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Full-Text Articles in Medicine and Health Sciences

Day Occupation Is Associated With Psychopathology For Adolescents And Young Adults With Down Syndrome, Kitty-Rose R. Foley, Peter Jacoby, Stewart Einfeld, Sonya Girdler, Jenny Bourke, Vivienne Riches, Helen Leonard Jan 2014

Day Occupation Is Associated With Psychopathology For Adolescents And Young Adults With Down Syndrome, Kitty-Rose R. Foley, Peter Jacoby, Stewart Einfeld, Sonya Girdler, Jenny Bourke, Vivienne Riches, Helen Leonard

Research outputs 2014 to 2021

Background: Young adults with Down syndrome experience increased rates of emotional and behavioural problems compared with the general population. Most adolescents with Down syndrome living in Western Australia participate in sheltered employment as their main day occupation. Relationship between day occupation and changes in behaviour has not been examined. Therefore, the aim of this research was to explore any relationship between post school day occupations and changes in the young person's behaviour.Methods: The Down syndrome Needs Opinion Wishes database was used for case ascertainment of young adults aged 15 to 32 years with Down syndrome. Families of 118 young people …


Effect Of Bdnf Val66met On Memory Decline And Hippocampal Atrophy In Prodromal Alzheimer's Disease: A Preliminary Study, Yen Y. Lim, Victor L. Villemagne, Simon M. Laws, David Ames, Robert H. Pietrzak, Kathryn A. Ellis, Karra Harrington, Pierrick Bourgeat, Ashley I. Bush, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff Jan 2014

Effect Of Bdnf Val66met On Memory Decline And Hippocampal Atrophy In Prodromal Alzheimer's Disease: A Preliminary Study, Yen Y. Lim, Victor L. Villemagne, Simon M. Laws, David Ames, Robert H. Pietrzak, Kathryn A. Ellis, Karra Harrington, Pierrick Bourgeat, Ashley I. Bush, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff

Research outputs 2014 to 2021

Objective: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ. Methods: Thirty-four adults with aMCI were recruited from the Australian, Imaging, Biomarkers and Lifestyle (AIBL) Study. Participants underwent PiB-PET and structural MRI neuroimaging, neuropsychological assessments and BDNF genotyping at baseline, 18 month, …


Psychophysiological Research Of Borderline Personality Disorder: Review And Implications For Biosocial Theory, Tara Cavazzi, Rodrigo Becerra Jan 2014

Psychophysiological Research Of Borderline Personality Disorder: Review And Implications For Biosocial Theory, Tara Cavazzi, Rodrigo Becerra

Research outputs 2014 to 2021

According to the Biosocial theory, Borderline Personality Disorder (BPD) is developed by a biological predisposition to hyperarousal and hyperreactivity combined with an invalidating environment. Although widely supported by subjective measures, the impaired insight present in BPD may skew results, and thus psychophysiological measures have been suggested as an alternative method of examining possible biological differences in BPD. The current review aimed to critically assess psychophysiological research of BPD by electronic searching of relevant databases, with 22 articles meeting inclusion criteria. Results showed that in contrast to the hyperarousal proposed in the Biosocial theory, BPD was associated with hypoarousal and hyporeactivity …


Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies, Prue Cormie, Suzanne K. Chambers, Robert U. Newton, Robert A. Gardiner, Nigel Spry, Dennis R. Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A. Galvão Jan 2014

Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies, Prue Cormie, Suzanne K. Chambers, Robert U. Newton, Robert A. Gardiner, Nigel Spry, Dennis R. Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A. Galvão

Research outputs 2014 to 2021

Background: Despite being a critical survivorship care issue, there is a clear gap in current knowledge of the optimal treatment of sexual dysfunction in men with prostate cancer. There is sound theoretical rationale and emerging evidence that exercise may be an innovative therapy to counteract sexual dysfunction in men with prostate cancer. Furthermore, despite the multidimensional aetiology of sexual dysfunction, there is a paucity of research investigating the efficacy of integrated treatment models. Therefore, the purpose of this study is to: 1) examine the efficacy of exercise as a therapy to aid in the management of sexual dysfunction in men …


Muscle Damage After A Tennis Match In Young Players, Rodrigo Vitasovic Gomes, Ricardo Santos, Ken Nosaka, Alexandre Moreira, Elen Miyabara, Marcelo Saldanha Aoki Jan 2014

