and 7, the labels “favour bilinguals” and “favours monolinguals” should be inverted. Therefore, it should be “favours monolinguals” and “favours bilinguals”. Please see below for the correct figures. © 2020, The Author(s).

Biopsychosocial Risk Factors And Knowledge Of Cervical Cancer Among Young Women: A Case Study From Kenya To Inform Hpv Prevention In Sub-Saharan Africa, Irene Ngune, Fatch Kalembo, Barbara Loessl, Lucy W. Kivuti-Bitok

Research outputs 2014 to 2021

Background Cervical cancer is the second most common female reproductive cancer after breast cancer with 84% of the cases in developing countries. A high uptake of human papilloma virus (HPV) vaccination and screening, and early diagnosis leads to a reduction of incidence and mortality rates. Yet uptake of screening is low in Sub-Saharan Africa and there is an increasing number of women presenting for treatment with advanced disease. Nine women in their twenties die from cervical cancer in Kenya every day. This paper presents the biopsychosocial risk factors that impact on cervical cancer knowledge among Kenyan women aged 15 to …

Can Instagram Be Used To Deliver An Evidence-Based Exercise Program For Young Women A Process Evaluation, Rachel G. Curtis, Jillian C. Ryan, Sarah M. Edney, Carol A. Maher

Research outputs 2014 to 2021

Background Instagram provides an opportunity to deliver low cost, accessible and appealing physical activity content. This study evaluated the feasibility of delivering an exercise program for young women using Instagram. Methods A single-group pre- and post-intervention trial examined the feasibility and preliminary efficacy of a 12-week Instagram-delivered program with young inactive women (n = 16; M = 23 years), which prescribed running and body weight exercises to complete three times per week. Daily Instagram posts delivered the exercises, video demonstrations and motivational content. Feasibility was evaluated by examining exposure (Instagram posts viewed per week), engagement (likes, comments and tags on …

Validity And Bias On The Online Active Australia Survey: Activity Level And Participant Factors Associated With Self-Report Bias, Rachel G. Curtis, Timothy Olds, Ronald Plotnikoff, Corneel Vandelanotte, Sarah Edney, Jillian Ryan, Carol Maher

Research outputs 2014 to 2021

Background This study examined the criterion validity of the online Active Australia Survey, using accelerometry as the criterion, and whether self-report bias was related to level of activity, age, sex, education, body mass index and health-related quality of life. Methods The online Active Australia Survey was validated against the GENEActiv accelerometer as a direct measure of activity. Participants (n = 344) wore an accelerometer for 7 days, completed the Active Australia Survey, and reported their health and demographic characteristics. A Spearman’s rank coefficient examined the association between minutes of moderate-to-vigorous physical activity recorded on the Active Australia Survey and GENEActiv …

Communicating Simply, But Not Too Simply: Reporting Of Participants And Speech And Language Interventions For Aphasia After Stroke, Release Collaboration, Marian C. Brady, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Louise R. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis Mt Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M. Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon-Ralph, Ann Charlotte Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca Shisler Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright

Research outputs 2014 to 2021

Purpose: Speech and language pathology (SLP) for aphasia is a complex intervention delivered to a heterogeneous population within diverse settings. Simplistic descriptions of participants and interventions in research hinder replication, interpretation of results, guideline and research developments through secondary data analyses. This study aimed to describe the availability of participant and intervention descriptors in existing aphasia research datasets.

Method: We systematically identified aphasia research datasets containing ≥10 participants with information on time since stroke and language ability. We extracted participant and SLP intervention descriptions and considered the availability of data compared to historical and current reporting standards. We developed an …

The Influence Of Biological Maturity On Dynamic Force–Time Variables And Vaulting Performance In Young Female Gymnasts, Sylvia Moeskops, Jon L. Oliver, Paul J. Read, John B. Cronin, Gregory D. Myer, G. Gregory Haff, Isabel S. Moore, Rhodri S. Lloyd

Research outputs 2014 to 2021

Purpose: This cross-sectional study investigated dynamic force–time variables and vaulting performance in young female gymnasts of different maturity status.

Methods: 120 gymnasts aged 5–14 years were sub-divided into maturity groupings using percent of predicted adult height (%PAH) attained. Participants performed three jumping protocols, the squat jump (SJ), countermovement jump (CMJ) and drop jump (DJ), before completing straight jump vaults that were recorded using two-dimensional video.

