Medicine and Health Sciences Commons^™

Prevalence Of Distress, Its Associated Factors And Referral To Support Services In People With Cancer, Deborah Kirk, Istvan (Ishti) Kabdebo, Lisa Whitehead

Research outputs 2014 to 2021

Aims and objectives:

To (i) characterise prevalence of distress amongst people diagnosed with cancer, (ii) determine factors associated with increasing distress, (iii) describe reported problems for those with clinically significant distress and (iv) investigate the factors associated with referral to support services.

Background:

International studies report a high prevalence of clinically significant distress in people with cancer. Australian studies are notably lacking. Additionally, clinicians still do not fully understand the factors associated with cancer-related distress.

Design:

Period prevalence study.

Methods:

Distress screening data were analysed for 1,071 people accessing the Cancer Council Western Australia information and support line between 01/01/2016–31/12/2018. …

Tweak/Fn14 Signalling Promotes Cholangiocarcinoma Niche Formation And Progression, Benjamin J. Dwyer, Edward J. Jarman, Jully Gogoi-Tiwari, Sofia Ferreira-Gonzalez, Luke Boulter, Rachel V. Guest, Timothy J. Kendall, Dominic Kurian, Alastair M. Kilpatrick, Andrew J. Robson, Eoghan O'Duibhir, Tak Yung Man, Lara Campana, Philip J. Starkey Lewis, Stephen J. Wigmore, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker, Stuart J. Forbes

Research outputs 2014 to 2021

Background & Aims: Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is known to signal via its receptor fibroblast growth factor-inducible 14 (Fn14) and induce cholangiocyte and myofibroblast proliferation in liver injury. We aimed to characterise its role in CCA. Methods: The expression of the TWEAK ligand and Fn14 receptor was assessed immunohistochemically and by bulk RNA and single cell transcriptomics of human liver tissue. Spatiotemporal dynamics of pathway regulation were comprehensively analysed in rat and mouse models of thioacetamide …

Fifteen Years Of The Australian Imaging, Biomarkers And Lifestyle (Aibl) Study: Progress And Observations From 2,359 Older Adults Spanning The Spectrum From Cognitive Normality To Alzheimer's Disease, Christopher Fowler, Stephanie R. Rainey-Smith, Sabine Bird, Julia Bomke, Pierrick Bourgeat, Belinda M. Brown, Samantha C. Burnham, Ashley I. Bush, Carolyn Chadunow, Steven Collins, James Doecke, Vincent Doré, Kathryn A. Ellis, Lis Evered, Amir Fazlollahi, Jurgen Fripp, Samantha L. Gardener, Simon Gibson, Robert Grenfell, Elise Harrison, Richard Head, Liang Jin, Adrian Kamer, Fiona Lamb, Nicola T. Lautenschlager, Simon M. Laws, Qiao-Xin Li, Lucy Lim, Yen Ying Lim, Andrea Louey, S. Lance Macaulay, Lucy Mackintosh, Ralph N. Martins, Paul Maruff, Colin L. Masters, Simon Mcbride, Lidija Milicica, Madeline Peretti, Kelly Pertile, Tenielle Porter, Morgan Radler, Alan Rembach, Joanne Robertson, Mark Rodrigues, Christopher C. Rowe, Rebecca Rumble, Olivier Salvado, Greg Savage, Brendan Silbert, Magdalene Soh, Hamid R. Sohrabi, Kevin Taddei, Tania Taddei, Christine Thai, Brett Trounson, Regan Tyrrell, Michael Vacher, Shiji Varghese, Victor L. Villemagne, Michael Weinborn, Michael Woodward, Ying Xia, David Ames, Aibl Investigators

Research outputs 2014 to 2021

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer's disease dementia (AD)) as an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an 'Enrichment cohort' (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance …

An Assessment Of The Hopping Strategy And Inter-Limb Asymmetry During The Triple Hop Test: A Test–Retest Pilot Study, Kyle Davey, Paul Read, Joseph Coyne, Paul Jarvis, Anthony Turner, Jon Brazier, Nejc Šarabon, Matthew J. Jordan, Chris Bishop