Muscle Damage After A Tennis Match In Young Players, Rodrigo Vitasovic Gomes, Ricardo Santos, Ken Nosaka, Alexandre Moreira, Elen Miyabara, Marcelo Saldanha Aoki

Research outputs 2014 to 2021

The present study investigated changes in indirect markers of muscle damage following a simulated tennis match play using nationally ranked young (17.6 ± 1.4 years) male tennis players. Ten young athletes played a 3-hour simulated match play on outdoor red clay courts following the International Tennis Federation rules. Muscle soreness, plasma creatine kinase activity (CK), serum myoglobin concentration (Mb), one repetition maximum (1RM) squat strength, and squat jump (SJ) and counter movement jump (CMJ) heights were assessed before, immediately after, and 24 and 48 h after the simulated match play. All parameters were also evaluated in a non-exercised group (control …


A Dynamic Evaluation Of How Kick Point Location Influences Swing Parameters And Related Launch Conditions, Christopher Joyce, Angus Burnett, Alvaro Reyes, Stephen Herbert Jan 2014

A Dynamic Evaluation Of How Kick Point Location Influences Swing Parameters And Related Launch Conditions, Christopher Joyce, Angus Burnett, Alvaro Reyes, Stephen Herbert

Research outputs 2014 to 2021

In golf, many parameters of the driver can be modified to maximise hitting distance. The main objective of this study was to determine whether drivers fitted with shafts having high and low kick points would alter selected swing parameters and related launch conditions. In total, 12 elite male golfers (handicap score = 1.2 ± 1.8) had three shots analysed for two drivers fitted with 'stiff' shafts with differing kick point location. Stiffness profiles of these shafts were also measured. Five swing and related launch parameters were measured using a real-time launch monitor. The locations of the low and high kick …


The Use Of Unregulated Staff: Time For Regulation?, Christine M. Duffield, Di E. Twigg, Judith D. Pugh, Gemma Evans, S Dimitrelis, Michael A. Roche Jan 2014

The Use Of Unregulated Staff: Time For Regulation?, Christine M. Duffield, Di E. Twigg, Judith D. Pugh, Gemma Evans, S Dimitrelis, Michael A. Roche

Research outputs 2014 to 2021

Internationally, shortages in the nursing workforce, escalating patient demands, and financial constraints within the health system have led to the growth of unlicensed nursing support workers. Recently, in relation to the largest publicly funded health system (National Health Service), it was reported that extensive substitution of registered nurses with unskilled nursing support workers resulted in inadequate patient care, increased morbidity and mortality rates, and negative nurse outcomes. We argue that it is timely to consider regulation of nursing support workers with their role and scope of practice clearly defined. Further, the addition of these workers in a complementary model of …


The Global Obesity Epidemic Is Related To Stroke, Dementia And Alzheimer's Disease, Ian J. Martins Jan 2014

The Global Obesity Epidemic Is Related To Stroke, Dementia And Alzheimer's Disease, Ian J. Martins

Research outputs 2014 to 2021

The global epidemic in obesity and diabetes has affected individuals in both the developing and developed world with the global death rate (63%) related to chronic diseases with 35% attributed to cardiovascular disease and stroke, 21 % to cancer and 12 % to chronic respiratory disease. The interest in connections between the global stroke epidemic, dementia and Alzheimer’s disease (AD) has increased with hypertension, smoking, diabetes, obesity, poor diet, physical inactivity, atrial fibrillation, excessive alcohol consumption, abnormal lipid profile and psychosocial stress/depression implicated in their pathogenesis. The connection between stroke and AD is possibly related to the low adiponectin and …


Toward An Ethics Of Reciprocity: Ethnobotanical Knowledge And Medicinal Plants As Cancer Therapies, John C. Ryan Jan 2014

Toward An Ethics Of Reciprocity: Ethnobotanical Knowledge And Medicinal Plants As Cancer Therapies, John C. Ryan

Research outputs 2014 to 2021

This article develops a reciprocity ethics of the environment through a discussion of ethnobotanical medicines used in the treatment of cancer. The moral virtue of reciprocity, defined as the returning of good when good is received or anticipated, is central to the posthumanist rethinking of human relationships to the plant world. As herbal medicines are used progressively more around the globe and as plant diversity decreases as a result of habitat loss and climate change, an ethics of reciprocity should be a concern for environmental philosophers and conservationists. Aldo Leopold’s land ethic and J. Baird Callicott’s distinction between deontological and …