Results: Jumping performance improved with biological maturity evidenced by the most mature gymnasts’ producing significantly more absolute force (P < 0.05; all d > 0.78), impulse (P < 0.05; all d > 0.75) and power (P < 0.05; all d > 0.91) than the least mature group, resulting in the …

Medical Injection And Access To Sterile Injection Equipment In Low- And Middle-Income Countries: A Meta-Analysis Of Demographic And Health Surveys (2010–2017), Emmanuel O. Adewuyi, Asa Auta

Research outputs 2014 to 2021

Background Unsafe injection practices contribute to increased risks of blood-borne infections, including human immunodeficiency virus, hepatitis B and hepatitis C viruses. The aim of this study was to estimate the prevalence of medical injections as well as assess the level of access to sterile injection equipment by demographic factors in low- and middle-income countries (LMICs). Methods We carried out a meta-analysis of nationally representative Demographic and Health Surveys (DHSs) conducted between 2010 and 2017 in 39 LMICs. Random effects meta-analysis was used in estimating pooled and disaggregated prevalence. All analyses were conducted using Stata version 14 and Microsoft Excel 2016. …

Preparing Student Paramedics For The Mental Health Challenges Of The Profession By Using The Wisdom Of The Experienced, Lisa Holmes, Natalie Ciccone, Lynne Cohen, Richard Brightwell

Research outputs 2014 to 2021

Given the significant mental health issues affecting our paramedics, there exists an urgent need to promote positive mental health and well-being among future cohorts of student paramedics. This study investigated the preparedness of student paramedics for the mental health challenges of the profession and explored the coping strategies used by experienced paramedics. The study was conducted in two parts. Part A comprised of two surveys which were developed and administered to 16 course coordinators and 302 students of the 16 accredited undergraduate paramedicine courses across Australia and New Zealand. The survey aimed to identify the perceived need for preparation within …

Association Of Myh9-Rs3752462 Polymorphisms With Chronic Kidney Disease Among Clinically Diagnosed Hypertensive Patients: A Case-Control Study In A Ghanaian Population, William K. Owiredu, Michael Appiah, Christian Obirikorang, Evans Asamoah Adu, Vincent Boima, Ernestine Kubi Amos-Abanyie, Priscilla Abena Akyaw, Eddie-Williams Owiredu, Emmanuel Acheampong

Research outputs 2014 to 2021

Background: Chronic kidney disease (CKD) is a significant comorbidity among hypertensive patients. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) have been demonstrated to be significantly associated with CKD, among African- and European-derived populations. We investigated the spectrum of MYH9-associated CKD among Ghanaian hypertensive patients. Methods: The study constituted a total of 264 hypertensive patients. Hypertensive patients with glomerular filtration rate (eGFR) < 60 ml/min/1.73m (CKD-EPI formula) or clinically diagnosed were defined as case subjects ( = 132) while those with eGFR ≥60 ml/min/1.73m were classified as control subjects ( = 132). Demographic data were obtained with a questionnaire and anthropometric measurements were taken. Five (5) millilitres (ml) of venous blood was drawn from study subjects into gel and EDTA vacutainer tubes. Two (2) mL of EDTA anticoagulated blood was used for genomic DNA extraction while three (3) mL of blood was processed to obtain serum for biochemical measurements. Genotyping of MYH9 polymorphisms (rs3752462) was done employing Tetra primer Amplification Refractory Mutation System (T-ARMS) polymerase chain reaction (PCR). Spot urine samples were also collected for urinalysis. Hardy-Weinberg population was assessed. Logistic regression models were used to assess the associations between single nucleotide polymorphisms and CKD. Results: The cases and control participants differed in terms of age, sex, family history, and duration of CKD (-value < 0.001). The minor allele frequencies of rs3752462 SNP were 0.820 and 0.567 respectively among the control and case subjects. Patients with the heterozygote genotype of rs3752462 (CT) were more likely to develop CKD [aOR = 7.82 (3.81-16.04)] whereas those with homozygote recessive variant (TT) were protective [aOR = 0.12 (0.06-0.25)]. Single nucleotide polymorphism of rs3752462 (CT genotype) was associated with increased proteinuria, albuminuria, and reduced eGFR. Conclusions: We have demonstrated that MYH9 polymorphisms exist among Ghanaian hypertensive patients and rs3752462 polymorphism of MYH9 is associated with CKD. This baseline indicates that further longitudinal and multi-institutional studies in larger cohorts in Ghana are warranted to evaluate MYH9 SNP as an independent predictor of CKD among hypertensive patients in Ghana.