Research outputs 2014 to 2021

The aims of the present study are to: (1) determine within-and between-session reliability of multiple metrics obtained during the triple hop test; and (2) determine any systematic bias in both the test and inter-limb asymmetry scores for these metrics. Thirteen male young American football athletes performed three trials of a triple hop test on each leg on two separate occasions. In addition to the total distance hopped, manual detection of touch down and toe-off were calculated via video analysis, enabling flight time (for each hop), ground contact time (GCT), reactive strength index (RSI), and leg stiffness (between hops) to be …

Comparison Of Experiences In Two Birth Cohorts Comprising Young Families With Children Under Four Years During The Initial Covid-19 Lockdown In Australia And The Uk: A Qualitative Study, Lisa Y. Gibson, Bridget Lockyer, Josie Dickerson, Charlotte Endacott, Sally Bridges, Rosemary R. C. Mceachan, Kate E. Pickett, Sarah Whalan, Natasha L. Bear, Desiree T. Silva, Susan L. Prescott, Jacqueline A. Davis

Research outputs 2014 to 2021

This study aims to understand the experience and impact of the initial COVID-19 lock-down in young families with children aged below 4 years. Free text questions were administered to participants in the ORIGINS (Australia) and Born in Bradford (UK) cohort studies to collect qualitative information on worries, concerns and enjoyable experiences during the pandemic. A total of 903 (400 for ORIGINS and 503 for BiB) participants completed the two surveys during April 2020. Despite varying in geography, levels of socio-economic disadvantage and their situational context during the pandemic, respondents from both cohorts reported similar worries and challenges during the lockdown …

Using Social Media In Health Literacy Research: A Promising Example Involving Facebook With Young Aboriginal And Torres Strait Islander Males From The Top End Of The Northern Territory, James A. Smith, Anthony Merlino, Ben Christie, Mick Adams, Jason Bonson, Richard H. Osborne, Murray Drummond, Barry Judd, David Aanundsen, Jesse Fleay, Himanshu Gupta

Research outputs 2014 to 2021

This brief report describes three key lessons learned during a health literacy research project with young Aboriginal and Torres Strait Islander males from the Top End of the Northern Territory (NT), Australia. More specifically, it is a methodologically focused paper that discusses processes associated with using a combination of yarning sessions and social media content as tools to unpack conceptualisations of health and well‐being among this marginalised population. The lessons discussed include (a) the utility of using social media in providing an authentic window into the lives of a hard‐to‐reach populations; (b) the need to carefully consider ethical implications; and …

Motor Developmental Outcomes In Children Exposed To Maternal Diabetes During Pregnancy: A Systematic Review And Meta-Analysis, Diana Arabiat, Mohammad A. L. Jabery, Vivien Kemp, Mark Jenkins, Lisa C. Whitehead, Gary Adams

Research outputs 2014 to 2021

© 2021 by the author. Licensee MDPI, Basel, Switzerland. Studies on the association of maternal diabetes with motor development in children provide inconsistent findings. We searched MEDLINE/PubMed, EMBASE, Emcare, PsycINFO, and Google Scholar databases for primary observational, case–control, or cohort studies that report on the motor development of children exposed to maternal diabetes during pregnancy. Quality appraisal and data extraction were performed independently and in duplicate. A meta-analysis of summary measures was performed using random-effect models. Eighteen studies were identified for inclusion, however, only 13 were included in the meta-analysis. Exposure to maternal diabetes during pregnancy was associated with a …

Searching For A Technology-Driven Acute Rheumatic Fever Test: The Start Study Protocol, Anna P. Ralph, Rachel Webb, Nicole J. Moreland, Reuben Mcgregor, Anthony Bosco, David Broadhurst, Timo Lassmann, Timothy C. Barnett, Rym Benothman, Jennifer Yan, Bo Remenyi, Julie Bennett, Nigel Wilson, Mark Mayo, Glenn Pearson, Tobias Kollmann, Jonathan R. Carapetis

Research outputs 2014 to 2021

Introduction:

The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. It is the precursor to rheumatic heart disease (RHD), a leading cause of health inequity and premature mortality for Indigenous peoples of Australia, New Zealand and internationally.