The Effect Of Double-Blind Carbohydrate Ingestion During 60 Km Of Self-Paced Exercise In Warm Ambient Conditions, Camila Nassif, Aline R. Gomes, Gustavo H.C. Peixoto, Mauro H. Chagas, Danusa D. Soares, Emerson Silami-Garcia, Eric J. Drinkwater, Jack Cannon, Frank E. Marino Jan 2014

The Effect Of Double-Blind Carbohydrate Ingestion During 60 Km Of Self-Paced Exercise In Warm Ambient Conditions, Camila Nassif, Aline R. Gomes, Gustavo H.C. Peixoto, Mauro H. Chagas, Danusa D. Soares, Emerson Silami-Garcia, Eric J. Drinkwater, Jack Cannon, Frank E. Marino

Research outputs 2014 to 2021

This study evaluated double blind ingestions of placebo (PLA) versus 6% carbohydrate (CHO) either as capsules (c) or beverage (b) during 60 km self-paced cycling in the heat (32C and 50% relative humidity).


High Fibre Diets And Alzheimer's Disease, Ian J. Martins, Warnakulasuriya M. Fernando Jan 2014

High Fibre Diets And Alzheimer's Disease, Ian J. Martins, Warnakulasuriya M. Fernando

Research outputs 2014 to 2021

The convergence of diet and AD may be related to the effects of phytosterols since plasma cholesterol is closely linked and regulated by phytosterols. Dietary fibre modifications that are low in fat and glucose reduce the risk for AD by not only effecting cell membranes and nutrient sensing G coupled receptors but also by regulating number of nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis. The peripheral sink Aβ hypothesis indicates that the peripheral clearance of Aβ …


Links Between Insulin Resistance, Lipoprotein Metabolism And Amyloidosis In Alzheimer's Disease, Ian J. Martins, Rhona Creegan Jan 2014

Links Between Insulin Resistance, Lipoprotein Metabolism And Amyloidosis In Alzheimer's Disease, Ian J. Martins, Rhona Creegan

Research outputs 2014 to 2021

The origins of premature brain aging and chronic disease progression are associated with atherogenic diets and sedentary lifestyles in Western communities. Interests in brain aging that involves non alcoholic fatty liver disease (NAFLD), the global stroke epidemic and neurodegeneration have become the focus of nutritional research. Atherogenic diets have been linked to plasma ceramide dysregulation and insulin resistance actively promoting chronic diseases and neurodegeneration in developed countries. Abnormal lipid signaling as observed in chronic diseases such as hypothyroidism, obesity and diabetes is connected to stroke and neurodegenerative diseases in man. Lipids that are involved in calcium and amyloid betahomeostasis are …


Traditional Chinese Medicine And New Concepts Of Predictive, Preventive And Personalized Medicine In Diagnosis And Treatment Of Suboptimal Health, Wei Wang, Alyce C. Russell, Yuxiang Yan Jan 2014

Traditional Chinese Medicine And New Concepts Of Predictive, Preventive And Personalized Medicine In Diagnosis And Treatment Of Suboptimal Health, Wei Wang, Alyce C. Russell, Yuxiang Yan

Research outputs 2014 to 2021

The premise of disease-related phenotypes is the definition of the counterpart normality in medical sciences. Contrary to clinical practices that can be carefully planned according to clinical needs, heterogeneity and uncontrollability is the essence of humans in carrying out health studies. Full characterization of consistent phenotypes that define the general population is the basis to individual difference normalization in personalized medicine. Self-claimed normal status may not represent health because asymptomatic subjects may carry chronic diseases at their early stage, such as cancer, diabetes mellitus and atherosclerosis. Currently, treatments for non-communicable chronic diseases (NCD) are implemented after disease onset, which is …


Changing Places: The Need To Alter The Start Point For Information Security Design, Elizabeth Coles-Kemp, Patricia A. Williams Jan 2014

Changing Places: The Need To Alter The Start Point For Information Security Design, Elizabeth Coles-Kemp, Patricia A. Williams

Research outputs 2014 to 2021

Information security is a necessary requirement of information sharing within an electronic health system because without it confidentiality, availability, or integrity controls are absent. Research shows that the application of security in this setting is subject to workarounds partly because of resistance to security controls from clinicians who feel that their voice is excluded from the security design process. Heeks' explored the nature of health system design and referred to the distance between system designer and practitioner as the 'design-reality gap'. To reduce this gap, systems designers typically deploy usercentred, participatory approaches to design. They use various forms of consultation …