Interdisciplinary Sport Research Can Better Predict Competition Performance, Identify Individual Differences, And Quantify Task Representation, Ben Piggott, Sean Müller, Paola Chivers, Ashley Cripps, Gerard Hoyne

Research outputs 2014 to 2021

Sport performance consists of interacting individual, task and environmental constraints, but research has used a monodisciplinary, rather than an interdisciplinary approach to understand performance. This study used Australian football (AF) as the exemplar sport to investigate the value of an interdisciplinary approach to understand sport performance. Through this, it was also possible to quantify individual differences and representative task design. Fifty-nine semi-professional Australian footballers participated. Based upon accessibility, combinations of these players completed physiological (3 × 1 km trial) and perceptual-cognitive-motor (small-sided game, SSG) tests, with coach rating of psychological skill (mental toughness coach, MTC). Univariate monodisciplinary models indicated that …

Large Reductions In Match Play Physical Performance Variables Across A Professional Football Season With Control For Situational And Contextual Variables, Matthew Springham, Sean Williams, Mark Waldron, Darren Burgess, Robert Usher Newton

Research outputs 2014 to 2021

This investigation examined match play physical performance across a professional football season using a multicamera computerized tracking system. A linear mixed-effects model, controlling for situational and contextual variables, identified decreases in team average total distance (TD): season quarter 1 (Q1) (11,047 m) > season quarter 2 (Q2) (10,473 m) ( = ; ES = ), season quarter 3 (Q3) (10,449 m) ( < 0.001; ES = ), and season quarter 4 (Q4) (10,385 m) ( < 0.001; ES = ); work rate (WR): Q1 (115 m/min) > Q3 (108 m/min) ( < 0.001; ES = ), Q4 (107 m/min) ( < 0.001; ES = ); Q2 (109 m/min) > Q4 (107 m/min) ( = 0.003; ES = ); high-speed running distance (HSR): Q1 (1,051 m) > Q2 (813 m) ( = 0.006; ES = ); number of high-speed runs (NHSR): Q1 (87) > Q2 (65) ( …

Associations Between Dietary Flavonoids And Retinal Microvasculature In Older Adults, Bamini Gopinath, Gerald Liew, Joshua Lewis, Nicola P. Bondonno, Catherine P. Bondonno, George Burlutsky, Jonathan M. Hodgson, Paul Mitchell

Research outputs 2014 to 2021

Purpose: In this study, we assessed whether there are independent associations between dietary total flavonoid intake and major flavonoid classes with retinal arteriolar and venular calibre.

Methods: Blue Mountains Eye Study participants aged 49+ years who had complete data on diet and retinal vessel measures were analysed (n = 2821). Dietary intake was assessed using a semi-quantitative Food-Frequency Questionnaire (FFQ). Flavonoid content of foods in the FFQ was estimated using the US Department of Agriculture Flavonoid, Isoflavone and Proanthocyanidin databases. Fundus photographs were taken and retinal vascular calibre was measured using validated computer-assisted techniques. The associations of intake of …

Dietary Inflammatory Index And The Aging Kidney In Older Women: A 10‑Year Prospective Cohort Study, Nicola P. Bondonno, Lauren Blekkenhorst, Anna L. Bird, Joshua R. Lewis, Johnathan M. Hodgson, Nitin Shivappa, James R. Hebert, Richard J. Woodman, Germaine Wong, Deborah A. Kerr, Wai H. Lim, Richard L. Prince

Research outputs 2014 to 2021

Purpose: Chronic inflammation plays a role in the pathogenesis of age-related renal disease and the diet can moderate systemic inflammation. The primary objective of this study was to examine the associations between a dietary inflammatory index ( DII®) score and renal function, the trajectory of renal function decline, and renal disease-related hospitalizations and/or mortality over 10 years.

Methods: The study was conducted in 1422 Western Australian women without prevalent chronic kidney disease and aged ≥ 70 years. Baseline dietary data, obtained from a validated food frequency questionnaire, were used to calculate a DII score for each individual.

Results: In this …

Antimicrobial Resistance In Clostridium Difficile Ribotype 017, Korakrit Imwattana, Daniel R. Knight, Brian Kullin, Deirdre A. Collins, Papanin Putsathit, Pattarachai Kiratisin, Thomas V. Riley

Research outputs 2014 to 2021

Introduction: Antimicrobial resistance (AMR) played an important role in the initial outbreaks of Clostridium difficile infection (CDI) in the 1970s. C. difficile ribotype (RT) 017 has emerged as the major strain of C. difficile in Asia, where antimicrobial use is poorly regulated. This strain has also caused CDI outbreaks around the world for almost 30 years. Many of these outbreaks were associated with clindamycin and fluoroquinolone resistance. AMR and selective pressure is likely to be responsible for the success of this RT and may drive future outbreaks.

Areas covered: This narrative journalarticle summarizes the prevalence and mechanisms of AMR in …