Methods and analysis:

Searching for a Technology-Driven Acute Rheumatic Fever Test' (START) is a biomarker discovery study that aims to detect and test a biomarker signature that distinguishes ARF cases from non-ARF, and use systems biology and serology to …

Integrated Guidance For Enhancing The Care Of Familial Hypercholesterolaemia In Australia, Gerald F. Watts, David R. Sullivan, David L. Hare, Karam M. Kostner, Ari E. Horton, Damon A. Bell, Tom Brett, Ronald J. Trent, Nicola K. Poplawski, Andrew C. Martin, Shubha Srinivasan, Robert N. Justo, Clara K. Chow, Jing Pang, Zanfina Ademi, Justin J. Ardill, Wendy Barnett, Timothy R. Bates, Lawrence J. Beilin, Warrick Bishop, J. Andrew Black, Peter Brett, Alex Brown, John R. Burnett, Christina A. Bursill, Alison Colley, Peter M. Clifton, Elif I. Ekinci, Luke Elias, Gemma A. Figtree, Brett H. Forge, Jacquie Garton-Smith, Dorothy F. Graham, Ian Hamilton-Craig, Christian R. Hamilton-Craig, Clare Heal, Charlotte M. Hespe, Amanda J. Hooper, Laurence G. Howes, Jodie Ingles, John Irvin, Edward D. Janus, Nadarajah Kangaharan, Anthony C. Keech, Andrew B. Kirke, Leonard Kritharides, Campbell V. Kyle, Paul Lacaze, Kirsten Lambert, Stephen C. H. Li, Wynand Malan, Stjepana Maticevic, Brendan M. Mcquillan, Sam Mirzaee, Trevor A. Mori, Allison C. Morton, David M. Colquhoun, Joanna C. Moullin, Paul J. Nestel, Kristen J. Nowak, Richard C. O'Brien, Nicholas Pachter, Michael M. Page, Annette Pedrotti, Peter J. Psaltis, Jan Radford, Nicola J. Reid, Elizabeth N. Robertson, Jacqueline D. M. Ryan, Mitchell N. Sarkies, Carl J. Schultz, Russell S. Scott, Christopher Semsarian, Leon A. Simons, Catherine Spinks, Andrew M. Tonkin, Frank Van Bockxmeer, Kathryn E. Waddell-Smith, Natalie C. Ward, Harvey D. White, Andrew M. Wilson, Ingrid Winship, Ann Marie Woodward, Stephen J. Nicholls, Fh Australasia Network Consensus Working Group

Research outputs 2014 to 2021

Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL)-cholesterol concentration and, if untreated, leads to premature atherosclerosis and coronary artery disease (CAD). There are approximately 100,000 people with FH in Australia. However, an overwhelming majority of those affected remain undetected and inadequately treated, consistent with FH being a leading challenge for public health genomics. To further address the unmet need, we provide an updated guidance, presented as a series of systematically collated recommendations, on the care of patients and families with FH. These recommendations have been informed by …

Digital Interventions To Improve Health Literacy Among Parents Of Children Aged 0 To 12 Years With A Health Condition: Systematic Review, Evalotte Mörelius, Suzanne Robinson, Diana Arabiat, Lisa Whitehead

Research outputs 2014 to 2021

Background:

Parental health literacy is associated with child health outcomes. Parents are increasingly turning to the internet to obtain health information. In response, health care providers are using digital interventions to communicate information to assist parents in managing their child’s health conditions. Despite the emergence of interventions to improve parental health literacy, to date, no systematic evaluation of the effectiveness of the interventions has been undertaken.