Parental Experiences Of Early Pulmonary Surveillance For Children With Cystic Fibrosis: A Research Proposal For Improved Family Psychosocial Outcomes, Cindy A. Branch-Smith, Tonia Douglas, Linda Shields, Stephen Stick, John Massie, Julie Ann Pooley Jan 2014

Parental Experiences Of Early Pulmonary Surveillance For Children With Cystic Fibrosis: A Research Proposal For Improved Family Psychosocial Outcomes, Cindy A. Branch-Smith, Tonia Douglas, Linda Shields, Stephen Stick, John Massie, Julie Ann Pooley

Research outputs 2014 to 2021

The Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF) conducts an early surveillance program (ESP) for children with cystic fibrosis (CF). The program has the potential to modify long term health outcomes for children through early detection of lung disease, long before signs and symptoms are apparent. The program is aimed specifically at infants and preschool children (~3 months to 6 years) who undergo annual, detailed and relatively invasive surveillance. Although the ESP has been operating for 10 years, how parents experience their child undergoing early surveillance of this nature, and the psychosocial factors that moderate these experiences, is …


Moderation Of Assessments In A School Of Nursing And Midwifery; Enhancing Student Assessment Experiences, Lesley J. Andrew, Beverley A. Ewens, Rowena H. Scott Jan 2014

Moderation Of Assessments In A School Of Nursing And Midwifery; Enhancing Student Assessment Experiences, Lesley J. Andrew, Beverley A. Ewens, Rowena H. Scott

Research outputs 2014 to 2021

This paper details a quality improvement initiative undertaken in 2013 within a School of Nursing and Midwifery, in Western Australia. The objective of the initiative was to support and enhance commencing student assessment experiences thorough the development of an evidence based, standardised assessment of moderation process.


Serum Concentrations Of The Biomarkers Ca125, Ca15-3, Ca72-4, Tpsa And Papp-A In Natural And Stimulated Ovarian Cycles, Melissa J. Stemp, Peter Roberts, Allison Mcclements, Vincent Chapple, Jay Natalwala, Michael L. Black, Phillip L. Matson Jan 2014

Serum Concentrations Of The Biomarkers Ca125, Ca15-3, Ca72-4, Tpsa And Papp-A In Natural And Stimulated Ovarian Cycles, Melissa J. Stemp, Peter Roberts, Allison Mcclements, Vincent Chapple, Jay Natalwala, Michael L. Black, Phillip L. Matson

Research outputs 2014 to 2021

Objective: Biomarkers associated with cancer screening (CA125, CA15-3, CA72-4, total prostate specific antigen [tPSA]) and the monitoring of pregnancy (pregnancy associated plasma protein-A [PAPP-A]) were measured during natural and stimulated ovarian cycles in disease-free non-pregnant women to determine if they could reflect normal events relating to ovulation and/or endometrial changes. Methods: A total of 73 blood samples (10 women) collected throughout the natural menstrual cycle, and 64 blood samples (11 women) taken during stimulated ovarian cycles, were analysed on the Roche Cobas e411 automated analyser. Results: Detectable levels of tPSA were measured in at least one point in the cycle …


En Attendant Centiloid, Victor L. Villemagne, Vincent Doré, Paul Yates, Belinda Brown, Rachel Mulligan, Pierrick Bourgeat, Robyn Veljanoski, Stephanie R. Rainey-Smith, Kevin Ong, Alan Rembach, Robert Williams, Samantha C. Burnham, Simon Laws, Olivier Salvado, Kevin Taddei, S. L. Macaulay, Ralph Martins, David Ames, Colin L. Masters, Christopher C. Rowe Jan 2014

En Attendant Centiloid, Victor L. Villemagne, Vincent Doré, Paul Yates, Belinda Brown, Rachel Mulligan, Pierrick Bourgeat, Robyn Veljanoski, Stephanie R. Rainey-Smith, Kevin Ong, Alan Rembach, Robert Williams, Samantha C. Burnham, Simon Laws, Olivier Salvado, Kevin Taddei, S. L. Macaulay, Ralph Martins, David Ames, Colin L. Masters, Christopher C. Rowe