Objective:

The aim of this review is to examine the effect of digital health interventions on health literacy among parents of children aged 0-12 years with a health condition. This includes evaluating parents’ engagement …

The Role Of C-Reactive Protein And Fibrinogen In The Development Of Intracerebral Hemorrhage: A Mendelian Randomization Study In European Population, Biyan Wang, Xiaoyu Zhang, Di Liu, Jie Zhang, Mingyang Cao, Xin Tian, Isinta E. Maranga, Xiaoni Meng, Qiuyue Tian, Feifei Tian, Weijie Cao, Wei Wang, Manshu Song, Youxin Wang

Research outputs 2014 to 2021

Background: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization. Method: We used single-nucleotide polymorphisms associated with CRP and fibrinogen as instrumental variables. The summary data on ICH were obtained from the International Stroke Genetics Consortium (1,545 cases and 1,481 controls). Two-sample Mendelian randomization estimates were performed to assess with inverse-variance weighted and sensitive analyses methods including the weighted median, the penalized weighted median, pleiotropy residual sum and outlier (MR-PRESSO) approaches. MR-Egger regression was used to explore the pleiotropy. …

Organizational Factors Associated With Health Worker Protection During The Covid-19 Pandemic In Four Provinces Of South Africa, Muzimkhulu Zungu, Kuku Voyi, Nosimilo Mlangeni, Saiendhra Vasudevan Moodley, Jonathan Ramodike, Nico Claassen, Elizabeth Wilcox, Nkululeko Thunzi, Annalee Yassi, Jerry Spiegel, Molebogeng Malotle

Research outputs 2014 to 2021

Background: Health workers, in short supply in many low-and-middle-income countries, are at increased risk of SARS-CoV-2 infection. This study aimed to assess how South Africa, prepared to protect its health workers from SARS-CoV-2 infection. Methods: This was a cross-sectional study design applying participatory action research in four provinces of South Africa. A semi-structured questionnaire and a qualitative observational HealthWISE walkthrough risk assessment was carried out to collect data on occupational safety and health (OSH) systems in 45 hospitals across four provinces to identify factors associated with health worker protection. Adapting the International Labour Organization (ILO) and World Health Organization (WHO) …

No Casual Relationship Between T2dm And The Risk Of Infectious Diseases: A Two-Sample Mendelian Randomization Study, Huachen Wang, Zheng Guo, Yulu Zheng, Chunyan Yu, Haifeng Hou, Bing Chen

Research outputs 2014 to 2021

Background: In epidemiological studies, it has been proven that the occurrence of type 2 diabetes mellitus (T2DM) is related to an increased risk of infectious diseases. However, it is still unclear whether the relationship is casual. Methods: We employed a two-sample Mendelian randomization (MR) to clarify the causal effect of T2DM on high-frequency infectious diseases: sepsis, skin and soft tissue infections (SSTIs), urinary tract infections (UTIs), pneumonia, and genito-urinary infection (GUI) in pregnancy. And then, we analyzed the genome-wide association study (GWAS) meta-analysis of European-descent individuals and conducted T2DM-related single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) that were associated with …

Reliability Of Isokinetic Tests Of Velocity‐ And Contraction Intensity‐Dependent Plantar Flexor Mechanical Properties, Matheus D. Pinto, Cody J. Wilson, Anthony D. Kay, Anthony J. Blazevich

Research outputs 2014 to 2021

“Flexibility” tests are traditionally performed voluntarily relaxed by rotating a joint slowly; however, functional activities are performed rapidly with voluntary/reflexive muscle activity. Here, we describe the reliabilities and differences in maximum ankle range of motion (ROM_max) and plantar flexor mechanical properties at several velocities and levels of voluntary force from a new test protocol on a commercially available dynamometer. Fifteen participants had their ankle joint dorsiflexed at 5, 30, and 60° s⁻¹ in two conditions: voluntarily relaxed and while producing 40% and 60% of maximal eccentric torque. Commonly reported variables describing ROM_max and resistance to stretch …

Impact Of Modern Antiviral Therapy Of Chronic Hepatitis B And C On Clinical Outcomes Of Liver Disease, Tiffany Khoo, Danielle Lam, John K. Olynyk

Research outputs 2014 to 2021

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic impacts. Previous treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by patients. The introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive developments. Decreasing the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence, the number of new infections. Antiviral treatments have decreased the rates of liver decompensation and as a result, lowered hospitalisation …

Foveal Avascular Zone And Choroidal Thickness Are Decreased In Subjects With Hard Drusen And Without High Genetic Risk Of Developing Alzheimer’S Disease, Inés López-Cuenca, Rosa De Hoz, Celia Alcantara-Rey, Elena Salobrar-García, Lorena Elvira-Hurtado, José A. Fernández-Albarral, Ana Barabash, Federico Ramírez-Toraño, Jaisalmer De Frutos-Lucas, Juan J. Salazar, Ana I. Ramírez, José M. Ramírez

Research outputs 2014 to 2021

A family history (FH+) of Alzheimer’s disease (AD) and ɛ4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ɛ4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ɛ4−, HD+) group compared with …

Summary Of Fetal Alcohol Spectrum Disorder (Fasd) Among Aboriginal And Torres Strait Islander People, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

Fetal Alcohol Spectrum Disorder (FASD) is a condition caused by alcohol exposure before birth. During pregnancy, alcohol freely crosses the placenta. The baby cannot process the alcohol and this may result in damage to the baby’s brain and body. Not all babies exposed to alcohol during pregnancy will develop FASD, but there is no safe level of alcohol use during pregnancy. FASD is a lifelong condition that results in cognitive, physical and behavioural disabilities. FASD occurs everywhere in Australia where people drink alcohol. Many women drink during pregnancy before they know they are pregnant and there is a lack of …

Into The Breech: A Multi-National E-Delphi Study Exploring Breech Presentation And Birth Care, Sara Morris

Research outputs 2014 to 2021

Aim: To establish consensus regarding care of women with a breech presenting fetus through the exploration of participants’ knowledge, experiences and opinions regarding breech presentation and care.

Design: Three round Delphi e-survey

Setting: Multi-national

Participants: A panel of fifteen midwives, four obstetricians and one academic with an interest in breech care and birth.

Methods: The initial survey comprised of open-ended questions. Answers were coded and integrated to form statements presented to participants over 3 sections in the second round due to the abundance of information collected from first round responses. Consensus was deemed reached if 70% or more of participants …

Feasibility, Tolerance And Effects Of Adding Impact Loading Exercise To Pulmonary Rehabilitation In People With Chronic Obstructive Pulmonary Disease: Study Protocol For A Pilot Randomised Controlled Trial, Erin Cecins, Kylie Hill, Dennis R. Taaffe, David Manners, Anne-Marie Hill, Robert U. Newton, Daniel A. Galvão, Vinicius Cavalheri

Research outputs 2014 to 2021

Background:

Chronic obstructive pulmonary disease (COPD) is a disorder linked with a multitude of extra pulmonary manifestations (also known as treatable traits), including low bone mineral density (BMD). To date, no specific guidelines exist for the management of BMD in this population. Impact loading exercise has been identified as an intervention that improves or maintains BMD in other populations. However, the feasibility of and tolerance to impact loading exercise has not been tested in people with COPD. The aim of the proposed study will be to investigate the feasibility and tolerance of adding impact loading exercise to a standard pulmonary …

The Tumor Suppressor Mir-642a-5p Targets Wilms Tumor 1 Gene And Cell-Cycle Progression In Prostate Cancer, Dianne J. Beveridge, Kirsty L. Richardson, Michael R. Epis, Rikki A. M. Brown, Lisa M. Stuart, Andrew J. Woo, Peter J. Leedman

Research outputs 2014 to 2021

RNA-based therapeutics are emerging as innovative options for cancer treatment, with microRNAs being attractive targets for therapy development. We previously implicated microRNA-642a-5p (miR-642a-5p) as a tumor suppressor in prostate cancer (PCa), and here we characterize its mode of action, using 22Rv1 PCa cells. In an in vivo xenograft tumor model, miR-642a-5p induced a significant decrease in tumor growth, compared to negative control. Using RNA-Sequencing, we identified gene targets of miR-642a-5p which were enriched for gene sets controlling cell cycle; downregulated genes included Wilms Tumor 1 gene (WT1), NUAK1, RASSF3 and SKP2; and upregulated genes included IGFBP3 and GPS2. Analysis of …

Navigate: A Study Protocol For A Randomised Controlled Trial Of An Online Treatment Decision Aid For Men With Low-Risk Prostate Cancer And Their Partners, Penelope Schofield, Karla Gough, Amelia Hyatt, Alan White, Mark Frydenberg, Suzanne Chambers, Louisa G. Gordon, Robert Gardiner, Declan G. Murphy, Lawrence Cavdon, Natalie Richards, Barbara Murphy, Stephen Quinn, Ilona Juraskova