Research outputs 2014 to 2021

Aims: Test the robustness of a linear regression transformation of semiquantitative values from different Aβ tracers into a single continuous scale. Study Design: Retrospective analysis. Place and Duration of Study: PET imaging data acquired in Melbourne and Perth, Australia, between August 2006 and May 2014. Methodology: Aβ imaging in 633 participants was performed with four different radiotracers: flutemetamol (n=267), florbetapir (n=195), florbetaben (n=126) and NAV4694 (n=45). SUVR were generated with the methods recommended for each tracer, and classified as high (Aβ+) or low (Aβ-) based on their respective thresholds. Linear regression transformation based on reported head-to-head comparisons of each tracer …


Shades Of Grey: The Need For A Multi-Disciplinary Approach To Research Investigating Alcohol And Ageing, Celia Wilkinson, Julie Dare Jan 2014

Shades Of Grey: The Need For A Multi-Disciplinary Approach To Research Investigating Alcohol And Ageing, Celia Wilkinson, Julie Dare

Research outputs 2014 to 2021

This paper calls for an increase in multi-disciplinary research on the issue of alcohol and ageing, to ensure public health interventions reflect the complex and diverse needs of older drinkers. Older people (65+ years) represent a unique segment of the population; compared to adolescents and younger people, they are more likely to have a range of co-morbid conditions and be taking prescribed medication, and are more physiologically vulnerable to the effects of alcohol. This suggests that from a public health perspective, alcohol use by older people is problematic. However, as with younger people, alcohol use is closely associated with socialisation …


Social Engagement, Setting And Alcohol Use Among A Sample Of Older Australians, Julie Dare, Celia Wilkinson, Steve Allsop, Stacey Waters, Sheila Mchale Jan 2014

Social Engagement, Setting And Alcohol Use Among A Sample Of Older Australians, Julie Dare, Celia Wilkinson, Steve Allsop, Stacey Waters, Sheila Mchale

Research outputs 2014 to 2021

The harms associated with risky alcohol consumption have long been researched and recognised in the health field. However, little available research has focused on older people, or extended analysis of alcohol use by this segment of the population beyond a bio-medical perspective. With the rapid ageing of the global population, research that investigates alcohol use amongst older people from a social perspective is important. This article reports on research with a group of older women and men, to identify and explain factors that influence alcohol consumption. In-depth interviews were conducted in Perth, Western Australia with 20 men and 22 women …


Carer Experiences With Rehabilitation In The Home: Speech Pathology Services For Stroke Survivors, Katy Stewart, Natalie Ciccone, Elizabeth Armstrong Jan 2014

Carer Experiences With Rehabilitation In The Home: Speech Pathology Services For Stroke Survivors, Katy Stewart, Natalie Ciccone, Elizabeth Armstrong

Research outputs 2014 to 2021

Caring for a stroke survivor can be a complex role with carers at an increased risk of mental health difficulties. Early supported discharge from hospital with rehabilitation in the home (RITH) allows stroke survivors to return home at an earlier stage in the recovery process, potentially placing an extra burden on carers. Being involved in intensive therapy,in the home, in the early days post-stroke may be difficult with the role and experiences of carers in RITH being underresearched. This paper identifies the roles, experiences and preferences of ten carers of stroke survivors with dysarthia and dysphagia. Many carers were involved …


Improving Health Professional's Knowledge Of Hepatitis B Using Cartoon Based Learning Tools: A Retrospective Analysis Of Pre And Post Tests, Moira G. Sim, Ashleigh C. Mcevoy, Toni D. Wain Ms, Eric L. Khong Jan 2014

Improving Health Professional's Knowledge Of Hepatitis B Using Cartoon Based Learning Tools: A Retrospective Analysis Of Pre And Post Tests, Moira G. Sim, Ashleigh C. Mcevoy, Toni D. Wain Ms, Eric L. Khong

Research outputs 2014 to 2021

Background: Hepatitis B serology is complex and a lack of knowledge in interpretation contributes to the inadequate levels of screening and referral for highly effective hepatitis antiviral treatments. This knowledge gap needs to be addressed so that current and future healthcare professionals are more confident in the detection and assessment of hepatitis B to improve the uptake of treatment and reduce long-term complications from the disease. Cartoons have been used effectively as a teaching tool in other settings and were considered as a potentially useful teaching aid in explaining hepatitis B serology. This study examines the impact of cartoons in …


Factors That Contribute To Balance And Mobility Impairments In Individuals With Huntington's Disease, Travis Cruickshank, Alvaro Reyes, Luis Peñailillo, Jennifer Thompson, Mel Ziman Jan 2014

Factors That Contribute To Balance And Mobility Impairments In Individuals With Huntington's Disease, Travis Cruickshank, Alvaro Reyes, Luis Peñailillo, Jennifer Thompson, Mel Ziman

Research outputs 2014 to 2021

Mobility and balance problems are common and often debilitating features of Huntington's disease (HD). In this exploratory study we aimed to investigate the influence of disease severity, severity of motor deficits, lower limb muscle strength, cognition, executive function, lean muscle mass and reactivity on mobility and balance.Twenty-two individuals with HD were recruited from the North Metropolitan Area Mental Health Service, Perth, Australia. Pertinent demographic, genetic and disease progression information was recorded prior to testing. Balance was assessed using dynamic and static balance tasks. Mobility was assessed using self-paced and fast-paced mobility measures. Cognitive and executive measures were used to assess …


Do Dance Floor Force Reduction And Static Stiffness Represent Dynamic Floor Stiffness During Dance Landings?, Luke S. Hopper, Jacqueline A. Alderson, Bruce C. Elliott, Timothy R. Ackland, Paul R. Fleming Jan 2014

Do Dance Floor Force Reduction And Static Stiffness Represent Dynamic Floor Stiffness During Dance Landings?, Luke S. Hopper, Jacqueline A. Alderson, Bruce C. Elliott, Timothy R. Ackland, Paul R. Fleming

Research outputs 2014 to 2021

Dance training on floors that are not 'sprung' are assumed to have direct implications for injury. Standards for dance floor manufacture in Europe and North America quantify floor force reduction by measuring the impact forces of drop masses. In addition, many studies of human mechanical adaptations to varied surfaces, have quantified test surfaces using measures of static stiffness. It is unclear whether these methods for the measurement of floor mechanical properties actually reflect dancer requirements or floor behaviour under dancer loading. The aim of this study was to compare the force reduction, static stiffness and dynamic stiffness of a range …


Positive Correlation Between The Expression Of Heag1 And Hif-1Α In Breast Cancers: An Observational Study, Qingxuan Lai, Ting Wang, Qingqing Guo, Yuxiang Zhang, Youxin Wang, Li Yuan, Rui Ling, Yan He, Wei Wang Jan 2014

Positive Correlation Between The Expression Of Heag1 And Hif-1Α In Breast Cancers: An Observational Study, Qingxuan Lai, Ting Wang, Qingqing Guo, Yuxiang Zhang, Youxin Wang, Li Yuan, Rui Ling, Yan He, Wei Wang

Research outputs 2014 to 2021

Objectives: To explore the expression patterns of Eag1 (ether á go-go 1) and HIF-1α (hypoxia-inducible factor 1α) in a cohort of patients with breast cancer. Setting: Department of general surgery in an upper first-class hospital in Xi'an, China. Participants: A total of 112 female Han Chinese patients with a diagnosis of invasive ductal carcinoma were included. Patients with main internal diseases, such as cardiovascular, endocrine, gastroenterological, haematological, infectious diseases, etc, were excluded. Primary and secondary outcome measures: Expression profiles of Eag1 and HIF-1α. Results: Eag1 and HIF-1α were overexpressed in the tumour tissues compared with the pair-matched control tissues, p=0.002 …


Development Of A Medical Academic Degree System In China, Lijuan Wu, Youxin Wang, Xiaoxia Peng, Manshu Song, Xiuhua Guo, Hugh Nelson, Wei Wang Jan 2014

Development Of A Medical Academic Degree System In China, Lijuan Wu, Youxin Wang, Xiaoxia Peng, Manshu Song, Xiuhua Guo, Hugh Nelson, Wei Wang

Research outputs 2014 to 2021

Context: The Chinese government launched a comprehensive healthcare reform to tackle challenges to health equities. Medical education will become the key for successful healthcare reform. Purpose:We describe the current status of the Chinese medical degree system and its evolution over the last 80 years. Content: Progress has been uneven, historically punctuated most dramatically by the Cultural Revolution. There is a great regional disparity. Doctors with limited tertiary education may be licensed to practice, whereas medical graduates with advanced doctorates may have limited clinical skills. There are undefined relationships between competing tertiary training streams, the academic professional degree, and the clinical …