Research outputs 2014 to 2021

© 2021, The Author(s). Background: Active surveillance (AS) is the disease management option of choice for low-risk prostate cancer. Despite this, men with low-risk prostate cancer (LRPC) find management decisions distressing and confusing. We developed Navigate, an online decision aid to help men and their partners make management decisions consistent with their values. The aims are to evaluate the impact of Navigate on uptake of AS; decision-making preparedness; decisional conflict, regret and satisfaction; quality of illness communication; and prostate cancer-specific quality of life and anxiety. In addition, the healthcare cost impact, cost-effectiveness and patterns of use of Navigate will be …

Feasibility And Efficacy Of A Multicomponent Exercise Medicine Programme In Patients With Pancreatic Cancer Undergoing Neoadjuvant Therapy (The Expan Trial): Study Protocol Of A Dual-Centre, Two-Armed Phase I Randomised Controlled Trial, Hao Luo, Daniel A. Galvao, Robert U. Newton, Colin Tang, Andrew Dean, Kevin Jasas, Mikael Johansson, Ian Yusoff, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

Introduction Exercise is emerging as a therapy in oncology for its physical and psychosocial benefits and potential effects on chemotherapy tolerability and efficacy. However, evidence from randomised controlled trials (RCTs) supporting exercise in patients with borderline resectable or locally advanced pancreatic cancer (PanCa) undergoing neoadjuvant therapy (NAT) are lacking. Methods and analysis The EXPAN trial is a dual-centre, two-armed, phase I RCT. Forty patients with borderline resectable or locally advanced PanCa undergoing NAT will be randomised equally to an exercise intervention group (individualised exercise+standard NAT) or a usual care control group (standard NAT). The exercise intervention will be supervised and …

Breeching The System: An Exploration Of Women’S Experiences And Breech Care Recommendations, Sara Morris

Research outputs 2014 to 2021

Aim:

This presentation reports the findings of a mixed methods study exploring women’s experiences of breech birth in Western Australia (WA) and professional recommendations for breech care.

Methods:

This pragmatic study consisted of a clinical guideline review, semi-structured interviews with women who had experienced a breech birth in WA and a multi-national e-Delphi study involving professionals with knowledge and/or experience of caring for women with a breech presenting fetus. These methods were deemed the optimal way of incorporating current clinical practice guidelines, with multi-disciplinary recommendations and consumer feedback.

Findings:

The clinical guideline review revealed similarities in antenatal care structure and …

Profile Of Immunoglobulin G N-Glycome In Covid-19 Patients: A Case-Control Study, Haifeng Hou, Huan Yang, Pengcheng Liu, Changwu Huang, Meng Wang, Yuejin Li, Mingsong Zhu, Jing Wang, Yuan Xu, Youxin Wang, Qingwei Ma, Dong Li, Pu Liao, Wei Wang

Research outputs 2014 to 2021

Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in …

Are National Cancer Control Indicators For Patient Experiences Being Met In Regional And Remote Australia? A Cross-Sectional Study Of Cancer Survivors Who Travelled For Treatment, Jeff Dunn, Belinda Goodwin, Joanne F. Aitken, Sonja March, Fiona Crawford-Williams, Michael Ireland, Nicholas Ralph, Leah Zajdlewicz, Arlen Rowe, Suzanne K. Chambers

Research outputs 2014 to 2021

Objective: To examine the health services experience of patients with cancer from regional and remote Australia using the Australian National Cancer Control Indicators (NCCI) guidelines as an assessment framework. Design: Cross-sectional. Setting Queensland non-for-profit cancer accommodation lodges. Participants: Participants were patients with cancer who travelled for treatment from rural and remote Queensland to major urban centres (n=518; age mean=64.6, SD=11.18). Outcome measures: Assessments included NCCI patient indicators, quality of life (QoL), psychological distress and unmet supportive care needs. Results: The frequency at which NCCI indicators were met ranged from 37.5% for receiving an assessment and care plan to 97.3% for …

Correction To: Navigate: A Study Protocol For A Randomised Controlled Trial Of An Online Treatment Decision Aid For Men With Low-Risk Prostate Cancer And Their Partners, Penelope Schofield, Karla Gough, Amelia Hyatt, Alan White, Mark Frydenberg, Suzanne Chambers, Louisa G. Gordon, Robert Gardiner, Declan G. Murphy, Lawrence Cavedon, Natalie Richards, Barbara Murphy, Stephen Quinn, Ilona Juraskova

Research outputs 2014 to 2021

© 2021, The Author(s). Following publication of the original article [1], we were notified of a typo in the spelling of the 10th author name, originally spelt as “Cavdon” instead of “Cavedon” (i.e., missing “e”). The original article has been corrected.

Whole Fat Dairy Products Do Not Adversely Affect Adiposity Or Cardiometabolic Risk Factors Inchildren In The Milky Way Study: A Double Blind Randomized Controlled Pilot Study, Analise Nicholl, Kane Deering, Kate J. Evelegh, Philippa Lyons-Wall, David Lawrence, Trevor A. Mori, Mario Kratz, Therese O'Sullivan

Research outputs 2014 to 2021

Background

Limited evidence supports the common public health guideline that children > 2 y of age should consume dairy with reduced fat content.

Objectives

We aimed to investigate the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity and biomarkers of cardiometabolic risk in healthy 4- to 6-y-old children.

Methods

The Milky Way Study enrolled 49 children (mean ± SD age: 5.2 ± 0.9 y; 47% girls) who were habitual consumers of whole-fat dairy, then randomly assigned them in a double-blind fashion to remain on whole-fat dairy or switch their dairy consumption to reduced-fat products for 3 mo. …

Gut Microbiota Interplay With Covid-19 Reveals Links To Host Lipid Metabolism Among Middle Eastern Populations, Mohammad Tahseen Al Bataineh, Andreas Henschel, Mira Mousa, Marianne Daou, Fathimathuz Waasia, Hussein Kannout, Mariam Khalili, Mohd Azzam Kayasseh, Abdulmajeed Alkhajeh, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Samuel F. Feng, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership

Research outputs 2014 to 2021

The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10–6) and Bacteroides (p-value = 5.67 × 10–8). We also revealed a higher relative abundance of the highly …

The Supportive Care Needs Of Regional And Remote Cancer Caregivers, Anna Stiller, Belinda C. Goodwin, Fiona Crawford-Williams, Sonja March, Michael Ireland, Joanne F. Aitken, Jeff Dunn, Suzanne K. Chambers

Research outputs 2014 to 2021

Objective: As cancer survival rates continue to increase, so will the demand for care from family and friends, particularly in more isolated settings. This study aims to examine the needs of cancer caregivers in regional and remote Australia. Methods: A total of 239 informal (i.e., non-professional) cancer caregivers (e.g., family/friends) from regional and remote Queensland, Australia, completed the Comprehensive Needs Assessment Tool for Cancer Caregivers (CNAT-C). The frequencies of individuals reporting specific needs were calculated. Logistic regression analyses assessed the association between unmet needs and demographic characteristics and cancer type. Results: The most frequently endorsed needs were lodging near hospital …

Does Warfarin Or Rivaroxaban At Low Anticoagulation Intensity Provide A Survival Benefit To Asian Patients With Atrial Fibrillation?, Dong Lin, Yequn Chen, Jian Yong, Shiwan Wu, Yan Zhou, Weiping Li, Xuerui Tan, Ruisheng Liu

Research outputs 2014 to 2021

Background: Low-dose rivaroxaban and low-intensity warfarin are widely used in Asia for patients with atrial fibrillation (AF). However, in Asians, it is unclear whether low-dose rivaroxaban and low-intensity warfarin can improve the prognosis of AF. In this study, we investigate the survival benefits of low-dose rivaroxaban and low-intensity warfarin in Asian patients with AF in clinical practice. Methods: This cohort study used medical records in a single tertiary hospital in China, between 2019 and 2020, to identify patients with AF who used rivaroxaban or warfarin, or had no anticoagulant therapy. Follow-ups were performed through telephone contact or medical record review. …