A Quantitative Analysis Of The Mass Media Coverage Of Genomics Medicine In China: A Call For Science Journalism In The Developing World, Feifei Zhao, Yan Chen, Siqi Ge, Xinwei Yu, Shuang Shao, Michael Black, Youxin Wang, Jie Zhang, Manshu Song, Wei Wang Jan 2014

A Quantitative Analysis Of The Mass Media Coverage Of Genomics Medicine In China: A Call For Science Journalism In The Developing World, Feifei Zhao, Yan Chen, Siqi Ge, Xinwei Yu, Shuang Shao, Michael Black, Youxin Wang, Jie Zhang, Manshu Song, Wei Wang

Research outputs 2014 to 2021

Science journalism is a previously neglected but rapidly growing area of scholarship in postgenomics medicine and socio-technical studies of knowledge-based innovations. Science journalism can help evaluate the quantity and quality of information flux between traditional scientific expert communities and the broader public, for example, in personalized medicine education. Newspapers can play a crucial role in science and health communication, and more importantly, in framing public engagement. However, research on the role of newspaper coverage of genomics-related articles has not been readily available in resource-limited settings. As genomics is rapidly expanding worldwide, this gap in newspaper reportage in China is therefore …


Risk Factors For Cerebrovascular Disease Mortality Among The Elderly In Beijing: A Competing Risk Analysis, Zhe Tang, Tao Zhou, Yanxia Luo, Changchun Xie, Da Huo, Lixin Tao, Lei Pan, Fei Sun, Huiping Zhu, Xinghua Yang, Wei Wang, Aoshuang Yan, Xia Li, Xiuhua Guo Jan 2014

Risk Factors For Cerebrovascular Disease Mortality Among The Elderly In Beijing: A Competing Risk Analysis, Zhe Tang, Tao Zhou, Yanxia Luo, Changchun Xie, Da Huo, Lixin Tao, Lei Pan, Fei Sun, Huiping Zhu, Xinghua Yang, Wei Wang, Aoshuang Yan, Xia Li, Xiuhua Guo

Research outputs 2014 to 2021

Objective: To examine the associations of combined lifestyle factors and physical conditions with cerebrovascular diseases (CBVD) mortality, after accounting for competing risk events, including death from cardiovascular diseases, cancers and other diseases. Methods: Data on 2010 subjects aged over 55 years were finally analyzed using competing risk models. All the subjects were interviewed by the Beijing Longitudinal Study of Aging (BLSA), in China, between 1 January 1992 and 30 August 2009. Results: Elderly females were at a lower risk of death from CBVD than elderly males (HR = 0.639, 95% CI = 0.457-0.895). Increasing age (HR = 1.543, 95% CI …


Pgc-1Α Mediated Muscle Aerobic Adaptations To Exercise, Heat And Cold Exposure, Mohammed Ihsan, Greig Watson, Chris R. Abbiss Jan 2014

Pgc-1Α Mediated Muscle Aerobic Adaptations To Exercise, Heat And Cold Exposure, Mohammed Ihsan, Greig Watson, Chris R. Abbiss

Research outputs 2014 to 2021

PGC-1α is regarded as a key regulator of mitochondrial biogenesis due to its central role in regulating the activity of key transcription factors associated with encoding mitochondrial components. Additionally, PGC-1α has shown to mediate adaptations that increase fat metabolism and angiogenesis, contributing to the overall oxidative phenotype of the muscle. While it is well established that exercise is a potent stimulator of PGC-1α, recent evidence indicates that heat and cold exposures may also influence mitochondrial biogenesis through the up-regulation of PGC-1α. This highlights the potential use of these modalities in conjunction with exercise to enhance training adaptations. As such, the …


Plain Language Review Of Physical Activity Among Indigenous Australians, Caitlin Gray Jan 2013

Plain Language Review Of Physical Activity Among Indigenous Australians, Caitlin Gray

Research outputs 2014 to 2021

This review provides information on physical activity among Aboriginal and Torres Strait Islander people. It is a valuable overview for people working in the area and aims to assists in the development/refinement of policies, strategies and programs. This review of physical activity among Aboriginal and Torres Strait Islander Australians has been prepared by the Australian Indigenous HealthInfoNet as a part of our contributions to 'closing the gap' in health between Aboriginal and Torres Strait Islander people and other Australians by making relevant, high quality knowledge and information easily accessible to policy makers, health service providers, program managers, clinicians, researchers …